SREBF2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description sterol regulatory element binding transcription factor 2|This gene encodes a member of the a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] (NCBI Entrez Gene Database, 6721)
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Genes

355 genes differentially expressed following the SREBF2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
MYLK4 myosin light chain kinase family, member 4 3.07488
PIWIL3 piwi-like RNA-mediated gene silencing 3 3.07488
POU1F1 POU class 1 homeobox 1 3.07488
TMPRSS15 transmembrane protease, serine 15 3.07488
TMEM229B transmembrane protein 229B 3.07488
TMEM132D transmembrane protein 132D 3.034
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 3.034
PCDHGA7 protocadherin gamma subfamily A, 7 3.034
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 3.034
GMNC geminin coiled-coil domain containing 3.034
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 3.034
TSGA13 testis specific, 13 3.034
AKAP3 A kinase (PRKA) anchor protein 3 3.034
TCP11L2 t-complex 11, testis-specific-like 2 3.034
ADGRG1 adhesion G protein-coupled receptor G1 3.034
HHEX hematopoietically expressed homeobox 3.034
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 3.034
S100Z S100 calcium binding protein Z 3.034
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 3.034
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18 3.034
VIT vitrin 3.034
PDE7B phosphodiesterase 7B 3.034
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 3.034
TMEM272 transmembrane protein 272 3.034
C11ORF42 chromosome 11 open reading frame 42 3.034
IL2RG interleukin 2 receptor, gamma 3.034
SIM1 single-minded family bHLH transcription factor 1 3.034
WASL-DT WASL divergent transcript 3.034
BDKRB2 bradykinin receptor B2 3.034
CFI complement factor I 3.034
CRX cone-rod homeobox 2.8847
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.8847
GNLY granulysin 2.8847
ACVRL1 activin A receptor type II-like 1 2.8847
CRIP1 cysteine-rich protein 1 (intestinal) 2.8847
SLC26A9 solute carrier family 26 (anion exchanger), member 9 2.8847
CLEC12A C-type lectin domain family 12, member A 2.8847
CD6 CD6 molecule 2.8847
ZNF467 zinc finger protein 467 2.8847
SIX2 SIX homeobox 2 2.8847
TCP11 t-complex 11, testis-specific 2.8847
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 2.8847
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 2.8847
CEP295NL CEP295 N-terminal like 2.8847
GATA5 GATA binding protein 5 2.8847
APLN apelin 2.8847
DDN dendrin 2.8847
GRXCR2 glutaredoxin, cysteine rich 2 2.8847
PGBDF plakoglobin binding and degradation factor 2.8847
TRAT1 T cell receptor associated transmembrane adaptor 1 2.8847
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 2.8847
UBE2U ubiquitin-conjugating enzyme E2U (putative) 2.8847
CA7 carbonic anhydrase VII 2.8847
PCDHB8 protocadherin beta 8 2.8847
GUCY2F guanylate cyclase 2F, retinal 2.8847
AKR1C2 aldo-keto reductase family 1, member C2 2.8847
TNNI1 troponin I type 1 (skeletal, slow) 2.8847
SPINK4 serine peptidase inhibitor, Kazal type 4 2.8847
CELF3 CUGBP, Elav-like family member 3 2.8847
ZNF556 zinc finger protein 556 2.8847
KCNIP3 Kv channel interacting protein 3, calsenilin 2.8847
FAM187B family with sequence similarity 187, member B 2.8847
TBC1D3I TBC1 domain family member 3I 2.8847
TMIGD1 transmembrane and immunoglobulin domain containing 1 2.8847
TMPRSS7 transmembrane protease, serine 7 2.8847
PAPOLB poly(A) polymerase beta (testis specific) 2.8847
FOXC2 forkhead box C2 2.8847
DOK7 docking protein 7 2.8847
CMKLR1 chemerin chemokine-like receptor 1 2.8847
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic 2.8847
CCDC42 coiled-coil domain containing 42 2.8847
ADGRG3 adhesion G protein-coupled receptor G3 2.8847
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 2.8847
H4C11 H4 clustered histone 11 2.8847
C20ORF204 chromosome 20 open reading frame 204 2.8847
MAJIN membrane anchored junction protein 2.8847
ITPRID1 ITPR interacting domain containing 1 2.8847
TERB1 telomere repeat binding bouquet formation protein 1 2.8847
TMEM275 transmembrane protein 275 2.8847
H2BC1 H2B clustered histone 1 2.8847
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 2.8847
NPIPB8 nuclear pore complex interacting protein family, member B8 2.8847
RAI14 retinoic acid induced 14 2.8847
VCX3B variable charge, X-linked 3B 2.8847
THPO thrombopoietin 2.8847
WNT11 wingless-type MMTV integration site family, member 11 2.8847
PRB2 proline-rich protein BstNI subfamily 2 2.8847
CCIN calicin 2.8847
PCDHA7 protocadherin alpha 7 2.8847
FOXD1 forkhead box D1 2.8847
ACTRT1 actin-related protein T1 2.8847
ANGPT4 angiopoietin 4 2.8847
OVOL3 ovo-like zinc finger 3 2.8847
NHLRC4 NHL repeat containing 4 2.8847
SAA1 serum amyloid A1 2.8847
PLB1 phospholipase B1 2.8847
RGS21 regulator of G-protein signaling 21 2.8847
S100G S100 calcium binding protein G 2.8847
CCR9 chemokine (C-C motif) receptor 9 2.8847
GJD3 gap junction protein, delta 3, 31.9kDa 2.8847
GNPDA1 glucosamine-6-phosphate deaminase 1 2.8847
FAM186B family with sequence similarity 186, member B 2.8847
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 2.8847
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 2.8847
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.8847
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 2.8847
NOG noggin 2.8847
POF1B premature ovarian failure, 1B 2.8847
C11ORF91 chromosome 11 open reading frame 91 2.8847
CXCR2 chemokine (C-X-C motif) receptor 2 2.8847
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.8847
WFDC6 WAP four-disulfide core domain 6 2.8847
HAVCR1 hepatitis A virus cellular receptor 1 2.8847
NPFFR1 neuropeptide FF receptor 1 2.8847
FNDC8 fibronectin type III domain containing 8 2.8847
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 2.8847
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 2.8847
PATE2 prostate and testis expressed 2 2.8847
MT1A metallothionein 1A 2.8847
LST1 leukocyte specific transcript 1 2.8847
PSORS1C1 psoriasis susceptibility 1 candidate 1 2.8847
POU3F2 POU class 3 homeobox 2 2.8847
MAPK11 mitogen-activated protein kinase 11 2.8847
IFIH1 interferon induced with helicase C domain 1 2.8847
CIDEA cell death-inducing DFFA-like effector a 2.8847
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 2.8847
MAB21L2 mab-21-like 2 (C. elegans) 2.8847
TMPPE transmembrane protein with metallophosphoesterase domain 2.8847
ORM2 orosomucoid 2 2.8847
NKX6-3 NK6 homeobox 3 2.8847
MYADML2 myeloid-associated differentiation marker-like 2 2.8847
FAIM2 Fas apoptotic inhibitory molecule 2 2.8847
RIN1 Ras and Rab interactor 1 2.8847
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 2.8847
CNGB1 cyclic nucleotide gated channel beta 1 2.8847
DRC7 dynein regulatory complex subunit 7 2.8847
SI sucrase-isomaltase (alpha-glucosidase) 2.8847
TF transferrin 2.8847
EMP1 epithelial membrane protein 1 2.8847
TBXA2R thromboxane A2 receptor 2.8847
C2CD4B C2 calcium-dependent domain containing 4B 2.8847
MS4A7 membrane-spanning 4-domains, subfamily A, member 7 2.8847
IL18 interleukin 18 2.8847
KLK3 kallikrein-related peptidase 3 2.8847
SAMD5 sterile alpha motif domain containing 5 2.8847
ZC3H11D zinc finger CCCH-type containing 11D 2.8847
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 2.8847
BCL2A1 BCL2-related protein A1 2.8847
COL22A1 collagen, type XXII, alpha 1 2.8847
OXT oxytocin/neurophysin I prepropeptide 2.8847
SHCBP1L SHC SH2-domain binding protein 1-like 2.8847
FGF9 fibroblast growth factor 9 2.8847
ANGPTL3 angiopoietin-like 3 2.8847
PRSS22 protease, serine, 22 2.8847
NRSN1 neurensin 1 2.8847
G6PC2 glucose-6-phosphatase, catalytic, 2 2.8847
CD36 CD36 molecule (thrombospondin receptor) 2.8847
SHISA3 shisa family member 3 2.8847
PITX1 paired-like homeodomain 1 2.8847
CDC14C cell division cycle 14C 2.8847
OR14A2 olfactory receptor, family 14, subfamily A, member 2 2.8847
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 2.8847
TRAF3IP3 TRAF3 interacting protein 3 2.8847
RXRG retinoid X receptor, gamma 2.8847
CCDC87 coiled-coil domain containing 87 2.8847
TMC8 transmembrane channel-like 8 2.8847
CSNK2A3 casein kinase 2, alpha 3 polypeptide 2.8847
CAPS calcyphosine 2.8847
GRAPL GRB2-related adaptor protein-like 2.8847
HBM hemoglobin, mu 2.8847
TGM3 transglutaminase 3 2.8847
ACY3 aminoacylase 3 2.8847
IFITM10 interferon induced transmembrane protein 10 2.8847
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 2.8723
AKT1S1 AKT1 substrate 1 (proline-rich) 2.80777
S1PR5 sphingosine-1-phosphate receptor 5 2.75633
LDHD lactate dehydrogenase D 2.75633
KLB klotho beta 2.75633
FYB2 FYN binding protein 2 2.75633
STAT4 signal transducer and activator of transcription 4 2.72464
WTIP Wilms tumor 1 interacting protein 2.72291
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 2.68672
PRSS12 protease, serine, 12 (neurotrypsin, motopsin) 2.5966
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B 2.58991
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 2.58223
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.57668
RAB24 RAB24, member RAS oncogene family 2.53157
STN1 STN1 subunit of CST complex 2.51701
EVPL envoplakin 2.45224
PNMA5 paraneoplastic Ma antigen family member 5 2.45224
OIT3 oncoprotein induced transcript 3 2.45224
PCDHA12 protocadherin alpha 12 2.44117
EXOC3 exocyst complex component 3 2.44027
FGF18 fibroblast growth factor 18 2.40991
NKX3-1 NK3 homeobox 1 2.40991
CLEC2D C-type lectin domain family 2, member D 2.40931
TMEM185B transmembrane protein 185B 2.39241
GCFC2 GC-rich sequence DNA-binding factor 2 2.39001
CHP1 calcineurin-like EF-hand protein 1 2.39001
SIAH3 siah E3 ubiquitin protein ligase family member 3 2.37847
ISM2 isthmin 2 2.37847
HMGA2 high mobility group AT-hook 2 2.36971
DRP2 dystrophin related protein 2 2.32749
PYCR1 pyrroline-5-carboxylate reductase 1 2.30537
CDK5 cyclin-dependent kinase 5 2.30475
NHSL1 NHS-like 1 2.28585
PLAAT5 phospholipase A and acyltransferase 5 2.28362
ZNF784 zinc finger protein 784 2.28362
CHD2 chromodomain helicase DNA binding protein 2 2.25445
TGOLN2 trans-golgi network protein 2 2.25209
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 2.23888
MTMR14 myotubularin related protein 14 2.22266
MEGF6 multiple EGF-like-domains 6 2.21765
RPL17 ribosomal protein L17 2.20924
PIGG phosphatidylinositol glycan anchor biosynthesis, class G 2.20589
WBP2 WW domain binding protein 2 2.19152
SLC16A14 solute carrier family 16, member 14 2.18989
TMTC1 transmembrane and tetratricopeptide repeat containing 1 2.18041
AFAP1L2 actin filament associated protein 1-like 2 2.18041
ZNF260 zinc finger protein 260 2.17334
CGREF1 cell growth regulator with EF-hand domain 1 2.17077
OXNAD1 oxidoreductase NAD-binding domain containing 1 2.16732
OSGIN2 oxidative stress induced growth inhibitor family member 2 2.16732
CNKSR1 connector enhancer of kinase suppressor of Ras 1 2.16717
COG4 component of oligomeric golgi complex 4 2.16717
DDB1 damage-specific DNA binding protein 1, 127kDa 2.16717
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 2.15081
GARIN1B golgi associated RAB2 interactor 1B 2.13023
NKAIN4 Na+/K+ transporting ATPase interacting 4 2.12489
RGMB repulsive guidance molecule family member b 2.10067
IRS1 insulin receptor substrate 1 2.083
ANKRD29 ankyrin repeat domain 29 2.0824
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 2.07269
KCTD17 potassium channel tetramerization domain containing 17 2.052
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 2.04056
CLTB clathrin, light chain B 2.03183
ZNF527 zinc finger protein 527 2.03144
TRPM2 transient receptor potential cation channel, subfamily M, member 2 2.03144
PRKCH protein kinase C, eta 2.01615
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like 2.0111
OFD1 oral-facial-digital syndrome 1 2.00505
SYT16 synaptotagmin XVI 2.00003

decreased expression

Symbol Name Standardized Value
SREBF2 sterol regulatory element binding transcription factor 2 -3.07488
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.034
LENG1 leukocyte receptor cluster (LRC) member 1 -3.034
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -3.034
CD200R1L CD200 receptor 1-like -3.034
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) -3.00332
ECM1 extracellular matrix protein 1 -3.00332
TMEM176B transmembrane protein 176B -2.8847
STXBP2 syntaxin binding protein 2 -2.8847
ZNF582 zinc finger protein 582 -2.8847
FPR2 formyl peptide receptor 2 -2.8847
FZD1 frizzled class receptor 1 -2.8847
CYTIP cytohesin 1 interacting protein -2.8847
CIITA class II, major histocompatibility complex, transactivator -2.8847
GYPE glycophorin E (MNS blood group) -2.8847
ACAN aggrecan -2.8847
TGFB3 transforming growth factor, beta 3 -2.8847
FAM229A family with sequence similarity 229, member A -2.8847
OXER1 oxoeicosanoid (OXE) receptor 1 -2.8847
LGALS9 lectin, galactoside-binding, soluble, 9 -2.8847
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 -2.8847
RGS7BP regulator of G-protein signaling 7 binding protein -2.8847
C1ORF202 chromosome 1 open reading frame 202 -2.8847
FAR1 fatty acyl CoA reductase 1 -2.8847
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -2.8847
SMIM41 small integral membrane protein 41 -2.8847
SVOP SV2 related protein homolog (rat) -2.8847
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.8847
FAM131C family with sequence similarity 131, member C -2.8847
NRIP2 nuclear receptor interacting protein 2 -2.8847
PGA5 pepsinogen 5, group I (pepsinogen A) -2.8847
BRICD5 BRICHOS domain containing 5 -2.8847
TPTE2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 -2.8847
FBXW12 F-box and WD repeat domain containing 12 -2.8847
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.8847
MSMO1 methylsterol monooxygenase 1 -2.8847
PRR13 proline rich 13 -2.8847
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 -2.8847
TMEM225B transmembrane protein 225B -2.8847
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) -2.85606
ZNF597 zinc finger protein 597 -2.81876
EVI2B ecotropic viral integration site 2B -2.81876
DPH1 diphthamide biosynthesis 1 -2.74612
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2 -2.73677
DCAF11 DDB1 and CUL4 associated factor 11 -2.72995
QRFPR pyroglutamylated RFamide peptide receptor -2.72291
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) -2.70424
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 -2.69028
PDGFRA platelet-derived growth factor receptor, alpha polypeptide -2.68911
IL15 interleukin 15 -2.68911
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -2.67971
GBA1 glucosylceramidase beta 1 -2.67782
TUG1 taurine up-regulated 1 (non-protein coding) -2.65018
ZCCHC17 zinc finger, CCHC domain containing 17 -2.63284
RUMY3 RUMY family member 3 -2.56948
RGL3 ral guanine nucleotide dissociation stimulator-like 3 -2.54958
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.54626
JRK Jrk homolog (mouse) -2.51701
ACAT2 acetyl-CoA acetyltransferase 2 -2.50682
THBS2 thrombospondin 2 -2.43576
TGFBR1 transforming growth factor, beta receptor 1 -2.43576
RBM12B RNA binding motif protein 12B -2.42882
TCEAL7 transcription elongation factor A (SII)-like 7 -2.40991
CSPP1 centrosome and spindle pole associated protein 1 -2.40991
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 -2.38208
ZNF567 zinc finger protein 567 -2.38001
ERCC2 excision repair cross-complementation group 2 -2.37847
YDJC YdjC homolog (bacterial) -2.30475
RP9 retinitis pigmentosa 9 (autosomal dominant) -2.29373
RPL37 ribosomal protein L37 -2.29373
KIF20B kinesin family member 20B -2.29314
SMIM24 small integral membrane protein 24 -2.28387
NELFCD negative elongation factor complex member C/D -2.28362
OLFM1 olfactomedin 1 -2.28362
CLNS1A chloride channel, nucleotide-sensitive, 1A -2.27471
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit -2.27471
SQLE squalene epoxidase -2.27454
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled -2.26739
DIAPH1 diaphanous-related formin 1 -2.24249
ZNF470 zinc finger protein 470 -2.24249
KPNA5 karyopherin alpha 5 (importin alpha 6) -2.22329
KIF13B kinesin family member 13B -2.21786
SPTB spectrin, beta, erythrocytic -2.20589
EMC2 ER membrane protein complex subunit 2 -2.18989
CR1 complement component (3b/4b) receptor 1 (Knops blood group) -2.18584
STK31 serine/threonine kinase 31 -2.18584
AGAP6 ArfGAP with GTPase domain, ankyrin repeat and PH domain 6 -2.16732
CDV3 CDV3 homolog (mouse) -2.16717
POPDC3 popeye domain containing 3 -2.16717
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 -2.15081
NLRP2 NLR family, pyrin domain containing 2 -2.15081
ANG angiogenin, ribonuclease, RNase A family, 5 -2.12774
OPHN1 oligophrenin 1 -2.12489
METTL3 methyltransferase like 3 -2.12213
DDX55 DEAD (Asp-Glu-Ala-Asp) box polypeptide 55 -2.11964
S1PR2 sphingosine-1-phosphate receptor 2 -2.11551
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -2.11551
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa -2.11551
DHCR24 24-dehydrocholesterol reductase -2.10133
MRPS14 mitochondrial ribosomal protein S14 -2.10067
FAM171B family with sequence similarity 171, member B -2.10067
NPDC1 neural proliferation, differentiation and control, 1 -2.09573
EVA1B eva-1 homolog B (C. elegans) -2.0821
UNKL unkempt family zinc finger-like -2.0703
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -2.06871
SPATA21 spermatogenesis associated 21 -2.0568
EFCAB7 EF-hand calcium binding domain 7 -2.03183
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like -2.03183
SFXN5 sideroflexin 5 -2.03144
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 -2.03115
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 -2.02232
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) -2.01315
FAAP24 FA core complex associated protein 24 -2.00505