SPI1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description Spi-1 proto-oncogene|This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6688)
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Genes

300 genes differentially expressed following the SPI1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FRMD7 FERM domain containing 7 3.12206
TSGA13 testis specific, 13 3.12206
PDIA2 protein disulfide isomerase family A, member 2 3.12206
PCDHB7 protocadherin beta 7 3.12206
PCDHB1 protocadherin beta 1 3.12206
OR5K1 olfactory receptor, family 5, subfamily K, member 1 3.12206
CAPNS2 calpain, small subunit 2 3.12206
OSGIN1 oxidative stress induced growth inhibitor 1 3.12206
PNMA5 paraneoplastic Ma antigen family member 5 3.12206
TM4SF20 transmembrane 4 L six family member 20 3.12206
BTC betacellulin 3.12206
GNLY granulysin 3.12206
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 3.12206
TBX20 T-box 20 3.12206
SLC22A14 solute carrier family 22, member 14 3.12206
ZNF582 zinc finger protein 582 3.12206
CD274 CD274 molecule 3.12206
AGTR1 angiotensin II receptor, type 1 3.12206
CLEC12A C-type lectin domain family 12, member A 3.12206
USP26 ubiquitin specific peptidase 26 3.12206
CHRND cholinergic receptor, nicotinic, delta (muscle) 3.12206
FAM180A family with sequence similarity 180, member A 3.12206
C8ORF48 chromosome 8 open reading frame 48 3.12206
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 3.12206
OR2J2 olfactory receptor, family 2, subfamily J, member 2 3.12206
NEUROG3 neurogenin 3 3.12206
KIF2B kinesin family member 2B 3.12206
DRGX dorsal root ganglia homeobox 3.12206
SPDYE11 speedy/RINGO cell cycle regulator family member E11 3.12206
SHE Src homology 2 domain containing E 3.12206
OR5V1 olfactory receptor, family 5, subfamily V, member 1 3.12206
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 3.12206
PRDM13 PR domain containing 13 3.12206
GYS2 glycogen synthase 2 (liver) 3.12206
OCSTAMP osteoclast stimulatory transmembrane protein 3.12206
KHDC3L KH domain containing 3-like, subcortical maternal complex member 3.12206
TMEM71 transmembrane protein 71 3.12206
ARHGAP36 Rho GTPase activating protein 36 3.12206
TYRP1 tyrosinase-related protein 1 3.12206
SIGLEC5 sialic acid binding Ig-like lectin 5 3.12206
ASB12 ankyrin repeat and SOCS box containing 12 3.12206
SSTR5 somatostatin receptor 5 3.12206
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 3.12206
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 3.12206
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 3.12206
TDRD9 tudor domain containing 9 3.12206
RNF39 ring finger protein 39 3.12206
OR2A1 olfactory receptor, family 2, subfamily A, member 1 3.12206
LOC124906892 uncharacterized LOC124906892 3.12206
PLAAT4 phospholipase A and acyltransferase 4 3.12206
HTD2 hydroxyacyl-thioester dehydratase type 2 3.12206
ROPN1L rhophilin associated tail protein 1-like 3.12206
VN1R1 vomeronasal 1 receptor 1 3.12206
DNAAF1 dynein, axonemal, assembly factor 1 3.12206
FMO2 flavin containing monooxygenase 2 (non-functional) 3.12206
FAM220A family with sequence similarity 220, member A 3.12206
TMPRSS4 transmembrane protease, serine 4 3.12206
SMPX small muscle protein, X-linked 3.12206
CBLIF cobalamin binding intrinsic factor 3.12206
RTL9 retrotransposon Gag like 9 3.12206
CALHM5 calcium homeostasis modulator family member 5 3.12206
SPMAP1 sperm microtubule associated protein 1 3.12206
FAM240A family with sequence similarity 240 member A 3.12206
C8ORF90 chromosome 8 open reading frame 90 3.12206
LOC124906010 uncharacterized LOC124906010 3.12206
H4C12 H4 clustered histone 12 3.12206
SMIM35 small integral membrane protein 35 3.12206
PEAK3 PEAK family member 3 3.12206
STPG3 sperm-tail PG-rich repeat containing 3 3.12206
GARIN5B golgi associated RAB2 interactor family member 5B 3.12206
RDH8 retinol dehydrogenase 8 (all-trans) 3.12206
MYL10 myosin, light chain 10, regulatory 3.12206
LTF lactotransferrin 3.12206
UROC1 urocanate hydratase 1 3.12206
AMHR2 anti-Mullerian hormone receptor, type II 3.12206
TUBA3E tubulin, alpha 3e 3.12206
PTPRQ protein tyrosine phosphatase, receptor type, Q 3.12206
PRB3 proline-rich protein BstNI subfamily 3 3.12206
DTHD1 death domain containing 1 3.12206
PCDHA2 protocadherin alpha 2 3.12206
RLBP1 retinaldehyde binding protein 1 3.12206
ATP13A5 ATPase type 13A5 3.12206
IL6 interleukin 6 3.12206
RUNX3 runt-related transcription factor 3 3.12206
ZNF257 zinc finger protein 257 3.12206
SOAT2 sterol O-acyltransferase 2 3.12206
WNT9B wingless-type MMTV integration site family, member 9B 3.12206
GDF7 growth differentiation factor 7 3.12206
LRRC72 leucine rich repeat containing 72 3.12206
SAMD11 sterile alpha motif domain containing 11 3.12206
PGLYRP1 peptidoglycan recognition protein 1 3.12206
S100G S100 calcium binding protein G 3.12206
INSRR insulin receptor-related receptor 3.12206
FAM186A family with sequence similarity 186, member A 3.12206
RS1 retinoschisin 1 3.12206
HAND1 heart and neural crest derivatives expressed 1 3.12206
ZNF132 zinc finger protein 132 3.12206
CGB2 chorionic gonadotropin, beta polypeptide 2 3.12206
DRD2 dopamine receptor D2 3.12206
PCDHGA7 protocadherin gamma subfamily A, 7 3.12206
WNT7B wingless-type MMTV integration site family, member 7B 3.12206
CCDC185 coiled-coil domain containing 185 3.12206
CCL17 chemokine (C-C motif) ligand 17 3.12206
CCL15 chemokine (C-C motif) ligand 15 3.12206
PDZRN4 PDZ domain containing ring finger 4 3.12206
COL6A5 collagen, type VI, alpha 5 3.12206
OAZ3 ornithine decarboxylase antizyme 3 3.12206
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 3.12206
CH25H cholesterol 25-hydroxylase 3.12206
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) 3.12206
OPRK1 opioid receptor, kappa 1 3.12206
LRTM2 leucine-rich repeats and transmembrane domains 2 3.12206
CDC20B cell division cycle 20B 3.12206
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) 3.12206
CTAGE4 CTAGE family, member 4 3.12206
CYSLTR1 cysteinyl leukotriene receptor 1 3.12206
DGCR6 DiGeorge syndrome critical region gene 6 3.12206
ZNF843 zinc finger protein 843 3.12206
KLK4 kallikrein-related peptidase 4 3.12206
SLC38A8 solute carrier family 38, member 8 3.12206
CD28 CD28 molecule 3.12206
NYX nyctalopin 3.12206
TSPAN19 tetraspanin 19 3.12206
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 3.12206
PLA2G2C phospholipase A2, group IIC 3.12206
GJB6 gap junction protein, beta 6, 30kDa 3.12206
PPP1R27 protein phosphatase 1, regulatory subunit 27 3.12206
FOXN1 forkhead box N1 3.12206
HOXA7 homeobox A7 3.12206
CRHBP corticotropin releasing hormone binding protein 3.12206
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) 3.12206
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 3.12206
LRRC15 leucine rich repeat containing 15 3.12206
SAMD9 sterile alpha motif domain containing 9 3.12206
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 3.12206
IL9R interleukin 9 receptor 3.12206
AMN amnion associated transmembrane protein 3.12206
PLA2G12B phospholipase A2, group XIIB 3.12206
TSPYL6 TSPY-like 6 3.12206
GJC2 gap junction protein, gamma 2, 47kDa 3.12206
NGB neuroglobin 3.12206
STEAP4 STEAP family member 4 3.12206
MMP12 matrix metallopeptidase 12 3.12206
PGPEP1L pyroglutamyl-peptidase I-like 3.12206
ALLC allantoicase 3.12206
NLRP6 NLR family, pyrin domain containing 6 3.12206
CLCNKA chloride channel, voltage-sensitive Ka 3.12206
CIB3 calcium and integrin binding family member 3 3.12206
SLC51B solute carrier family 51, beta subunit 3.12206
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 3.12206
CHAD chondroadherin 3.12206
LPA lipoprotein, Lp(a) 3.12206
NLRP3 NLR family, pyrin domain containing 3 3.12206
OR6J1 olfactory receptor, family 6, subfamily J, member 1 (gene/pseudogene) 3.12206
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 3.12206
ERAP2 endoplasmic reticulum aminopeptidase 2 3.12206
DHRS9 dehydrogenase/reductase (SDR family) member 9 3.12206
WFDC11 WAP four-disulfide core domain 11 3.12206
CLEC2A C-type lectin domain family 2, member A 3.12206
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 3.12206
NEUROD4 neuronal differentiation 4 3.12206
ICAM5 intercellular adhesion molecule 5, telencephalin 3.12206
APOL4 apolipoprotein L, 4 3.12206
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 3.12206
PRRX1 paired related homeobox 1 3.12206
TMIGD2 transmembrane and immunoglobulin domain containing 2 3.12206
DYTN dystrotelin 3.12206
PRND prion protein 2 (dublet) 3.12206
ZNF534 zinc finger protein 534 3.12206
STMND1 stathmin domain containing 1 3.12206
PNPLA7 patatin-like phospholipase domain containing 7 3.07912
FMNL1 formin-like 1 3.0368
SAMD15 sterile alpha motif domain containing 15 3.01327
DUSP26 dual specificity phosphatase 26 (putative) 3.01327
CABIN1 calcineurin binding protein 1 2.96947
CD300A CD300a molecule 2.96224
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase 2.84468
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 2.82694
SNORC secondary ossification center associated regulator of chondrocyte maturation 2.53688
ETF1 eukaryotic translation termination factor 1 2.52918
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.51742
CTNNBIP1 catenin, beta interacting protein 1 2.39179
CFAP43 cilia and flagella associated protein 43 2.34936
PRAF2 PRA1 domain family, member 2 2.34038
NINJ2 ninjurin 2 2.34038
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) 2.32637
KLF4 Kruppel-like factor 4 (gut) 2.32574
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 2.31862
C19ORF73 chromosome 19 open reading frame 73 2.30197
TNR tenascin R 2.28068
MCFD2 multiple coagulation factor deficiency 2 2.26887
F2 coagulation factor II (thrombin) 2.25711
UVSSA UV-stimulated scaffold protein A 2.24621
LCMT2 leucine carboxyl methyltransferase 2 2.24509
MBLAC1 metallo-beta-lactamase domain containing 1 2.21592
MFN1 mitofusin 1 2.21592
TMEM109 transmembrane protein 109 2.16763
SLC35D3 solute carrier family 35, member D3 2.16677
RDH13 retinol dehydrogenase 13 (all-trans/9-cis) 2.15821
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 2.15145
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 2.1377
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 2.13137
MED4 mediator complex subunit 4 2.13137
ASB6 ankyrin repeat and SOCS box containing 6 2.12567
SETD9 SET domain containing 9 2.07307
PROS1 protein S (alpha) 2.05088
WDR73 WD repeat domain 73 2.04944
CHERP calcium homeostasis endoplasmic reticulum protein 2.02544
SPAG17 sperm associated antigen 17 2.02338
ZNF583 zinc finger protein 583 2.01702

decreased expression

Symbol Name Standardized Value
SHISA7 shisa family member 7 -3.12206
RASL10A RAS-like, family 10, member A -3.12206
ADAM29 ADAM metallopeptidase domain 29 -3.12206
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 -3.12206
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 -3.12206
OR2H2 olfactory receptor, family 2, subfamily H, member 2 -3.12206
CARD6 caspase recruitment domain family, member 6 -3.12206
NKX3-1 NK3 homeobox 1 -3.12206
CSPG4 chondroitin sulfate proteoglycan 4 -3.12206
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion -3.12206
LOXL4 lysyl oxidase-like 4 -3.12206
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) -3.12206
PTGER3 prostaglandin E receptor 3 (subtype EP3) -3.12206
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 -3.12206
TUBB1 tubulin, beta 1 class VI -3.12206
PODNL1 podocan-like 1 -3.12206
PAX7 paired box 7 -3.12206
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial -3.12206
DCHS2 dachsous cadherin-related 2 -3.12206
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) -3.12206
EBI3 Epstein-Barr virus induced 3 -3.12206
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 -3.12206
MZB1 marginal zone B and B1 cell-specific protein -3.12206
ZNF524 zinc finger protein 524 -3.12206
PLPP4 phospholipid phosphatase 4 -3.12206
GATA4 GATA binding protein 4 -3.12206
DUSP9 dual specificity phosphatase 9 -3.12206
MUSTN1 musculoskeletal, embryonic nuclear protein 1 -3.12206
TBXA2R thromboxane A2 receptor -3.12206
ERVV-2 endogenous retrovirus group V, member 2 -3.12206
RASD1 RAS, dexamethasone-induced 1 -3.12206
LAMB4 laminin, beta 4 -3.12206
PCSK1 proprotein convertase subtilisin/kexin type 1 -3.12206
KCNT1 potassium channel, sodium activated subfamily T, member 1 -3.12206
ADAM2 ADAM metallopeptidase domain 2 -3.12206
TMEM278 transmembrane protein 278 -3.12206
WDR49 WD repeat domain 49 -3.12206
CXORF58 chromosome X open reading frame 58 -3.12206
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic -3.12206
INSM1 insulinoma-associated 1 -3.12206
TSPAN13 tetraspanin 13 -3.07912
KLF16 Kruppel-like factor 16 -2.92204
GPM6A glycoprotein M6A -2.91173
HNMT histamine N-methyltransferase -2.81023
PRPF31 pre-mRNA processing factor 31 -2.80222
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) -2.80165
STAR steroidogenic acute regulatory protein -2.78767
ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) -2.66998
ZNF319 zinc finger protein 319 -2.61745
BRD3 bromodomain containing 3 -2.60743
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae) -2.59295
AP2M1 adaptor-related protein complex 2, mu 1 subunit -2.57431
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.55044
OR2A14 olfactory receptor, family 2, subfamily A, member 14 -2.52862
MTURN maturin, neural progenitor differentiation regulator homolog (Xenopus) -2.52862
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -2.52862
CSRNP1 cysteine-serine-rich nuclear protein 1 -2.52862
CA9 carbonic anhydrase IX -2.4797
PCP4L1 Purkinje cell protein 4 like 1 -2.4797
CHODL chondrolectin -2.41625
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2 -2.37211
OLFM1 olfactomedin 1 -2.36645
HMGB3 high mobility group box 3 -2.24621
IGSF22 immunoglobulin superfamily, member 22 -2.24241
GPR34 G protein-coupled receptor 34 -2.24241
MAP1S microtubule-associated protein 1S -2.22924
C3ORF49 chromosome 3 open reading frame 49 -2.21592
NSUN3 NOP2/Sun domain family, member 3 -2.21592
NOL7 nucleolar protein 7, 27kDa -2.1822
CYC1 cytochrome c-1 -2.16677
NHEJ1 nonhomologous end-joining factor 1 -2.15875
ARHGEF33 Rho guanine nucleotide exchange factor (GEF) 33 -2.1377
ARHGAP30 Rho GTPase activating protein 30 -2.1377
CD1D CD1d molecule -2.1377
RPLP0 ribosomal protein, large, P0 -2.13198
ZEB1 zinc finger E-box binding homeobox 1 -2.13137
MAST4 microtubule associated serine/threonine kinase family member 4 -2.09057
MRPL10 mitochondrial ribosomal protein L10 -2.07925
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -2.07849
KDM4D lysine (K)-specific demethylase 4D -2.05926
VLDLR very low density lipoprotein receptor -2.05088
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -2.05082
MYO15B myosin XVB -2.04944
SLC35B1 solute carrier family 35, member B1 -2.04734
DAB2IP DAB2 interacting protein -2.02544
USPL1 ubiquitin specific peptidase like 1 -2.02544
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 -2.02544
PILRB paired immunoglobin-like type 2 receptor beta -2.02338
UBE3A ubiquitin protein ligase E3A -2.02141
SPATA1 spermatogenesis associated 1 -2.00296