SPIB Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description Spi-B transcription factor (Spi-1/PU.1 related)|The protein encoded by this gene is a transcriptional activator that binds to the PU-box (5'-GAGGAA-3') and acts as a lymphoid-specific enhancer. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] (NCBI Entrez Gene Database, 6689)
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Genes

344 genes differentially expressed following the SPIB gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SLA2 Src-like-adaptor 2 3.47442
LRRC32 leucine rich repeat containing 32 3.47442
CA1 carbonic anhydrase I 3.47442
TMEM88 transmembrane protein 88 3.47442
C11ORF86 chromosome 11 open reading frame 86 3.47442
GH1 growth hormone 1 3.47442
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 3.47442
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 3.47442
GFRA3 GDNF family receptor alpha 3 3.47442
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 3.47442
HORMAD2 HORMA domain containing 2 3.47442
SBSN suprabasin 3.47442
TLR5 toll-like receptor 5 3.47442
LRRC74B leucine rich repeat containing 74B 3.47442
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 3.47442
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 3.47442
HRG histidine-rich glycoprotein 3.47442
STOML1 stomatin (EPB72)-like 1 3.47442
MEIS1 Meis homeobox 1 3.47442
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 3.47442
PGBD4 piggyBac transposable element derived 4 3.47442
TAFA3 TAFA chemokine like family member 3 3.47442
TMC3 transmembrane channel-like 3 3.47442
CAPSL calcyphosine-like 3.47442
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 3.47442
FPR2 formyl peptide receptor 2 3.47442
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 3.47442
CLEC2A C-type lectin domain family 2, member A 3.47442
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) 3.47442
KRT23 keratin 23, type I 3.33099
SIX2 SIX homeobox 2 3.33099
PGAM4 phosphoglycerate mutase family member 4 3.33099
NANOS2 nanos homolog 2 (Drosophila) 3.33099
LAX1 lymphocyte transmembrane adaptor 1 3.33099
SLC16A11 solute carrier family 16, member 11 3.33099
CELF3 CUGBP, Elav-like family member 3 3.33099
FOLR1 folate receptor 1 (adult) 3.33099
HBZ hemoglobin, zeta 3.33099
PCDHGB3 protocadherin gamma subfamily B, 3 3.33099
LRRC14B leucine rich repeat containing 14B 3.33099
RFPL3 ret finger protein-like 3 3.33099
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 3.33099
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 3.33099
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 3.33099
DLX4 distal-less homeobox 4 3.33099
LONRF3 LON peptidase N-terminal domain and ring finger 3 3.33099
RFX6 regulatory factor X, 6 3.33099
PRDM16 PR domain containing 16 3.33099
TNIP3 TNFAIP3 interacting protein 3 3.33099
ALPK2 alpha-kinase 2 3.33099
GYPB glycophorin B (MNS blood group) 3.33099
HCRTR2 hypocretin (orexin) receptor 2 3.33099
SH2D6 SH2 domain containing 6 3.33099
WT1 Wilms tumor 1 3.33099
SIGLEC5 sialic acid binding Ig-like lectin 5 3.33099
SCNN1G sodium channel, non voltage gated 1 gamma subunit 3.33099
SSTR5 somatostatin receptor 5 3.33099
CCL3L3 chemokine (C-C motif) ligand 3-like 3 3.33099
DIRAS2 DIRAS family, GTP-binding RAS-like 2 3.33099
EVPL envoplakin 3.33099
PRR20G proline rich 20G 3.33099
PNLIPRP1 pancreatic lipase-related protein 1 3.33099
VN1R2 vomeronasal 1 receptor 2 3.33099
ELOVL3 ELOVL fatty acid elongase 3 3.33099
FIMP1 fertilization-influencing membrane protein 1 3.33099
MLN motilin 3.33099
SMLR1 small leucine-rich protein 1 3.33099
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 3.33099
OR52R1 olfactory receptor, family 52, subfamily R, member 1 (gene/pseudogene) 3.33099
MYEOV myeloma overexpressed 3.33099
PROP1 PROP paired-like homeobox 1 3.33099
AVPR1A arginine vasopressin receptor 1A 3.33099
OR10H1 olfactory receptor, family 10, subfamily H, member 1 3.33099
EXOC1L exocyst complex component 1 like 3.33099
SYT15B synaptotagmin 15B 3.33099
LY6L lymphocyte antigen 6 family member L 3.33099
MAJIN membrane anchored junction protein 3.33099
DNAAF6 dynein axonemal assembly factor 6 3.33099
CFAP157 cilia and flagella associated protein 157 3.33099
CCN6 cellular communication network factor 6 3.33099
GGTA1 glycoprotein alpha-galactosyltransferase 1 (inactive) 3.33099
SQOR sulfide quinone oxidoreductase 3.33099
ZNF705A zinc finger protein 705A 3.33099
SYT15 synaptotagmin XV 3.33099
TEX101 testis expressed 101 3.33099
PTGDR2 prostaglandin D2 receptor 2 3.33099
DMP1 dentin matrix acidic phosphoprotein 1 3.33099
PRB3 proline-rich protein BstNI subfamily 3 3.33099
CDX2 caudal type homeobox 2 3.33099
MYH15 myosin, heavy chain 15 3.33099
CPNE6 copine VI (neuronal) 3.33099
SCARA5 scavenger receptor class A, member 5 3.33099
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 3.33099
UROC1 urocanate hydratase 1 3.33099
ZIC4 Zic family member 4 3.33099
TLR7 toll-like receptor 7 3.33099
CNTN6 contactin 6 3.33099
ASIC3 acid sensing (proton gated) ion channel 3 3.33099
GDF6 growth differentiation factor 6 3.33099
LRRC72 leucine rich repeat containing 72 3.33099
S100B S100 calcium binding protein B 3.33099
ARMS2 age-related maculopathy susceptibility 2 3.33099
PIWIL3 piwi-like RNA-mediated gene silencing 3 3.33099
KCNT1 potassium channel, sodium activated subfamily T, member 1 3.33099
C1QL2 complement component 1, q subcomponent-like 2 3.33099
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 3.33099
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 3.33099
IL12A interleukin 12A 3.33099
THTPA thiamine triphosphatase 3.33099
BTNL2 butyrophilin-like 2 3.33099
AQP9 aquaporin 9 3.33099
CXCR4 chemokine (C-X-C motif) receptor 4 3.33099
C9ORF64 chromosome 9 open reading frame 64 3.33099
CYSLTR1 cysteinyl leukotriene receptor 1 3.33099
KLHL41 kelch-like family member 41 3.33099
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 3.33099
CLDN34 claudin 34 3.33099
NOG noggin 3.33099
CLIC5 chloride intracellular channel 5 3.33099
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 3.33099
HSPB9 heat shock protein, alpha-crystallin-related, B9 3.33099
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 3.33099
PCDHGB4 protocadherin gamma subfamily B, 4 3.33099
PCDHGB2 protocadherin gamma subfamily B, 2 3.33099
CCL27 chemokine (C-C motif) ligand 27 3.33099
KCNK4 potassium channel, two pore domain subfamily K, member 4 3.33099
ZSCAN4 zinc finger and SCAN domain containing 4 3.33099
DNTT DNA nucleotidylexotransferase 3.33099
IL19 interleukin 19 3.33099
SLC22A24 solute carrier family 22, member 24 3.33099
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 3.33099
ORM2 orosomucoid 2 3.33099
EFCC1 EF-hand and coiled-coil domain containing 1 3.33099
NOTCH2 notch 2 3.33099
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 3.33099
EOMES eomesodermin 3.33099
DRC7 dynein regulatory complex subunit 7 3.33099
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 3.33099
CTSO cathepsin O 3.33099
ZIM2 zinc finger, imprinted 2 3.33099
TMEM31 transmembrane protein 31 3.33099
KLK15 kallikrein-related peptidase 15 3.33099
C20ORF144 chromosome 20 open reading frame 144 3.33099
ITGB6 integrin, beta 6 3.33099
MAGED4B melanoma antigen family D4B 3.33099
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 3.33099
NTN5 netrin 5 3.33099
CDH17 cadherin 17, LI cadherin (liver-intestine) 3.33099
VAV1 vav 1 guanine nucleotide exchange factor 3.33099
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 3.33099
ZNF679 zinc finger protein 679 3.33099
LST1 leukocyte specific transcript 1 3.33099
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 3.33099
CHAT choline O-acetyltransferase 3.33099
NLRP6 NLR family, pyrin domain containing 6 3.33099
PODN podocan 3.33099
ABHD16B abhydrolase domain containing 16B 3.33099
HOXB1 homeobox B1 3.33099
MS4A10 membrane-spanning 4-domains, subfamily A, member 10 3.33099
DCST2 DC-STAMP domain containing 2 3.33099
NCKAP5 NCK-associated protein 5 3.33099
CHRDL2 chordin-like 2 3.33099
IL17B interleukin 17B 3.33099
NKPD1 NTPase, KAP family P-loop domain containing 1 3.33099
IFITM10 interferon induced transmembrane protein 10 3.33099
CLCF1 cardiotrophin-like cytokine factor 1 3.33099
NUTM2A NUT family member 2A 3.33099
POU3F2 POU class 3 homeobox 2 3.33099
CDCP2 CUB domain containing protein 2 3.33099
GREM1 gremlin 1, DAN family BMP antagonist 3.33099
MAGEA12 melanoma antigen family A12 3.33099
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 3.25605
FAM162B family with sequence similarity 162, member B 3.23899
GJB3 gap junction protein, beta 3, 31kDa 3.07504
SH3BGR SH3 domain binding glutamate-rich protein 3.06943
CEP290 centrosomal protein 290kDa 3.04571
TIPE3 TNF alpha induced protein 8 like 3 3.03586
FAM90A1 family with sequence similarity 90, member A1 2.91939
SYTL2 synaptotagmin-like 2 2.85971
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 2.8424
LSR lipolysis stimulated lipoprotein receptor 2.76717
CACHD1 cache domain containing 1 2.74285
SAMD3 sterile alpha motif domain containing 3 2.71375
ZNF446 zinc finger protein 446 2.69221
RMDN3 regulator of microtubule dynamics 3 2.69209
TMEM182 transmembrane protein 182 2.6805
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 2.57568
PNPLA2 patatin-like phospholipase domain containing 2 2.54113
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 2.53803
MTAP methylthioadenosine phosphorylase 2.53196
CCDC121 coiled-coil domain containing 121 2.50648
NSUN2 NOP2/Sun RNA methyltransferase family, member 2 2.49729
NPM2 nucleophosmin/nucleoplasmin 2 2.49167
TPPP tubulin polymerization promoting protein 2.49167
HOOK2 hook microtubule-tethering protein 2 2.45984
MMP19 matrix metallopeptidase 19 2.43255
GPR161 G protein-coupled receptor 161 2.38449
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 2.3717
NFYA nuclear transcription factor Y, alpha 2.35761
RPAP1 RNA polymerase II associated protein 1 2.35761
WDR62 WD repeat domain 62 2.35318
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 2.35246
HEATR5B HEAT repeat containing 5B 2.35246
ZNF311 zinc finger protein 311 2.29062
GPR78 G protein-coupled receptor 78 2.27055
GPR179 G protein-coupled receptor 179 2.26851
FAM177B family with sequence similarity 177, member B 2.26851
PID1 phosphotyrosine interaction domain containing 1 2.25464
VKORC1L1 vitamin K epoxide reductase complex, subunit 1-like 1 2.24613
SCRT2 scratch family zinc finger 2 2.23442
ATXN7 ataxin 7 2.23442
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 2.23442
MROH1 maestro heat-like repeat family member 1 2.22913
ARHGAP15 Rho GTPase activating protein 15 2.21925
WNT4 wingless-type MMTV integration site family, member 4 2.21925
RTBDN retbindin 2.21925
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 2.21925
ETNK1 ethanolamine kinase 1 2.18795
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1 2.18245
KIFBP kinesin family binding protein 2.18245
HIPK2 homeodomain interacting protein kinase 2 2.18245
HRH2 histamine receptor H2 2.13266
SORBS1 sorbin and SH3 domain containing 1 2.11639
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1 2.08982
VIL1 villin 1 2.06255
NDUFAF2 NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 2.06255
ZNF609 zinc finger protein 609 2.05967
PRIMPOL primase and polymerase (DNA-directed) 2.05967
C19ORF25 chromosome 19 open reading frame 25 2.05411
SAMD14 sterile alpha motif domain containing 14 2.03321
GLI4 GLI family zinc finger 4 2.02886
SEPTIN5 septin 5 2.01364
NAV1 neuron navigator 1 2.01317
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 2.00594

decreased expression

Symbol Name Standardized Value
TMEM190 transmembrane protein 190 -3.47442
EQTN equatorin, sperm acrosome associated -3.47442
ADAM21 ADAM metallopeptidase domain 21 -3.47442
CFAP53 cilia and flagella associated protein 53 -3.47442
FOXJ1 forkhead box J1 -3.47442
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like -3.47442
PCP4L1 Purkinje cell protein 4 like 1 -3.47442
TMEM272 transmembrane protein 272 -3.47442
FLI1 Fli-1 proto-oncogene, ETS transcription factor -3.47442
DAO D-amino-acid oxidase -3.33099
MEOX2 mesenchyme homeobox 2 -3.33099
PDCD1 programmed cell death 1 -3.33099
PADI1 peptidyl arginine deiminase, type I -3.33099
PIWIL1 piwi-like RNA-mediated gene silencing 1 -3.33099
PRAM1 PML-RARA regulated adaptor molecule 1 -3.33099
CD86 CD86 molecule -3.33099
CES3 carboxylesterase 3 -3.33099
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 -3.33099
GCKR glucokinase (hexokinase 4) regulator -3.33099
C6ORF58 chromosome 6 open reading frame 58 -3.33099
ACOT12 acyl-CoA thioesterase 12 -3.33099
PON1 paraoxonase 1 -3.33099
PRR22 proline rich 22 -3.33099
GLUD2 glutamate dehydrogenase 2 -3.33099
NKD2 naked cuticle homolog 2 (Drosophila) -3.33099
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 -3.33099
FCN3 ficolin (collagen/fibrinogen domain containing) 3 -3.33099
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type -3.33099
LEKR1 leucine, glutamate and lysine rich 1 -3.33099
MROH9 maestro heat-like repeat family member 9 -3.33099
UPK1B uroplakin 1B -3.33099
NHLH1 nescient helix loop helix 1 -3.33099
ITGB7 integrin, beta 7 -3.33099
PHF24 PHD finger protein 24 -3.33099
IDI2 isopentenyl-diphosphate delta isomerase 2 -3.33099
STYXL2 serine/threonine/tyrosine interacting like 2 -3.33099
C11ORF42 chromosome 11 open reading frame 42 -3.33099
SMIM41 small integral membrane protein 41 -3.33099
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 -3.33099
SH2D4B SH2 domain containing 4B -3.33099
IL21R interleukin 21 receptor -3.33099
STARD6 StAR-related lipid transfer (START) domain containing 6 -3.33099
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 -3.33099
VCX3B variable charge, X-linked 3B -3.33099
CLRN1 clarin 1 -3.33099
TRPC6 transient receptor potential cation channel, subfamily C, member 6 -3.25775
COASY CoA synthase -3.25762
LAG3 lymphocyte-activation gene 3 -3.16935
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like -3.06943
LMOD1 leiomodin 1 (smooth muscle) -2.89944
WIPF3 WAS/WASL interacting protein family, member 3 -2.85415
BASP1 brain abundant, membrane attached signal protein 1 -2.74285
RASL12 RAS-like, family 12 -2.66637
MARS2 methionyl-tRNA synthetase 2, mitochondrial -2.6486
SNTA1 syntrophin, alpha 1 -2.64358
L2HGDH L-2-hydroxyglutarate dehydrogenase -2.64358
DLL3 delta-like 3 (Drosophila) -2.57568
ENDOD1 endonuclease domain containing 1 -2.51603
TRIL TLR4 interactor with leucine-rich repeats -2.50435
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 -2.49729
CERK ceramide kinase -2.49253
CSP2 CS pseudogene 2 -2.49244
FDX2 ferredoxin 2 -2.49244
ZNF841 zinc finger protein 841 -2.49244
DKK2 dickkopf WNT signaling pathway inhibitor 2 -2.48707
SACK1H scaffolding CK1 anchoring protein H -2.45984
TERF2IP telomeric repeat binding factor 2, interacting protein -2.43075
VAV2 vav 2 guanine nucleotide exchange factor -2.33721
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -2.33199
SYNE1 spectrin repeat containing, nuclear envelope 1 -2.33121
SNRPN small nuclear ribonucleoprotein polypeptide N -2.30769
TRMT61B tRNA methyltransferase 61B -2.29062
SET SET nuclear proto-oncogene -2.27983
KCTD8 potassium channel tetramerization domain containing 8 -2.27447
LDB3 LIM domain binding 3 -2.26998
PCDHB14 protocadherin beta 14 -2.26744
RREB1 ras responsive element binding protein 1 -2.26518
LAMA4 laminin, alpha 4 -2.25464
CHPF chondroitin polymerizing factor -2.21925
TRIM28 tripartite motif containing 28 -2.21925
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -2.17665
EXOSC3 exosome component 3 -2.16865
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae) -2.16865
NAPB N-ethylmaleimide-sensitive factor attachment protein, beta -2.15593
HELZ helicase with zinc finger -2.15538
MRPL30 mitochondrial ribosomal protein L30 -2.14014
SRF serum response factor (c-fos serum response element-binding transcription factor) -2.12371
SETDB2 SET domain, bifurcated 2 -2.11183
RERG RAS-like, estrogen-regulated, growth inhibitor -2.10358
H4C6 H4 clustered histone 6 -2.10123
DSCAML1 Down syndrome cell adhesion molecule like 1 -2.10116
ARMC9 armadillo repeat containing 9 -2.09393
C19ORF12 chromosome 19 open reading frame 12 -2.07939
MON2 MON2 homolog (S. cerevisiae) -2.07939
DOP1A DOP1 leucine zipper like protein A -2.06532
CDC27 cell division cycle 27 -2.06048
MED29 mediator complex subunit 29 -2.05277
TCEAL3 transcription elongation factor A (SII)-like 3 -2.05277
CDKL4 cyclin-dependent kinase-like 4 -2.04535
TTPAL tocopherol (alpha) transfer protein-like -2.03911
AOC2 amine oxidase, copper containing 2 (retina-specific) -2.0344
PRKACA protein kinase, cAMP-dependent, catalytic, alpha -2.02901
HIGD1A HIG1 hypoxia inducible domain family, member 1A -2.02748
TENM2 teneurin transmembrane protein 2 -2.01847
ZBTB7C zinc finger and BTB domain containing 7C -2.01845
PTBP1 polypyrimidine tract binding protein 1 -2.0171
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -2.01317
PTPN3 protein tyrosine phosphatase, non-receptor type 3 -2.01317
SRSF2 serine/arginine-rich splicing factor 2 -2.00802
ZNF154 zinc finger protein 154 -2.00032