SPOP Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description speckle-type POZ protein|This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8405)
External Link http://www.ncbi.nlm.nih.gov/gene/8405
Similar Terms
Downloads & Tools

Genes

65 interacting proteins for SPOP from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
AR androgen receptor
ATM ATM serine/threonine kinase
BMI1 BMI1 proto-oncogene, polycomb ring finger
CGGBP1 CGG triplet repeat binding protein 1
CSNK1E casein kinase 1, epsilon
CUL3 cullin 3
DAXX death-domain associated protein
DDIT3 DNA-damage-inducible transcript 3
DOK2 docking protein 2, 56kDa
DPPA2 developmental pluripotency associated 2
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EEF1A1P5 eukaryotic translation elongation factor 1 alpha 1 pseudogene 5
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ESR1 estrogen receptor 1
FADD Fas (TNFRSF6)-associated via death domain
GCC1 GRIP and coiled-coil domain containing 1
GDI1 GDP dissociation inhibitor 1
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
H2AFY H2A histone family, member Y
H3F3A H3 histone, family 3A
H3F3C H3 histone, family 3C
HCST hematopoietic cell signal transducer
HIST1H3B histone cluster 1, H3b
HIST1H4F histone cluster 1, H4f
HIST2H3A histone cluster 2, H3a
HIST3H3 histone cluster 3, H3
HNRNPL heterogeneous nuclear ribonucleoprotein L
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
KLHL7 kelch-like family member 7
KPNA1 karyopherin alpha 1 (importin alpha 5)
KPNA5 karyopherin alpha 5 (importin alpha 6)
KPNA6 karyopherin alpha 6 (importin alpha 7)
KPNB1 karyopherin (importin) beta 1
MYD88 myeloid differentiation primary response 88
MYO5A myosin VA (heavy chain 12, myoxin)
MYO5C myosin VC
NCOA3 nuclear receptor coactivator 3
NRF1 nuclear respiratory factor 1
NUP153 nucleoporin 153kDa
PDX1 pancreatic and duodenal homeobox 1
PIAS1 protein inhibitor of activated STAT, 1
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
POM121 POM121 transmembrane nucleoporin
PPAN peter pan homolog (Drosophila)
RPS27 ribosomal protein S27
RPS27L ribosomal protein S27-like
RTN3 reticulon 3
RXRB retinoid X receptor, beta
SIRT2 sirtuin 2
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
SRRM1 serine/arginine repetitive matrix 1
TRAF1 TNF receptor-associated factor 1
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TUBA1C tubulin, alpha 1c
TUBB tubulin, beta class I
UBC ubiquitin C
UBE2E3 ubiquitin-conjugating enzyme E2E 3
USP9X ubiquitin specific peptidase 9, X-linked
ZBTB16 zinc finger and BTB domain containing 16