SRM Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description spermidine synthase|The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6723)
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Genes

301 genes differentially expressed following the SRM gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
MAGEB2 melanoma antigen family B2 2.5487
OR5P3 olfactory receptor, family 5, subfamily P, member 3 2.5487
HLF hepatic leukemia factor 2.5487
HRH4 histamine receptor H4 2.5487
VCX2 variable charge, X-linked 2 2.5487
ZNF503 zinc finger protein 503 2.5487
ADGRE3 adhesion G protein-coupled receptor E3 2.5487
IGFL2 IGF-like family member 2 2.5487
IGFL3 IGF-like family member 3 2.5487
PRICKLE4 prickle homolog 4 (Drosophila) 2.5487
NDRG1 N-myc downstream regulated 1 2.5487
PIGR polymeric immunoglobulin receptor 2.5487
PDILT protein disulfide isomerase-like, testis expressed 2.5487
CLDN2 claudin 2 2.5487
VIT vitrin 2.5487
CD300LG CD300 molecule-like family member g 2.5487
OR2A2 olfactory receptor, family 2, subfamily A, member 2 2.5487
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 2.5487
ZDHHC19 zinc finger, DHHC-type containing 19 2.5487
OR2A25 olfactory receptor, family 2, subfamily A, member 25 2.5487
PRB1 proline-rich protein BstNI subfamily 1 2.5487
MEP1A meprin A, alpha (PABA peptide hydrolase) 2.5487
TRIM10 tripartite motif containing 10 2.5487
FGL2 fibrinogen-like 2 2.5487
GLUD2 glutamate dehydrogenase 2 2.5487
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.5487
F7 coagulation factor VII (serum prothrombin conversion accelerator) 2.5487
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 2.5487
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 2.5487
CD68 CD68 molecule 2.5487
CCDC38 coiled-coil domain containing 38 2.5487
PNOC prepronociceptin 2.5487
OR5V1 olfactory receptor, family 5, subfamily V, member 1 2.5487
IL2RA interleukin 2 receptor, alpha 2.5487
PTGFR prostaglandin F receptor (FP) 2.5487
TAL2 T-cell acute lymphocytic leukemia 2 2.5487
ADAD2 adenosine deaminase domain containing 2 2.5487
PCDHB6 protocadherin beta 6 2.5487
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 2.5487
CNTNAP4 contactin associated protein-like 4 2.5487
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 2.5487
GJB3 gap junction protein, beta 3, 31kDa 2.5487
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 2.5487
BATF basic leucine zipper transcription factor, ATF-like 2.5487
ASB14 ankyrin repeat and SOCS box containing 14 2.5487
SFXN3 sideroflexin 3 2.5487
ATOH7 atonal homolog 7 (Drosophila) 2.5487
THPO thrombopoietin 2.5487
LOC124909439 uncharacterized LOC124909439 2.5487
CFAP97D1 CFAP97 domain containing 1 2.5487
H2BC3 H2B clustered histone 3 2.5487
KASH5 KASH domain containing 5 2.5487
RTL9 retrotransposon Gag like 9 2.5487
RAB6D RAB6D, member RAS oncogene family 2.5487
H2BC1 H2B clustered histone 1 2.5487
VN1R2 vomeronasal 1 receptor 2 2.5487
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 2.5487
TMPRSS7 transmembrane protease, serine 7 2.5487
CIBAR2 CBY1 interacting BAR domain containing 2 2.5487
MYMK myomaker, myoblast fusion factor 2.5487
AKAIN1 A-kinase anchor inhibitor 1 2.5487
LOC128125816 uncharacterized LOC128125816 2.5487
DRC5 dynein regulatory complex subunit 5 2.5487
EPCIP exosomal polycystin 1 interacting protein 2.5487
IL6ST-DT IL6ST divergent transcript 2.5487
LRRC8C-DT LRRC8C divergent transcript 2.5487
NHERF4 NHERF family PDZ scaffold protein 4 2.5487
C8ORF90 chromosome 8 open reading frame 90 2.5487
SMIM45 small integral membrane protein 45 2.5487
H4C14 H4 clustered histone 14 2.5487
TMPRSS3 transmembrane protease, serine 3 2.5487
IQCF1 IQ motif containing F1 2.5487
SMPX small muscle protein, X-linked 2.5487
GLP2R glucagon-like peptide 2 receptor 2.5487
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G 2.5487
UBL4B ubiquitin-like 4B 2.5487
SH3TC1 SH3 domain and tetratricopeptide repeats 1 2.5487
TLR6 toll-like receptor 6 2.5487
NHLRC4 NHL repeat containing 4 2.5487
SAT1 spermidine/spermine N1-acetyltransferase 1 2.5487
DMBX1 diencephalon/mesencephalon homeobox 1 2.5487
TACSTD2 tumor-associated calcium signal transducer 2 2.5487
C1QTNF9 C1q and tumor necrosis factor related protein 9 2.5487
LSP1 lymphocyte-specific protein 1 2.5487
RASAL3 RAS protein activator like 3 2.5487
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1 2.5487
PCP4L1 Purkinje cell protein 4 like 1 2.5487
MSGN1 mesogenin 1 2.5487
BEST3 bestrophin 3 2.5487
LRRC72 leucine rich repeat containing 72 2.5487
FRK fyn-related Src family tyrosine kinase 2.5487
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa 2.5487
OOSP1 oocyte secreted protein 1, pseudogene 2.5487
SPDYC speedy/RINGO cell cycle regulator family member C 2.5487
CXCL16 chemokine (C-X-C motif) ligand 16 2.5487
CSNK2A3 casein kinase 2, alpha 3 polypeptide 2.5487
TMIGD2 transmembrane and immunoglobulin domain containing 2 2.5487
OR10J1 olfactory receptor, family 10, subfamily J, member 1 2.5487
EDN1 endothelin 1 2.5487
LCT lactase 2.5487
EFCAB3 EF-hand calcium binding domain 3 2.5487
EHF ets homologous factor 2.5487
BTNL9 butyrophilin-like 9 2.5487
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 2.5487
CDHR5 cadherin-related family member 5 2.5487
GLT1D1 glycosyltransferase 1 domain containing 1 2.5487
BRD9 bromodomain containing 9 2.5487
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 2.5487
MAPK11 mitogen-activated protein kinase 11 2.5487
HEMGN hemogen 2.5487
ACSM1 acyl-CoA synthetase medium-chain family member 1 2.5487
AGR2 anterior gradient 2 2.5487
ZNF367 zinc finger protein 367 2.5487
NACA2 nascent polypeptide-associated complex alpha subunit 2 2.5487
LRRC46 leucine rich repeat containing 46 2.5487
KCNK4 potassium channel, two pore domain subfamily K, member 4 2.5487
DCT dopachrome tautomerase 2.5487
CLEC4D C-type lectin domain family 4, member D 2.5487
HUS1B HUS1 checkpoint homolog b (S. pombe) 2.5487
CD27 CD27 molecule 2.5487
RGS8 regulator of G-protein signaling 8 2.5487
CLEC1A C-type lectin domain family 1, member A 2.5487
DEFB136 defensin, beta 136 2.5487
CAPSL calcyphosine-like 2.5487
TYR tyrosinase 2.5487
TSPAN13 tetraspanin 13 2.5487
SLC35F4 solute carrier family 35, member F4 2.5487
POU4F2 POU class 4 homeobox 2 2.5487
NR5A1 nuclear receptor subfamily 5, group A, member 1 2.5487
CDH17 cadherin 17, LI cadherin (liver-intestine) 2.5487
CGB2 chorionic gonadotropin, beta polypeptide 2 2.5487
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 2.5487
DRD3 dopamine receptor D3 2.5487
DRD2 dopamine receptor D2 2.5487
PDK4 pyruvate dehydrogenase kinase, isozyme 4 2.5487
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 2.5487
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 2.5487
SIAH3 siah E3 ubiquitin protein ligase family member 3 2.5487
SIRPG signal-regulatory protein gamma 2.5487
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 2.5487
LCN1 lipocalin 1 2.5487
CHAD chondroadherin 2.5487
SYMPK symplekin 2.5487
CDCP2 CUB domain containing protein 2 2.5487
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 2.5487
CD8B CD8b molecule 2.5487
CLCNKA chloride channel, voltage-sensitive Ka 2.5487
FCAR Fc fragment of IgA receptor 2.5487
ANXA1 annexin A1 2.5487
ALLC allantoicase 2.5487
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.5487
PF4V1 platelet factor 4 variant 1 2.5487
ZPLD1 zona pellucida-like domain containing 1 2.5487
ST18 suppression of tumorigenicity 18, zinc finger 2.5487
PADI6 peptidyl arginine deiminase, type VI 2.5487
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 2.5487
RAB7B RAB7B, member RAS oncogene family 2.5487
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 2.5487
ACKR2 atypical chemokine receptor 2 2.5487
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 2.5487
PLGLB2 plasminogen-like B2 2.5487
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 2.5487
RTP4 receptor (chemosensory) transporter protein 4 2.5487
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 2.5487
FGF7 fibroblast growth factor 7 2.5487
EPO erythropoietin 2.5487
PODN podocan 2.5487
SOST sclerostin 2.5487
ASCL3 achaete-scute family bHLH transcription factor 3 2.5487
LPA lipoprotein, Lp(a) 2.5487
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 2.5487
EXOG endo/exonuclease (5'-3'), endonuclease G-like 2.53192
MPND MPN domain containing 2.52129
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 2.4953
CKAP4 cytoskeleton-associated protein 4 2.4953
CSAG3 CSAG family, member 3 2.41696
FAM240A family with sequence similarity 240 member A 2.41696
FAM76A family with sequence similarity 76, member A 2.41696
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 2.41368
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) 2.41345
ENSA endosulfine alpha 2.41345
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa 2.35811
PPP1R21 protein phosphatase 1, regulatory subunit 21 2.33806
HDLBP high density lipoprotein binding protein 2.33806
ATRAID all-trans retinoic acid-induced differentiation factor 2.31666
STXBP4 syntaxin binding protein 4 2.31666
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 2.31378
KLHL10 kelch-like family member 10 2.31378
PSORS1C2 psoriasis susceptibility 1 candidate 2 2.28224
CCDC134 coiled-coil domain containing 134 2.27978
TMEM132A transmembrane protein 132A 2.26172
SOX2 SRY (sex determining region Y)-box 2 2.25375
LACC1 laccase (multicopper oxidoreductase) domain containing 1 2.23076
UBN2 ubinuclein 2 2.22475
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein 2.22152
AGA aspartylglucosaminidase 2.21211
NPBWR1 neuropeptides B/W receptor 1 2.19541
MROH9 maestro heat-like repeat family member 9 2.17343
OSER1 oxidative stress responsive serine-rich 1 2.15929
HMBOX1 homeobox containing 1 2.15663
CCDC157 coiled-coil domain containing 157 2.1472
ZNF33B zinc finger protein 33B 2.10216
CIAO3 cytosolic iron-sulfur assembly component 3 2.09594
FBXL7 F-box and leucine-rich repeat protein 7 2.09238
COQ3 coenzyme Q3 methyltransferase 2.07206
PNMA3 paraneoplastic Ma antigen 3 2.07206
RPSA2 ribosomal protein SA 2 2.04775
MAN1A1 mannosidase, alpha, class 1A, member 1 2.04474
ZNF785 zinc finger protein 785 2.0316
NAIP NLR family, apoptosis inhibitory protein 2.03153

decreased expression

Symbol Name Standardized Value
SPAG5 sperm associated antigen 5 -2.5487
PKD1L1 polycystic kidney disease 1 like 1 -2.5487
ZFP57 ZFP57 zinc finger protein -2.5487
OR13A1 olfactory receptor, family 13, subfamily A, member 1 -2.5487
ACE angiotensin I converting enzyme -2.5487
CCDC159 coiled-coil domain containing 159 -2.5487
TMEM132E transmembrane protein 132E -2.5487
ERICH6 glutamate-rich 6 -2.5487
IGFL4 IGF-like family member 4 -2.5487
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 -2.5487
TSC22D3 TSC22 domain family, member 3 -2.5487
LRRC38 leucine rich repeat containing 38 -2.5487
NOD2 nucleotide-binding oligomerization domain containing 2 -2.5487
TCEAL5 transcription elongation factor A (SII)-like 5 -2.5487
ACADL acyl-CoA dehydrogenase, long chain -2.5487
PRSS36 protease, serine, 36 -2.5487
POPDC2 popeye domain containing 2 -2.5487
ATF2 activating transcription factor 2 -2.5487
ZC3HAV1L zinc finger CCCH-type, antiviral 1-like -2.5487
SLC38A10 solute carrier family 38, member 10 -2.5487
THRSP thyroid hormone responsive -2.5487
HYKK hydroxylysine kinase -2.5487
C3ORF18 chromosome 3 open reading frame 18 -2.5487
FAM163A family with sequence similarity 163, member A -2.5487
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 -2.5487
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) -2.5487
AOAH acyloxyacyl hydrolase (neutrophil) -2.5487
SLC22A31 solute carrier family 22, member 31 -2.5487
DPP9 dipeptidyl-peptidase 9 -2.5487
CLDN16 claudin 16 -2.5487
ARID1A AT rich interactive domain 1A (SWI-like) -2.5487
ARSL arylsulfatase L -2.5487
C10ORF105 chromosome 10 open reading frame 105 -2.5487
PLPP1 phospholipid phosphatase 1 -2.5487
SMIM17 small integral membrane protein 17 -2.5487
NPNT nephronectin -2.5487
POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD) -2.5487
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 -2.5487
BAHCC1 BAH domain and coiled-coil containing 1 -2.5487
SYCP1 synaptonemal complex protein 1 -2.5487
PCDHA13 protocadherin alpha 13 -2.5487
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta -2.5487
USH1G Usher syndrome 1G (autosomal recessive) -2.5487
FSHR follicle stimulating hormone receptor -2.5487
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 -2.5487
BTG4 B-cell translocation gene 4 -2.5487
SLC67A1 solute carrier family 67 member 1 -2.53539
DHODH dihydroorotate dehydrogenase (quinone) -2.53192
ZNF93 zinc finger protein 93 -2.50322
ZNF516 zinc finger protein 516 -2.50322
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 -2.45494
KLHDC8B kelch domain containing 8B -2.43475
OPRD1 opioid receptor, delta 1 -2.41696
CCNY cyclin Y -2.41246
TOMM6 translocase of outer mitochondrial membrane 6 homolog (yeast) -2.38238
SLC38A5 solute carrier family 38, member 5 -2.38238
ARID5A AT rich interactive domain 5A (MRF1-like) -2.36957
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.36188
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 -2.32679
SRM spermidine synthase -2.31802
CALD1 caldesmon 1 -2.3054
LAMP1 lysosomal-associated membrane protein 1 -2.30244
CIP2A cellular inhibitor of PP2A -2.28253
FANK1 fibronectin type III and ankyrin repeat domains 1 -2.27506
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -2.27165
KANTR KDM5C adjacent non-coding transcript -2.27165
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.26835
TRAPPC1 trafficking protein particle complex 1 -2.24246
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -2.23903
RIBC2 RIB43A domain with coiled-coils 2 -2.23838
CD58 CD58 molecule -2.23076
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) -2.23076
TMEM236 transmembrane protein 236 -2.21751
PRSS27 protease, serine 27 -2.21751
FAM133A family with sequence similarity 133, member A -2.18573
CYTH1 cytohesin 1 -2.18343
MACROH2A1 macroH2A.1 histone -2.15524
COL5A1 collagen, type V, alpha 1 -2.1487
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 -2.14152
GLIS1 GLIS family zinc finger 1 -2.09594
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 -2.09402
PRPF18 pre-mRNA processing factor 18 -2.09354
PCNX2 pecanex 2 -2.07277
RNF144A ring finger protein 144A -2.0723
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 -2.06037
C1ORF54 chromosome 1 open reading frame 54 -2.05754
IFT88 intraflagellar transport 88 -2.05145
SPATA13 spermatogenesis associated 13 -2.04584
CMC1 C-x(9)-C motif containing 1 -2.04337
RETSAT retinol saturase (all-trans-retinol 13,14-reductase) -2.03153
ADGRA2 adhesion G protein-coupled receptor A2 -2.00268