SP1 Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description Sp1 transcription factor|The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014] (NCBI Entrez Gene Database, 6667)
External Link http://www.ncbi.nlm.nih.gov/gene/6667
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188 interacting proteins for hub protein SP1 from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
AATF apoptosis antagonizing transcription factor
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AHR aryl hydrocarbon receptor
AR androgen receptor
ARHGAP21 Rho GTPase activating protein 21
ARNT aryl hydrocarbon receptor nuclear translocator
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila)
ATF7IP activating transcription factor 7 interacting protein
ATF7IP2 activating transcription factor 7 interacting protein 2
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL6 B-cell CLL/lymphoma 6
BCOR BCL6 corepressor
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
C3ORF17 chromosome 3 open reading frame 17
CABP1 calcium binding protein 1
CASP3 caspase 3, apoptosis-related cysteine peptidase
CBX5 chromobox homolog 5
CCNA1 cyclin A1
CCNA2 cyclin A2
CCND1 cyclin D1
CD2 CD2 molecule
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHD3 chromodomain helicase DNA binding protein 3
CREBBP CREB binding protein
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRX cone-rod homeobox
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTBP1 C-terminal binding protein 1
CTCFL CCCTC-binding factor (zinc finger protein)-like
DCAF6 DDB1 and CUL4 associated factor 6
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DMPK dystrophia myotonica-protein kinase
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DROSHA drosha, ribonuclease type III
E2F1 E2F transcription factor 1
E2F2 E2F transcription factor 2
E2F3 E2F transcription factor 3
EGR1 early growth response 1
ELF1 E74-like factor 1 (ets domain transcription factor)
EP300 E1A binding protein p300
EPAS1 endothelial PAS domain protein 1
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
ESRRA estrogen-related receptor alpha
ESRRB estrogen-related receptor beta
ESRRG estrogen-related receptor gamma
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EXOSC10 exosome component 10
FYN FYN proto-oncogene, Src family tyrosine kinase
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GATA1 GATA binding protein 1 (globin transcription factor 1)
GATA3 GATA binding protein 3
GATA4 GATA binding protein 4
GATA6 GATA binding protein 6
GRB2 growth factor receptor-bound protein 2
GTF2B general transcription factor IIB
HBZ hemoglobin, zeta
HCFC1 host cell factor C1
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC3 histone deacetylase 3
HDAC4 histone deacetylase 4
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGA1 high mobility group AT-hook 1
HNF4A hepatocyte nuclear factor 4, alpha
HOXC11 homeobox C11
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA8 heat shock 70kDa protein 8
HTT huntingtin
JUN jun proto-oncogene
KIF1A kinesin family member 1A
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
LDB1 LIM domain binding 1
LMO2 LIM domain only 2 (rhombotin-like 1)
MAN1A2 mannosidase, alpha, class 1A, member 2
MAPK1 mitogen-activated protein kinase 1
MAPK11 mitogen-activated protein kinase 11
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MECP2 methyl CpG binding protein 2
MEF2C myocyte enhancer factor 2C
MEF2D myocyte enhancer factor 2D
MIER1 mesoderm induction early response 1, transcriptional regulator
MIS18BP1 MIS18 binding protein 1
MSX1 msh homeobox 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYOD1 myogenic differentiation 1
MYOG myogenin (myogenic factor 4)
NANOG Nanog homeobox
NAP1L1 nucleosome assembly protein 1-like 1
NCK1 NCK adaptor protein 1
NCL nucleolin
NCOR1 nuclear receptor corepressor 1
NCOR2 nuclear receptor corepressor 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFYA nuclear transcription factor Y, alpha
NFYB nuclear transcription factor Y, beta
NFYC nuclear transcription factor Y, gamma
NOS3 nitric oxide synthase 3 (endothelial cell)
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR5A1 nuclear receptor subfamily 5, group A, member 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OSBP oxysterol binding protein
PARP1 poly (ADP-ribose) polymerase 1
PER3 period circadian clock 3
PFDN5 prefoldin subunit 5
PGR progesterone receptor
PHC2 polyhomeotic homolog 2 (Drosophila)
PML promyelocytic leukemia
POGZ pogo transposable element with ZNF domain
POU2F1 POU class 2 homeobox 1
POU5F1 POU class 5 homeobox 1
PPARG peroxisome proliferator-activated receptor gamma
PPIG peptidylprolyl isomerase G (cyclophilin G)
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PRKCZ protein kinase C, zeta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSIP1 PC4 and SFRS1 interacting protein 1
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PURA purine-rich element binding protein A
RAD51 RAD51 recombinase
RARA retinoic acid receptor, alpha
RB1 retinoblastoma 1
RBBP4 retinoblastoma binding protein 4
RBL1 retinoblastoma-like 1
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REST RE1-silencing transcription factor
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF4 ring finger protein 4
RUNX1 runt-related transcription factor 1
RXRA retinoid X receptor, alpha
S1PR1 sphingosine-1-phosphate receptor 1
SENP6 SUMO1/sentrin specific peptidase 6
SF3A1 splicing factor 3a, subunit 1, 120kDa
SFPQ splicing factor proline/glutamine-rich
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIN3A SIN3 transcription regulator family member A
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
SOX10 SRY (sex determining region Y)-box 10
SOX8 SRY (sex determining region Y)-box 8
SP1 Sp1 transcription factor
SP3 Sp3 transcription factor
SP4 Sp4 transcription factor
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
SRF serum response factor (c-fos serum response element-binding transcription factor)
SRY sex determining region Y
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SUB1 SUB1 homolog (S. cerevisiae)
SUMO1 small ubiquitin-like modifier 1
SYK spleen tyrosine kinase
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
TAL1 T-cell acute lymphocytic leukemia 1
TBP TATA box binding protein
TBX21 T-box 21
TERT telomerase reverse transcriptase
TLX3 T-cell leukemia homeobox 3
TP53 tumor protein p53
TPI1 triosephosphate isomerase 1
UBC ubiquitin C
USP39 ubiquitin specific peptidase 39
UTRN utrophin
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
YY1 YY1 transcription factor
ZBTB16 zinc finger and BTB domain containing 16
ZBTB7A zinc finger and BTB domain containing 7A
ZBTB7B zinc finger and BTB domain containing 7B