SPTA1 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description spectrin, alpha, erythrocytic 1|Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6708)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GNF2_SPTA1
Similar Terms
Downloads & Tools

Genes

81 co-expressed genes for SPTA1 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ACSL6 acyl-CoA synthetase long-chain family member 6
AHSP alpha hemoglobin stabilizing protein
ALAD aminolevulinate dehydratase
ALAS2 5'-aminolevulinate synthase 2
ANK1 ankyrin 1, erythrocytic
BLVRB biliverdin reductase B
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BSG basigin (Ok blood group)
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CDC27 cell division cycle 27
CLIC2 chloride intracellular channel 2
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CTSE cathepsin E
DCAF11 DDB1 and CUL4 associated factor 11
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1
EPB42 erythrocyte membrane protein band 4.2
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FBXO7 F-box protein 7
FBXO9 F-box protein 9
FECH ferrochelatase
FOXO3 forkhead box O3
GATA1 GATA binding protein 1 (globin transcription factor 1)
GCLC glutamate-cysteine ligase, catalytic subunit
GLRX5 glutaredoxin 5
GYPA glycophorin A (MNS blood group)
GYPB glycophorin B (MNS blood group)
GYPC glycophorin C (Gerbich blood group)
GYPE glycophorin E (MNS blood group)
H1F0 H1 histone family, member 0
HBD hemoglobin, delta
HBQ1 hemoglobin, theta 1
HIST1H4C histone cluster 1, H4c
HMBS hydroxymethylbilane synthase
ISCA1 iron-sulfur cluster assembly 1
KAT2B K(lysine) acetyltransferase 2B
KEL Kell blood group, metallo-endopeptidase
KLF1 Kruppel-like factor 1 (erythroid)
MAP2K3 mitogen-activated protein kinase kinase 3
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MARK3 MAP/microtubule affinity-regulating kinase 3
MINPP1 multiple inositol-polyphosphate phosphatase 1
MPP1 membrane protein, palmitoylated 1, 55kDa
MXI1 MAX interactor 1, dimerization protein
NFE2 nuclear factor, erythroid 2
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
OSBP2 oxysterol binding protein 2
PPOX protoporphyrinogen oxidase
RAD23A RAD23 homolog A (S. cerevisiae)
RANBP10 RAN binding protein 10
RHAG Rh-associated glycoprotein
RHCE Rh blood group, CcEe antigens
RHD Rh blood group, D antigen
RNF123 ring finger protein 123
RPIA ribose 5-phosphate isomerase A
SELENBP1 selenium binding protein 1
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SMOX spermine oxidase
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPTA1 spectrin, alpha, erythrocytic 1
SPTB spectrin, beta, erythrocytic
TAL1 T-cell acute lymphocytic leukemia 1
TFDP1 transcription factor Dp-1
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TMCC2 transmembrane and coiled-coil domain family 2
TRAK2 trafficking protein, kinesin binding 2
TRIM10 tripartite motif containing 10
TRIM58 tripartite motif containing 58
TSPAN5 tetraspanin 5
TSPO2 translocator protein 2
UBE2O ubiquitin-conjugating enzyme E2O
UROD uroporphyrinogen decarboxylase
XK X-linked Kx blood group
XPO7 exportin 7