SPOP Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description speckle-type POZ protein|This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8405)
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Genes

358 genes differentially expressed following the SPOP gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TMEM229A transmembrane protein 229A 2.61849
MUC6 mucin 6, oligomeric mucus/gel-forming 2.61849
GAL galanin/GMAP prepropeptide 2.61849
ZNF462 zinc finger protein 462 2.61849
TM4SF4 transmembrane 4 L six family member 4 2.61849
SSTR1 somatostatin receptor 1 2.61849
PGBDF plakoglobin binding and degradation factor 2.61849
TCHH trichohyalin 2.61849
IL5RA interleukin 5 receptor, alpha 2.61849
OR10A2 olfactory receptor, family 10, subfamily A, member 2 2.61849
SLC25A45 solute carrier family 25, member 45 2.61849
AADACL3 arylacetamide deacetylase-like 3 2.61849
TRIM10 tripartite motif containing 10 2.61849
BSND barttin CLCNK-type chloride channel accessory beta subunit 2.61849
IGFL4 IGF-like family member 4 2.61849
ATP13A4 ATPase type 13A4 2.61849
OR2A25 olfactory receptor, family 2, subfamily A, member 25 2.61849
TBX20 T-box 20 2.61849
RAET1E retinoic acid early transcript 1E 2.61849
GPR75 G protein-coupled receptor 75 2.61849
UPK3B uroplakin 3B 2.61849
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 2.61849
C18ORF25 chromosome 18 open reading frame 25 2.61849
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.61849
WDR87 WD repeat domain 87 2.61849
COLEC10 collectin sub-family member 10 (C-type lectin) 2.61849
PAX5 paired box 5 2.61849
PLCH2 phospholipase C, eta 2 2.61849
OLFM4 olfactomedin 4 2.61849
MUC20 mucin 20, cell surface associated 2.61849
ATOH7 atonal homolog 7 (Drosophila) 2.61849
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 2.61849
ACY3 aminoacylase 3 2.61849
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 2.61849
PRR29 proline rich 29 2.61849
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 2.61849
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 2.61849
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22 2.61849
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 2.61849
TPRX1 tetra-peptide repeat homeobox 1 2.61849
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 2.61849
S100A5 S100 calcium binding protein A5 2.61849
GMNC geminin coiled-coil domain containing 2.61849
MUSK muscle, skeletal, receptor tyrosine kinase 2.61849
SSTR3 somatostatin receptor 3 2.61849
GUCY2F guanylate cyclase 2F, retinal 2.61849
MGARP mitochondria-localized glutamic acid-rich protein 2.61849
MS4A18 membrane-spanning 4-domains, subfamily A, member 18 2.61849
TMEM217 transmembrane protein 217 2.61849
SPP2 secreted phosphoprotein 2, 24kDa 2.61849
UMODL1 uromodulin-like 1 2.61849
OCSTAMP osteoclast stimulatory transmembrane protein 2.61849
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 2.61849
DLL4 delta-like 4 (Drosophila) 2.61849
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A 2.61849
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 2.61849
FAM240A family with sequence similarity 240 member A 2.61849
SPACA9 sperm acrosome associated 9 2.61849
TMEM271 transmembrane protein 271 2.61849
COPS9 COP9 signalosome subunit 9 2.61849
SEPTIN14 septin 14 2.61849
PSPN persephin 2.61849
CES4A carboxylesterase 4A 2.61849
TMOD4 tropomodulin 4 (muscle) 2.61849
ALDOB aldolase B, fructose-bisphosphate 2.61849
MT3 metallothionein 3 2.61849
ROPN1B rhophilin associated tail protein 1B 2.61849
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 2.61849
DIPK2B divergent protein kinase domain 2B 2.61849
GARIN1A golgi associated RAB2 interactor 1A 2.61849
ATP5MGL ATP synthase membrane subunit g like 2.61849
DEFB109B defensin beta 109B 2.61849
C1ORF232 chromosome 1 open reading frame 230 2.61849
LOC124903372 uncharacterized LOC124903372 2.61849
GNG5B G protein subunit gamma 5B 2.61849
MCTS2 MCTS family member 2 2.61849
UBE2L5 ubiquitin conjugating enzyme E2 L5 2.61849
CFAP107 cilia and flagella associated protein 107 2.61849
TEX13C TEX13 family member C 2.61849
TEX46 testis expressed 46 2.61849
NFILZ NFIL3 like basic leucine zipper 2.61849
H1-8 H1.8 linker histone 2.61849
ADGRG3 adhesion G protein-coupled receptor G3 2.61849
ADGRG7 adhesion G protein-coupled receptor G7 2.61849
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 2.61849
CCR8 chemokine (C-C motif) receptor 8 2.61849
TCF23 transcription factor 23 2.61849
INSRR insulin receptor-related receptor 2.61849
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 2.61849
PRKCB protein kinase C, beta 2.61849
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 2.61849
THPO thrombopoietin 2.61849
IRF5 interferon regulatory factor 5 2.61849
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.61849
PTPRQ protein tyrosine phosphatase, receptor type, Q 2.61849
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.61849
FGFBP1 fibroblast growth factor binding protein 1 2.61849
GDF6 growth differentiation factor 6 2.61849
FOXD4L5 forkhead box D4-like 5 2.61849
TFF3 trefoil factor 3 (intestinal) 2.61849
PROX2 prospero homeobox 2 2.61849
PAPOLB poly(A) polymerase beta (testis specific) 2.61849
ASB5 ankyrin repeat and SOCS box containing 5 2.61849
RDH8 retinol dehydrogenase 8 (all-trans) 2.61849
SRPK2 SRSF protein kinase 2 2.61849
MYEOV myeloma overexpressed 2.61849
C10ORF53 chromosome 10 open reading frame 53 2.61849
SELL selectin L 2.61849
GATA1 GATA binding protein 1 (globin transcription factor 1) 2.61849
CSAG2 CSAG family, member 2 2.61849
PCDHA3 protocadherin alpha 3 2.61849
TBC1D26 TBC1 domain family, member 26 2.61849
ARR3 arrestin 3, retinal (X-arrestin) 2.61849
S100Z S100 calcium binding protein Z 2.61849
ANKRD65 ankyrin repeat domain 65 2.61849
SCML4 sex comb on midleg-like 4 (Drosophila) 2.61849
CAMK2B calcium/calmodulin-dependent protein kinase II beta 2.61849
CPA4 carboxypeptidase A4 2.61849
CDH10 cadherin 10, type 2 (T2-cadherin) 2.61849
POU2AF1 POU class 2 associating factor 1 2.61849
VWA7 von Willebrand factor A domain containing 7 2.61849
TEX19 testis expressed 19 2.61849
AQP8 aquaporin 8 2.61849
FATE1 fetal and adult testis expressed 1 2.61849
CST4 cystatin S 2.61849
GNG8 guanine nucleotide binding protein (G protein), gamma 8 2.61849
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 2.61849
ERMN ermin, ERM-like protein 2.61849
PMP2 peripheral myelin protein 2 2.61849
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 2.61849
CLEC7A C-type lectin domain family 7, member A 2.61849
KCNK4 potassium channel, two pore domain subfamily K, member 4 2.61849
MRLN myoregulin 2.61849
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 2.61849
CLDN34 claudin 34 2.61849
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 2.61849
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 2.61849
GCGR glucagon receptor 2.61849
GSC2 goosecoid homeobox 2 2.61849
OR2C1 olfactory receptor, family 2, subfamily C, member 1 2.61849
KCNA4 potassium channel, voltage gated shaker related subfamily A, member 4 2.61849
WNT4 wingless-type MMTV integration site family, member 4 2.61849
TEX26 testis expressed 26 2.61849
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 2.61849
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 2.61849
RAD9B RAD9 homolog B (S. pombe) 2.61849
CFI complement factor I 2.61849
MOS v-mos Moloney murine sarcoma viral oncogene homolog 2.61849
NOBOX NOBOX oogenesis homeobox 2.61849
GPR61 G protein-coupled receptor 61 2.61849
SVOP SV2 related protein homolog (rat) 2.61849
HK3 hexokinase 3 (white cell) 2.61849
PTPN20 protein tyrosine phosphatase, non-receptor type 20 2.61849
ITGB6 integrin, beta 6 2.61849
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 2.61849
AMH anti-Mullerian hormone 2.61849
RIPK3 receptor-interacting serine-threonine kinase 3 2.61849
DLX2 distal-less homeobox 2 2.61849
NR5A1 nuclear receptor subfamily 5, group A, member 1 2.61849
IP6K3 inositol hexakisphosphate kinase 3 2.61849
ITGAD integrin, alpha D 2.61849
ANKRD33 ankyrin repeat domain 33 2.61849
LPAR2 lysophosphatidic acid receptor 2 2.61849
FOXG1 forkhead box G1 2.61849
ROM1 retinal outer segment membrane protein 1 2.61849
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 2.61849
SPDYE2B speedy/RINGO cell cycle regulator family member E2B 2.61849
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 2.61849
ZPLD1 zona pellucida-like domain containing 1 2.61849
TGM6 transglutaminase 6 2.61849
TMPRSS12 transmembrane (C-terminal) protease, serine 12 2.61849
GRAPL GRB2-related adaptor protein-like 2.61849
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 2.61849
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 2.61849
GCM2 glial cells missing homolog 2 (Drosophila) 2.61849
PPP1R3A protein phosphatase 1, regulatory subunit 3A 2.61849
PSEN1 presenilin 1 2.61849
ASCL5 achaete-scute family bHLH transcription factor 5 2.61849
C5ORF47 chromosome 5 open reading frame 47 2.61849
HRG histidine-rich glycoprotein 2.61849
NPR3 natriuretic peptide receptor 3 2.61849
CD22 CD22 molecule 2.61849
LPAR5 lysophosphatidic acid receptor 5 2.61849
R3HDML R3H domain containing-like 2.61849
MAEL maelstrom spermatogenic transposon silencer 2.61849
POU3F2 POU class 3 homeobox 2 2.61849
PITX3 paired-like homeodomain 3 2.61849
LKAAEAR1 LKAAEAR motif containing 1 2.61849
SLITRK6 SLIT and NTRK-like family, member 6 2.61849
CEP72 centrosomal protein 72kDa 2.61849
CLCA4 chloride channel accessory 4 2.61849
KLC1 kinesin light chain 1 2.59282
AMD1 adenosylmethionine decarboxylase 1 2.50101
MSC musculin 2.49908
SCN3B sodium channel, voltage gated, type III beta subunit 2.49908
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 2.49908
CCDC172 coiled-coil domain containing 172 2.48651
DSTN destrin (actin depolymerizing factor) 2.47778
BICRA BRD4 interacting chromatin remodeling complex associated protein 2.41084
USP9X ubiquitin specific peptidase 9, X-linked 2.41009
SSBP3 single stranded DNA binding protein 3 2.39142
CPHXL2 cytoplasmic polyadenylated homeobox like 2 2.38444
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide 2.36292
NPIPB2 nuclear pore complex interacting protein family member B2 2.34478
NOP14 NOP14 nucleolar protein 2.32808
PALM3 paralemmin 3 2.32192
MT1F metallothionein 1F 2.31878
SHISA5 shisa family member 5 2.29975
SH3GLB2 SH3-domain GRB2-like endophilin B2 2.29301
KLF1 Kruppel-like factor 1 (erythroid) 2.29301
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) 2.29301
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 2.27729
RBIS ribosomal biogenesis factor 2.27704
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated 2.2691
DOCK4 dedicator of cytokinesis 4 2.26237
TRPC1 transient receptor potential cation channel, subfamily C, member 1 2.26201
MTAP methylthioadenosine phosphorylase 2.25293
IRAK4 interleukin-1 receptor-associated kinase 4 2.25199
KRT10 keratin 10, type I 2.24978
ELP1 elongator acetyltransferase complex subunit 1 2.24978
CLSPN claspin 2.23976
QSOX1 quiescin Q6 sulfhydryl oxidase 1 2.21878
BCAS4 breast carcinoma amplified sequence 4 2.18667
ZNF326 zinc finger protein 326 2.18316
APELA apelin receptor early endogenous ligand 2.17961
KDR kinase insert domain receptor 2.17819
COBLL1 cordon-bleu WH2 repeat protein-like 1 2.17392
UXS1 UDP-glucuronate decarboxylase 1 2.15597
SRBD1 S1 RNA binding domain 1 2.15597
SEC31B SEC31 homolog B (S. cerevisiae) 2.14153
QRICH1 glutamine-rich 1 2.13722
USO1 USO1 vesicle transport factor 2.13717
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7 2.13623
TRAPPC13 trafficking protein particle complex 13 2.13333
KLF6 Kruppel-like factor 6 2.13325
RAP2C RAP2C, member of RAS oncogene family 2.11753
RHOA ras homolog family member A 2.10326
BICD2 bicaudal D homolog 2 (Drosophila) 2.09693
GDPGP1 GDP-D-glucose phosphorylase 1 2.09632
RGS2 regulator of G-protein signaling 2 2.09431
CCDC141 coiled-coil domain containing 141 2.09302
MRPL32 mitochondrial ribosomal protein L32 2.07626
CREB3L4 cAMP responsive element binding protein 3-like 4 2.06381
TFB2M transcription factor B2, mitochondrial 2.0578
B3GAT1 beta-1,3-glucuronyltransferase 1 2.0578
WDR62 WD repeat domain 62 2.05214
CITED4 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 2.05158
MRPS9 mitochondrial ribosomal protein S9 2.04588
TMEM163 transmembrane protein 163 2.04588
FGF4 fibroblast growth factor 4 2.04432
GPX8 glutathione peroxidase 8 (putative) 2.04432
EFNA2 ephrin-A2 2.04257
HACL1 2-hydroxyacyl-CoA lyase 1 2.02966
FOXB1 forkhead box B1 2.02649
SGO1 shugoshin 1 2.02034
TSLP thymic stromal lymphopoietin 2.00492
RCOR3 REST corepressor 3 2.00492

decreased expression

Symbol Name Standardized Value
LRRC55 leucine rich repeat containing 55 -2.61849
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled -2.61849
VWC2 von Willebrand factor C domain containing 2 -2.61849
SLC25A41 solute carrier family 25, member 41 -2.61849
CCDC121 coiled-coil domain containing 121 -2.61849
C5AR2 complement component 5a receptor 2 -2.61849
CD177 CD177 molecule -2.61849
FOSB FBJ murine osteosarcoma viral oncogene homolog B -2.61849
FAM240C family with sequence similarity 240 member C -2.61849
PCDHGB7 protocadherin gamma subfamily B, 7 -2.61849
SMKR1 small lysine-rich protein 1 -2.61849
VCX3B variable charge, X-linked 3B -2.61849
FRMPD1 FERM and PDZ domain containing 1 -2.61849
ZNF571 zinc finger protein 571 -2.61849
ZC3HAV1L zinc finger CCCH-type, antiviral 1-like -2.61849
RAB9B RAB9B, member RAS oncogene family -2.61849
FAM221B family with sequence similarity 221, member B -2.61849
RGL4 ral guanine nucleotide dissociation stimulator-like 4 -2.61849
SLCO1B1 solute carrier organic anion transporter family, member 1B1 -2.61849
BCAR1 breast cancer anti-estrogen resistance 1 -2.61849
GTPBP4 GTP binding protein 4 -2.61849
TAS2R31 taste receptor, type 2, member 31 -2.61849
OR2A7 olfactory receptor, family 2, subfamily A, member 7 -2.61849
TMIE transmembrane inner ear -2.61849
SERTAD1 SERTA domain containing 1 -2.61849
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 -2.61849
C11ORF96 chromosome 11 open reading frame 96 -2.61849
CXCR2 chemokine (C-X-C motif) receptor 2 -2.61849
ZNF843 zinc finger protein 843 -2.61849
PLN phospholamban -2.61849
SIM1 single-minded family bHLH transcription factor 1 -2.61849
C2ORF72 chromosome 2 open reading frame 72 -2.61849
ZNF846 zinc finger protein 846 -2.61849
TM4SF18 transmembrane 4 L six family member 18 -2.61849
MSR1 macrophage scavenger receptor 1 -2.61849
SMIM26 small integral membrane protein 26 -2.61849
PLCD4 phospholipase C, delta 4 -2.61849
SLC7A10 solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10 -2.61849
PPP2R2B protein phosphatase 2, regulatory subunit B, beta -2.61849
MIEN1 migration and invasion enhancer 1 -2.61849
ZBTB8B zinc finger and BTB domain containing 8B -2.61849
NPIPB8 nuclear pore complex interacting protein family, member B8 -2.61849
TMED3 transmembrane emp24 protein transport domain containing 3 -2.61849
NLRP14 NLR family, pyrin domain containing 14 -2.61849
TMEM204 transmembrane protein 204 -2.61849
CDCA2 cell division cycle associated 2 -2.60217
HCK HCK proto-oncogene, Src family tyrosine kinase -2.59926
CHMP4A charged multivesicular body protein 4A -2.51278
BLTP2 bridge-like lipid transfer protein family member 2 -2.51278
GSDMB gasdermin B -2.50382
THSD7A thrombospondin, type I, domain containing 7A -2.50101
CCDC148 coiled-coil domain containing 148 -2.47013
MTERF1 mitochondrial transcription termination factor 1 -2.4487
DMRTA1 DMRT-like family A1 -2.42969
KIF2A kinesin heavy chain member 2A -2.41724
CFAP57 cilia and flagella associated protein 57 -2.41084
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 -2.39142
ZFPM1 zinc finger protein, FOG family member 1 -2.37733
ASIC2 acid sensing (proton gated) ion channel 2 -2.37564
RNF182 ring finger protein 182 -2.36292
GAS2 growth arrest-specific 2 -2.35753
LMTK2 lemur tyrosine kinase 2 -2.32808
ACYP1 acylphosphatase 1, erythrocyte (common) type -2.2808
CHERP calcium homeostasis endoplasmic reticulum protein -2.27729
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -2.27729
ABLIM1 actin binding LIM protein 1 -2.27267
ZFHX2 zinc finger homeobox 2 -2.2691
MTSS1 metastasis suppressor 1 -2.2691
VWCE von Willebrand factor C and EGF domains -2.26201
NAE1 NEDD8 activating enzyme E1 subunit 1 -2.24978
PPP1R3E protein phosphatase 1, regulatory subunit 3E -2.22933
LRRC57 leucine rich repeat containing 57 -2.20931
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 -2.1994
RAB38 RAB38, member RAS oncogene family -2.19495
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) -2.19323
ZNF70 zinc finger protein 70 -2.18667
TRIM17 tripartite motif containing 17 -2.18667
CCDC184 coiled-coil domain containing 184 -2.18667
MMP11 matrix metallopeptidase 11 -2.18219
TIGD2 tigger transposable element derived 2 -2.17819
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 -2.17787
RIMS3 regulating synaptic membrane exocytosis 3 -2.17531
DPY19L2 dpy-19-like 2 (C. elegans) -2.15412
PROSER3 proline and serine rich 3 -2.15123
ATAD3A ATPase family, AAA domain containing 3A -2.14538
RNF19B ring finger protein 19B -2.14488
SPOP speckle-type POZ protein -2.14252
CD37 CD37 molecule -2.13849
RPS5 ribosomal protein S5 -2.13717
RTL8C retrotransposon Gag like 8C -2.13717
XXYLT1 xyloside xylosyltransferase 1 -2.13333
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -2.13333
GCC2 GRIP and coiled-coil domain containing 2 -2.09431
SKIDA1 SKI/DACH domain containing 1 -2.07506
SPATA6L spermatogenesis associated 6-like -2.07142
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 -2.06381
PHTF2 putative homeodomain transcription factor 2 -2.0575
GSTA4 glutathione S-transferase alpha 4 -2.03664
PPP6C protein phosphatase 6, catalytic subunit -2.03664
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -2.01535
ZNF221 zinc finger protein 221 -2.01044