SPI1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description Spi-1 proto-oncogene|This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6688)
External Link http://www.ncbi.nlm.nih.gov/gene/6688
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Genes

146 interacting proteins for SPI1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ALYREF Aly/REF export factor
ATF1 activating transcription factor 1
AZU1 azurocidin 1
BANF1 barrier to autointegration factor 1
BCL6 B-cell CLL/lymphoma 6
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CMSS1 cms1 ribosomal small subunit homolog (yeast)
CNBP CCHC-type zinc finger, nucleic acid binding protein
CREBBP CREB binding protein
CREM cAMP responsive element modulator
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CTSG cathepsin G
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
E2F1 E2F transcription factor 1
E2F2 E2F transcription factor 2
E2F3 E2F transcription factor 3
ELF1 E74-like factor 1 (ets domain transcription factor)
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
ETV1 ets variant 1
EWSR1 EWS RNA-binding protein 1
EXOSC1 exosome component 1
EXOSC10 exosome component 10
EXOSC2 exosome component 2
EXOSC4 exosome component 4
EXOSC5 exosome component 5
EXOSC6 exosome component 6
EXOSC8 exosome component 8
EXOSC9 exosome component 9
FOS FBJ murine osteosarcoma viral oncogene homolog
FTSJ3 FtsJ homolog 3 (E. coli)
FUS FUS RNA binding protein
GATA1 GATA binding protein 1 (globin transcription factor 1)
GATA2 GATA binding protein 2
GATA3 GATA binding protein 3
GFI1 growth factor independent 1 transcription repressor
H1FX H1 histone family, member X
HDAC1 histone deacetylase 1
HDAC3 histone deacetylase 3
HIST1H1B histone cluster 1, H1b
HIST1H4F histone cluster 1, H4f
HMGB1 high mobility group box 1
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HNRNPM heterogeneous nuclear ribonucleoprotein M
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HOXA10 homeobox A10
HSPA8 heat shock 70kDa protein 8
IRF1 interferon regulatory factor 1
IRF4 interferon regulatory factor 4
IRF8 interferon regulatory factor 8
JUN jun proto-oncogene
KAT6A K(lysine) acetyltransferase 6A
LIG3 ligase III, DNA, ATP-dependent
LYZ lysozyme
MAPK1 mitogen-activated protein kinase 1
MAPK15 mitogen-activated protein kinase 15
MAPK3 mitogen-activated protein kinase 3
MAPK6 mitogen-activated protein kinase 6
MAPK7 mitogen-activated protein kinase 7
MAPK8 mitogen-activated protein kinase 8
MECP2 methyl CpG binding protein 2
MITF microphthalmia-associated transcription factor
MNDA myeloid cell nuclear differentiation antigen
MPG N-methylpurine-DNA glycosylase
MSH2 mutS homolog 2
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFYA nuclear transcription factor Y, alpha
NONO non-POU domain containing, octamer-binding
NUCLEOLIN nucleolin multifunctional protein
PARP1 poly (ADP-ribose) polymerase 1
PIP prolactin-induced protein
PML promyelocytic leukemia
POLG polymerase (DNA directed), gamma
POLR1C polymerase (RNA) I polypeptide C, 30kDa
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
POLR3A polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
POLR3B polymerase (RNA) III (DNA directed) polypeptide B
POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD)
POLRMT polymerase (RNA) mitochondrial (DNA directed)
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKCD protein kinase C, delta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
RARA retinoic acid receptor, alpha
RB1 retinoblastoma 1
RBM14 RNA binding motif protein 14
RBM28 RNA binding motif protein 28
RBMX RNA binding motif protein, X-linked
RFC1 replication factor C (activator 1) 1, 145kDa
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RNASE3 ribonuclease, RNase A family, 3
RPA1 replication protein A1, 70kDa
RPL22 ribosomal protein L22
RPL24 ribosomal protein L24
RPL31 ribosomal protein L31
RPL4 ribosomal protein L4
RPS10 ribosomal protein S10
RPS11 ribosomal protein S11
RPS15A ribosomal protein S15a
RPS24 ribosomal protein S24
RPS25 ribosomal protein S25
RPS3 ribosomal protein S3
RPS4X ribosomal protein S4, X-linked
RPS6 ribosomal protein S6
RPS7 ribosomal protein S7
RPS8 ribosomal protein S8
RPUSD3 RNA pseudouridylate synthase domain containing 3
RSL1D1 ribosomal L1 domain containing 1
SIN3A SIN3 transcription regulator family member A
SKI SKI proto-oncogene
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae)
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein)
SRP9 signal recognition particle 9kDa
SSBP1 single-stranded DNA binding protein 1, mitochondrial
SSRP1 structure specific recognition protein 1
SUB1 SUB1 homolog (S. cerevisiae)
TBP TATA box binding protein
TCEANC2 transcription elongation factor A (SII) N-terminal and central domain containing 2
TFAM transcription factor A, mitochondrial
TFDP1 transcription factor Dp-1
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TMX1 thioredoxin-related transmembrane protein 1
TOP1 topoisomerase (DNA) I
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
VAV1 vav 1 guanine nucleotide exchange factor
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YBX1 Y box binding protein 1