SPO11 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description SPO11 meiotic protein covalently bound to DSB|Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 23626)
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Genes

349 genes differentially expressed following the SPO11 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ZNF492 zinc finger protein 492 3.23105
ADGRD1 adhesion G protein-coupled receptor D1 3.23105
NPAS4 neuronal PAS domain protein 4 3.23105
HBZ hemoglobin, zeta 3.23105
SIGLEC15 sialic acid binding Ig-like lectin 15 3.23105
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 3.23105
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 3.23105
PCDH12 protocadherin 12 3.23105
NUTM2A NUT family member 2A 3.23105
IL5 interleukin 5 3.23105
NGB neuroglobin 3.23105
TRIM55 tripartite motif containing 55 3.23105
FNDC9 fibronectin type III domain containing 9 3.23105
PCDHA7 protocadherin alpha 7 3.23105
GFI1B growth factor independent 1B transcription repressor 3.23105
OR52A5 olfactory receptor, family 52, subfamily A, member 5 3.23105
CAMK2B calcium/calmodulin-dependent protein kinase II beta 3.23105
LRRC74B leucine rich repeat containing 74B 3.23105
SP6 Sp6 transcription factor 3.23105
CCNI2 cyclin I family, member 2 3.23105
ANXA8 annexin A8 3.23105
GARIN1A golgi associated RAB2 interactor 1A 3.23105
BTBD16 BTB (POZ) domain containing 16 3.23105
SPEGNB SPEG neighbor 3.23105
OXER1 oxoeicosanoid (OXE) receptor 1 3.23105
KLK4 kallikrein-related peptidase 4 3.23105
TMEM52B transmembrane protein 52B 3.12058
ADTRP androgen-dependent TFPI-regulating protein 3.12058
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 3.12058
PRSS22 protease, serine, 22 3.12058
TPH1 tryptophan hydroxylase 1 3.12058
EPPIN epididymal peptidase inhibitor 3.12058
GLUD2 glutamate dehydrogenase 2 3.12058
MUC1 mucin 1, cell surface associated 3.12058
TMEM87B transmembrane protein 87B 3.12058
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 3.12058
TRIM15 tripartite motif containing 15 3.12058
IL22RA1 interleukin 22 receptor, alpha 1 3.12058
CNTNAP4 contactin associated protein-like 4 3.12058
GNLY granulysin 3.12058
CCL5 chemokine (C-C motif) ligand 5 3.12058
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 3.12058
TYRP1 tyrosinase-related protein 1 3.12058
CPLX3 complexin 3 3.12058
ATOH1 atonal homolog 1 (Drosophila) 3.12058
CCHCR1 coiled-coil alpha-helical rod protein 1 3.12058
LVRN laeverin 3.12058
HIC1 hypermethylated in cancer 1 3.12058
CCDC38 coiled-coil domain containing 38 3.12058
HES2 hes family bHLH transcription factor 2 3.12058
NWD2 NACHT and WD repeat domain containing 2 3.12058
NCKAP1L NCK-associated protein 1-like 3.12058
CCDC87 coiled-coil domain containing 87 3.12058
SLC39A4 solute carrier family 39 (zinc transporter), member 4 3.12058
TRIM74 tripartite motif containing 74 3.12058
C19ORF67 chromosome 19 open reading frame 67 3.12058
GYPB glycophorin B (MNS blood group) 3.12058
TUBB1 tubulin, beta 1 class VI 3.12058
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 3.12058
ASB10 ankyrin repeat and SOCS box containing 10 3.12058
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 3.12058
SLC26A9 solute carrier family 26 (anion exchanger), member 9 3.12058
SPMIP1 sperm microtubule inner protein 1 3.12058
FOXN4 forkhead box N4 3.12058
MYZAP myocardial zonula adherens protein 3.12058
C1QTNF9B C1q and tumor necrosis factor related protein 9B 3.12058
PROZ protein Z, vitamin K-dependent plasma glycoprotein 3.12058
OR1C1 olfactory receptor, family 1, subfamily C, member 1 3.12058
SRPK3 SRSF protein kinase 3 3.12058
GRAP GRB2-related adaptor protein 3.12058
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 3.12058
ZNF705A zinc finger protein 705A 3.12058
IL7R interleukin 7 receptor 3.12058
CCER2 coiled-coil glutamate-rich protein 2 3.12058
GPX6 glutathione peroxidase 6 3.12058
ZNF593OS ZNF593 opposite strand 3.12058
LY6L lymphocyte antigen 6 family member L 3.12058
EZHIP EZH inhibitory protein 3.12058
CFAP107 cilia and flagella associated protein 107 3.12058
DUSP29 dual specificity phosphatase 29 3.12058
CFAP65 cilia and flagella associated protein 65 3.12058
STYXL2 serine/threonine/tyrosine interacting like 2 3.12058
STING1 stimulator of interferon response cGAMP interactor 1 3.12058
H2BC1 H2B clustered histone 1 3.12058
PTH1R parathyroid hormone 1 receptor 3.12058
RGS21 regulator of G-protein signaling 21 3.12058
CELA2A chymotrypsin-like elastase family, member 2A 3.12058
VIT vitrin 3.12058
PRB2 proline-rich protein BstNI subfamily 2 3.12058
PCDHA5 protocadherin alpha 5 3.12058
RS1 retinoschisin 1 3.12058
GRXCR1 glutaredoxin, cysteine rich 1 3.12058
FPR3 formyl peptide receptor 3 3.12058
PRB1 proline-rich protein BstNI subfamily 1 3.12058
PLVAP plasmalemma vesicle associated protein 3.12058
UCN urocortin 3.12058
ZSCAN5B zinc finger and SCAN domain containing 5B 3.12058
ERVFRD-1 endogenous retrovirus group FRD, member 1 3.12058
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 3.12058
TCF23 transcription factor 23 3.12058
SPDYC speedy/RINGO cell cycle regulator family member C 3.12058
RASAL3 RAS protein activator like 3 3.12058
C1QTNF8 C1q and tumor necrosis factor related protein 8 3.12058
TBX3 T-box 3 3.12058
OR2A12 olfactory receptor, family 2, subfamily A, member 12 3.12058
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 3.12058
UROC1 urocanate hydratase 1 3.12058
CKM creatine kinase, muscle 3.12058
CLIP4 CAP-GLY domain containing linker protein family, member 4 3.12058
OR52H1 olfactory receptor, family 52, subfamily H, member 1 3.12058
ASCL2 achaete-scute family bHLH transcription factor 2 3.12058
TMEM204 transmembrane protein 204 3.12058
DRD1 dopamine receptor D1 3.12058
HELT helt bHLH transcription factor 3.12058
ALAS2 5'-aminolevulinate synthase 2 3.12058
CHI3L2 chitinase 3-like 2 3.12058
THBD thrombomodulin 3.12058
KLK11 kallikrein-related peptidase 11 3.12058
KRT17 keratin 17, type I 3.12058
COL6A5 collagen, type VI, alpha 5 3.12058
C20ORF144 chromosome 20 open reading frame 144 3.12058
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 3.12058
PLA2G4E phospholipase A2, group IVE 3.12058
MAGEB17 melanoma antigen family B17 3.12058
KLK5 kallikrein-related peptidase 5 3.12058
PRSS57 protease, serine, 57 3.12058
PRSS56 protease, serine, 56 3.12058
ZNF366 zinc finger protein 366 3.12058
PCDHGB1 protocadherin gamma subfamily B, 1 3.12058
CALHM3 calcium homeostasis modulator 3 3.12058
PLET1 placenta expressed transcript 1 3.12058
PKDREJ polycystin (PKD) family receptor for egg jelly 3.12058
PRM1 protamine 1 3.12058
NIPAL4 NIPA-like domain containing 4 3.12058
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 3.12058
CYSLTR2 cysteinyl leukotriene receptor 2 3.12058
CTAGE4 CTAGE family, member 4 3.12058
UBQLNL ubiquilin-like 3.12058
RAD51AP2 RAD51 associated protein 2 3.12058
MAB21L1 mab-21-like 1 (C. elegans) 3.12058
AMMECR1L AMMECR1-like 3.12058
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 3.12058
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 3.12058
NPPA natriuretic peptide A 3.12058
CRTAM cytotoxic and regulatory T cell molecule 3.12058
NUTM2B NUT family member 2B 3.12058
TYR tyrosinase 3.12058
CD8A CD8a molecule 3.12058
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 3.12058
TMEM45B transmembrane protein 45B 3.12058
ADCY4 adenylate cyclase 4 3.12058
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 3.12058
GJB6 gap junction protein, beta 6, 30kDa 3.12058
FKBP1C FK506 binding protein 1C 3.12058
SPNS3 spinster homolog 3 (Drosophila) 3.12058
ZNF831 zinc finger protein 831 3.12058
TAS2R41 taste receptor, type 2, member 41 3.12058
ANGPTL3 angiopoietin-like 3 3.12058
GOLGA8N golgin A8 family, member N 3.12058
GPRC5D G protein-coupled receptor, class C, group 5, member D 3.12058
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 3.12058
CLCA4 chloride channel accessory 4 3.12058
NYX nyctalopin 3.12058
CALR3 calreticulin 3 3.12058
CFB complement factor B 3.12058
LST1 leukocyte specific transcript 1 3.12058
CTXN2 cortexin 2 3.12058
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 3.12058
GH1 growth hormone 1 3.12058
GSTA1 glutathione S-transferase alpha 1 3.12058
DLX3 distal-less homeobox 3 3.12058
DLX2 distal-less homeobox 2 3.12058
CTSS cathepsin S 3.12058
CHRM4 cholinergic receptor, muscarinic 4 3.12058
BCL2L15 BCL2-like 15 3.12058
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene) 3.12058
RBBP8NL RBBP8 N-terminal like 3.12058
OR2J3 olfactory receptor, family 2, subfamily J, member 3 3.12058
RAD9B RAD9 homolog B (S. pombe) 3.12058
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B 3.02499
PDE7B phosphodiesterase 7B 3.0107
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 3.0107
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 2.95376
SEPTIN6 septin 6 2.91442
DERL3 derlin 3 2.91331
SEPHS2 selenophosphate synthetase 2 2.78124
GOLPH3 golgi phosphoprotein 3 (coat-protein) 2.76397
KRTCAP3 keratinocyte associated protein 3 2.76397
LCA5 Leber congenital amaurosis 5 2.73388
EMC7 ER membrane protein complex subunit 7 2.6865
APOE apolipoprotein E 2.65038
TBP TATA box binding protein 2.6062
ZNF699 zinc finger protein 699 2.55426
ZNF836 zinc finger protein 836 2.55426
SNTG2 syntrophin, gamma 2 2.54696
SLC39A9 solute carrier family 39, member 9 2.54696
PPAN peter pan homolog (Drosophila) 2.54627
ALX1 ALX homeobox 1 2.52918
ACE angiotensin I converting enzyme 2.49386
SMIM10L1 small integral membrane protein 10 like 1 2.48881
ASRGL1 asparaginase like 1 2.47977
SPATA2 spermatogenesis associated 2 2.47173
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 2.46659
LYST lysosomal trafficking regulator 2.43529
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit 2.41493
HAPLN3 hyaluronan and proteoglycan link protein 3 2.40235
ZNF696 zinc finger protein 696 2.40235
ST14 suppression of tumorigenicity 14 (colon carcinoma) 2.40235
SDSL serine dehydratase-like 2.3949
R3HDML R3H domain containing-like 2.38136
TRPA1 transient receptor potential cation channel, subfamily A, member 1 2.37355
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1 2.36228
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 2.30537
PDHX pyruvate dehydrogenase complex, component X 2.30537
DIAPH2 diaphanous-related formin 2 2.29542
SPI1 Spi-1 proto-oncogene 2.28973
PTAR1 protein prenyltransferase alpha subunit repeat containing 1 2.25952
CHSY3 chondroitin sulfate synthase 3 2.25952
PLIN3 perilipin 3 2.24938
ING2 inhibitor of growth family, member 2 2.23494
MRPS31 mitochondrial ribosomal protein S31 2.20009
ZNF551 zinc finger protein 551 2.19352
IMP3 IMP3, U3 small nucleolar ribonucleoprotein 2.19041
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 2.18999
CCN1 cellular communication network factor 1 2.18981
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit 2.18726
C12ORF76 chromosome 12 open reading frame 76 2.18374
ACD adrenocortical dysplasia homolog (mouse) 2.1826
STX8 syntaxin 8 2.1826
CLDN4 claudin 4 2.17387
CSK c-src tyrosine kinase 2.17188
MIEF1 mitochondrial elongation factor 1 2.15384
API5 apoptosis inhibitor 5 2.14656
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 2.13517
ELP1 elongator acetyltransferase complex subunit 1 2.11121
ZSWIM5 zinc finger, SWIM-type containing 5 2.09553
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 2.08225
FSTL1 follistatin-like 1 2.03757
ZDHHC21 zinc finger, DHHC-type containing 21 2.03352
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 2.03297
IQSEC1 IQ motif and Sec7 domain 1 2.02967
MGAM maltase-glucoamylase 2.027
GOLGA6C golgin A6 family, member C 2.027
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 2.027
KLHL10 kelch-like family member 10 2.027
WBP2NL WBP2 N-terminal like 2.027
ARL15 ADP-ribosylation factor-like 15 2.027
WDR47 WD repeat domain 47 2.00239
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 2.00239

decreased expression

Symbol Name Standardized Value
CCDC159 coiled-coil domain containing 159 -3.23105
LGALS9 lectin, galactoside-binding, soluble, 9 -3.23105
RUMY3 RUMY family member 3 -3.23105
MSC musculin -3.23105
ASPH aspartate beta-hydroxylase -3.23105
LOX lysyl oxidase -3.23105
KBTBD12 kelch repeat and BTB (POZ) domain containing 12 -3.12058
ZNF214 zinc finger protein 214 -3.12058
OR14A16 olfactory receptor, family 14, subfamily A, member 16 -3.12058
FOXP3 forkhead box P3 -3.12058
ALLC allantoicase -3.12058
TGM1 transglutaminase 1 -3.12058
NECTIN4 nectin cell adhesion molecule 4 -3.12058
FGF9 fibroblast growth factor 9 -3.12058
VN1R1 vomeronasal 1 receptor 1 -3.12058
WNT3A wingless-type MMTV integration site family, member 3A -3.12058
NPIPA8 nuclear pore complex interacting protein family, member A8 -3.12058
OSGIN1 oxidative stress induced growth inhibitor 1 -3.12058
PPP1R16A protein phosphatase 1, regulatory subunit 16A -3.12058
ALOX12 arachidonate 12-lipoxygenase -3.12058
LOC390937 Ets2 repressor factor-like -3.12058
MIP major intrinsic protein of lens fiber -3.12058
BNC1 basonuclin 1 -3.12058
IFT70A intraflagellar transport 70A -3.12058
OLFML1 olfactomedin-like 1 -3.12058
CREG2 cellular repressor of E1A-stimulated genes 2 -3.12058
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 -3.12058
ZC3H11C zinc finger CCCH-type containing 11C -3.12058
ADRA2A adrenoceptor alpha 2A -3.12058
S100Z S100 calcium binding protein Z -3.12058
AFF4 AF4/FMR2 family, member 4 -3.12058
DRD2 dopamine receptor D2 -3.12058
TRAPPC11 trafficking protein particle complex 11 -3.12058
SCT secretin -3.12058
WDR25 WD repeat domain 25 -2.8967
ZNF644 zinc finger protein 644 -2.78913
PEF1 penta-EF-hand domain containing 1 -2.78124
SLC66A2 solute carrier family 66 member 2 -2.70605
PDCD11 programmed cell death 11 -2.70038
HSPB11 heat shock protein family B (small), member 11 -2.66688
SMIM36 small integral membrane protein 36 -2.64583
DESI2 desumoylating isopeptidase 2 -2.64056
CUBN cubilin (intrinsic factor-cobalamin receptor) -2.58501
LDHC lactate dehydrogenase C -2.56612
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 -2.56612
LRRC17 leucine rich repeat containing 17 -2.56612
GRK4 G protein-coupled receptor kinase 4 -2.55814
NR4A1 nuclear receptor subfamily 4, group A, member 1 -2.55814
RAB11B RAB11B, member RAS oncogene family -2.55814
CD200 CD200 molecule -2.55426
LHFPL5 lipoma HMGIC fusion partner-like 5 -2.54987
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 -2.5191
POU2AF3 POU class 2 homeobox associating factor 3 -2.4735
ZNF276 zinc finger protein 276 -2.45605
RNF128 ring finger protein 128, E3 ubiquitin protein ligase -2.4436
C9ORF153 chromosome 9 open reading frame 153 -2.40235
WASHC3 WASH complex subunit 3 -2.38136
ZMYM1 zinc finger, MYM-type 1 -2.35857
STAG3 stromal antigen 3 -2.33359
ACTN1 actinin, alpha 1 -2.32517
ZNF106 zinc finger protein 106 -2.30537
ZNF583 zinc finger protein 583 -2.30537
SLC35F4 solute carrier family 35, member F4 -2.24889
CFAP20DC CFAP20 domain containing -2.24239
NCLN nicalin -2.23494
CHP1 calcineurin-like EF-hand protein 1 -2.21202
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 -2.19352
HACL2 2-hydroxyacyl-CoA lyase 2 -2.19352
HLA-G major histocompatibility complex, class I, G -2.19352
ACSF2 acyl-CoA synthetase family member 2 -2.19352
TDRP testis development related protein -2.19352
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) -2.19352
FN1 fibronectin 1 -2.19352
IQCC IQ motif containing C -2.19352
ACAD9 acyl-CoA dehydrogenase family, member 9 -2.19352
TNC tenascin C -2.19352
ACTR5 ARP5 actin-related protein 5 homolog (yeast) -2.1826
FCGBP Fc fragment of IgG binding protein -2.1826
CHMP1B charged multivesicular body protein 1B -2.17013
H2BC11 H2B clustered histone 11 -2.16418
DDHD1 DDHD domain containing 1 -2.15384
C1ORF226 chromosome 1 open reading frame 226 -2.15384
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -2.14818
EMILIN2 elastin microfibril interfacer 2 -2.1449
TECPR1 tectonin beta-propeller repeat containing 1 -2.13873
RHBDF1 rhomboid 5 homolog 1 (Drosophila) -2.11121
TINAGL1 tubulointerstitial nephritis antigen-like 1 -2.11121
EML5 echinoderm microtubule associated protein like 5 -2.09905
FANCD2 Fanconi anemia, complementation group D2 -2.09323
ETFB electron-transfer-flavoprotein, beta polypeptide -2.09214
TRIM24 tripartite motif containing 24 -2.08156
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 -2.06782
PAIP2B poly(A) binding protein interacting protein 2B -2.06782
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 -2.06654
PTGES prostaglandin E synthase -2.06654
NXPH2 neurexophilin 2 -2.04295
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli) -2.03757
ZBED8L ZBED8 like -2.03757
LDAH lipid droplet associated hydrolase -2.00495
GAA glucosidase, alpha; acid -2.00363