SSH1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description slingshot protein phosphatase 1|The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 54434)
Similar Terms
Downloads & Tools

Genes

329 genes differentially expressed following the SSH1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TRMT61A tRNA methyltransferase 61A 3.39988
TCAP titin-cap 3.39988
SNTN sentan, cilia apical structure protein 3.39988
IL21R interleukin 21 receptor 3.39988
SFN stratifin 3.39988
CLDN2 claudin 2 3.39988
SLITRK1 SLIT and NTRK-like family, member 1 3.39988
EPO erythropoietin 3.39988
NXPE2 neurexophilin and PC-esterase domain family, member 2 3.39988
APOB apolipoprotein B 3.39988
KIF4B kinesin family member 4B 3.39988
ERICH3 glutamate-rich 3 3.39988
SPRR2F small proline-rich protein 2F 3.39988
TSLP thymic stromal lymphopoietin 3.39988
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 3.39988
OR2A1 olfactory receptor, family 2, subfamily A, member 1 3.39988
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 3.39988
GJC2 gap junction protein, gamma 2, 47kDa 3.39988
PITX3 paired-like homeodomain 3 3.39988
GALR3 galanin receptor 3 3.39988
GSDMA gasdermin A 3.39988
PLAAT2 phospholipase A and acyltransferase 2 3.39988
PRELP proline/arginine-rich end leucine-rich repeat protein 3.39988
OR10A6 olfactory receptor, family 10, subfamily A, member 6 (gene/pseudogene) 3.38294
PDZD9 PDZ domain containing 9 3.38294
CX3CL1 chemokine (C-X3-C motif) ligand 1 3.38294
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 3.38294
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 3.38294
HCRTR1 hypocretin (orexin) receptor 1 3.38294
IQCJ IQ motif containing J 3.38294
DDN dendrin 3.38294
PKD1L1 polycystic kidney disease 1 like 1 3.38294
KRT20 keratin 20, type I 3.38294
SH3TC1 SH3 domain and tetratricopeptide repeats 1 3.38294
ZNF467 zinc finger protein 467 3.38294
LDHC lactate dehydrogenase C 3.38294
DMRTC1B DMRT-like family C1B 3.38294
NFAM1 NFAT activating protein with ITAM motif 1 3.38294
TMEM89 transmembrane protein 89 3.38294
LRRC61 leucine rich repeat containing 61 3.38294
HBZ hemoglobin, zeta 3.38294
MUC22 mucin 22 3.38294
TAS2R10 taste receptor, type 2, member 10 3.38294
SLC39A12 solute carrier family 39 (zinc transporter), member 12 3.38294
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 3.38294
NR4A3 nuclear receptor subfamily 4, group A, member 3 3.38294
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 3.38294
PSCA prostate stem cell antigen 3.38294
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 3.38294
TLX3 T-cell leukemia homeobox 3 3.38294
GPR26 G protein-coupled receptor 26 3.38294
SLC9C2 solute carrier family 9, member C2 (putative) 3.38294
FHL5 four and a half LIM domains 5 3.38294
BIRC3 baculoviral IAP repeat containing 3 3.38294
C1ORF141 chromosome 1 open reading frame 141 3.38294
TDRD9 tudor domain containing 9 3.38294
OCM2 oncomodulin 2 3.38294
ZNF324B zinc finger protein 324B 3.38294
MRGPRX3 MAS-related GPR, member X3 3.38294
TEX53 testis expressed 53 3.38294
OR6F1 olfactory receptor, family 6, subfamily F, member 1 3.38294
ANO3 anoctamin 3 3.38294
ADRB3 adrenoceptor beta 3 3.38294
RDH8 retinol dehydrogenase 8 (all-trans) 3.38294
SPMIP10 sperm microtubule inner protein 10 3.38294
SPATA25 spermatogenesis associated 25 3.38294
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 3.38294
TRIM49B tripartite motif containing 49B 3.38294
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 3.38294
PDC phosducin 3.38294
FIMP1 fertilization-influencing membrane protein 1 3.38294
TRAPPC3L trafficking protein particle complex 3-like 3.38294
PNMA6F PNMA family member 6F 3.38294
FAM237A family with sequence similarity 237 member A 3.38294
NOTCH2NLB notch 2 N-terminal like B 3.38294
PEAK3 PEAK family member 3 3.38294
ELOA2 elongin A2 3.38294
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 3.38294
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 3.38294
ERVW-1 endogenous retrovirus group W, member 1 3.38294
ROPN1B rhophilin associated tail protein 1B 3.38294
OSTN osteocrin 3.38294
HNF1B HNF1 homeobox B 3.38294
LGSN lengsin, lens protein with glutamine synthetase domain 3.38294
KLHL33 kelch-like family member 33 3.38294
ACTL10 actin-like 10 3.38294
RS1 retinoschisin 1 3.38294
ISM2 isthmin 2 3.38294
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 3.38294
FAM153A family with sequence similarity 153, member A 3.38294
RNF151 ring finger protein 151 3.38294
ENPP7 ectonucleotide pyrophosphatase/phosphodiesterase 7 3.38294
TXLNB taxilin beta 3.38294
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 3.38294
TUBA3D tubulin, alpha 3d 3.38294
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 3.38294
GDF9 growth differentiation factor 9 3.38294
LRRC72 leucine rich repeat containing 72 3.38294
FRK fyn-related Src family tyrosine kinase 3.38294
TIMD4 T-cell immunoglobulin and mucin domain containing 4 3.38294
IL1R2 interleukin 1 receptor, type II 3.38294
PGA5 pepsinogen 5, group I (pepsinogen A) 3.38294
TSPO2 translocator protein 2 3.38294
PIWIL1 piwi-like RNA-mediated gene silencing 1 3.38294
GOLGA7B golgin A7 family, member B 3.38294
VWA5B2 von Willebrand factor A domain containing 5B2 3.38294
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 3.38294
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 3.38294
TRIM55 tripartite motif containing 55 3.38294
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 3.38294
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 3.38294
VWA3B von Willebrand factor A domain containing 3B 3.38294
ISL2 ISL LIM homeobox 2 3.38294
THBD thrombomodulin 3.38294
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 3.38294
CDRT15L2 CMT1A duplicated region transcript 15-like 2 3.38294
CPA4 carboxypeptidase A4 3.38294
TBC1D10C TBC1 domain family, member 10C 3.38294
EDN3 endothelin 3 3.38294
EDN1 endothelin 1 3.38294
CST4 cystatin S 3.38294
POF1B premature ovarian failure, 1B 3.38294
EHF ets homologous factor 3.38294
TNR tenascin R 3.38294
AQP9 aquaporin 9 3.38294
CDHR5 cadherin-related family member 5 3.38294
TIGD3 tigger transposable element derived 3 3.38294
FBXL22 F-box and leucine-rich repeat protein 22 3.38294
KLK6 kallikrein-related peptidase 6 3.38294
C8G complement component 8, gamma polypeptide 3.38294
ORM1 orosomucoid 1 3.38294
IGIP IgA-inducing protein 3.38294
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 3.38294
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 3.38294
ARHGAP40 Rho GTPase activating protein 40 3.38294
GAS2L2 growth arrest-specific 2 like 2 3.38294
EOMES eomesodermin 3.38294
FOXN1 forkhead box N1 3.38294
OR52N4 olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene) 3.38294
MYLK2 myosin light chain kinase 2 3.38294
RGS4 regulator of G-protein signaling 4 3.38294
SLCO2B1 solute carrier organic anion transporter family, member 2B1 3.38294
IL9R interleukin 9 receptor 3.38294
SPHKAP SPHK1 interactor, AKAP domain containing 3.38294
POU4F1 POU class 4 homeobox 1 3.38294
PRSS33 protease, serine, 33 3.38294
OR14J1 olfactory receptor, family 14, subfamily J, member 1 3.38294
NT5C1B 5'-nucleotidase, cytosolic IB 3.38294
CTSE cathepsin E 3.38294
PGR progesterone receptor 3.38294
CFP complement factor properdin 3.38294
NOG noggin 3.38294
PRSS54 protease, serine, 54 3.38294
GPBAR1 G protein-coupled bile acid receptor 1 3.38294
FGF16 fibroblast growth factor 16 3.38294
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 3.38294
PLA2G4D phospholipase A2, group IVD (cytosolic) 3.38294
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 3.38294
ANXA8 annexin A8 3.38294
GPR17 G protein-coupled receptor 17 3.38294
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 3.38294
TBC1D26 TBC1 domain family, member 26 3.38294
MAPK11 mitogen-activated protein kinase 11 3.38294
OR56B1 olfactory receptor, family 56, subfamily B, member 1 3.38294
SMIM22 small integral membrane protein 22 3.38294
GCM1 glial cells missing homolog 1 (Drosophila) 3.38294
C10ORF90 chromosome 10 open reading frame 90 3.38294
HSF4 heat shock transcription factor 4 3.38294
TMEM132D transmembrane protein 132D 3.38294
NLRP13 NLR family, pyrin domain containing 13 3.38294
CD8A CD8a molecule 3.38294
CLIC3 chloride intracellular channel 3 3.38294
NACA2 nascent polypeptide-associated complex alpha subunit 2 3.38294
CDH10 cadherin 10, type 2 (T2-cadherin) 3.35791
MUSTN1 musculoskeletal, embryonic nuclear protein 1 3.35791
ARG1 arginase 1 3.35791
ATRAID all-trans retinoic acid-induced differentiation factor 3.07057
PLK3 polo-like kinase 3 2.97014
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae) 2.92409
LBR lamin B receptor 2.87206
RBM7 RNA binding motif protein 7 2.81719
CD109 CD109 molecule 2.77402
TUBD1 tubulin, delta 1 2.7552
RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1 2.68507
DGKE diacylglycerol kinase, epsilon 64kDa 2.64952
CBR4 carbonyl reductase 4 2.64439
LPXN leupaxin 2.64439
TJP3 tight junction protein 3 2.60688
SLC14A2 solute carrier family 14 (urea transporter), member 2 2.54068
MEGF10-DT MEGF10 divergent transcript 2.54068
SEPTIN1 septin 1 2.49159
DGCR6 DiGeorge syndrome critical region gene 6 2.46988
PARP10 poly (ADP-ribose) polymerase family, member 10 2.46988
HMCN2 hemicentin 2 2.43801
FILIP1L filamin A interacting protein 1-like 2.41398
POLR1G RNA polymerase I subunit G 2.3883
AURKB aurora kinase B 2.37153
COPZ1 coatomer protein complex, subunit zeta 1 2.36261
MMP24OS MMP24 opposite strand 2.35362
H4C13 H4 clustered histone 13 2.35337
CDCP2 CUB domain containing protein 2 2.35337
DUSP26 dual specificity phosphatase 26 (putative) 2.35337
SPEF2 sperm flagellar 2 2.35337
DUSP9 dual specificity phosphatase 9 2.35337
ZBTB42 zinc finger and BTB domain containing 42 2.35337
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 2.35337
RAB11FIP5 RAB11 family interacting protein 5 (class I) 2.30005
METTL1 methyltransferase like 1 2.30005
PDE8B phosphodiesterase 8B 2.29365
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.2774
HK1 hexokinase 1 2.26858
DENND4A DENN/MADD domain containing 4A 2.26582
CPHXL2 cytoplasmic polyadenylated homeobox like 2 2.26121
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae) 2.24416
SV2B synaptic vesicle glycoprotein 2B 2.21568
RPAIN RPA interacting protein 2.20694
CINP cyclin-dependent kinase 2 interacting protein 2.18793
SHROOM2 shroom family member 2 2.17674
C1ORF54 chromosome 1 open reading frame 54 2.13835
SULT4A1 sulfotransferase family 4A, member 1 2.13216
MTA3 metastasis associated 1 family, member 3 2.13122
ERBB2 erb-b2 receptor tyrosine kinase 2 2.13122
BEX2 brain expressed X-linked 2 2.12462
PPA2 pyrophosphatase (inorganic) 2 2.12012
PARD3B par-3 family cell polarity regulator beta 2.10429
GNG7 guanine nucleotide binding protein (G protein), gamma 7 2.07018
SIRT1 sirtuin 1 2.06175
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 2.04261
TXNRD2 thioredoxin reductase 2 2.03531
CTNND1 catenin (cadherin-associated protein), delta 1 2.03388
CNOT6 CCR4-NOT transcription complex, subunit 6 2.01285
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 2.00634
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 2.00164

decreased expression

Symbol Name Standardized Value
ACP3 acid phosphatase 3 -3.39988
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -3.38294
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) -3.38294
MKX mohawk homeobox -3.38294
THRSP thyroid hormone responsive -3.35791
RORC RAR-related orphan receptor C -3.35791
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E -3.35791
C1ORF87 chromosome 1 open reading frame 87 -3.35791
IFT70A intraflagellar transport 70A -3.35791
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma -3.35791
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C -3.35791
GPRC5D G protein-coupled receptor, class C, group 5, member D -3.35791
LOXL4 lysyl oxidase-like 4 -3.35791
LCN10 lipocalin 10 -3.35791
OR6A2 olfactory receptor, family 6, subfamily A, member 2 -3.35791
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like -3.35791
MUC20 mucin 20, cell surface associated -3.35791
TACSTD2 tumor-associated calcium signal transducer 2 -3.35791
GTSF1 gametocyte specific factor 1 -3.35791
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal -3.35791
TMPPE transmembrane protein with metallophosphoesterase domain -3.35791
UNC5CL unc-5 homolog C (C. elegans)-like -3.35791
TPPP3 tubulin polymerization-promoting protein family member 3 -3.35791
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) -3.35791
NPIPB7 nuclear pore complex interacting protein family, member B7 -3.35791
ZAR1L zygote arrest 1-like -3.35791
TMEM225B transmembrane protein 225B -3.35791
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 -3.35791
MTMR11 myotubularin related protein 11 -3.35791
TEKT5 tektin 5 -3.35791
C22ORF42 chromosome 22 open reading frame 42 -3.35791
ZXDC ZXD family zinc finger C -3.31987
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) -3.24219
LASP1 LIM and SH3 protein 1 -3.18363
DMAC2L distal membrane arm assembly component 2 like -2.87206
CHEK1 checkpoint kinase 1 -2.80862
FIBCD1 fibrinogen C domain containing 1 -2.77474
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1 -2.6151
MRPL48 mitochondrial ribosomal protein L48 -2.5984
FAM107B family with sequence similarity 107, member B -2.59749
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 -2.58494
ARMCX6 armadillo repeat containing, X-linked 6 -2.54068
ITFG2 integrin alpha FG-GAP repeat containing 2 -2.50688
PRKCA protein kinase C, alpha -2.50238
SIDT2 SID1 transmembrane family, member 2 -2.44172
GULP1 GULP, engulfment adaptor PTB domain containing 1 -2.40375
RASD1 RAS, dexamethasone-induced 1 -2.39591
RAB9B RAB9B, member RAS oncogene family -2.39591
BOC BOC cell adhesion associated, oncogene regulated -2.36465
ATXN3 ataxin 3 -2.35337
LARS2 leucyl-tRNA synthetase 2, mitochondrial -2.35337
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase -2.31839
PTPRN protein tyrosine phosphatase, receptor type, N -2.31839
CPED1 cadherin-like and PC-esterase domain containing 1 -2.31839
KLK14 kallikrein-related peptidase 14 -2.31723
TMEM169 transmembrane protein 169 -2.31683
DYDC2 DPY30 domain containing 2 -2.31683
KLK8 kallikrein-related peptidase 8 -2.30005
ZNF221 zinc finger protein 221 -2.30005
CIAO1 cytosolic iron-sulfur assembly component 1 -2.30005
COMMD8 COMM domain containing 8 -2.29695
DIS3L2 DIS3 like 3'-5' exoribonuclease 2 -2.29614
SPTBN2 spectrin, beta, non-erythrocytic 2 -2.29293
PRPS2 phosphoribosyl pyrophosphate synthetase 2 -2.28458
ZNF543 zinc finger protein 543 -2.2842
TENM2 teneurin transmembrane protein 2 -2.27457
TMEM191C transmembrane protein 191C -2.25361
CDH12 cadherin 12, type 2 (N-cadherin 2) -2.23954
MPPED1 metallophosphoesterase domain containing 1 -2.23954
PGAM2 phosphoglycerate mutase 2 (muscle) -2.23954
HOMER2 homer scaffolding protein 2 -2.23332
SDC3 syndecan 3 -2.21095
KMT5C lysine methyltransferase 5C -2.21095
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10 -2.20694
TMEM68 transmembrane protein 68 -2.20538
UBXN2A UBX domain protein 2A -2.20354
CD96 CD96 molecule -2.15021
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -2.1466
ZRANB2 zinc finger, RAN-binding domain containing 2 -2.14554
COPS3 COP9 signalosome subunit 3 -2.13939
PYGO2 pygopus family PHD finger 2 -2.13216
KIAA1549L KIAA1549-like -2.13216
TMEM115 transmembrane protein 115 -2.13122
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.12462
NUDT16L1 nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1 -2.07018
CHID1 chitinase domain containing 1 -2.07002
TOMM34 translocase of outer mitochondrial membrane 34 -2.06019
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) -2.04906
MVK mevalonate kinase -2.04261
PNMA1 paraneoplastic Ma antigen 1 -2.04144
OMA1 OMA1 zinc metallopeptidase -2.01994
BBX bobby sox homolog (Drosophila) -2.01555
THBS4 thrombospondin 4 -2.00636
ZNF664 zinc finger protein 664 -2.00419
SCML1 sex comb on midleg-like 1 (Drosophila) -2.00168
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 -2.00164