SREBF2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description sterol regulatory element binding transcription factor 2|This gene encodes a member of the a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] (NCBI Entrez Gene Database, 6721)
External Link http://www.ncbi.nlm.nih.gov/gene/6721
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Genes

70 interacting proteins for SREBF2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABLIM1 actin binding LIM protein 1
ABLIM2 actin binding LIM protein family, member 2
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARRB1 arrestin, beta 1
ATF6 activating transcription factor 6
ATF7IP activating transcription factor 7 interacting protein
ATXN1 ataxin 1
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8AP2 caspase 8 associated protein 2
CDK8 cyclin-dependent kinase 8
COPS5 COP9 signalosome subunit 5
CREB1 cAMP responsive element binding protein 1
CREBBP CREB binding protein
DHCR24 24-dehydrocholesterol reductase
EGR1 early growth response 1
EP300 E1A binding protein p300
ERLIN2 ER lipid raft associated 2
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FHL3 four and a half LIM domains 3
GOLGB1 golgin B1
HDAC3 histone deacetylase 3
HINFP histone H4 transcription factor
HNF4A hepatocyte nuclear factor 4, alpha
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HTT huntingtin
INSIG1 insulin induced gene 1
INSIG2 insulin induced gene 2
ITGB4 integrin, beta 4
KLF13 Kruppel-like factor 13
KPNB1 karyopherin (importin) beta 1
LZTR1 leucine-zipper-like transcription regulator 1
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAX MYC associated factor X
MBTPS1 membrane-bound transcription factor peptidase, site 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MED1 mediator complex subunit 1
MED15 mediator complex subunit 15
MED6 mediator complex subunit 6
MRPS6 mitochondrial ribosomal protein S6
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAE1 NEDD8 activating enzyme E1 subunit 1
NFYA nuclear transcription factor Y, alpha
NFYC nuclear transcription factor Y, gamma
NPAT nuclear protein, ataxia-telangiectasia locus
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
PARK7 parkinson protein 7
PIAS1 protein inhibitor of activated STAT, 1
PIAS2 protein inhibitor of activated STAT, 2
PIAS3 protein inhibitor of activated STAT, 3
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
RAB11B RAB11B, member RAS oncogene family
RNF139 ring finger protein 139
SCAP SREBF chaperone
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMAD3 SMAD family member 3
SP1 Sp1 transcription factor
SPTBN1 spectrin, beta, non-erythrocytic 1
SREBF1 sterol regulatory element binding transcription factor 1
SUMO1 small ubiquitin-like modifier 1
SUMO2 small ubiquitin-like modifier 2
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TP53 tumor protein p53
TRRAP transformation/transcription domain-associated protein
TTC1 tetratricopeptide repeat domain 1
UBC ubiquitin C
UBE2I ubiquitin-conjugating enzyme E2I
ZDHHC17 zinc finger, DHHC-type containing 17
ZMYM2 zinc finger, MYM-type 2
ZYX zyxin