SRM Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description spermidine synthase|The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6723)
External Link https://ncbi.nlm.nih.gov/gene/6723
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Genes

500 genes differentially expressed following the SRM gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
TM4SF1 transmembrane 4 L six family member 1 0.0224395
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0162606
AKR1C3 aldo-keto reductase family 1, member C3 0.0159185
EFNA1 ephrin-A1 0.0158721
FBLN1 fibulin 1 0.0158691
KRT18 keratin 18, type I 0.0151686
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.0151325
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.0150225
COL5A2 collagen, type V, alpha 2 0.0146652
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 0.0145002
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0138232
CFB complement factor B 0.0137156
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0136324
CLU clusterin 0.0135637
THBS2 thrombospondin 2 0.0133018
CFI complement factor I 0.0132416
TSPAN7 tetraspanin 7 0.0130443
IFI27 interferon, alpha-inducible protein 27 0.0129374
DEFB1 defensin, beta 1 0.0128453
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0128241
IFI44L interferon-induced protein 44-like 0.0126296
RHOB ras homolog family member B 0.0125856
CRIP1 cysteine-rich protein 1 (intestinal) 0.0125023
CD9 CD9 molecule 0.0124998
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.0124604
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.0123499
CCN2 cellular communication network factor 2 0.0123006
ZNF217 zinc finger protein 217 0.01209
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.0120602
MT1G metallothionein 1G 0.0119572
MX2 MX dynamin-like GTPase 2 0.0117487
COL14A1 collagen, type XIV, alpha 1 0.0117145
ATF3 activating transcription factor 3 0.011691
MX1 MX dynamin-like GTPase 1 0.0116617
PPIC peptidylprolyl isomerase C (cyclophilin C) 0.0115046
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0113889
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 0.0113867
MT1H metallothionein 1H 0.0112979
MGP matrix Gla protein 0.0112832
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0112339
GUSBP3 glucuronidase, beta pseudogene 3 0.0112264
MMP10 matrix metallopeptidase 10 0.0112148
NPY1R neuropeptide Y receptor Y1 0.0111124
LYPD1 LY6/PLAUR domain containing 1 0.011109
IFI6 interferon, alpha-inducible protein 6 0.0110807
MZB1 marginal zone B and B1 cell-specific protein 0.0110508
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0109172
HSPB1 heat shock 27kDa protein 1 0.0109008
HIST3H2A histone cluster 3, H2a 0.0108836
FXYD3 FXYD domain containing ion transport regulator 3 0.010854
NXN nucleoredoxin 0.0108371
MXRA7 matrix-remodelling associated 7 0.0108254
DDAH2 dimethylarginine dimethylaminohydrolase 2 0.0108033
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) 0.0107389
MXRA5 matrix-remodelling associated 5 0.0107389
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0107132
MAL mal, T-cell differentiation protein 0.0106854
IFITM1 interferon induced transmembrane protein 1 0.0106332
LCN2 lipocalin 2 0.0105931
LAMA5 laminin, alpha 5 0.0105091
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0105064
TSPAN1 tetraspanin 1 0.0104706
BST2 bone marrow stromal cell antigen 2 0.0104658
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0104318
EDN1 endothelin 1 0.0104246
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 0.010424
TGM2 transglutaminase 2 0.0104091
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 0.0104008
C9ORF16 chromosome 9 open reading frame 16 0.0103551
INHBA inhibin, beta A 0.010297
DUSP3 dual specificity phosphatase 3 0.0102313
BIK BCL2-interacting killer (apoptosis-inducing) 0.0102285
RAMP1 receptor (G protein-coupled) activity modifying protein 1 0.0101844
CTSZ cathepsin Z 0.0101368
S100A10 S100 calcium binding protein A10 0.0100926
MT1HL1 metallothionein 1H-like 1 0.0100628
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 0.00999532
DMTF1 cyclin D binding myb-like transcription factor 1 0.00999398
DCN decorin 0.00997877
FRMD4B FERM domain containing 4B 0.00996718
TBX3 T-box 3 0.00993747
IRF7 interferon regulatory factor 7 0.00993542
TRIM22 tripartite motif containing 22 0.00991179
AHNAK2 AHNAK nucleoprotein 2 0.00990559
EMP1 epithelial membrane protein 1 0.00988912
ZBED2 zinc finger, BED-type containing 2 0.00978423
CEL carboxyl ester lipase 0.00977725
CFD complement factor D (adipsin) 0.00975
MMP7 matrix metallopeptidase 7 0.00974592
ASPN asporin 0.00974506
IGFBP6 insulin-like growth factor binding protein 6 0.00970434
RELN reelin 0.00964055
C10ORF10 chromosome 10 open reading frame 10 0.00962854
USP18 ubiquitin specific peptidase 18 0.00959011
PTGIS prostaglandin I2 (prostacyclin) synthase 0.00954713
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.00945282
ASS1 argininosuccinate synthase 1 0.00943587
ADA adenosine deaminase 0.0094297
ECM1 extracellular matrix protein 1 0.00942088
KRT19 keratin 19, type I 0.00940148
CCNG2 cyclin G2 0.00937677
IFI44 interferon-induced protein 44 0.00931857
MSMB microseminoprotein, beta- 0.00926185
CHKB choline kinase beta 0.00924184
POLR2D polymerase (RNA) II (DNA directed) polypeptide D 0.00923813
SORBS1 sorbin and SH3 domain containing 1 0.00922475
ST18 suppression of tumorigenicity 18, zinc finger 0.00910536
UBE2L6 ubiquitin-conjugating enzyme E2L 6 0.00906953
C3 complement component 3 0.00902524
CHRDL1 chordin-like 1 0.00899986
ACTA2 actin, alpha 2, smooth muscle, aorta 0.00895171
FBLN2 fibulin 2 0.00893612
SERTAD2 SERTA domain containing 2 0.00891044
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.00890479
PLAAT3 phospholipase A and acyltransferase 3 0.00888611
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.00885641
DYNLL1 dynein, light chain, LC8-type 1 0.00883543
MT2A metallothionein 2A 0.00881831
CTSK cathepsin K 0.00881574
RAI14 retinoic acid induced 14 0.00880634
CES1 carboxylesterase 1 0.00877101
ZDHHC11 zinc finger, DHHC-type containing 11 0.0087674
ADIPOQ adiponectin, C1Q and collagen domain containing 0.00876443
SRPX sushi-repeat containing protein, X-linked 0.00876212
ATP9A ATPase, class II, type 9A 0.00876159
AMOTL2 angiomotin like 2 0.00875283
ARHGAP29 Rho GTPase activating protein 29 0.00873413
CASP2 caspase 2, apoptosis-related cysteine peptidase 0.00872089
FLRT3 fibronectin leucine rich transmembrane protein 3 0.00870539
WISP2 WNT1 inducible signaling pathway protein 2 0.00868662
VCAN versican 0.00866974
MMP11 matrix metallopeptidase 11 0.00865702
MT1E metallothionein 1E 0.00862032
THBS3 thrombospondin 3 0.00860597
ADIRF adipogenesis regulatory factor 0.0086003
PGGHG protein-glucosylgalactosylhydroxylysine glucosidase 0.00859926
PXDC1 PX domain containing 1 0.00858905
AKAP12 A kinase (PRKA) anchor protein 12 0.00858896
RNH1 ribonuclease/angiogenin inhibitor 1 0.00858844
VWF von Willebrand factor 0.00857235
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 0.00856202
PCBP4 poly(rC) binding protein 4 0.00853886
SMAD3 SMAD family member 3 0.00847837
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 0.00845084
CLEC3B C-type lectin domain family 3, member B 0.00842395
LSM1 LSM1, U6 small nuclear RNA associated 0.00840422
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.00835101
ACAT1 acetyl-CoA acetyltransferase 1 0.00832364
ISG15 ISG15 ubiquitin-like modifier 0.00828781
GEM GTP binding protein overexpressed in skeletal muscle 0.00827756
IL1R1 interleukin 1 receptor, type I 0.00827098
PCOLCE procollagen C-endopeptidase enhancer 0.00824749
CPB1 carboxypeptidase B1 (tissue) 0.00823919
MDK midkine (neurite growth-promoting factor 2) 0.00823009
COMP cartilage oligomeric matrix protein 0.00820988
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) 0.00819593
C1S complement component 1, s subcomponent 0.00819362
CIDEC cell death-inducing DFFA-like effector c 0.00819078
AKR1C2 aldo-keto reductase family 1, member C2 0.00817899
RIN2 Ras and Rab interactor 2 0.00816685
MFAP4 microfibrillar-associated protein 4 0.00816346
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 0.00814895
DDIT3 DNA-damage-inducible transcript 3 0.00812931
MTMR11 myotubularin related protein 11 0.00812703
CLEC11A C-type lectin domain family 11, member A 0.00810096
ZNF652 zinc finger protein 652 0.00808052
PLIN1 perilipin 1 0.00805535
FN1 fibronectin 1 0.00804012
IFITM2 interferon induced transmembrane protein 2 0.00802238
AXL AXL receptor tyrosine kinase 0.00800417
ISG20 interferon stimulated exonuclease gene 20kDa 0.00798988
HDAC9 histone deacetylase 9 0.0079867
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 0.00798367
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.00797572
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 0.0079734
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 0.00795686
PALLD palladin, cytoskeletal associated protein 0.00795534
GLRX glutaredoxin (thioltransferase) 0.00794405
BLNK B-cell linker 0.00793408
LPAR6 lysophosphatidic acid receptor 6 0.00792212
CD99 CD99 molecule 0.00789534
CSRP2 cysteine and glycine-rich protein 2 0.00788764
TPD52L2 tumor protein D52-like 2 0.00787507
REG1A regenerating islet-derived 1 alpha 0.00785106
GPI glucose-6-phosphate isomerase 0.00780862
PHYH phytanoyl-CoA 2-hydroxylase 0.00779802
CEMIP cell migration inducing protein, hyaluronan binding 0.00778365
MAST4 microtubule associated serine/threonine kinase family member 4 0.00776643
LAMB2 laminin, beta 2 (laminin S) 0.00775906
NPEPL1 aminopeptidase-like 1 0.00772341
MYO5C myosin VC 0.00771417
XAF1 XIAP associated factor 1 0.00770753
CCNA2 cyclin A2 0.00769705
AEBP1 AE binding protein 1 0.00768842
AKR1C1 aldo-keto reductase family 1, member C1 0.00767078
BBC3 BCL2 binding component 3 0.00765308
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.00765088
S100A8 S100 calcium binding protein A8 0.00764911
NNMT nicotinamide N-methyltransferase 0.00763896
DUSP22 dual specificity phosphatase 22 0.00761594
HOXB2 homeobox B2 0.00760692
TGIF1 TGFB-induced factor homeobox 1 0.0075985
DPEP1 dipeptidase 1 (renal) 0.00758387
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 0.00757333
ELN elastin 0.00756646
DSTN destrin (actin depolymerizing factor) 0.00756043
AGTR1 angiotensin II receptor, type 1 0.00755558
BTG2 BTG family, member 2 0.00753261
GABARAPL1 GABA(A) receptor-associated protein like 1 0.00752403
AMIGO2 adhesion molecule with Ig-like domain 2 0.0075024
MED13 mediator complex subunit 13 0.0074968
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.00748382
ZFP36L2 ZFP36 ring finger protein-like 2 0.00745
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F 0.00744758
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.00743474
DIXDC1 DIX domain containing 1 0.00740565
NR2F6 nuclear receptor subfamily 2, group F, member 6 0.0073734
ANXA2P2 annexin A2 pseudogene 2 0.00737241
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.00736161
SLC39A4 solute carrier family 39 (zinc transporter), member 4 0.00735015
C8ORF4 chromosome 8 open reading frame 4 0.00734864
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.00733119
TUBB2A tubulin, beta 2A class IIa 0.0072952
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 0.00729295
GADD45B growth arrest and DNA-damage-inducible, beta 0.00726537
UPP1 uridine phosphorylase 1 0.00725846
NRCAM neuronal cell adhesion molecule 0.00725774
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.00725592
PRRX2 paired related homeobox 2 0.00724668
SAMD4A sterile alpha motif domain containing 4A 0.00724558
IFI35 interferon-induced protein 35 0.0072423
DACH1 dachshund family transcription factor 1 0.00723553
FSTL1 follistatin-like 1 0.00722535
ICAM1 intercellular adhesion molecule 1 0.00721868
FILIP1L filamin A interacting protein 1-like 0.00719924
COLEC12 collectin sub-family member 12 0.007175
RTP4 receptor (chemosensory) transporter protein 4 0.00717138
NID1 nidogen 1 0.00713663
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) 0.00711848
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.00711035
MFAP5 microfibrillar associated protein 5 0.00709832
S100A9 S100 calcium binding protein A9 0.00708756
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 0.00708389
MVP major vault protein 0.00707459
ETHE1 ethylmalonic encephalopathy 1 0.0070743
BGN biglycan 0.00707291
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 0.00706958
IGFBP5 insulin-like growth factor binding protein 5 0.00705917
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 0.00704995
MISP mitotic spindle positioning 0.00704447

decreased expression

Symbol Name Standardized Value
CA2 carbonic anhydrase II -0.0249474
STK10 serine/threonine kinase 10 -0.0231765
FABP7 fatty acid binding protein 7, brain -0.017453
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0152566
TMEM45A transmembrane protein 45A -0.0139853
FCGBP Fc fragment of IgG binding protein -0.0137868
MAP7 microtubule-associated protein 7 -0.0137485
ARG1 arginase 1 -0.0136757
NPTX2 neuronal pentraxin II -0.0132624
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 -0.0129405
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) -0.0127626
DLK1 delta-like 1 homolog (Drosophila) -0.01266
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 -0.0125459
RAD23B RAD23 homolog B (S. cerevisiae) -0.0124724
TSPYL5 TSPY-like 5 -0.0122094
CD40 CD40 molecule, TNF receptor superfamily member 5 -0.0119704
COPS7A COP9 signalosome subunit 7A -0.0117829
PLXNC1 plexin C1 -0.0116726
SCG5 secretogranin V -0.0115555
MMP9 matrix metallopeptidase 9 -0.0114768
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 -0.0113259
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0110385
CALML5 calmodulin-like 5 -0.010811
PIP prolactin-induced protein -0.0107641
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -0.0106803
CXCL9 chemokine (C-X-C motif) ligand 9 -0.0105648
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide -0.0104466
LTF lactotransferrin -0.0104374
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0101488
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28 -0.0100686
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 -0.00992767
MFAP3L microfibrillar-associated protein 3-like -0.0098202
CX3CR1 chemokine (C-X3-C motif) receptor 1 -0.0098173
PROM1 prominin 1 -0.00978498
SARAF store-operated calcium entry-associated regulatory factor -0.00968945
SH3BGRL SH3 domain binding glutamate-rich protein like -0.00967548
ANXA6 annexin A6 -0.00958525
KIF14 kinesin family member 14 -0.00953014
NLGN4X neuroligin 4, X-linked -0.00952723
TMX1 thioredoxin-related transmembrane protein 1 -0.00945741
MEIS2 Meis homeobox 2 -0.00939455
PON3 paraoxonase 3 -0.00938097
PLP1 proteolipid protein 1 -0.00935145
XPO7 exportin 7 -0.00933747
SCGB1D2 secretoglobin, family 1D, member 2 -0.0093322
GAL galanin/GMAP prepropeptide -0.00926227
MYBPC1 myosin binding protein C, slow type -0.00920271
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.00915791
PEG3 paternally expressed 3 -0.00913962
PTN pleiotrophin -0.00908498
IGFBP4 insulin-like growth factor binding protein 4 -0.00903585
WWC3 WWC family member 3 -0.00895586
FOXG1 forkhead box G1 -0.00891504
NAV2 neuron navigator 2 -0.0088019
CPOX coproporphyrinogen oxidase -0.00878829
ORC1 origin recognition complex, subunit 1 -0.00874648
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 -0.00873075
GANAB glucosidase, alpha; neutral AB -0.00871213
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 -0.00869424
PLEK pleckstrin -0.00867396
ADAM28 ADAM metallopeptidase domain 28 -0.0086189
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.00861086
PDE10A phosphodiesterase 10A -0.00860638
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.00859867
HMGN5 high mobility group nucleosome binding domain 5 -0.00856588
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) -0.00856073
CCNB1 cyclin B1 -0.00854951
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.00854643
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) -0.00854296
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.00854081
DSC2 desmocollin 2 -0.00851068
HYOU1 hypoxia up-regulated 1 -0.0085053
CCL5 chemokine (C-C motif) ligand 5 -0.00847501
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 -0.00845185
ADAMDEC1 ADAM-like, decysin 1 -0.00840865
RCAN1 regulator of calcineurin 1 -0.00836525
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -0.00834907
TNIK TRAF2 and NCK interacting kinase -0.00833875
AIM2 absent in melanoma 2 -0.00833563
GOLM1 golgi membrane protein 1 -0.00832384
CRISP3 cysteine-rich secretory protein 3 -0.00831326
SLC38A1 solute carrier family 38, member 1 -0.00827386
CLDN8 claudin 8 -0.00827366
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 -0.00826888
PTGDR prostaglandin D2 receptor (DP) -0.00819282
TCEAL2 transcription elongation factor A (SII)-like 2 -0.00810486
FCN1 ficolin (collagen/fibrinogen domain containing) 1 -0.00809621
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 -0.00808662
SCGB2A1 secretoglobin, family 2A, member 1 -0.00805664
TPBG trophoblast glycoprotein -0.00805545
CD59 CD59 molecule, complement regulatory protein -0.00804057
SLC26A3 solute carrier family 26 (anion exchanger), member 3 -0.00802471
RADX RPA1 related single stranded DNA binding protein, X-linked -0.00802432
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.00793916
RUNX3 runt-related transcription factor 3 -0.0079391
XK X-linked Kx blood group -0.00792176
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) -0.00790945
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 -0.00789903
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.00788821
FRZB frizzled-related protein -0.00784447
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -0.00779072
CPE carboxypeptidase E -0.00778506
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 -0.00778219
SERBP1 SERPINE1 mRNA binding protein 1 -0.00776597
RAP2A RAP2A, member of RAS oncogene family -0.00768559
HSDL2 hydroxysteroid dehydrogenase like 2 -0.00768481
CLC Charcot-Leyden crystal galectin -0.00766707
LY75 lymphocyte antigen 75 -0.0076526
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 -0.00763235
RNF128 ring finger protein 128, E3 ubiquitin protein ligase -0.00762699
APMAP adipocyte plasma membrane associated protein -0.007586
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.00755838
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.00752623
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase) -0.00752056
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) -0.00751759
KLHL2 kelch-like family member 2 -0.00751562
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 -0.00744114
THBD thrombomodulin -0.00742374
ANO1 anoctamin 1, calcium activated chloride channel -0.00740239
GCG glucagon -0.00739195
IMPACT impact RWD domain protein -0.00737856
EREG epiregulin -0.0073779
CLEC7A C-type lectin domain family 7, member A -0.00737323
CALML3 calmodulin-like 3 -0.0073602
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.00735948
RAD23A RAD23 homolog A (S. cerevisiae) -0.00730701
KIF1A kinesin family member 1A -0.00730014
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 -0.00729726
CCDC47 coiled-coil domain containing 47 -0.00728934
NFYC nuclear transcription factor Y, gamma -0.00727929
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 -0.00725364
OIP5 Opa interacting protein 5 -0.0071977
RBM8A RNA binding motif protein 8A -0.00718823
MBL2 mannose-binding lectin (protein C) 2, soluble -0.00718208
BCLAF1 BCL2-associated transcription factor 1 -0.00717419
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.00715569
CAPZB capping protein (actin filament) muscle Z-line, beta -0.0071433
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 -0.00713877
PADI2 peptidyl arginine deiminase, type II -0.00713284
DEFA4 defensin, alpha 4, corticostatin -0.00712925
PRKD3 protein kinase D3 -0.00710893
LRRC31 leucine rich repeat containing 31 -0.00710687
DHFR dihydrofolate reductase -0.00710187
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -0.00709599
CA12 carbonic anhydrase XII -0.00708875
CNOT7 CCR4-NOT transcription complex, subunit 7 -0.00708057
MYOM2 myomesin 2 -0.00706851
UGT2A3 UDP glucuronosyltransferase 2 family, polypeptide A3 -0.0070679
SRPRA SRP receptor subunit alpha -0.00706417
ICMT isoprenylcysteine carboxyl methyltransferase -0.0070309
HMGN2 high mobility group nucleosomal binding domain 2 -0.00700573
GSTA1 glutathione S-transferase alpha 1 -0.00698965
DSC1 desmocollin 1 -0.00697776
TXNIP thioredoxin interacting protein -0.00696739
SPINK5 serine peptidase inhibitor, Kazal type 5 -0.00695517
UBE4B ubiquitination factor E4B -0.00689727
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.00689415
SLC38A4 solute carrier family 38, member 4 -0.00688251
FAM172A family with sequence similarity 172, member A -0.00687676
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 -0.0068548
IDO1 indoleamine 2,3-dioxygenase 1 -0.00682637
PRSS8 protease, serine, 8 -0.00682425
SCGB2A2 secretoglobin, family 2A, member 2 -0.00682418
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.00681782
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.00681167
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.00680637
GAD1 glutamate decarboxylase 1 (brain, 67kDa) -0.00679171
RBM3 RNA binding motif (RNP1, RRM) protein 3 -0.00678886
ACP2 acid phosphatase 2, lysosomal -0.00675771
AQP8 aquaporin 8 -0.0067443
TFF3 trefoil factor 3 (intestinal) -0.0067438
TMED5 transmembrane emp24 protein transport domain containing 5 -0.00673702
GYPA glycophorin A (MNS blood group) -0.0067162
DERL1 derlin 1 -0.00671125
CA3 carbonic anhydrase III -0.0066977
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 -0.00668991
FMO3 flavin containing monooxygenase 3 -0.00668792
UFM1 ubiquitin-fold modifier 1 -0.00666035
REEP1 receptor accessory protein 1 -0.00664775
SUCO SUN domain containing ossification factor -0.00664355
SUB1 SUB1 homolog (S. cerevisiae) -0.00663075
PDZD8 PDZ domain containing 8 -0.00661303
CKAP2 cytoskeleton associated protein 2 -0.00661165
PLK4 polo-like kinase 4 -0.00657033
MYO1F myosin IF -0.00656096
HACD3 3-hydroxyacyl-CoA dehydratase 3 -0.00655444
SLC35A5 solute carrier family 35, member A5 -0.00654964
STMN2 stathmin 2 -0.00654943
MAGT1 magnesium transporter 1 -0.00654155
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0065309
LRRC47 leucine rich repeat containing 47 -0.00652707
MGAM maltase-glucoamylase -0.00651484
IL20RA interleukin 20 receptor, alpha -0.00650581
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -0.00650125
HCRT hypocretin (orexin) neuropeptide precursor -0.00649611
LEPROTL1 leptin receptor overlapping transcript-like 1 -0.00647393
PRC1 protein regulator of cytokinesis 1 -0.00647317
PPT1 palmitoyl-protein thioesterase 1 -0.00646792
LINC00623 long intergenic non-protein coding RNA 623 -0.00645721
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae) -0.00645365
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9 -0.00645355
DIAPH2 diaphanous-related formin 2 -0.00643868
RBL1 retinoblastoma-like 1 -0.00642886
RPIA ribose 5-phosphate isomerase A -0.00641892
IL7 interleukin 7 -0.00640626
PSPH phosphoserine phosphatase -0.00640392
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) -0.00639718
RNF138 ring finger protein 138, E3 ubiquitin protein ligase -0.00638153
FOXL2 forkhead box L2 -0.00637038
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.00636753
P4HB prolyl 4-hydroxylase, beta polypeptide -0.00636623
USP22 ubiquitin specific peptidase 22 -0.00636481
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 -0.00636379
SLTM SAFB-like, transcription modulator -0.00636131
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 -0.00636038
LRRC40 leucine rich repeat containing 40 -0.006349
TFDP1 transcription factor Dp-1 -0.0063261
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O -0.00631178
TRMT5 tRNA methyltransferase 5 -0.00630371
HCRTR1 hypocretin (orexin) receptor 1 -0.00627006
ANO3 anoctamin 3 -0.00626465
ZNF395 zinc finger protein 395 -0.00624552
MIA3 melanoma inhibitory activity family, member 3 -0.00623512
TMA16 translation machinery associated 16 homolog (S. cerevisiae) -0.00623459
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.00622163
CRABP1 cellular retinoic acid binding protein 1 -0.00622145
E2F2 E2F transcription factor 2 -0.00622082
UBE2E3 ubiquitin-conjugating enzyme E2E 3 -0.0062204
RCN2 reticulocalbin 2, EF-hand calcium binding domain -0.00621714
TSPAN5 tetraspanin 5 -0.00621118
KLHDC8A kelch domain containing 8A -0.00620896
RAB14 RAB14, member RAS oncogene family -0.00620028
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 -0.00619686
OLFM1 olfactomedin 1 -0.0061896
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -0.00617359
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.00615945
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 -0.00615497
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 -0.00615175
PF4 platelet factor 4 -0.00614759
CDHR1 cadherin-related family member 1 -0.00614562
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A -0.00614506
GUCY2C guanylate cyclase 2C -0.0061338
DGKZ diacylglycerol kinase, zeta -0.00612843
KLF5 Kruppel-like factor 5 (intestinal) -0.00612593
SPRY4 sprouty homolog 4 (Drosophila) -0.00611781
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) -0.00610456
IRAK3 interleukin-1 receptor-associated kinase 3 -0.00610246
PBK PDZ binding kinase -0.00609563
CREB3L1 cAMP responsive element binding protein 3-like 1 -0.00609331
WIPF1 WAS/WASL interacting protein family, member 1 -0.00608282