SSC4D Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description scavenger receptor cysteine rich family member with 4 domains (NCBI Entrez Gene Database, 136853)
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Genes

349 genes differentially expressed following the SSC4D gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FTCD formimidoyltransferase cyclodeaminase 3.29846
LEP leptin 3.29846
FGF6 fibroblast growth factor 6 3.29846
SMCO1 single-pass membrane protein with coiled-coil domains 1 3.29846
SMCO2 single-pass membrane protein with coiled-coil domains 2 3.29846
SCIN scinderin 3.29846
INSRR insulin receptor-related receptor 3.29846
NPFF neuropeptide FF-amide peptide precursor 3.29846
ELL3 elongation factor RNA polymerase II-like 3 3.29846
PRDM8 PR domain containing 8 3.29846
MYOG myogenin (myogenic factor 4) 3.29846
KCNIP3 Kv channel interacting protein 3, calsenilin 3.29846
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 3.29846
NHLRC4 NHL repeat containing 4 3.29846
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 3.29846
LONRF2 LON peptidase N-terminal domain and ring finger 2 3.29846
NPIPA5 nuclear pore complex interacting protein family, member A5 3.29846
IAPP islet amyloid polypeptide 3.29846
C1QL4 complement component 1, q subcomponent-like 4 3.29846
FXYD2 FXYD domain containing ion transport regulator 2 3.29846
PITX2 paired-like homeodomain 2 3.29846
MAGEC3 melanoma antigen family C3 3.29846
MMP12 matrix metallopeptidase 12 3.29846
IFITM10 interferon induced transmembrane protein 10 3.29846
PPP1R3D protein phosphatase 1, regulatory subunit 3D 3.29846
PPP1R3E protein phosphatase 1, regulatory subunit 3E 3.29846
RSPO3 R-spondin 3 3.29846
TEX35 testis expressed 35 3.29846
TEX36 testis expressed 36 3.29846
FAM131C family with sequence similarity 131, member C 3.29846
KCNK15 potassium channel, two pore domain subfamily K, member 15 3.29846
GPRC5A G protein-coupled receptor, class C, group 5, member A 3.29846
ASCL3 achaete-scute family bHLH transcription factor 3 3.29846
ASCL2 achaete-scute family bHLH transcription factor 2 3.29846
AOC1 amine oxidase, copper containing 1 3.29846
GGN gametogenetin 3.29846
FMR1NB fragile X mental retardation 1 neighbor 3.29846
MEIOB meiosis specific with OB domains 3.29846
SOX30 SRY (sex determining region Y)-box 30 3.29846
TMEM215 transmembrane protein 215 3.29846
RTN4RL1 reticulon 4 receptor-like 1 3.29846
ELF5 E74-like factor 5 (ets domain transcription factor) 3.29846
FAM180B family with sequence similarity 180, member B 3.29846
IYD iodotyrosine deiodinase 3.29846
MPEG1 macrophage expressed 1 3.29846
PTPRH protein tyrosine phosphatase, receptor type, H 3.29846
RAI2 retinoic acid induced 2 3.29846
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 3.29846
BTC betacellulin 3.29846
NXPE1 neurexophilin and PC-esterase domain family, member 1 3.29846
CARD18 caspase recruitment domain family, member 18 3.29846
NR1H4 nuclear receptor subfamily 1, group H, member 4 3.29846
CRYAB crystallin, alpha B 3.29846
CD274 CD274 molecule 3.29846
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 3.29846
SLC22A14 solute carrier family 22, member 14 3.29846
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 3.29846
NOTO notochord homeobox 3.29846
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma 3.29846
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma 3.29846
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 3.29846
TMEM151A transmembrane protein 151A 3.29846
ECEL1 endothelin converting enzyme-like 1 3.29846
ALPK2 alpha-kinase 2 3.29846
KCNRG potassium channel regulator 3.29846
LYNX1 Ly6/neurotoxin 1 3.29846
C12ORF71 chromosome 12 open reading frame 71 3.29846
SUSD2 sushi domain containing 2 3.29846
BIRC3 baculoviral IAP repeat containing 3 3.29846
SIX2 SIX homeobox 2 3.29846
SHISA7 shisa family member 7 3.29846
TACSTD2 tumor-associated calcium signal transducer 2 3.29846
CBLN2 cerebellin 2 precursor 3.29846
ADTRP androgen-dependent TFPI-regulating protein 3.29846
DUSP10 dual specificity phosphatase 10 3.29846
AMBP alpha-1-microglobulin/bikunin precursor 3.29846
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 3.29846
ASPA aspartoacylase 3.29846
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 3.29846
MFAP4 microfibrillar-associated protein 4 3.29846
FCRL5 Fc receptor-like 5 3.29846
SPNS2 spinster homolog 2 (Drosophila) 3.29846
PMP2 peripheral myelin protein 2 3.29846
TAT tyrosine aminotransferase 3.29846
CIROZ ciliated left-right organizer protein containing ZP-N domains 3.29846
PCDHGA1 protocadherin gamma subfamily A, 1 3.29846
TNNI3K TNNI3 interacting kinase 3.29846
SLC47A2 solute carrier family 47 (multidrug and toxin extrusion), member 2 3.29846
OAZ3 ornithine decarboxylase antizyme 3 3.29846
WFDC1 WAP four-disulfide core domain 1 3.29846
PROP1 PROP paired-like homeobox 1 3.29846
CDHR4 cadherin-related family member 4 3.29846
CXCR6 chemokine (C-X-C motif) receptor 6 3.29846
HCRT hypocretin (orexin) neuropeptide precursor 3.29846
RGS11 regulator of G-protein signaling 11 3.29846
SHOX2 short stature homeobox 2 3.29846
ZNF524 zinc finger protein 524 3.29846
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 3.29846
RGCC regulator of cell cycle 3.29846
MT3 metallothionein 3 3.29846
FBXO40 F-box protein 40 3.29846
ZNF831 zinc finger protein 831 3.29846
C8ORF90 chromosome 8 open reading frame 90 3.29846
RIN1 Ras and Rab interactor 1 3.29846
LGALS12 lectin, galactoside-binding, soluble, 12 3.29846
CSF1R colony stimulating factor 1 receptor 3.29846
IDI2 isopentenyl-diphosphate delta isomerase 2 3.29846
CIMAP1B ciliary microtubule associated protein 1B 3.29846
INSYN1 inhibitory synaptic factor 1 3.29846
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 3.29846
H3-5 H3.5 histone 3.29846
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 3.29846
ITGA10 integrin, alpha 10 3.29846
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2 3.29846
ILDR2 immunoglobulin-like domain containing receptor 2 3.29846
CFAP47 cilia and flagella associated protein 47 3.29846
FNDC9 fibronectin type III domain containing 9 3.29846
GAL3ST2 galactose-3-O-sulfotransferase 2 3.29846
STAB1 stabilin 1 3.29846
SLITRK6 SLIT and NTRK-like family, member 6 3.29846
MYH7 myosin, heavy chain 7, cardiac muscle, beta 3.29846
EPO erythropoietin 3.29846
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 3.29846
PKD2L1 polycystic kidney disease 2-like 1 3.29846
CARD6 caspase recruitment domain family, member 6 3.29846
VMAC vimentin-type intermediate filament associated coiled-coil protein 3.29846
PRAM1 PML-RARA regulated adaptor molecule 1 3.29846
ECM1 extracellular matrix protein 1 3.29846
ANKRD62 ankyrin repeat domain 62 3.29846
NTSR1 neurotensin receptor 1 (high affinity) 3.29846
PDCD6 programmed cell death 6 3.29846
TBC1D3L TBC1 domain family, member 3L 3.29846
SMIM22 small integral membrane protein 22 3.29846
CLDN16 claudin 16 3.29846
STAB2 stabilin 2 3.29846
PRAP1 proline-rich acidic protein 1 3.29846
TRPM8 transient receptor potential cation channel, subfamily M, member 8 3.29846
C1ORF74 chromosome 1 open reading frame 74 3.29846
FGFBP1 fibroblast growth factor binding protein 1 3.29846
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 3.29846
SPTBN5 spectrin, beta, non-erythrocytic 5 3.29846
VHLL von Hippel-Lindau tumor suppressor-like 3.29846
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 3.29846
MORC1 MORC family CW-type zinc finger 1 3.29846
TRPM1 transient receptor potential cation channel, subfamily M, member 1 3.29846
NGF nerve growth factor (beta polypeptide) 3.29846
VSIG1 V-set and immunoglobulin domain containing 1 3.29846
POTEE POTE ankyrin domain family, member E 3.29846
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 3.29846
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 3.22882
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 3.22882
OPRM1 opioid receptor, mu 1 3.22882
TNS1-AS1 TNS1 antisense RNA 1 3.11756
C19ORF73 chromosome 19 open reading frame 73 3.11746
C1QTNF1 C1q and tumor necrosis factor related protein 1 2.97623
GNRHR gonadotropin-releasing hormone receptor 2.97623
FCHO1 FCH domain only 1 2.97335
KRTAP5-11 keratin associated protein 5-11 2.95999
ELAC1 elaC ribonuclease Z 1 2.87437
PALM3 paralemmin 3 2.87017
ANKRD13A ankyrin repeat domain 13A 2.83385
USP6 ubiquitin specific peptidase 6 2.76662
MGST1 microsomal glutathione S-transferase 1 2.76242
ZDHHC23 zinc finger, DHHC-type containing 23 2.64375
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 2.62797
WIF1 WNT inhibitory factor 1 2.60687
CHERP calcium homeostasis endoplasmic reticulum protein 2.56415
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 2.50021
DDB2 damage-specific DNA binding protein 2, 48kDa 2.50021
TMPPE transmembrane protein with metallophosphoesterase domain 2.50021
NANOS3 nanos homolog 3 (Drosophila) 2.46754
NUP205 nucleoporin 205kDa 2.44149
AUP1 ancient ubiquitous protein 1 2.44149
FBRS fibrosin 2.44149
TMEM52 transmembrane protein 52 2.41065
CD7 CD7 molecule 2.39534
MCHR1 melanin-concentrating hormone receptor 1 2.37142
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 2.37142
SLFN13 schlafen family member 13 2.37142
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 2.34232
SMAGP small cell adhesion glycoprotein 2.32181
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 2.31766
MRPL34 mitochondrial ribosomal protein L34 2.31309
PLN phospholamban 2.29527
PCDHGA5 protocadherin gamma subfamily A, 5 2.29527
RPL26 ribosomal protein L26 2.29527
GCNT7 glucosaminyl (N-acetyl) transferase family member 7 2.29527
OIP5 Opa interacting protein 5 2.29527
ALS2CL ALS2 C-terminal like 2.29527
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 2.29262
SLCO5A1 solute carrier organic anion transporter family, member 5A1 2.24982
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 2.24738
EXOG endo/exonuclease (5'-3'), endonuclease G-like 2.22949
HSPE1 heat shock 10kDa protein 1 2.22321
APIP APAF1 interacting protein 2.22321
ZNF740 zinc finger protein 740 2.20268
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase 2.18358
GARRE1 granule associated Rac and RHOG effector 1 2.18162
SPRYD4 SPRY domain containing 4 2.18047
FBXO5 F-box protein 5 2.1737
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 2.15913
LHFPL1 lipoma HMGIC fusion partner-like 1 2.15379
BRD1 bromodomain containing 1 2.14965
ZNF43 zinc finger protein 43 2.13736
MBNL2 muscleblind-like splicing regulator 2 2.13465
ACOT11 acyl-CoA thioesterase 11 2.1191
CHD1L chromodomain helicase DNA binding protein 1-like 2.1161
APOLD1 apolipoprotein L domain containing 1 2.10868
IZUMO2 IZUMO family member 2 2.10713
NKAP NFKB activating protein 2.10702
AFG1L AFG1 like ATPase 2.10702
NBPF9 neuroblastoma breakpoint family, member 9 2.09834
ZNF296 zinc finger protein 296 2.09748
KCNMB4 potassium channel subfamily M regulatory beta subunit 4 2.08195
PPIF peptidylprolyl isomerase F 2.08195
RPS3A ribosomal protein S3A 2.06439
AGAP4 ArfGAP with GTPase domain, ankyrin repeat and PH domain 4 2.05976
RPL36AL ribosomal protein L36a-like 2.0576
KLHDC8B kelch domain containing 8B 2.05715
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.05012
BDH2 3-hydroxybutyrate dehydrogenase, type 2 2.04598
LHFPL5 lipoma HMGIC fusion partner-like 5 2.03629
EIF3B eukaryotic translation initiation factor 3, subunit B 2.02894
RPL7A ribosomal protein L7a 2.02852
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent) 2.02009
ZNF671 zinc finger protein 671 2.00833
STRN3 striatin, calmodulin binding protein 3 2.00791
CCDC136 coiled-coil domain containing 136 2.00397

decreased expression

Symbol Name Standardized Value
MEDAG mesenteric estrogen-dependent adipogenesis -3.29846
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A -3.29846
KBTBD11 kelch repeat and BTB (POZ) domain containing 11 -3.29846
PPP1R3C protein phosphatase 1, regulatory subunit 3C -3.22882
GBA1 glucosylceramidase beta 1 -3.22882
FGF16 fibroblast growth factor 16 -3.22882
C6ORF52 chromosome 6 open reading frame 52 -3.22882
CELA2B chymotrypsin-like elastase family, member 2B -3.22882
IQCJ IQ motif containing J -3.22882
PKD1L1 polycystic kidney disease 1 like 1 -3.22882
H4C2 H4 clustered histone 2 -3.22882
ATP8B4 ATPase, class I, type 8B, member 4 -3.22882
BRICD5 BRICHOS domain containing 5 -3.22882
SYTL5 synaptotagmin-like 5 -3.22882
CCDC163 CCDC163 homolog -3.22882
LCA5L Leber congenital amaurosis 5-like -3.22882
SOST sclerostin -3.22882
TCEAL5 transcription elongation factor A (SII)-like 5 -3.22882
REM2 RAS (RAD and GEM)-like GTP binding 2 -3.22882
TMEM213 transmembrane protein 213 -3.22882
ATOH1 atonal homolog 1 (Drosophila) -3.22882
AGBL4 ATP/GTP binding protein-like 4 -3.22882
GPR162 G protein-coupled receptor 162 -3.22882
TMEM196 transmembrane protein 196 -3.22882
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -3.22882
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) -3.22882
CFAP299 cilia and flagella associated protein 299 -3.22882
ACP4 acid phosphatase 4 -3.22882
UBXN11 UBX domain protein 11 -3.22882
MAG myelin associated glycoprotein -3.22882
BCL3 B-cell CLL/lymphoma 3 -3.22882
ZC3H11C zinc finger CCCH-type containing 11C -3.22882
MAP10 microtubule-associated protein 10 -3.22882
RBM46 RNA binding motif protein 46 -3.22882
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 -3.22882
MBOAT4 membrane bound O-acyltransferase domain containing 4 -3.22882
TMEM74B transmembrane protein 74B -3.22882
MYT1L myelin transcription factor 1-like -3.22882
DEFB131B defensin beta 131B -3.22882
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13 -3.22882
KLF9 Kruppel-like factor 9 -3.22882
ABTB1 ankyrin repeat and BTB (POZ) domain containing 1 -3.22882
TEX264 testis expressed 264 -3.22882
HMGN1 high mobility group nucleosome binding domain 1 -3.09242
PNMA8A PNMA family member 8A -3.0551
ZNF487 zinc finger protein 487 -3.02914
TMEM144 transmembrane protein 144 -3.02914
ODAD4 outer dynein arm docking complex subunit 4 -3.02914
C21ORF58 chromosome 21 open reading frame 58 -2.79641
ATOSA atos homolog A -2.73018
SEC14L6 SEC14-like 6 (S. cerevisiae) -2.72722
PSEN2 presenilin 2 -2.68854
NSD1 nuclear receptor binding SET domain protein 1 -2.67365
BOD1L1 biorientation of chromosomes in cell division 1-like 1 -2.61349
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) -2.60522
CCDC196 coiled-coil domain containing 196 -2.58599
KCTD18 potassium channel tetramerization domain containing 18 -2.58599
C2CD4C C2 calcium-dependent domain containing 4C -2.58599
NLRP12 NLR family, pyrin domain containing 12 -2.53769
BBS10 Bardet-Biedl syndrome 10 -2.53148
ZDBF2 zinc finger, DBF-type containing 2 -2.47344
RASIP1 Ras interacting protein 1 -2.46754
ELN elastin -2.46754
PFKM phosphofructokinase, muscle -2.46746
CD163L1 CD163 molecule-like 1 -2.45859
MCOLN3 mucolipin 3 -2.45859
TFAM transcription factor A, mitochondrial -2.45211
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta -2.44942
RRAGB Ras-related GTP binding B -2.42954
RAP1GAP2 RAP1 GTPase activating protein 2 -2.42794
HENMT1 HEN1 methyltransferase homolog 1 (Arabidopsis) -2.42444
DUSP7 dual specificity phosphatase 7 -2.40271
EIF4H eukaryotic translation initiation factor 4H -2.40271
SPAG9 sperm associated antigen 9 -2.39648
SDC3 syndecan 3 -2.32181
TFCP2 transcription factor CP2 -2.29527
LDLR low density lipoprotein receptor -2.28516
CACNB1 calcium channel, voltage-dependent, beta 1 subunit -2.28375
TJP3 tight junction protein 3 -2.28375
NFX1 nuclear transcription factor, X-box binding 1 -2.27734
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -2.26482
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -2.25287
ATF7IP activating transcription factor 7 interacting protein -2.22949
PGAP6 post-GPI attachment to proteins 6 -2.21962
ELOVL2 ELOVL fatty acid elongase 2 -2.18225
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 -2.18225
FBXL4 F-box and leucine-rich repeat protein 4 -2.18047
HS1BP3 HCLS1 binding protein 3 -2.16191
MAP1A microtubule-associated protein 1A -2.15904
CD82 CD82 molecule -2.15904
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 -2.15379
FAM20B family with sequence similarity 20, member B -2.15379
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -2.15379
HSF2BP heat shock transcription factor 2 binding protein -2.14976
RIMS1 regulating synaptic membrane exocytosis 1 -2.14699
PRR13 proline rich 13 -2.13916
IL6R interleukin 6 receptor -2.13736
ENO3 enolase 3 (beta, muscle) -2.13736
HMOX1 heme oxygenase 1 -2.13515
DYNLT2 dynein light chain Tctex-type 2 -2.10702
RFX1 regulatory factor X, 1 (influences HLA class II expression) -2.095
RAB30 RAB30, member RAS oncogene family -2.08195
SAXO6 stabilizer of axonemal microtubules 6 -2.08076
PCDH11X protocadherin 11 X-linked -2.08076
ORAI1 ORAI calcium release-activated calcium modulator 1 -2.07451
KIF23 kinesin family member 23 -2.07451
ALG10 ALG10, alpha-1,2-glucosyltransferase -2.06439
FBXL16 F-box and leucine-rich repeat protein 16 -2.06439
IL6ST-DT IL6ST divergent transcript -2.06439
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 -2.04598
MCMDC2 minichromosome maintenance domain containing 2 -2.04372
NAF1 nuclear assembly factor 1 ribonucleoprotein -2.04114
PGAP1 post-GPI attachment to proteins 1 -2.0364
ZDHHC12 zinc finger, DHHC-type containing 12 -2.03629
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 -2.03628
MTUS2 microtubule associated tumor suppressor candidate 2 -2.0295
ACAA1 acetyl-CoA acyltransferase 1 -2.0295
ZNF507 zinc finger protein 507 -2.0276
ZNF34 zinc finger protein 34 -2.02009
GADD45A growth arrest and DNA-damage-inducible, alpha -2.01598
THAP11 THAP domain containing 11 -2.00833