SSH1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description slingshot protein phosphatase 1|The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 54434)
External Link http://www.ncbi.nlm.nih.gov/gene/54434
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58 interacting proteins for SSH1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACP2 acid phosphatase 2, lysosomal
ACTA1 actin, alpha 1, skeletal muscle
ACTB actin, beta
ADNP activity-dependent neuroprotector homeobox
ADNP2 ADNP homeobox 2
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa
BARD1 BRCA1 associated RING domain 1
C2ORF69 chromosome 2 open reading frame 69
CBX1 chromobox homolog 1
CBX3 chromobox homolog 3
CBX5 chromobox homolog 5
CCDC148 coiled-coil domain containing 148
CFL1 cofilin 1 (non-muscle)
CFL2 cofilin 2 (muscle)
CHAF1A chromatin assembly factor 1, subunit A (p150)
CHAF1B chromatin assembly factor 1, subunit B (p60)
CHAMP1 chromosome alignment maintaining phosphoprotein 1
CHD3 chromodomain helicase DNA binding protein 3
CHD4 chromodomain helicase DNA binding protein 4
CORO1B coronin, actin binding protein, 1B
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
DSTN destrin (actin depolymerizing factor)
DTNA dystrobrevin, alpha
EIF5B eukaryotic translation initiation factor 5B
ELAVL1 ELAV like RNA binding protein 1
FAT1 FAT atypical cadherin 1
FMN1 formin 1
H2AFV H2A histone family, member V
HIST1H2AB histone cluster 1, H2ab
HIST1H2AD histone cluster 1, H2ad
HIST1H2BB histone cluster 1, H2bb
HIST1H2BF histone cluster 1, H2bf
HIST1H4F histone cluster 1, H4f
HIST3H3 histone cluster 3, H3
INTS1 integrator complex subunit 1
KPNA3 karyopherin alpha 3 (importin alpha 4)
KPNA4 karyopherin alpha 4 (importin alpha 3)
LIMK1 LIM domain kinase 1
LIMK2 LIM domain kinase 2
NINL ninein-like
NLN neurolysin (metallopeptidase M3 family)
NRF1 nuclear respiratory factor 1
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
POGZ pogo transposable element with ZNF domain
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKD1 protein kinase D1
PRKD2 protein kinase D2
SIRT7 sirtuin 7
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
TRIM28 tripartite motif containing 28
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZBED4 zinc finger, BED-type containing 4
ZCCHC11 zinc finger, CCHC domain containing 11