SPI1 Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description Spi-1 proto-oncogene|This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6688)
External Link https://ncbi.nlm.nih.gov/gene/6688
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Genes

500 genes differentially expressed following the SPI1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0211554
IGFBP5 insulin-like growth factor binding protein 5 0.0126437
SPINK1 serine peptidase inhibitor, Kazal type 1 0.0125761
ADIRF adipogenesis regulatory factor 0.0120928
LGALS4 lectin, galactoside-binding, soluble, 4 0.0119314
CLCA1 chloride channel accessory 1 0.0113872
SDC2 syndecan 2 0.0109171
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.0108373
REG1A regenerating islet-derived 1 alpha 0.0105136
GLUL glutamate-ammonia ligase 0.0102976
FCGBP Fc fragment of IgG binding protein 0.0102931
SCRG1 stimulator of chondrogenesis 1 0.0102833
FGFR3 fibroblast growth factor receptor 3 0.0098619
CIAO3 cytosolic iron-sulfur assembly component 3 0.00977355
GJA1 gap junction protein, alpha 1, 43kDa 0.00975371
IKZF1 IKAROS family zinc finger 1 (Ikaros) 0.00938518
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.00934565
MMP12 matrix metallopeptidase 12 0.00931562
MUC2 mucin 2, oligomeric mucus/gel-forming 0.00892125
CA12 carbonic anhydrase XII 0.00885697
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.00882308
HEBP2 heme binding protein 2 0.00864353
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 0.00854017
REG3A regenerating islet-derived 3 alpha 0.00853169
KRT20 keratin 20, type I 0.00842148
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11 0.00834672
DEFA5 defensin, alpha 5, Paneth cell-specific 0.00827927
ADAMDEC1 ADAM-like, decysin 1 0.00821965
COMP cartilage oligomeric matrix protein 0.00815726
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.00815254
RSL24D1 ribosomal L24 domain containing 1 0.00812707
TFF3 trefoil factor 3 (intestinal) 0.00809618
TXNIP thioredoxin interacting protein 0.00803206
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 0.00801445
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.00799074
PRDX4 peroxiredoxin 4 0.00795401
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.00790008
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.00785093
CASP2 caspase 2, apoptosis-related cysteine peptidase 0.00783869
RPS5 ribosomal protein S5 0.00765526
FABP1 fatty acid binding protein 1, liver 0.00761194
CD40 CD40 molecule, TNF receptor superfamily member 5 0.00759719
SELENOF selenoprotein F 0.00758932
ADAM28 ADAM metallopeptidase domain 28 0.0075537
AREG amphiregulin 0.00755146
TM4SF4 transmembrane 4 L six family member 4 0.00753684
APOD apolipoprotein D 0.00747021
RCN2 reticulocalbin 2, EF-hand calcium binding domain 0.00739976
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.00736767
FAM3C family with sequence similarity 3, member C 0.00732854
IPO13 importin 13 0.0072663
E2F2 E2F transcription factor 2 0.00725697
CENPX centromere protein X 0.00723451
MAOA monoamine oxidase A 0.007114
REG1B regenerating islet-derived 1 beta 0.00704106
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 0.00703372
HMGB3 high mobility group box 3 0.0070248
SEPP1 selenoprotein P, plasma, 1 0.00702237
GOLT1B golgi transport 1B 0.00701521
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein 0.00700126
SPINK4 serine peptidase inhibitor, Kazal type 4 0.00697712
SST somatostatin 0.00695281
TRAPPC2L trafficking protein particle complex 2-like 0.00695261
MAN1A1 mannosidase, alpha, class 1A, member 1 0.00692737
PTTG1 pituitary tumor-transforming 1 0.0069229
PERP PERP, TP53 apoptosis effector 0.00691282
MMP9 matrix metallopeptidase 9 0.00690863
PPP1R16B protein phosphatase 1, regulatory subunit 16B 0.00686509
RBX1 ring-box 1, E3 ubiquitin protein ligase 0.00683979
DEFA6 defensin, alpha 6, Paneth cell-specific 0.00682115
PIGR polymeric immunoglobulin receptor 0.00677978
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 0.00675123
RPA3 replication protein A3, 14kDa 0.00673254
ECI2 enoyl-CoA delta isomerase 2 0.00671535
HOXC6 homeobox C6 0.00669692
MAP7 microtubule-associated protein 7 0.00668924
FAM162A family with sequence similarity 162, member A 0.00668686
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.00667058
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.00666394
CCNB1 cyclin B1 0.00664674
CLU clusterin 0.00662864
CFD complement factor D (adipsin) 0.006614
GPX2 glutathione peroxidase 2 0.0066083
TMEM14B transmembrane protein 14B 0.00658896
NDUFA6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa 0.00658832
SNRPG small nuclear ribonucleoprotein polypeptide G 0.00658634
RBBP4 retinoblastoma binding protein 4 0.00656175
MRPL18 mitochondrial ribosomal protein L18 0.00655279
SELENOT selenoprotein T 0.00652813
NCK1 NCK adaptor protein 1 0.00651103
STMN2 stathmin 2 0.00648971
TSPAN6 tetraspanin 6 0.00648648
GLUD2 glutamate dehydrogenase 2 0.00646995
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 0.00645791
CD209 CD209 molecule 0.00644725
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 0.00644358
MYCBP MYC binding protein 0.0064342
TWF1 twinfilin actin binding protein 1 0.00642243
TMEM14A transmembrane protein 14A 0.0064088
CALD1 caldesmon 1 0.00640657
UFD1 ubiquitin recognition factor in ER associated degradation 1 0.00640325
METTL7A methyltransferase like 7A 0.0063849
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 0.00637975
TMEM50B transmembrane protein 50B 0.00637325
COMMD8 COMM domain containing 8 0.00637132
MXRA7 matrix-remodelling associated 7 0.00634898
DEF8 differentially expressed in FDCP 8 homolog (mouse) 0.00632214
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 0.00631808
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) 0.00630467
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 0.00630358
MRPL42 mitochondrial ribosomal protein L42 0.00629797
CKS2 CDC28 protein kinase regulatory subunit 2 0.00624182
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 0.00623606
FDX1 ferredoxin 1 0.00623484
PDCD10 programmed cell death 10 0.0062287
GUCA2A guanylate cyclase activator 2A (guanylin) 0.00620415
RPL14 ribosomal protein L14 0.00618493
OLFM4 olfactomedin 4 0.00612666
ZG16 zymogen granule protein 16 0.0061032
MPC2 mitochondrial pyruvate carrier 2 0.00608948
PCOLCE2 procollagen C-endopeptidase enhancer 2 0.00608659
ADM adrenomedullin 0.00608401
H1-2 H1.2 linker histone, cluster member 0.00604844
ACOT13 acyl-CoA thioesterase 13 0.00603809
FOXD1 forkhead box D1 0.00602422
KRT5 keratin 5, type II 0.00601912
SSR1 signal sequence receptor, alpha 0.00600558
BEX1 brain expressed, X-linked 1 0.00598139
SNAI2 snail family zinc finger 2 0.00598105
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide 0.00594482
ATP5PF ATP synthase peripheral stalk subunit F6 0.00593677
CA2 carbonic anhydrase II 0.00593586
SOD1 superoxide dismutase 1, soluble 0.0059351
COMMD10 COMM domain containing 10 0.00592154
NUTF2 nuclear transport factor 2 0.00591572
HNRNPL heterogeneous nuclear ribonucleoprotein L 0.00590923
SSBP1 single-stranded DNA binding protein 1, mitochondrial 0.00590517
PPA2 pyrophosphatase (inorganic) 2 0.00590032
MRPL39 mitochondrial ribosomal protein L39 0.00587505
KRT6B keratin 6B, type II 0.00587501
CLEC3B C-type lectin domain family 3, member B 0.00587468
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) 0.00586352
ISYNA1 inositol-3-phosphate synthase 1 0.00585234
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 0.00583743
FXYD2 FXYD domain containing ion transport regulator 2 0.00581598
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.00581259
PCLAF PCNA clamp associated factor 0.00578519
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.00577908
F3 coagulation factor III (thromboplastin, tissue factor) 0.00577735
WDR61 WD repeat domain 61 0.00575011
SCGB1D2 secretoglobin, family 1D, member 2 0.00574939
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.00574567
TCTN2 tectonic family member 2 0.00574187
RPS25 ribosomal protein S25 0.00574126
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 0.00573625
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 0.00573484
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) 0.0057079
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 0.00567553
TXNDC15 thioredoxin domain containing 15 0.00567124
TXNL1 thioredoxin-like 1 0.00566846
TMEM126B transmembrane protein 126B 0.00566744
NUSAP1 nucleolar and spindle associated protein 1 0.00566008
CLEC2B C-type lectin domain family 2, member B 0.00565733
EEF1B2 eukaryotic translation elongation factor 1 beta 2 0.00565506
ACAT1 acetyl-CoA acetyltransferase 1 0.00565134
DCXR dicarbonyl/L-xylulose reductase 0.00564552
OLFM1 olfactomedin 1 0.00562603
METTL5 methyltransferase like 5 0.00560767
CNOT4 CCR4-NOT transcription complex, subunit 4 0.00560701
TRAM1 translocation associated membrane protein 1 0.00558347
GSTM3 glutathione S-transferase mu 3 (brain) 0.00555417
VIL1 villin 1 0.00553673
RANBP1 RAN binding protein 1 0.00553645
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 0.00552325
ALDOB aldolase B, fructose-bisphosphate 0.00551268
HMGB1 high mobility group box 1 0.00549726
MAT2B methionine adenosyltransferase II, beta 0.00548755
AOC1 amine oxidase, copper containing 1 0.00548091
TTYH1 tweety family member 1 0.00547974
ANGPT1 angiopoietin 1 0.00547499
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.00547051
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.00546222
MRPS16 mitochondrial ribosomal protein S16 0.00546183
DSTN destrin (actin depolymerizing factor) 0.00545498
CGRRF1 cell growth regulator with ring finger domain 1 0.00545317
CLDND1 claudin domain containing 1 0.00544739
RGCC regulator of cell cycle 0.00542181
MAB21L2 mab-21-like 2 (C. elegans) 0.00541692
COPS4 COP9 signalosome subunit 4 0.00541354
RAB4A RAB4A, member RAS oncogene family 0.00541259
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 0.00540583
SEPTIN11 septin 11 0.0054017
MT3 metallothionein 3 0.00537759
TPRKB TP53RK binding protein 0.00537449
PBLD phenazine biosynthesis-like protein domain containing 0.00537051
FSD1 fibronectin type III and SPRY domain containing 1 0.00536886
SGPP1 sphingosine-1-phosphate phosphatase 1 0.0053649
PCCA propionyl CoA carboxylase, alpha polypeptide 0.00536432
RAB1A RAB1A, member RAS oncogene family 0.00533463
RPL13 ribosomal protein L13 0.00532799
MOB4 MOB family member 4, phocein 0.00532378
VTCN1 V-set domain containing T cell activation inhibitor 1 0.00532352
HMGB2 high mobility group box 2 0.0053132
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 0.0052979
MRPL13 mitochondrial ribosomal protein L13 0.0052954
NTS neurotensin 0.00528617
RWDD1 RWD domain containing 1 0.00528587
KRAS Kirsten rat sarcoma viral oncogene homolog 0.00527782
DCK deoxycytidine kinase 0.00526286
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 0.00525207
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 0.0052361
DAXX death-domain associated protein 0.00522571
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 0.00522384
SLC17A4 solute carrier family 17, member 4 0.00522296
TMEM176A transmembrane protein 176A 0.00522074
SKAP2 src kinase associated phosphoprotein 2 0.00521882
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.00521318
PRPH peripherin 0.00520965
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.00520412
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 0.00520167
CDC42 cell division cycle 42 0.00520125
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 0.00517663
ATG5 autophagy related 5 0.00516816
SCN3A sodium channel, voltage gated, type III alpha subunit 0.00516791
GTF2A2 general transcription factor IIA, 2, 12kDa 0.00516663
NRN1 neuritin 1 0.00516644
ANKRD12 ankyrin repeat domain 12 0.00515831
RPL10A ribosomal protein L10a 0.00515792
ETFA electron-transfer-flavoprotein, alpha polypeptide 0.00515568
SDHAF3 succinate dehydrogenase complex assembly factor 3 0.00515368
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 0.00514859
TMEM106C transmembrane protein 106C 0.00514726
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.005141
RAB25 RAB25, member RAS oncogene family 0.00513465
RAMP1 receptor (G protein-coupled) activity modifying protein 1 0.00512874
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 0.00512485
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 0.00511699
TMEM47 transmembrane protein 47 0.00511647
NDRG1 N-myc downstream regulated 1 0.00511266
MRPL11 mitochondrial ribosomal protein L11 0.00509936
COLEC12 collectin sub-family member 12 0.00509884
LYPLA1 lysophospholipase I 0.00509321
HLA-DOB major histocompatibility complex, class II, DO beta 0.00509256
MSRA methionine sulfoxide reductase A 0.00508538
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.00508373
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.0050788
FKBP5 FK506 binding protein 5 0.00506832
RBM3 RNA binding motif (RNP1, RRM) protein 3 0.00506201
PHB prohibitin 0.00504149
DDHD2 DDHD domain containing 2 0.00503939

decreased expression

Symbol Name Standardized Value
MX1 MX dynamin-like GTPase 1 -0.0169049
IFI44L interferon-induced protein 44-like -0.0152182
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0148742
AQP3 aquaporin 3 (Gill blood group) -0.0137682
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -0.0137001
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -0.0135777
ISG15 ISG15 ubiquitin-like modifier -0.013567
BST2 bone marrow stromal cell antigen 2 -0.0133479
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 -0.0131252
TNNC1 troponin C type 1 (slow) -0.0131247
NIBAN1 niban apoptosis regulator 1 -0.012679
IFI44 interferon-induced protein 44 -0.0125794
SVIL supervillin -0.0120366
IFI27 interferon, alpha-inducible protein 27 -0.0117072
COL4A5 collagen, type IV, alpha 5 -0.0115278
LGALS13 lectin, galactoside-binding, soluble, 13 -0.0111075
KLHL41 kelch-like family member 41 -0.0110173
ARID4A AT rich interactive domain 4A (RBP1-like) -0.010963
DLK1 delta-like 1 homolog (Drosophila) -0.0108382
TACSTD2 tumor-associated calcium signal transducer 2 -0.0108031
LAMP3 lysosomal-associated membrane protein 3 -0.0107861
MLPH melanophilin -0.0107117
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -0.0106532
HSPA1A heat shock 70kDa protein 1A -0.0106262
IL32 interleukin 32 -0.0104906
TNNC2 troponin C type 2 (fast) -0.010307
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0102949
CKM creatine kinase, muscle -0.00997445
ACTA1 actin, alpha 1, skeletal muscle -0.00995433
KAZN kazrin, periplakin interacting protein -0.0098377
MB myoglobin -0.00981563
LIMCH1 LIM and calponin homology domains 1 -0.00974598
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa -0.00951102
DAPK1 death-associated protein kinase 1 -0.00942303
STAT1 signal transducer and activator of transcription 1, 91kDa -0.00941867
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.00938626
ZNF185 zinc finger protein 185 (LIM domain) -0.00932209
LYPD1 LY6/PLAUR domain containing 1 -0.00923548
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.00919359
KRT7 keratin 7, type II -0.00919006
DACH1 dachshund family transcription factor 1 -0.00918992
CRISP3 cysteine-rich secretory protein 3 -0.00912743
OXTR oxytocin receptor -0.00910755
MSRB2 methionine sulfoxide reductase B2 -0.0090491
ABLIM1 actin binding LIM protein 1 -0.00904697
RFTN1 raftlin, lipid raft linker 1 -0.00904669
IGFBP4 insulin-like growth factor binding protein 4 -0.00904421
ANOS1 anosmin 1 -0.00896935
TNIP1 TNFAIP3 interacting protein 1 -0.00885998
MYBPC1 myosin binding protein C, slow type -0.00885255
FLRT3 fibronectin leucine rich transmembrane protein 3 -0.00878362
CAPN3 calpain 3, (p94) -0.00873242
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.00872281
TGM2 transglutaminase 2 -0.00871189
IRF9 interferon regulatory factor 9 -0.00861616
RRAGD Ras-related GTP binding D -0.00860035
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 -0.00856376
TTN titin -0.00855256
SOX11 SRY (sex determining region Y)-box 11 -0.00852602
ALCAM activated leukocyte cell adhesion molecule -0.00844545
BASP1 brain abundant, membrane attached signal protein 1 -0.00838139
C5AR1 complement component 5a receptor 1 -0.00837922
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -0.00837188
NAV2 neuron navigator 2 -0.00835557
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -0.0083378
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -0.00830852
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta -0.00826875
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 -0.00826407
SMPX small muscle protein, X-linked -0.00818182
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.00817269
IRS2 insulin receptor substrate 2 -0.00814394
MX2 MX dynamin-like GTPase 2 -0.00810845
PDLIM5 PDZ and LIM domain 5 -0.0080633
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) -0.00806042
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 -0.00803325
RNF167 ring finger protein 167 -0.00802246
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.00801625
SLC43A3 solute carrier family 43, member 3 -0.00796531
MYL1 myosin, light chain 1, alkali; skeletal, fast -0.00792659
MGLL monoglyceride lipase -0.00791272
TNS1 tensin 1 -0.0078527
MSLN mesothelin -0.00782749
SLPI secretory leukocyte peptidase inhibitor -0.00781388
CTNND1 catenin (cadherin-associated protein), delta 1 -0.00779326
HACD1 3-hydroxyacyl-CoA dehydratase 1 -0.00778428
IRF7 interferon regulatory factor 7 -0.00777464
MYOZ2 myozenin 2 -0.00774127
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) -0.00773341
CDH3 cadherin 3, type 1, P-cadherin (placental) -0.00767493
MYL2 myosin, light chain 2, regulatory, cardiac, slow -0.00767173
HSPB8 heat shock 22kDa protein 8 -0.00764331
NEFH neurofilament, heavy polypeptide -0.00763487
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.00763443
IFI6 interferon, alpha-inducible protein 6 -0.00763011
ANXA3 annexin A3 -0.00755185
SPAG1 sperm associated antigen 1 -0.0075389
SCEL sciellin -0.00750868
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 -0.00748621
MYO1C myosin IC -0.00746225
ADO 2-aminoethanethiol (cysteamine) dioxygenase -0.00744266
ZFAND5 zinc finger, AN1-type domain 5 -0.00743122
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -0.00742759
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.00735554
PXDN peroxidasin -0.00735508
VLDLR very low density lipoprotein receptor -0.00733343
MVP major vault protein -0.00726451
RRAD Ras-related associated with diabetes -0.00726407
SCUBE2 signal peptide, CUB domain, EGF-like 2 -0.00726368
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.007245
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 -0.00723067
RSAD2 radical S-adenosyl methionine domain containing 2 -0.00721666
S100A12 S100 calcium binding protein A12 -0.00721602
USP18 ubiquitin specific peptidase 18 -0.00720193
EGR2 early growth response 2 -0.00719461
ZDHHC6 zinc finger, DHHC-type containing 6 -0.00718194
IER2 immediate early response 2 -0.00717054
TSPYL5 TSPY-like 5 -0.00715596
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.00714957
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.00714107
TSPAN8 tetraspanin 8 -0.00714051
DST dystonin -0.00710573
RET ret proto-oncogene -0.0070677
COL1A1 collagen, type I, alpha 1 -0.00706452
JARID2 jumonji, AT rich interactive domain 2 -0.00705524
HSPH1 heat shock 105kDa/110kDa protein 1 -0.00704307
CFB complement factor B -0.00702995
FXYD3 FXYD domain containing ion transport regulator 3 -0.00702991
ENO3 enolase 3 (beta, muscle) -0.00701788
HCP5 HLA complex P5 (non-protein coding) -0.00700034
MAGED1 melanoma antigen family D1 -0.00696615
CHD9 chromodomain helicase DNA binding protein 9 -0.00696176
TIMP1 TIMP metallopeptidase inhibitor 1 -0.00696062
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1 -0.00694279
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -0.00694195
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 -0.00693648
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.00690587
TRIP6 thyroid hormone receptor interactor 6 -0.00689248
CLGN calmegin -0.0068889
RRBP1 ribosome binding protein 1 -0.00688844
ARMCX1 armadillo repeat containing, X-linked 1 -0.00688797
LAPTM4B lysosomal protein transmembrane 4 beta -0.00687617
ADRB2 adrenoceptor beta 2, surface -0.00685783
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -0.00685439
ADGRF5 adhesion G protein-coupled receptor F5 -0.00683449
QPRT quinolinate phosphoribosyltransferase -0.00683036
IFRD1 interferon-related developmental regulator 1 -0.00680267
EDNRA endothelin receptor type A -0.00679751
IFITM1 interferon induced transmembrane protein 1 -0.00678145
LBH limb bud and heart development -0.00677735
WARS1 tryptophanyl-tRNA synthetase 1 -0.0067525
MYH2 myosin, heavy chain 2, skeletal muscle, adult -0.00674518
PLK2 polo-like kinase 2 -0.00672315
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) -0.00671663
EGFL6 EGF-like-domain, multiple 6 -0.00671459
IFI16 interferon, gamma-inducible protein 16 -0.00670309
PLXNC1 plexin C1 -0.0066824
SAMD9 sterile alpha motif domain containing 9 -0.00668126
TRIM14 tripartite motif containing 14 -0.00665957
TJP2 tight junction protein 2 -0.00662831
FN1 fibronectin 1 -0.00662683
HLA-C major histocompatibility complex, class I, C -0.00662477
TRIM22 tripartite motif containing 22 -0.0066194
BIN1 bridging integrator 1 -0.00661744
PLXNB2 plexin B2 -0.00659803
HK1 hexokinase 1 -0.00658039
COL4A1 collagen, type IV, alpha 1 -0.00657129
GSDME gasdermin E -0.00656874
HBB hemoglobin, beta -0.00656722
SP110 SP110 nuclear body protein -0.00649987
TUG1 taurine up-regulated 1 (non-protein coding) -0.00649205
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 -0.00649122
FBP1 fructose-1,6-bisphosphatase 1 -0.00648379
LUM lumican -0.00647947
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D -0.00646301
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.00645668
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha -0.0064472
PARP12 poly (ADP-ribose) polymerase family, member 12 -0.00643408
FCN1 ficolin (collagen/fibrinogen domain containing) 1 -0.00642981
ACSL1 acyl-CoA synthetase long-chain family member 1 -0.00641036
HLA-F major histocompatibility complex, class I, F -0.00640816
IFIH1 interferon induced with helicase C domain 1 -0.00640117
SELL selectin L -0.00639324
GPC3 glypican 3 -0.00638118
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.00637987
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -0.00637302
STK10 serine/threonine kinase 10 -0.00634878
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.00633554
LONP1 lon peptidase 1, mitochondrial -0.00632231
AZGP1 alpha-2-glycoprotein 1, zinc-binding -0.00632102
TNNI2 troponin I type 2 (skeletal, fast) -0.00629099
HECA headcase homolog (Drosophila) -0.00626545
SYNPO2L synaptopodin 2-like -0.00626144
FOSL2 FOS-like antigen 2 -0.00624161
HCLS1 hematopoietic cell-specific Lyn substrate 1 -0.00624131
ATF3 activating transcription factor 3 -0.00620274
PARD3 par-3 family cell polarity regulator -0.00619765
HLA-B major histocompatibility complex, class I, B -0.00619157
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase -0.00617294
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -0.00614552
LTF lactotransferrin -0.00614223
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.00613313
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) -0.00611728
MYBPC2 myosin binding protein C, fast type -0.00610742
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.00609534
PDZRN3 PDZ domain containing ring finger 3 -0.00608456
TACC2 transforming, acidic coiled-coil containing protein 2 -0.00608177
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.00607293
RETREG1 reticulophagy regulator 1 -0.00605316
TBC1D4 TBC1 domain family, member 4 -0.00602993
CELF2 CUGBP, Elav-like family member 2 -0.00600158
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A -0.00599089
CX3CR1 chemokine (C-X3-C motif) receptor 1 -0.00599056
UBR4 ubiquitin protein ligase E3 component n-recognin 4 -0.00598241
PRUNE2 prune homolog 2 (Drosophila) -0.00595622
RUNX3 runt-related transcription factor 3 -0.00595357
WNT5A wingless-type MMTV integration site family, member 5A -0.00594848
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic -0.00593582
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 -0.00593129
EPHA2 EPH receptor A2 -0.00591968
TNIK TRAF2 and NCK interacting kinase -0.00591187
WT1 Wilms tumor 1 -0.00591061
GAB2 GRB2-associated binding protein 2 -0.00590917
MMP7 matrix metallopeptidase 7 -0.00590862
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -0.00590159
FMO2 flavin containing monooxygenase 2 (non-functional) -0.0058994
PDZK1IP1 PDZK1 interacting protein 1 -0.00589371
VGLL4 vestigial-like family member 4 -0.00589072
XAF1 XIAP associated factor 1 -0.005867
MAP7D1 MAP7 domain containing 1 -0.00586682
BCL3 B-cell CLL/lymphoma 3 -0.00585243
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.00585036
ADGRL2 adhesion G protein-coupled receptor L2 -0.0058391
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 -0.00583492
TNNI1 troponin I type 1 (skeletal, slow) -0.00582624
CTSH cathepsin H -0.00582399
AFF1 AF4/FMR2 family, member 1 -0.00580783
RNF144A ring finger protein 144A -0.0057951
PBX3 pre-B-cell leukemia homeobox 3 -0.0057949
FXYD5 FXYD domain containing ion transport regulator 5 -0.00578906
RIN2 Ras and Rab interactor 2 -0.00578519
CCND3 cyclin D3 -0.00578376
NCF2 neutrophil cytosolic factor 2 -0.00575871
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.00575747
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 -0.00575427
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.00575072
CUX1 cut-like homeobox 1 -0.0057236
PNMA2 paraneoplastic Ma antigen 2 -0.00570468
WDR45 WD repeat domain 45 -0.00569772
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) -0.0056973
ZYX zyxin -0.0056902