SPARC Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description secreted protein, acidic, cysteine-rich (osteonectin)|This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. [provided by RefSeq, Dec 2011] (NCBI Entrez Gene Database, 6678)
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Genes

302 genes differentially expressed following the SPARC gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CSTA cystatin A (stefin A) 3.48658
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 3.48658
CCER2 coiled-coil glutamate-rich protein 2 3.48658
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 3.48658
C5AR2 complement component 5a receptor 2 3.48658
NYX nyctalopin 3.48658
PRRX1 paired related homeobox 1 3.48658
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 3.48658
PARP10 poly (ADP-ribose) polymerase family, member 10 3.48658
CCL5 chemokine (C-C motif) ligand 5 3.48658
ADM5 adrenomedullin 5 (putative) 3.48658
HAO2 hydroxyacid oxidase 2 (long chain) 3.48658
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 3.48658
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 3.48658
TMEM236 transmembrane protein 236 3.48658
UNC13C unc-13 homolog C (C. elegans) 3.48658
SLC39A5 solute carrier family 39 (zinc transporter), member 5 3.48658
USP26 ubiquitin specific peptidase 26 3.48658
TTC24 tetratricopeptide repeat domain 24 3.48658
ZNF436 zinc finger protein 436 3.48658
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 3.48658
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 3.43192
SLC30A4 solute carrier family 30 (zinc transporter), member 4 3.43192
CD160 CD160 molecule 3.43192
ZNF662 zinc finger protein 662 3.43192
TCHH trichohyalin 3.43192
SLC26A1 solute carrier family 26 (anion exchanger), member 1 3.43192
C21ORF140 chromosome 21 open reading frame 140 3.43192
AADACL4 arylacetamide deacetylase-like 4 3.43192
MUC5B mucin 5B, oligomeric mucus/gel-forming 3.43192
SIGLEC9 sialic acid binding Ig-like lectin 9 3.43192
XCL2 chemokine (C motif) ligand 2 3.43192
TAL2 T-cell acute lymphocytic leukemia 2 3.43192
GIMAP4 GTPase, IMAP family member 4 3.43192
SPINT3 serine peptidase inhibitor, Kunitz type, 3 3.43192
HOXB1 homeobox B1 3.43192
HAND1 heart and neural crest derivatives expressed 1 3.43192
ACY3 aminoacylase 3 3.43192
HMX3 H6 family homeobox 3 3.43192
BMP3 bone morphogenetic protein 3 3.43192
PRDM12 PR domain containing 12 3.43192
PTK6 protein tyrosine kinase 6 3.43192
MUC22 mucin 22 3.43192
SPRR1B small proline-rich protein 1B 3.43192
LRRC63 leucine rich repeat containing 63 3.43192
WNT8B wingless-type MMTV integration site family, member 8B 3.43192
NPIPA3 nuclear pore complex interacting protein family, member A3 3.43192
S100A5 S100 calcium binding protein A5 3.43192
LCN12 lipocalin 12 3.43192
MS4A14 membrane-spanning 4-domains, subfamily A, member 14 3.43192
SLC9C2 solute carrier family 9, member C2 (putative) 3.43192
CD3D CD3d molecule, delta (CD3-TCR complex) 3.43192
MUC1 mucin 1, cell surface associated 3.43192
MAGEA8 melanoma antigen family A8 3.43192
PDF peptide deformylase (mitochondrial) 3.43192
WNT16 wingless-type MMTV integration site family, member 16 3.43192
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 3.43192
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 3.43192
PARVG parvin, gamma 3.43192
CSAG1 chondrosarcoma associated gene 1 3.43192
GDF7 growth differentiation factor 7 3.43192
GDF9 growth differentiation factor 9 3.43192
KRT82 keratin 82, type II 3.43192
KIF13A kinesin family member 13A 3.43192
FAM90A11 family with sequence similarity 90 member A11 3.43192
SPATA31H1 SPATA31 subfamily H member 1 3.43192
SMIM42 small integral membrane protein 42 3.43192
FYB2 FYN binding protein 2 3.43192
AKAIN1 A-kinase anchor inhibitor 1 3.43192
TUBB8B tubulin beta 8B 3.43192
RTL9 retrotransposon Gag like 9 3.43192
GBP3 guanylate binding protein 3 3.43192
LRRC70 leucine rich repeat containing 70 3.43192
ADIG adipogenin 3.43192
LYRM2 LYR motif containing 2 3.43192
CFHR2 complement factor H-related 2 3.43192
LY86 lymphocyte antigen 86 3.43192
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4 3.43192
AVPR1B arginine vasopressin receptor 1B 3.43192
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 3.43192
CX3CL1 chemokine (C-X3-C motif) ligand 1 3.43192
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 3.43192
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 3.43192
LIPF lipase, gastric 3.43192
C1QL2 complement component 1, q subcomponent-like 2 3.43192
RNF113B ring finger protein 113B 3.43192
TPTE transmembrane phosphatase with tensin homology 3.43192
DMBX1 diencephalon/mesencephalon homeobox 1 3.43192
ULBP1 UL16 binding protein 1 3.43192
PANX3 pannexin 3 3.43192
NKX2-4 NK2 homeobox 4 3.43192
NKX2-2 NK2 homeobox 2 3.43192
FAM90A24 family with sequence similarity 90 member A24 3.43192
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 3.43192
OTOP1 otopetrin 1 3.43192
ENDOU endonuclease, polyU-specific 3.43192
APOH apolipoprotein H (beta-2-glycoprotein I) 3.43192
OR13G1 olfactory receptor, family 13, subfamily G, member 1 3.43192
LGALS12 lectin, galactoside-binding, soluble, 12 3.43192
OR6X1 olfactory receptor, family 6, subfamily X, member 1 3.43192
DEFB135 defensin, beta 135 3.43192
PLA2G4D phospholipase A2, group IVD (cytosolic) 3.43192
F13B coagulation factor XIII, B polypeptide 3.43192
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 3.43192
FCN1 ficolin (collagen/fibrinogen domain containing) 1 3.43192
FIGLA folliculogenesis specific basic helix-loop-helix 3.43192
IHH indian hedgehog 3.43192
TBC1D21 TBC1 domain family, member 21 3.43192
CYP8B1 cytochrome P450, family 8, subfamily B, polypeptide 1 3.43192
RBMXL2 RNA binding motif protein, X-linked-like 2 3.43192
SIGLEC15 sialic acid binding Ig-like lectin 15 3.43192
KLK12 kallikrein-related peptidase 12 3.43192
DLX2 distal-less homeobox 2 3.43192
VWA7 von Willebrand factor A domain containing 7 3.43192
MCCD1 mitochondrial coiled-coil domain 1 3.43192
MAB21L1 mab-21-like 1 (C. elegans) 3.43192
CDH19 cadherin 19, type 2 3.43192
PKDREJ polycystin (PKD) family receptor for egg jelly 3.43192
WFDC9 WAP four-disulfide core domain 9 3.43192
GCOM1 GRINL1A complex locus 1 3.43192
OR9A2 olfactory receptor, family 9, subfamily A, member 2 3.43192
PRSS33 protease, serine, 33 3.43192
KLHL1 kelch-like family member 1 3.43192
CST1 cystatin SN 3.43192
TSPAN19 tetraspanin 19 3.43192
C9ORF57 chromosome 9 open reading frame 57 3.43192
PHACTR3 phosphatase and actin regulator 3 3.43192
BIN2 bridging integrator 2 3.43192
NLRP5 NLR family, pyrin domain containing 5 3.43192
LY6G6C lymphocyte antigen 6 complex, locus G6C 3.43192
PDK4 pyruvate dehydrogenase kinase, isozyme 4 3.43192
IL17B interleukin 17B 3.43192
ST18 suppression of tumorigenicity 18, zinc finger 3.43192
PADI6 peptidyl arginine deiminase, type VI 3.43192
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 3.43192
CHRDL2 chordin-like 2 3.43192
C5ORF46 chromosome 5 open reading frame 46 3.43192
POU3F3 POU class 3 homeobox 3 3.43192
CLCA2 chloride channel accessory 2 3.43192
CRTAM cytotoxic and regulatory T cell molecule 3.43192
PXT1 peroxisomal, testis specific 1 3.43192
ANGPTL3 angiopoietin-like 3 3.43192
GPR174 G protein-coupled receptor 174 3.43192
GOLGA8T golgin A8 family, member T 3.43192
CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 3.43192
GRAPL GRB2-related adaptor protein-like 3.40347
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 3.35957
LIG1 ligase I, DNA, ATP-dependent 3.29005
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 3.28978
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 3.22876
CLIC6 chloride intracellular channel 6 2.95404
FKBP10 FK506 binding protein 10, 65 kDa 2.93253
CERS3 ceramide synthase 3 2.9258
SPAG4 sperm associated antigen 4 2.66639
PRAM1 PML-RARA regulated adaptor molecule 1 2.64917
FANCD2OS FANCD2 opposite strand 2.59602
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 2.52189
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 2.46681
STX19 syntaxin 19 2.4342
SFRP4 secreted frizzled-related protein 4 2.40082
KLHDC8A kelch domain containing 8A 2.40082
C1ORF116 chromosome 1 open reading frame 116 2.38731
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) 2.38731
ALX4 ALX homeobox 4 2.38731
CRYGN crystallin, gamma N 2.38731
CCDC27 coiled-coil domain containing 27 2.38731
FAM216B family with sequence similarity 216, member B 2.38731
CDH23 cadherin-related 23 2.38731
DEFB131B defensin beta 131B 2.38731
ZAR1L zygote arrest 1-like 2.38731
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) 2.38731
AWAT1 acyl-CoA wax alcohol acyltransferase 1 2.38198
RSF1 remodeling and spacing factor 1 2.38017
RBP5 retinol binding protein 5, cellular 2.34352
MAP3K21 mitogen-activated protein kinase kinase kinase 21 2.34307
GMCL1 germ cell-less, spermatogenesis associated 1 2.32566
RB1CC1 RB1-inducible coiled-coil 1 2.32506
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 2.28429
LRP6 low density lipoprotein receptor-related protein 6 2.27526
IFT80 intraflagellar transport 80 2.26924
HTT huntingtin 2.26276
PDZD9 PDZ domain containing 9 2.25868
PARK7 parkinson protein 7 2.25868
ARR3 arrestin 3, retinal (X-arrestin) 2.25868
TENT4A terminal nucleotidyltransferase 4A 2.2568
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 2.24643
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 2.24643
MYO19 myosin XIX 2.24643
IRF2BPL interferon regulatory factor 2 binding protein-like 2.2451
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 2.23255
FAM110D family with sequence similarity 110, member D 2.23255
POLR1G RNA polymerase I subunit G 2.22928
PPIG peptidylprolyl isomerase G (cyclophilin G) 2.22162
OSBPL3 oxysterol binding protein-like 3 2.21124
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 2.20936
LUZP2 leucine zipper protein 2 2.17305
KIAA0319 KIAA0319 2.17083
GANC glucosidase, alpha; neutral C 2.16986
EPHX3 epoxide hydrolase 3 2.16472
TMUB1 transmembrane and ubiquitin-like domain containing 1 2.16469
ADSL adenylosuccinate lyase 2.12117
NCOR1 nuclear receptor corepressor 1 2.12117
BMS1 BMS1 ribosome biogenesis factor 2.11833
WNK3 WNK lysine deficient protein kinase 3 2.11744
SBSPON somatomedin B and thrombospondin, type 1 domain containing 2.1165
TBCC tubulin folding cofactor C 2.10667
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 2.09372
ETFRF1 electron transfer flavoprotein regulatory factor 1 2.09148
EDARADD EDAR-associated death domain 2.09148
RGS3 regulator of G-protein signaling 3 2.06579
TBC1D20 TBC1 domain family, member 20 2.06579
BACE1 beta-site APP-cleaving enzyme 1 2.02331
FAAP100 FA core complex associated protein 100 2.02268
ASTN2 astrotactin 2 2.02076
ACTN2 actinin, alpha 2 2.0175
H2AC16 H2A clustered histone 16 2.01418
ZNF568 zinc finger protein 568 2.01418
WDR53 WD repeat domain 53 2.01418
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 2.00636
TET1 tet methylcytosine dioxygenase 1 2.00209
EMC4 ER membrane protein complex subunit 4 2.0017

decreased expression

Symbol Name Standardized Value
SIAH3 siah E3 ubiquitin protein ligase family member 3 -3.48658
KCNK2 potassium channel, two pore domain subfamily K, member 2 -3.48658
COL6A6 collagen, type VI, alpha 6 -3.48658
NBPF8 neuroblastoma breakpoint family, member 8 -3.48658
PEAK3 PEAK family member 3 -3.43192
ATOH8 atonal homolog 8 (Drosophila) -3.43192
CSNK2A3 casein kinase 2, alpha 3 polypeptide -3.43192
NR4A3 nuclear receptor subfamily 4, group A, member 3 -3.43192
SOST sclerostin -3.43192
TMEM88 transmembrane protein 88 -3.43192
TMEM215 transmembrane protein 215 -3.43192
TRPM1 transient receptor potential cation channel, subfamily M, member 1 -3.43192
DLL4 delta-like 4 (Drosophila) -3.43192
OLFM3 olfactomedin 3 -3.43192
SLC35G5 solute carrier family 35, member G5 -3.43192
CBLIF cobalamin binding intrinsic factor -3.43192
VSIR V-set immunoregulatory receptor -3.43192
SPI1 Spi-1 proto-oncogene -3.43192
TLR7 toll-like receptor 7 -3.43192
MAG myelin associated glycoprotein -3.43192
PCDHB10 protocadherin beta 10 -3.43192
SPINK5 serine peptidase inhibitor, Kazal type 5 -3.43192
AKR1C2 aldo-keto reductase family 1, member C2 -3.43192
GLUD2 glutamate dehydrogenase 2 -3.43192
EPX eosinophil peroxidase -3.43192
GDF6 growth differentiation factor 6 -3.43192
GPR68 G protein-coupled receptor 68 -3.43192
FAM120B family with sequence similarity 120B -3.43192
NPM2 nucleophosmin/nucleoplasmin 2 -3.3737
ZNF813 zinc finger protein 813 -3.30117
CDIP1 cell death-inducing p53 target 1 -3.02323
GRIA3 glutamate receptor, ionotropic, AMPA 3 -3.02323
NOXRED1 NADP-dependent oxidoreductase domain containing 1 -2.8592
RPL14 ribosomal protein L14 -2.80459
ANKRD65 ankyrin repeat domain 65 -2.74553
SURF2 surfeit 2 -2.53377
FAM149A family with sequence similarity 149, member A -2.47932
NOL12 nucleolar protein 12 -2.4645
HPSE heparanase -2.43116
ZNF846 zinc finger protein 846 -2.41265
COXFA4 cytochrome c oxidase associated subunit FA4 -2.40064
CD79B CD79b molecule, immunoglobulin-associated beta -2.38731
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -2.38198
RECQL4 RecQ protein-like 4 -2.353
GLB1L3 galactosidase, beta 1-like 3 -2.353
IHO1 interactor of HORMAD1 1 -2.34726
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow -2.34726
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 -2.34726
SHOX short stature homeobox -2.33497
TMEM65 transmembrane protein 65 -2.33456
ANOS1 anosmin 1 -2.31546
SLCO1B1 solute carrier organic anion transporter family, member 1B1 -2.30478
SAXO4 stabilizer of axonemal microtubules 4 -2.30478
MBLAC2 metallo-beta-lactamase domain containing 2 -2.28399
ZNF761 zinc finger protein 761 -2.28399
ACACB acetyl-CoA carboxylase beta -2.27784
CAPN15 calpain 15 -2.26456
CSNK1G1 casein kinase 1, gamma 1 -2.24951
ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit -2.22229
OMA1 OMA1 zinc metallopeptidase -2.19553
LDHAL6A lactate dehydrogenase A-like 6A -2.19282
VEPH1 ventricular zone expressed PH domain-containing 1 -2.19282
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) -2.16469
PLEK2 pleckstrin 2 -2.16326
MAT1A methionine adenosyltransferase I, alpha -2.12869
TMEM260 transmembrane protein 260 -2.1229
TMEM145 transmembrane protein 145 -2.12117
ZNF480 zinc finger protein 480 -2.12117
MRPS34 mitochondrial ribosomal protein S34 -2.11833
HEXIM2 hexamethylene bis-acetamide inducible 2 -2.10468
DCAF8 DDB1 and CUL4 associated factor 8 -2.0944
TMPO thymopoietin -2.09148
ZRANB1 zinc finger, RAN-binding domain containing 1 -2.09079
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon -2.06071
RPS10 ribosomal protein S10 -2.06071
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 -2.05662
SUMO1 small ubiquitin-like modifier 1 -2.0525
ABHD2 abhydrolase domain containing 2 -2.03909
ABHD18 abhydrolase domain containing 18 -2.02805
TRIM13 tripartite motif containing 13 -2.02561
MDH2 malate dehydrogenase 2, NAD (mitochondrial) -2.02331