SRF Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description serum response factor (c-fos serum response element-binding transcription factor)|This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014] (NCBI Entrez Gene Database, 6722)
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Genes

332 genes differentially expressed following the SRF gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CARD18 caspase recruitment domain family, member 18 3.69066
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 3.69066
LILRB5 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5 3.69066
XCL1 chemokine (C motif) ligand 1 3.69066
SSTR5 somatostatin receptor 5 3.69066
CIITA class II, major histocompatibility complex, transactivator 3.69066
CC2D2B coiled-coil and C2 domain containing 2B 3.69066
ADAD2 adenosine deaminase domain containing 2 3.69066
MYCT1 myc target 1 3.69066
C12ORF71 chromosome 12 open reading frame 71 3.69066
CLEC19A C-type lectin domain family 19, member A 3.69066
CASP4 caspase 4, apoptosis-related cysteine peptidase 3.69066
NPPC natriuretic peptide C 3.69066
SLC46A3 solute carrier family 46, member 3 3.69066
GNLY granulysin 3.69066
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 3.69066
CELF6 CUGBP, Elav-like family member 6 3.69066
PLIN1 perilipin 1 3.69066
SPINK4 serine peptidase inhibitor, Kazal type 4 3.69066
PCDHB4 protocadherin beta 4 3.69066
GLYAT glycine-N-acyltransferase 3.69066
CXCL2 chemokine (C-X-C motif) ligand 2 3.69066
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 3.69066
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 3.69066
IL18R1 interleukin 18 receptor 1 3.69066
SPAG8 sperm associated antigen 8 3.69066
STAP1 signal transducing adaptor family member 1 3.69066
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 3.69066
RBP4 retinol binding protein 4, plasma 3.69066
FXYD2 FXYD domain containing ion transport regulator 2 3.69066
PSD2 pleckstrin and Sec7 domain containing 2 3.69066
PITX3 paired-like homeodomain 3 3.69066
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 3.69066
PRDM1 PR domain containing 1, with ZNF domain 3.69066
C1ORF146 chromosome 1 open reading frame 146 3.69066
CX3CR1 chemokine (C-X3-C motif) receptor 1 3.69066
TMEM89 transmembrane protein 89 3.69066
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 3.69066
TRPC5OS TRPC5 opposite strand 3.69066
SLC39A12 solute carrier family 39 (zinc transporter), member 12 3.69066
LGALS2 lectin, galactoside-binding, soluble, 2 3.69066
HMX3 H6 family homeobox 3 3.69066
GYS2 glycogen synthase 2 (liver) 3.69066
MRGPRX3 MAS-related GPR, member X3 3.69066
EXOC1L exocyst complex component 1 like 3.69066
ALX4 ALX homeobox 4 3.69066
RHCG Rh family, C glycoprotein 3.69066
FRG2C FSHD region gene 2 family, member C 3.69066
FCMR Fc fragment of IgM receptor 3.69066
GRAP GRB2-related adaptor protein 3.69066
GCSAM germinal center-associated, signaling and motility 3.69066
SPATC1 spermatogenesis and centriole associated 1 3.69066
MROH5 maestro heat-like repeat family member 5 3.69066
NPIPB8 nuclear pore complex interacting protein family, member B8 3.69066
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 3.69066
OTOF otoferlin 3.69066
SPAAR small regulatory polypeptide of amino acid response 3.69066
H3-7 H3.7 histone (putative) 3.69066
IHO1 interactor of HORMAD1 1 3.69066
SPEM2 SPEM family member 2 3.69066
CFAP141 cilia and flagella associated protein 141 3.69066
CCDC190 coiled-coil domain containing 190 3.69066
CCN5 cellular communication network factor 5 3.69066
STYXL2 serine/threonine/tyrosine interacting like 2 3.69066
SQOR sulfide quinone oxidoreductase 3.69066
ZAR1L zygote arrest 1-like 3.69066
FRK fyn-related Src family tyrosine kinase 3.69066
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 3.69066
ITK IL2-inducible T-cell kinase 3.69066
TRIM60 tripartite motif containing 60 3.69066
LIPJ lipase, family member J 3.69066
CPED1 cadherin-like and PC-esterase domain containing 1 3.69066
FAM153A family with sequence similarity 153, member A 3.69066
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 3.69066
CD5 CD5 molecule 3.69066
LRRD1 leucine-rich repeats and death domain containing 1 3.69066
SCN10A sodium channel, voltage gated, type X alpha subunit 3.69066
PTP4A1 protein tyrosine phosphatase type IVA, member 1 3.69066
CLDN22 claudin 22 3.69066
C1QTNF8 C1q and tumor necrosis factor related protein 8 3.69066
LEF1 lymphoid enhancer-binding factor 1 3.69066
BHLHA9 basic helix-loop-helix family, member a9 3.69066
TFEC transcription factor EC 3.69066
OVOL3 ovo-like zinc finger 3 3.69066
ZNF575 zinc finger protein 575 3.69066
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 3.69066
NR1I3 nuclear receptor subfamily 1, group I, member 3 3.69066
FGF23 fibroblast growth factor 23 3.69066
NPIPB15 nuclear pore complex interacting protein family, member B15 3.69066
FAM163A family with sequence similarity 163, member A 3.69066
WFDC6 WAP four-disulfide core domain 6 3.69066
TDRD10 tudor domain containing 10 3.69066
TPSB2 tryptase beta 2 (gene/pseudogene) 3.69066
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 3.69066
CDH10 cadherin 10, type 2 (T2-cadherin) 3.69066
CLEC4D C-type lectin domain family 4, member D 3.69066
PATE4 prostate and testis expressed 4 3.69066
PLA1A phospholipase A1 member A 3.69066
NOX3 NADPH oxidase 3 3.69066
CXCR5 chemokine (C-X-C motif) receptor 5 3.69066
TMEM132D transmembrane protein 132D 3.69066
TMEM132E transmembrane protein 132E 3.69066
ZNF132 zinc finger protein 132 3.69066
RSAD2 radical S-adenosyl methionine domain containing 2 3.69066
HBE1 hemoglobin, epsilon 1 3.69066
MRLN myoregulin 3.69066
GPR12 G protein-coupled receptor 12 3.69066
DQX1 DEAQ box RNA-dependent ATPase 1 3.69066
CLRN1 clarin 1 3.69066
EGR3 early growth response 3 3.69066
ZNF596 zinc finger protein 596 3.69066
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 3.69066
PFN4 profilin family, member 4 3.69066
GPR150 G protein-coupled receptor 150 3.69066
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 3.69066
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 3.69066
FAM151A family with sequence similarity 151, member A 3.69066
CNGB1 cyclic nucleotide gated channel beta 1 3.69066
TTC24 tetratricopeptide repeat domain 24 3.69066
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 3.69066
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 3.69066
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 3.69066
RGS8 regulator of G-protein signaling 8 3.69066
OCM oncomodulin 3.69066
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 3.69066
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 3.69066
TF transferrin 3.69066
MORN5 MORN repeat containing 5 3.69066
CRTAM cytotoxic and regulatory T cell molecule 3.69066
IGLL1 immunoglobulin lambda-like polypeptide 1 3.69066
HIGD2B HIG1 hypoxia inducible domain family, member 2B 3.69066
CTRB1 chymotrypsinogen B1 3.69066
RAD9B RAD9 homolog B (S. pombe) 3.69066
ZNF474 zinc finger protein 474 3.69066
PRSS50 protease, serine, 50 3.69066
ACSM4 acyl-CoA synthetase medium-chain family member 4 3.69066
ASCL1 achaete-scute family bHLH transcription factor 1 3.69066
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 3.69066
PPY pancreatic polypeptide 3.69066
CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 3.69066
TRAF3IP3 TRAF3 interacting protein 3 3.69066
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21 3.69066
MAEL maelstrom spermatogenic transposon silencer 3.69066
EPO erythropoietin 3.69066
SCN3A sodium channel, voltage gated, type III alpha subunit 3.69066
IL10RA interleukin 10 receptor, alpha 3.69066
ITPKA inositol-trisphosphate 3-kinase A 3.69066
CHRM4 cholinergic receptor, muscarinic 4 3.69066
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 3.69066
KIF12 kinesin family member 12 3.69066
PADI6 peptidyl arginine deiminase, type VI 3.69066
BMX BMX non-receptor tyrosine kinase 3.69066
OR3A1 olfactory receptor, family 3, subfamily A, member 1 3.69066
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 3.69066
TEX38 testis expressed 38 3.69066
A1CF APOBEC1 complementation factor 3.69066
ANXA1 annexin A1 3.69066
PTPN7 protein tyrosine phosphatase, non-receptor type 7 3.69066
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 3.69066
ALLC allantoicase 3.69066
FCN3 ficolin (collagen/fibrinogen domain containing) 3 3.69066
RNF148 ring finger protein 148 3.69066
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 3.56568
RFTN2 raftlin family member 2 3.29604
SPRY4 sprouty homolog 4 (Drosophila) 2.89134
GIP gastric inhibitory polypeptide 2.8297
ETNPPL ethanolamine-phosphate phospho-lyase 2.7631
ZNF699 zinc finger protein 699 2.71213
GGACT gamma-glutamylamine cyclotransferase 2.48847
JHY junctional cadherin complex regulator 2.48847
JOSD2 Josephin domain containing 2 2.48847
MECR mitochondrial trans-2-enoyl-CoA reductase 2.47912
ADGRB1 adhesion G protein-coupled receptor B1 2.45587
PI15 peptidase inhibitor 15 2.43456
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2.40259
GALNT9 polypeptide N-acetylgalactosaminyltransferase 9 2.40259
THTPA thiamine triphosphatase 2.40259
ZSCAN18 zinc finger and SCAN domain containing 18 2.37328
FAT3 FAT atypical cadherin 3 2.37256
ZNF667 zinc finger protein 667 2.35953
ZBTB4 zinc finger and BTB domain containing 4 2.32256
RIPK2 receptor-interacting serine-threonine kinase 2 2.31246
BIN3 bridging integrator 3 2.30712
H2BC4 H2B clustered histone 4 2.29618
CWC27 CWC27 spliceosome-associated protein homolog (S. cerevisiae) 2.28968
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 2.28968
ZNF358 zinc finger protein 358 2.28862
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 2.28277
MRPL35 mitochondrial ribosomal protein L35 2.26442
ZNF534 zinc finger protein 534 2.25133
AZGP1 alpha-2-glycoprotein 1, zinc-binding 2.25133
TTPA tocopherol (alpha) transfer protein 2.25133
STRC stereocilin 2.25052
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 2.24116
CD38 CD38 molecule 2.23789
VN1R1 vomeronasal 1 receptor 1 2.23789
POU5F2 POU domain class 5, transcription factor 2 2.23789
ANKRD13A ankyrin repeat domain 13A 2.23789
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 2.23789
FAM162B family with sequence similarity 162, member B 2.19591
RECQL4 RecQ protein-like 4 2.19481
H4C4 H4 clustered histone 4 2.19344
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 2.19074
TRPM3 transient receptor potential cation channel, subfamily M, member 3 2.15618
ADAM19 ADAM metallopeptidase domain 19 2.14546
SPRY2 sprouty homolog 2 (Drosophila) 2.13583
IL17RC interleukin 17 receptor C 2.13339
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa 2.09963
ABHD18 abhydrolase domain containing 18 2.09199
FNTB farnesyltransferase, CAAX box, beta 2.08874
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 2.04553
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 2.04426
RNF150 ring finger protein 150 2.01667
KATNA1 katanin p60 (ATPase containing) subunit A 1 2.00391

decreased expression

Symbol Name Standardized Value
APOA1 apolipoprotein A-I -3.69066
ZMYND15 zinc finger, MYND-type containing 15 -3.69066
SPX spexin hormone -3.69066
MMP21 matrix metallopeptidase 21 -3.69066
KCNRG potassium channel regulator -3.69066
HES3 hes family bHLH transcription factor 3 -3.69066
AMIGO1 adhesion molecule with Ig-like domain 1 -3.69066
MBLAC1 metallo-beta-lactamase domain containing 1 -3.69066
DCLK3 doublecortin-like kinase 3 -3.69066
GAD1 glutamate decarboxylase 1 (brain, 67kDa) -3.69066
C5AR1 complement component 5a receptor 1 -3.69066
ACTB actin, beta -3.69066
TMEM184A transmembrane protein 184A -3.69066
CAMK1G calcium/calmodulin-dependent protein kinase IG -3.69066
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 -3.69066
NFE2 nuclear factor, erythroid 2 -3.69066
GPR171 G protein-coupled receptor 171 -3.69066
ZNF804B zinc finger protein 804B -3.69066
LY6G5C lymphocyte antigen 6 complex, locus G5C -3.69066
TLCD2 TLC domain containing 2 -3.69066
OLFML1 olfactomedin-like 1 -3.69066
FAM167A family with sequence similarity 167, member A -3.69066
IL11RA interleukin 11 receptor, alpha -3.69066
ZC3H11D zinc finger CCCH-type containing 11D -3.69066
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7 -3.69066
SCIMP SLP adaptor and CSK interacting membrane protein -3.69066
GPR87 G protein-coupled receptor 87 -3.69066
LGALS14 lectin, galactoside-binding, soluble, 14 -3.69066
TUBA4B tubulin, alpha 4b -3.69066
TBX10 T-box 10 -3.69066
SPATS1 spermatogenesis associated, serine-rich 1 -3.69066
ZNF304 zinc finger protein 304 -3.69066
GOLGA8N golgin A8 family, member N -3.69066
TTC16 tetratricopeptide repeat domain 16 -3.69066
PCDHB12 protocadherin beta 12 -3.69066
SIAH3 siah E3 ubiquitin protein ligase family member 3 -3.69066
PSKH2 protein serine kinase H2 -3.69066
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 -3.69066
ISL1 ISL LIM homeobox 1 -3.69066
ZNF436 zinc finger protein 436 -3.69066
PCDHA5 protocadherin alpha 5 -3.69066
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) -3.69066
SCARF1 scavenger receptor class F, member 1 -3.69066
EFCAB5 EF-hand calcium binding domain 5 -3.6452
PIGA phosphatidylinositol glycan anchor biosynthesis, class A -3.23386
TSPEAR thrombospondin-type laminin G domain and EAR repeats -3.11167
CFAP68 cilia and flagella associated protein 68 -2.96026
MACIR macrophage immunometabolism regulator -2.86709
GPAA1 glycosylphosphatidylinositol anchor attachment 1 -2.81181
CRABP2 cellular retinoic acid binding protein 2 -2.79883
GANAB glucosidase, alpha; neutral AB -2.75913
TPM2 tropomyosin 2 (beta) -2.69165
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -2.63589
PCDHA4 protocadherin alpha 4 -2.59146
FAM86B2 family with sequence similarity 86, member B2 -2.59146
JAG2 jagged 2 -2.59146
CNN2 calponin 2 -2.55459
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -2.54621
SNX19 sorting nexin 19 -2.54042
ATRIP ATR interacting protein -2.52425
NPR1 natriuretic peptide receptor 1 -2.44263
TPM1 tropomyosin 1 (alpha) -2.44261
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 -2.44144
CMC4 C-x(9)-C motif containing 4 -2.43706
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -2.43568
MYADM myeloid-associated differentiation marker -2.37661
POLR1D polymerase (RNA) I polypeptide D, 16kDa -2.37256
ZUP1 zinc finger containing ubiquitin peptidase 1 -2.35621
BBLN bublin coiled coil protein -2.34393
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.30802
IGF1R insulin-like growth factor 1 receptor -2.29266
PDCD2L programmed cell death 2-like -2.28968
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.28968
GFY golgi-associated, olfactory signaling regulator -2.28968
ZIC1 Zic family member 1 -2.28968
CAPN13 calpain 13 -2.28968
RIPK4 receptor-interacting serine-threonine kinase 4 -2.28968
OSBPL10 oxysterol binding protein-like 10 -2.28277
TDRD5 tudor domain containing 5 -2.27546
PLD3 phospholipase D family, member 3 -2.26914
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -2.26711
ACTG1 actin gamma 1 -2.26447
MBOAT1 membrane bound O-acyltransferase domain containing 1 -2.26119
SLC46A1 solute carrier family 46 (folate transporter), member 1 -2.25961
CLIC4 chloride intracellular channel 4 -2.24533
THEM4 thioesterase superfamily member 4 -2.2441
TMEM39A transmembrane protein 39A -2.24116
ZFP91 ZFP91 zinc finger protein -2.24116
DBT dihydrolipoamide branched chain transacylase E2 -2.23789
ADIPOR1 adiponectin receptor 1 -2.23047
PPARG peroxisome proliferator-activated receptor gamma -2.22864
C11ORF71 chromosome 11 open reading frame 71 -2.21278
SQSTM1 sequestosome 1 -2.19298
LPP LIM domain containing preferred translocation partner in lipoma -2.18768
RANBP6 RAN binding protein 6 -2.18126
SMAP2 small ArfGAP2 -2.17751
RECQL5 RecQ protein-like 5 -2.17751
POLR3H polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) -2.17192
VCP valosin containing protein -2.13583
HEATR1 HEAT repeat containing 1 -2.13583
TPO thyroid peroxidase -2.13551
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2) -2.12395
TEKT3 tektin 3 -2.12395
NT5C2 5'-nucleotidase, cytosolic II -2.11536
TMEM17 transmembrane protein 17 -2.11156
EGFL8 EGF-like-domain, multiple 8 -2.11156
C2CD4C C2 calcium-dependent domain containing 4C -2.11156
BCL7B B-cell CLL/lymphoma 7B -2.07674
CYYR1 cysteine/tyrosine-rich 1 -2.05786
MYL9 myosin, light chain 9, regulatory -2.05786
SEC14L1 SEC14-like 1 (S. cerevisiae) -2.05145
FEM1B fem-1 homolog b (C. elegans) -2.05089
BABAM1 BRISC and BRCA1 A complex member 1 -2.04725
BMI1 BMI1 proto-oncogene, polycomb ring finger -2.04725
VSTM5 V-set and transmembrane domain containing 5 -2.04725
USB1 U6 snRNA biogenesis 1 -2.03272
CHCHD5 coiled-coil-helix-coiled-coil-helix domain containing 5 -2.02544
ACTN4 actinin, alpha 4 -2.02318