SSH1 Gene Set

Dataset DEPOD Substrates of Phosphatases
Category physical interactions
Type phosphatase
Description slingshot protein phosphatase 1|The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 54434)
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4 substrates of the phosphatase SSH1 from the curated DEPOD Substrates of Phosphatases dataset.

Symbol Name
CFL1 cofilin 1 (non-muscle)
CORO1B coronin, actin binding protein, 1B
DSTN destrin (actin depolymerizing factor)
LIMK1 LIM domain kinase 1