SREBF1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description sterol regulatory element binding transcription factor 1|This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6720)
External Link http://www.ncbi.nlm.nih.gov/gene/6720
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73 interacting proteins for SREBF1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AR androgen receptor
ATM ATM serine/threonine kinase
ATXN1 ataxin 1
ATXN1L ataxin 1-like
CASP3 caspase 3, apoptosis-related cysteine peptidase
CDK1 cyclin-dependent kinase 1
CDK8 cyclin-dependent kinase 8
CREB1 cAMP responsive element binding protein 1
CREBBP CREB binding protein
DHCR24 24-dehydrocholesterol reductase
EGF epidermal growth factor
EP300 E1A binding protein p300
ERLIN2 ER lipid raft associated 2
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
GSK3B glycogen synthase kinase 3 beta
HDAC9 histone deacetylase 9
HNF4A hepatocyte nuclear factor 4, alpha
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
INSIG1 insulin induced gene 1
INSIG2 insulin induced gene 2
KAT2A K(lysine) acetyltransferase 2A
KAT2B K(lysine) acetyltransferase 2B
KLF13 Kruppel-like factor 13
LMNA lamin A/C
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAX MYC associated factor X
MBTPS1 membrane-bound transcription factor peptidase, site 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MED1 mediator complex subunit 1
MED12 mediator complex subunit 12
MED13 mediator complex subunit 13
MED14 mediator complex subunit 14
MED15 mediator complex subunit 15
MED17 mediator complex subunit 17
MED21 mediator complex subunit 21
MED23 mediator complex subunit 23
MED24 mediator complex subunit 24
MED25 mediator complex subunit 25
MED26 mediator complex subunit 26
MED6 mediator complex subunit 6
MED7 mediator complex subunit 7
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYB v-myb avian myeloblastosis viral oncogene homolog
NR0B1 nuclear receptor subfamily 0, group B, member 1
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
RPS27A ribosomal protein S27a
RPTOR regulatory associated protein of MTOR, complex 1
RUVBL2 RuvB-like AAA ATPase 2
SCAP SREBF chaperone
SIRT1 sirtuin 1
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SP1 Sp1 transcription factor
SREBF2 sterol regulatory element binding transcription factor 2
SUMO1 small ubiquitin-like modifier 1
SUMO2 small ubiquitin-like modifier 2
TADA2B transcriptional adaptor 2B
TADA3 transcriptional adaptor 3
TP53 tumor protein p53
TRRAP transformation/transcription domain-associated protein
TWIST2 twist family bHLH transcription factor 2
UBC ubiquitin C
UBE2I ubiquitin-conjugating enzyme E2I
USF1 upstream transcription factor 1
YY1 YY1 transcription factor
ZBTB7A zinc finger and BTB domain containing 7A
ZBTB7C zinc finger and BTB domain containing 7C