SRC_UP.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/SRC_UP.V1_UP
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Genes

350 genes differentially expressed following the SRC_UP.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
A1BG-AS1 A1BG antisense RNA 1
AAAS achalasia, adrenocortical insufficiency, alacrimia
AADAC arylacetamide deacetylase
ABTB1 ankyrin repeat and BTB (POZ) domain containing 1
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
ACY3 aminoacylase 3
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AIM2 absent in melanoma 2
AMER1 APC membrane recruitment protein 1
ANGPTL6 angiopoietin-like 6
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
APC2 adenomatosis polyposis coli 2
APOA5 apolipoprotein A-V
ARRDC1-AS1 ARRDC1 antisense RNA 1
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATOX1 antioxidant 1 copper chaperone
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2
BAHD1 bromo adjacent homology domain containing 1
BCL2 B-cell CLL/lymphoma 2
BCRP3 breakpoint cluster region pseudogene 3
BMF Bcl2 modifying factor
BRWD1-IT2 BRWD1 intronic transcript 2 (non-protein coding)
C19ORF73 chromosome 19 open reading frame 73
C2ORF73 chromosome 2 open reading frame 73
CABP2 calcium binding protein 2
CALML5 calmodulin-like 5
CAPS calcyphosine
CCDC23 coiled-coil domain containing 23
CCDC65 coiled-coil domain containing 65
CD70 CD70 molecule
CDRT15 CMT1A duplicated region transcript 15
CEACAM19 carcinoembryonic antigen-related cell adhesion molecule 19
CFAP45 cilia and flagella associated protein 45
CFAP46 cilia and flagella associated protein 46
CFAP74 cilia and flagella associated protein 74
CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10
CLDN9 claudin 9
CLIP3 CAP-GLY domain containing linker protein 3
COL26A1 collagen, type XXVI, alpha 1
COL4A4 collagen, type IV, alpha 4
COX4I2 cytochrome c oxidase subunit IV isoform 2 (lung)
CPLX2 complexin 2
CRTAC1 cartilage acidic protein 1
DCLRE1A DNA cross-link repair 1A
DLL3 delta-like 3 (Drosophila)
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22
DTX2 deltex 2, E3 ubiquitin ligase
DUOXA2 dual oxidase maturation factor 2
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
ESR2 estrogen receptor 2 (ER beta)
ETV7 ets variant 7
FAM182B family with sequence similarity 182, member B
FBLN2 fibulin 2
FBXO44 F-box protein 44
FES FES proto-oncogene, tyrosine kinase
FGF23 fibroblast growth factor 23
FMN2 formin 2
FNDC4 fibronectin type III domain containing 4
FNDC8 fibronectin type III domain containing 8
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXO4 forkhead box O4
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
GALK1 galactokinase 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GP2 glycoprotein 2 (zymogen granule membrane)
GPR15 G protein-coupled receptor 15
GPR55 G protein-coupled receptor 55
GPX5 glutathione peroxidase 5
GRWD1 glutamate-rich WD repeat containing 1
HDLBP high density lipoprotein binding protein
HMX1 H6 family homeobox 1
HPX hemopexin
IBA57-AS1 IBA57 antisense RNA 1 (head to head)
ICAM5 intercellular adhesion molecule 5, telencephalin
IGFALS insulin-like growth factor binding protein, acid labile subunit
IPO5 importin 5
IRF8 interferon regulatory factor 8
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3
KCNQ1DN KCNQ1 downstream neighbor (non-protein coding)
LAMC3 laminin, gamma 3
LAMP3 lysosomal-associated membrane protein 3
LCE3D late cornified envelope 3D
LEKR1 leucine, glutamate and lysine rich 1
LELP1 late cornified envelope-like proline-rich 1
LGI4 leucine-rich repeat LGI family, member 4
LINC00112 long intergenic non-protein coding RNA 112
LOC100289650 uncharacterized LOC100289650
LOC100506127 putative uncharacterized protein FLJ37770-like
LOC254896 uncharacterized LOC254896
LOC283194 uncharacterized LOC283194
LOC283475 uncharacterized LOC283475
LPO lactoperoxidase
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
LYZL4 lysozyme-like 4
MAMDC4 MAM domain containing 4
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
MATK megakaryocyte-associated tyrosine kinase
MBD3L1 methyl-CpG binding domain protein 3-like 1
MED10 mediator complex subunit 10
MGC39584 uncharacterized LOC441058
MIOX myo-inositol oxygenase
MLXIPL MLX interacting protein-like
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MORN3 MORN repeat containing 3
MRPS34 mitochondrial ribosomal protein S34
MTMR9LP myotubularin related protein 9-like, pseudogene
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1
NAT8L N-acetyltransferase 8-like (GCN5-related, putative)
NEU1 sialidase 1 (lysosomal sialidase)
NKX6-3 NK6 homeobox 3
NMRK2 nicotinamide riboside kinase 2
NPC1L1 NPC1-like 1
NUDT4P1 nudix (nucleoside diphosphate linked moiety X)-type motif 4 pseudogene 1
NYX nyctalopin
OPRL1 opiate receptor-like 1
OR1F1 olfactory receptor, family 1, subfamily F, member 1
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PCP4 Purkinje cell protein 4
PDZD7 PDZ domain containing 7
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
PI16 peptidase inhibitor 16
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
POU3F2 POU class 3 homeobox 2
PPP1R3B protein phosphatase 1, regulatory subunit 3B
PRADC1 protease-associated domain containing 1
PRPS1L1 phosphoribosyl pyrophosphate synthetase 1-like 1
PRR3 proline rich 3
QPCTL glutaminyl-peptide cyclotransferase-like
RAB3A RAB3A, member RAS oncogene family
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RFXANK regulatory factor X-associated ankyrin-containing protein
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
SCARF2 scavenger receptor class F, member 2
SEC11C SEC11 homolog C (S. cerevisiae)
SH3BGR SH3 domain binding glutamate-rich protein
SLC22A6 solute carrier family 22 (organic anion transporter), member 6
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC26A1 solute carrier family 26 (anion exchanger), member 1
SLC35F4 solute carrier family 35, member F4
SLC4A9 solute carrier family 4, sodium bicarbonate cotransporter, member 9
SMO smoothened, frizzled class receptor
SMTNL1 smoothelin-like 1
SOCS1 suppressor of cytokine signaling 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
STAB2 stabilin 2
STAC3 SH3 and cysteine rich domain 3
SUGCT succinyl-CoA:glutarate-CoA transferase
SULT4A1 sulfotransferase family 4A, member 1
SYN1 synapsin I
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
TCEAL3 transcription elongation factor A (SII)-like 3
TECTA tectorin alpha
TFR2 transferrin receptor 2
TM4SF5 transmembrane 4 L six family member 5
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2
TMEM106C transmembrane protein 106C
TMEM11 transmembrane protein 11
TMEM255B transmembrane protein 255B
TMEM88 transmembrane protein 88
TMSB4Y thymosin beta 4, Y-linked
TMUB1 transmembrane and ubiquitin-like domain containing 1
TONSL tonsoku-like, DNA repair protein
TOX3 TOX high mobility group box family member 3
TRIM15 tripartite motif containing 15
TTC21A tetratricopeptide repeat domain 21A
TTC25 tetratricopeptide repeat domain 25
UBIAD1 UbiA prenyltransferase domain containing 1
VN1R2 vomeronasal 1 receptor 2
VPS37D vacuolar protein sorting 37 homolog D (S. cerevisiae)
VWA3B von Willebrand factor A domain containing 3B
WTIP Wilms tumor 1 interacting protein
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)

decreased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
ACSL4 acyl-CoA synthetase long-chain family member 4
ACTL6A actin-like 6A
ADA adenosine deaminase
ADGRE1 adhesion G protein-coupled receptor E1
ADGRF1 adhesion G protein-coupled receptor F1
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide
ANO7 anoctamin 7
APITD1 apoptosis-inducing, TAF9-like domain 1
ARL15 ADP-ribosylation factor-like 15
ARRDC3 arrestin domain containing 3
ARSJ arylsulfatase family, member J
ATAD2 ATPase family, AAA domain containing 2
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
C10ORF10 chromosome 10 open reading frame 10
C11ORF72 chromosome 11 open reading frame 72
C14ORF142 chromosome 14 open reading frame 142
C17ORF64 chromosome 17 open reading frame 64
C1ORF159 chromosome 1 open reading frame 159
C8B complement component 8, beta polypeptide
C9ORF41 chromosome 9 open reading frame 41
CA7 carbonic anhydrase VII
CAPN12 calpain 12
CARD16 caspase recruitment domain family, member 16
CDCA7 cell division cycle associated 7
CDK11B cyclin-dependent kinase 11B
CENPH centromere protein H
CERKL ceramide kinase-like
CHAC2 ChaC, cation transport regulator homolog 2 (E. coli)
CLCA4 chloride channel accessory 4
CMTR2 cap methyltransferase 2
COBL cordon-bleu WH2 repeat protein
COL8A1 collagen, type VIII, alpha 1
COMMD9 COMM domain containing 9
COQ4 coenzyme Q4
CPPED1 calcineurin-like phosphoesterase domain containing 1
CSAD cysteine sulfinic acid decarboxylase
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CWH43 cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)
CXCL5 chemokine (C-X-C motif) ligand 5
DCAF17 DDB1 and CUL4 associated factor 17
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DISC1 disrupted in schizophrenia 1
DISP2 dispatched homolog 2 (Drosophila)
DPYD dihydropyrimidine dehydrogenase
DTWD1 DTW domain containing 1
E2F8 E2F transcription factor 8
EIF3CL eukaryotic translation initiation factor 3, subunit C-like
EMB embigin
EREG epiregulin
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM153A family with sequence similarity 153, member A
FAM173B family with sequence similarity 173, member B
FANCL Fanconi anemia, complementation group L
FRMD4B FERM domain containing 4B
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GFRA3 GDNF family receptor alpha 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
GJB6 gap junction protein, beta 6, 30kDa
GRID1 glutamate receptor, ionotropic, delta 1
GTF2H2 general transcription factor IIH, polypeptide 2, 44kDa
HOXB2 homeobox B2
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM10 interferon induced transmembrane protein 10
IL7R interleukin 7 receptor
IRAK2 interleukin-1 receptor-associated kinase 2
IRGC immunity-related GTPase family, cinema
IRX5 iroquois homeobox 5
IVL involucrin
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KIAA0754 KIAA0754
KIAA1841 KIAA1841
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
LIG1 ligase I, DNA, ATP-dependent
LOC285181 uncharacterized LOC285181
LOC401131 uncharacterized LOC401131
LOC554174 uncharacterized LOC554174
LOC644295 KIAA1143 pseudogene
LOC90784 uncharacterized LOC90784
LYPD3 LY6/PLAUR domain containing 3
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MEGF6 multiple EGF-like-domains 6
MGARP mitochondria-localized glutamic acid-rich protein
MIR17HG miR-17-92 cluster host gene
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP3 matrix metallopeptidase 3
MN1 meningioma (disrupted in balanced translocation) 1
MON1A MON1 secretory trafficking family member A
MYSM1 Myb-like, SWIRM and MPN domains 1
NBEAL1 neurobeachin-like 1
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NID2 nidogen 2 (osteonidogen)
NLRP8 NLR family, pyrin domain containing 8
NOL12 nucleolar protein 12
NPY5R neuropeptide Y receptor Y5
NRP1 neuropilin 1
NYNRIN NYN domain and retroviral integrase containing
OTUD6B OTU domain containing 6B
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PC pyruvate carboxylase
PCDH19 protocadherin 19
PCDHB4 protocadherin beta 4
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
PKP2 plakophilin 2
PLAT plasminogen activator, tissue
PLK4 polo-like kinase 4
POLR1A polymerase (RNA) I polypeptide A, 194kDa
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PPIL1 peptidylprolyl isomerase (cyclophilin)-like 1
PRR19 proline rich 19
PRSS33 protease, serine, 33
PTBP2 polypyrimidine tract binding protein 2
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB33B RAB33B, member RAS oncogene family
RACGAP1 Rac GTPase activating protein 1
RAP1A RAP1A, member of RAS oncogene family
RARA retinoic acid receptor, alpha
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RFTN1 raftlin, lipid raft linker 1
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
RNF220 ring finger protein 220
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
RTN4IP1 reticulon 4 interacting protein 1
S100A9 S100 calcium binding protein A9
S1PR3 sphingosine-1-phosphate receptor 3
SCRN2 secernin 2
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC7A14 solute carrier family 7, member 14
SNX32 sorting nexin 32
SOAT1 sterol O-acyltransferase 1
SPDYE1 speedy/RINGO cell cycle regulator family member E1
SPNS3 spinster homolog 3 (Drosophila)
SPRR1B small proline-rich protein 1B
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
STARD3 StAR-related lipid transfer (START) domain containing 3
STK17B serine/threonine kinase 17b
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
SYT1 synaptotagmin I
SYT15 synaptotagmin XV
TGM5 transglutaminase 5
TMCO2 transmembrane and coiled-coil domains 2
TMEM14A transmembrane protein 14A
TMOD1 tropomodulin 1
TREML1 triggering receptor expressed on myeloid cells-like 1
TRIM73 tripartite motif containing 73
TTC14 tetratricopeptide repeat domain 14
UHRF1 ubiquitin-like with PHD and ring finger domains 1
UNC119 unc-119 homolog (C. elegans)
UTS2R urotensin 2 receptor
WASH3P WAS protein family homolog 3 pseudogene
WT1-AS WT1 antisense RNA
ZBED2 zinc finger, BED-type containing 2
ZNF135 zinc finger protein 135
ZNF3 zinc finger protein 3
ZNF436 zinc finger protein 436
ZNF451 zinc finger protein 451
ZNF628 zinc finger protein 628
ZNF721 zinc finger protein 721
ZNF782 zinc finger protein 782
ZNF789 zinc finger protein 789