SRF Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description serum response factor (c-fos serum response element-binding transcription factor)|This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014] (NCBI Entrez Gene Database, 6722)
External Link http://www.ncbi.nlm.nih.gov/gene/6722
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Genes

93 interacting proteins for SRF from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ASCC1 activating signal cointegrator 1 complex subunit 1
ASCC2 activating signal cointegrator 1 complex subunit 2
ASCC3 activating signal cointegrator 1 complex subunit 3
ATF6 activating transcription factor 6
BARX2 BARX homeobox 2
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK4 calcium/calmodulin-dependent protein kinase IV
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CD63 CD63 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CIRBP cold inducible RNA binding protein
CNTN2 contactin 2 (axonal)
CREB1 cAMP responsive element binding protein 1
CREBBP CREB binding protein
CRIP2 cysteine-rich protein 2
CSNK2A1 casein kinase 2, alpha 1 polypeptide
DMPK dystrophia myotonica-protein kinase
ELK1 ELK1, member of ETS oncogene family
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
EPC1 enhancer of polycomb homolog 1 (Drosophila)
ETV4 ets variant 4
EWSR1 EWS RNA-binding protein 1
FHL1 four and a half LIM domains 1
FHL2 four and a half LIM domains 2
FHL3 four and a half LIM domains 3
FHL5 four and a half LIM domains 5
FLI1 Fli-1 proto-oncogene, ETS transcription factor
GATA4 GATA binding protein 4
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa
GTF2I general transcription factor IIi
HDAC3 histone deacetylase 3
HDAC4 histone deacetylase 4
HMGA1 high mobility group AT-hook 1
HOPX HOP homeobox
KAT5 K(lysine) acetyltransferase 5
KDM6A lysine (K)-specific demethylase 6A
MAPK11 mitogen-activated protein kinase 11
MAPK14 mitogen-activated protein kinase 14
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MINPP1 multiple inositol-polyphosphate phosphatase 1
MKL1 megakaryoblastic leukemia (translocation) 1
MKL2 MKL/myocardin-like 2
MYOCD myocardin
MYOD1 myogenic differentiation 1
MYOG myogenin (myogenic factor 4)
NCOA1 nuclear receptor coactivator 1
NCOA6 nuclear receptor coactivator 6
NCOR2 nuclear receptor corepressor 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFYA nuclear transcription factor Y, alpha
NKX2-3 NK2 homeobox 3
NKX2-5 NK2 homeobox 5
NKX3-1 NK3 homeobox 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
ONECUT1 one cut homeobox 1
PELP1 proline, glutamate and leucine rich protein 1
PML promyelocytic leukemia
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCA protein kinase C, alpha
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRKG1 protein kinase, cGMP-dependent, type I
PRRX1 paired related homeobox 1
PYCARD PYD and CARD domain containing
RARG retinoic acid receptor, gamma
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
RXRA retinoid X receptor, alpha
RXRG retinoid X receptor, gamma
SHBG sex hormone-binding globulin
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SMAD7 SMAD family member 7
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SP1 Sp1 transcription factor
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRFBP1 serum response factor binding protein 1
SSRP1 structure specific recognition protein 1
SUMO1 small ubiquitin-like modifier 1
TCF3 transcription factor 3
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase
UBE2I ubiquitin-conjugating enzyme E2I