SRC Gene Set

Dataset Kinase Library Tyrosine Kinome Atlas
Category proteomics
Type kinase
Description SRC proto-oncogene, non-receptor tyrosine kinase|This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6714)
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100 substrates of the kinase SRC from the Kinase Library Tyrosine Kinome Atlas dataset.

Symbol Name Standardized Value
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 100.0
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) 99.93
ZCCHC3 zinc finger, CCHC domain containing 3 99.8
CSNK2A2 casein kinase 2, alpha prime polypeptide 99.71
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 99.71
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 99.59
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 99.54
ANKRD26 ankyrin repeat domain 26 99.52
RABGAP1L RAB GTPase activating protein 1-like 99.45
F5 coagulation factor V (proaccelerin, labile factor) 99.43
ZNF512 zinc finger protein 512 99.34
TEX2 testis expressed 2 99.32
VCP valosin containing protein 99.3
SMG8 SMG8 nonsense mediated mRNA decay factor 99.25
SIPA1L1 signal-induced proliferation-associated 1 like 1 99.23
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa 99.12
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 98.99
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 98.86
GIMAP1 GTPase, IMAP family member 1 98.82
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough 98.82
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 98.62
FHIT fragile histidine triad 98.51
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 98.51
EPHA7 EPH receptor A7 98.47
RGS10 regulator of G-protein signaling 10 98.43
EXPH5 exophilin 5 98.42
CLEC12B C-type lectin domain family 12, member B 98.42
GPR19 G protein-coupled receptor 19 98.4
CD300LB CD300 molecule-like family member b 98.38
MTMR10 myotubularin related protein 10 98.36
CHERP calcium homeostasis endoplasmic reticulum protein 98.32
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 98.31
LOC102725035 leukocyte immunoglobulin-like receptor subfamily B member 3 98.31
CKAP4 cytoskeleton-associated protein 4 98.2
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 98.175
RALY RALY heterogeneous nuclear ribonucleoprotein 98.16
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 98.09
NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing 98.01
ACE2 angiotensin I converting enzyme 2 97.97
PILRA paired immunoglobin-like type 2 receptor alpha 97.94
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 97.94
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 97.92
RGS14 regulator of G-protein signaling 14 97.9
MCC mutated in colorectal cancers 97.72
SHANK2 SH3 and multiple ankyrin repeat domains 2 97.66
LYSMD2 LysM, putative peptidoglycan-binding, domain containing 2 97.64
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4 97.62
FCRL6 Fc receptor-like 6 97.57
RRM1 ribonucleotide reductase M1 97.55
KAT2B K(lysine) acetyltransferase 2B 97.5
ZC3HAV1L zinc finger CCCH-type, antiviral 1-like 97.46
DPH6 diphthamine biosynthesis 6 97.42
SON SON DNA binding protein 97.34
PARD6B par-6 family cell polarity regulator beta 97.26
RFTN1 raftlin, lipid raft linker 1 97.18
TARS1 threonyl-tRNA synthetase 1 97.16
FAM20B family with sequence similarity 20, member B 97.11
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 97.07
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) 97.07
CHD2 chromodomain helicase DNA binding protein 2 97.02
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 96.96
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) 96.93
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 96.91
ATP5PO ATP synthase peripheral stalk subunit OSCP 96.89
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 96.8
HAVCR2 hepatitis A virus cellular receptor 2 96.78
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3 96.72
MX2 MX dynamin-like GTPase 2 96.59
RFC5 replication factor C (activator 1) 5, 36.5kDa 96.58
AHCY adenosylhomocysteinase 96.54
PRKN parkin RBR E3 ubiquitin protein ligase 96.52
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 96.52
MTO1 mitochondrial tRNA translation optimization 1 96.52
PLCL2 phospholipase C-like 2 96.48
LY9 lymphocyte antigen 9 96.475
CTCF CCCTC-binding factor (zinc finger protein) 96.34
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 96.28
FES FES proto-oncogene, tyrosine kinase 96.27
PTPRB protein tyrosine phosphatase, receptor type, B 96.11
TRIM25 tripartite motif containing 25 96.08
IPO9 importin 9 96.04
GRIA2 glutamate receptor, ionotropic, AMPA 2 96.04
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa 96.02
DOK3 docking protein 3 95.97
KLC3 kinesin light chain 3 95.91
VAV1 vav 1 guanine nucleotide exchange factor 95.84
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 95.77
LY6G6F lymphocyte antigen 6 complex, locus G6F 95.75
THEMIS2 thymocyte selection associated family member 2 95.73
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 95.715
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 95.68
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 95.64
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 95.58
PRMT3 protein arginine methyltransferase 3 95.56
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) 95.51
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 95.49
TWF1 twinfilin actin binding protein 1 95.45
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) 95.36
PROM1 prominin 1 95.315
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1 95.29