SRC Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description SRC proto-oncogene, non-receptor tyrosine kinase|This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6714)
External Link http://www.ncbi.nlm.nih.gov/gene/6714
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Genes

229 substrates of the kinase SRC from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
AATK apoptosis-associated tyrosine kinase
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADAM12 ADAM metallopeptidase domain 12
ADRBK1 adrenergic, beta, receptor kinase 1
AFAP1 actin filament associated protein 1
AGTR1 angiotensin II receptor, type 1
AKAP8 A kinase (PRKA) anchor protein 8
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANXA1 annexin A1
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APP amyloid beta (A4) precursor protein
AR androgen receptor
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ARHGAP35 Rho GTPase activating protein 35
ARHGAP5 Rho GTPase activating protein 5
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ATXN2L ataxin 2-like
BCAR1 breast cancer anti-estrogen resistance 1
BCLAF1 BCL2-associated transcription factor 1
BDKRB2 bradykinin receptor B2
BMX BMX non-receptor tyrosine kinase
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBLC Cbl proto-oncogene C, E3 ubiquitin protein ligase
CCDC88A coiled-coil domain containing 88A
CD46 CD46 molecule, complement regulatory protein
CDC42 cell division cycle 42
CDCP1 CUB domain containing protein 1
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH5 cadherin 5, type 2 (vascular endothelium)
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFL1 cofilin 1 (non-muscle)
CHKA choline kinase alpha
CHN2 chimerin 2
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CLTC clathrin, heavy chain (Hc)
CNN2 calponin 2
CNN3 calponin 3, acidic
CORO7 coronin 7
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND1 catenin (cadherin-associated protein), delta 1
CTNND2 catenin (cadherin-associated protein), delta 2
CTTN cortactin
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila)
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DDR2 discoidin domain receptor tyrosine kinase 2
DGKA diacylglycerol kinase, alpha 80kDa
DLG4 discs, large homolog 4 (Drosophila)
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DVL2 dishevelled segment polarity protein 2
EFNB1 ephrin-B1
EGFR epidermal growth factor receptor
EMD emerin
ESR1 estrogen receptor 1
EWSR1 EWS RNA-binding protein 1
EZR ezrin
FBXO5 F-box protein 5
FCRL3 Fc receptor-like 3
FER fer (fps/fes related) tyrosine kinase
FHIT fragile histidine triad
FHOD1 formin homology 2 domain containing 1
FIP1L1 factor interacting with PAPOLA and CPSF1
FLOT1 flotillin 1
FLT4 fms-related tyrosine kinase 4
FUBP1 far upstream element (FUSE) binding protein 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
G6PD glucose-6-phosphate dehydrogenase
GAB1 GRB2-associated binding protein 1
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GJA1 gap junction protein, alpha 1, 43kDa
GLRB glycine receptor, beta
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GRB10 growth factor receptor-bound protein 10
GRB2 growth factor receptor-bound protein 2
GRIK2 glutamate receptor, ionotropic, kainate 2
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GSN gelsolin
GTF2I general transcription factor IIi
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HCRTR1 hypocretin (orexin) receptor 1
HIPK2 homeodomain interacting protein kinase 2
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPK heterogeneous nuclear ribonucleoprotein K
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
IGF1R insulin-like growth factor 1 receptor
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB7 integrin, beta 7
JUP junction plakoglobin
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3
KDR kinase insert domain receptor
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KHSRP KH-type splicing regulatory protein
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRT19 keratin 19, type I
L1CAM L1 cell adhesion molecule
LRP1 low density lipoprotein receptor-related protein 1
MAPT microtubule-associated protein tau
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEGF10 multiple EGF-like-domains 10
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MPZL1 myelin protein zero-like 1
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
MYH9 myosin, heavy chain 9, non-muscle
MYLK myosin light chain kinase
NCKIPSD NCK interacting protein with SH3 domain
NDFIP2 Nedd4 family interacting protein 2
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
NELFCD negative elongation factor complex member C/D
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGEF neuronal guanine nucleotide exchange factor
NOS2 nitric oxide synthase 2, inducible
NOXA1 NADPH oxidase activator 1
NPHP1 nephronophthisis 1 (juvenile)
OCLN occludin
OPRM1 opioid receptor, mu 1
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1
PDPK1 3-phosphoinositide dependent protein kinase 1
PELP1 proline, glutamate and leucine rich protein 1
PFN1 profilin 1
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLD2 phospholipase D2
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2
PLSCR1 phospholipid scramblase 1
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PRDX1 peroxiredoxin 1
PRKCD protein kinase C, delta
PRKD1 protein kinase D1
PROM1 prominin 1
PTEN phosphatase and tensin homolog
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRA protein tyrosine phosphatase, receptor type, A
PTPRJ protein tyrosine phosphatase, receptor type, J
PTTG1IP pituitary tumor-transforming 1 interacting protein
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
PXN paxillin
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RBM10 RNA binding motif protein 10
RET ret proto-oncogene
RGS16 regulator of G-protein signaling 16
RHBG Rh family, B glycoprotein (gene/pseudogene)
RHOU ras homolog family member U
RMDN3 regulator of microtubule dynamics 3
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
RRAS related RAS viral (r-ras) oncogene homolog
SDC2 syndecan 2
SDC4 syndecan 4
SDCBP syndecan binding protein (syntenin)
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
SF3B2 splicing factor 3b, subunit 2, 145kDa
SFPQ splicing factor proline/glutamine-rich
SH3GL1 SH3-domain GRB2-like 1
SH3GLB1 SH3-domain GRB2-like endophilin B1
SH3PXD2A SH3 and PX domains 2A
SH3PXD2B SH3 and PX domains 2B
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SORBS1 sorbin and SH3 domain containing 1
SPRY2 sprouty homolog 2 (Drosophila)
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRRT serrate, RNA effector molecule
STAP2 signal transducing adaptor family member 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
SYNJ2 synaptojanin 2
TERT telomerase reverse transcriptase
TFG TRK-fused gene
TFRC transferrin receptor
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THRAP3 thyroid hormone receptor associated protein 3
TIAM1 T-cell lymphoma invasion and metastasis 1
TLR3 toll-like receptor 3
TNS3 tensin 3
TRIP10 thyroid hormone receptor interactor 10
TRIP6 thyroid hormone receptor interactor 6
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TRPV4 transient receptor potential cation channel, subfamily V, member 4
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7
UNC5C unc-5 homolog C (C. elegans)
VAMP7 vesicle-associated membrane protein 7
VAV1 vav 1 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
VIL1 villin 1
WASF1 WAS protein family, member 1
WBP2 WW domain binding protein 2
WNK4 WNK lysine deficient protein kinase 4
WWOX WW domain containing oxidoreductase
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZC3H4 zinc finger CCCH-type containing 4