SSH3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description slingshot protein phosphatase 3|The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008] (NCBI Entrez Gene Database, 54961)
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Genes

301 genes differentially expressed following the SSH3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ERAP2 endoplasmic reticulum aminopeptidase 2 2.37949
C2CD4D C2 calcium-dependent domain containing 4D 2.37949
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 2.37949
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 2.37949
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 2.37949
TAS1R1 taste receptor, type 1, member 1 2.37949
CXCR6 chemokine (C-X-C motif) receptor 6 2.37949
TNR tenascin R 2.37949
CSTA cystatin A (stefin A) 2.37949
CALML6 calmodulin-like 6 2.37949
CARD9 caspase recruitment domain family, member 9 2.37949
CTRC chymotrypsin C (caldecrin) 2.37949
CD19 CD19 molecule 2.37949
THRSP thyroid hormone responsive 2.37949
SPDYE11 speedy/RINGO cell cycle regulator family member E11 2.37949
FGR FGR proto-oncogene, Src family tyrosine kinase 2.37949
TSPAN19 tetraspanin 19 2.37949
DRC5 dynein regulatory complex subunit 5 2.37949
CFAP299 cilia and flagella associated protein 299 2.37949
ANKRD55 ankyrin repeat domain 55 2.37949
ALPP alkaline phosphatase, placental 2.37949
IL5RA interleukin 5 receptor, alpha 2.31017
TM4SF20 transmembrane 4 L six family member 20 2.31017
PCDHB1 protocadherin beta 1 2.31017
PAX6 paired box 6 2.31017
SLC16A11 solute carrier family 16, member 11 2.31017
TRIM33 tripartite motif containing 33 2.31017
ADGRE1 adhesion G protein-coupled receptor E1 2.31017
TBC1D3I TBC1 domain family member 3I 2.31017
SIGLECL1 SIGLEC family like 1 2.31017
TEX54 testis expressed 54 2.31017
SLC26A1 solute carrier family 26 (anion exchanger), member 1 2.31017
FAM167A family with sequence similarity 167, member A 2.31017
DLK1 delta-like 1 homolog (Drosophila) 2.31017
SOX1 SRY (sex determining region Y)-box 1 2.31017
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 2.31017
SLC16A6 solute carrier family 16, member 6 2.31017
XTBD1 XRN2 binding domain containing 1 2.31017
ACY3 aminoacylase 3 2.31017
MYO1G myosin IG 2.31017
IL2RA interleukin 2 receptor, alpha 2.31017
ZFYVE27 zinc finger, FYVE domain containing 27 2.31017
COPZ2 coatomer protein complex, subunit zeta 2 2.31017
CPB2 carboxypeptidase B2 (plasma) 2.31017
CPB1 carboxypeptidase B1 (tissue) 2.31017
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 2.31017
RGPD4 RANBP2-like and GRIP domain containing 4 2.31017
PCDH8 protocadherin 8 2.31017
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 2.31017
SPEGNB SPEG neighbor 2.31017
OTUD6A OTU deubiquitinase 6A 2.31017
SP7 Sp7 transcription factor 2.31017
CIITA class II, major histocompatibility complex, transactivator 2.31017
MUSK muscle, skeletal, receptor tyrosine kinase 2.31017
CAMKV CaM kinase-like vesicle-associated 2.31017
COL19A1 collagen, type XIX, alpha 1 2.31017
MYOCOS myocilin opposite strand 2.31017
GATA3 GATA binding protein 3 2.31017
THAP12 THAP domain containing 12 2.31017
SQOR sulfide quinone oxidoreductase 2.31017
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 2.31017
LY6K lymphocyte antigen 6 complex, locus K 2.31017
MYL10 myosin, light chain 10, regulatory 2.31017
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 2.31017
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 2.31017
SPRY2 sprouty homolog 2 (Drosophila) 2.31017
EFL1 elongation factor like GTPase 1 2.31017
CIMIP2B ciliary microtubule inner protein 2B 2.31017
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 2.31017
A4GNT alpha-1,4-N-acetylglucosaminyltransferase 2.31017
GPX5 glutathione peroxidase 5 2.31017
ROPN1B rhophilin associated tail protein 1B 2.31017
DEFB108B defensin, beta 108B 2.31017
LTA lymphotoxin alpha 2.31017
MPDZ multiple PDZ domain protein 2.31017
TAOK1 TAO kinase 1 2.31017
OR2A1 olfactory receptor, family 2, subfamily A, member 1 2.31017
PCDHA8 protocadherin alpha 8 2.31017
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.31017
WNT11 wingless-type MMTV integration site family, member 11 2.31017
SIM2 single-minded family bHLH transcription factor 2 2.31017
CFAP206 cilia and flagella associated protein 206 2.31017
AJM1 apical junction component 1 homolog 2.31017
TMEM276-ZFTRAF1 TMEM276-ZFTRAF1 readthrough 2.31017
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 2.31017
TRARG1 trafficking regulator of GLUT4 (SLC2A4) 1 2.31017
CDSN corneodesmosin 2.31017
BARX2 BARX homeobox 2 2.31017
SAA2 serum amyloid A2 2.31017
VCX3A variable charge, X-linked 3A 2.31017
SAMD11 sterile alpha motif domain containing 11 2.31017
TMEM271 transmembrane protein 271 2.31017
WAPL WAPL cohesin release factor 2.31017
SERINC4 serine incorporator 4 2.31017
CH25H cholesterol 25-hydroxylase 2.31017
PPIAL4C peptidylprolyl isomerase A (cyclophilin A)-like 4C 2.31017
GALK1 galactokinase 1 2.31017
GAL3ST2 galactose-3-O-sulfotransferase 2 2.31017
SYNGR4 synaptogyrin 4 2.31017
PMP2 peripheral myelin protein 2 2.31017
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 2.31017
GNG8 guanine nucleotide binding protein (G protein), gamma 8 2.31017
PRSS38 protease, serine, 38 2.31017
BARHL2 BarH-like homeobox 2 2.31017
OR5B2 olfactory receptor, family 5, subfamily B, member 2 2.31017
PAQR3 progestin and adipoQ receptor family member III 2.31017
SLC38A8 solute carrier family 38, member 8 2.31017
FGF10 fibroblast growth factor 10 2.31017
CT55 cancer/testis antigen 55 2.31017
PIP prolactin-induced protein 2.31017
C16ORF78 chromosome 16 open reading frame 78 2.31017
KRAS Kirsten rat sarcoma viral oncogene homolog 2.31017
WFDC9 WAP four-disulfide core domain 9 2.31017
TLR10 toll-like receptor 10 2.31017
DRD5 dopamine receptor D5 2.31017
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 2.31017
KLK7 kallikrein-related peptidase 7 2.31017
SPATA9 spermatogenesis associated 9 2.31017
GLOD5 glyoxalase domain containing 5 2.31017
CHIT1 chitinase 1 (chitotriosidase) 2.31017
TBC1D15 TBC1 domain family, member 15 2.31017
CLRN1 clarin 1 2.31017
C8G complement component 8, gamma polypeptide 2.31017
NUP98 nucleoporin 98kDa 2.31017
FGF16 fibroblast growth factor 16 2.31017
OR56B1 olfactory receptor, family 56, subfamily B, member 1 2.31017
WFDC10A WAP four-disulfide core domain 10A 2.31017
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 2.31017
ETHE1 ethylmalonic encephalopathy 1 2.31017
GSDMA gasdermin A 2.31017
STOM stomatin 2.31017
SLC36A3 solute carrier family 36, member 3 2.31017
MYOZ2 myozenin 2 2.31017
ZNF648 zinc finger protein 648 2.31017
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 2.31017
C5ORF46 chromosome 5 open reading frame 46 2.31017
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.31017
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 2.31017
CD226 CD226 molecule 2.31017
WFDC11 WAP four-disulfide core domain 11 2.31017
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 2.31017
KRTAP5-2 keratin associated protein 5-2 2.31017
PADI1 peptidyl arginine deiminase, type I 2.31017
TGM4 transglutaminase 4 2.31017
PSG2 pregnancy specific beta-1-glycoprotein 2 2.31017
QRFP pyroglutamylated RFamide peptide 2.31017
GRAP2 GRB2-related adaptor protein 2 2.31017
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.31017
CLPS colipase, pancreatic 2.31017
FCAR Fc fragment of IgA receptor 2.31017
PLA2G5 phospholipase A2, group V 2.31017
EPHB3 EPH receptor B3 2.31017
IFNK interferon, kappa 2.31017
TMPRSS13 transmembrane protease, serine 13 2.31017
CDC25B cell division cycle 25B 2.31017
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 2.31017
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 2.31017
MAPKBP1 mitogen-activated protein kinase binding protein 1 2.30834
TEKTIP1 tektin bundle interacting protein 1 2.30168
RHBDD2 rhomboid domain containing 2 2.30168
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 2.30168
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 2.30168
SYCP3 synaptonemal complex protein 3 2.30168
MRPL53 mitochondrial ribosomal protein L53 2.30168
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 2.30168
CLIP4 CAP-GLY domain containing linker protein family, member 4 2.30168
PCDHB12 protocadherin beta 12 2.30168
GMFG glia maturation factor, gamma 2.30168
PLEK2 pleckstrin 2 2.30168
TMEM185B transmembrane protein 185B 2.26336
ABHD3 abhydrolase domain containing 3 2.23609
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 2.22362
WASHC4 WASH complex subunit 4 2.22362
SERBP1 SERPINE1 mRNA binding protein 1 2.21623
CCNA2 cyclin A2 2.21437
FBXL4 F-box and leucine-rich repeat protein 4 2.17162
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 2.17051
NLN neurolysin (metallopeptidase M3 family) 2.15968
GLRA2 glycine receptor, alpha 2 2.15968
SQLE squalene epoxidase 2.15968
SERINC1 serine incorporator 1 2.13919
LZTS2 leucine zipper, putative tumor suppressor 2 2.10633
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa 2.10283
TRMT10C tRNA methyltransferase 10 homolog C (S. cerevisiae) 2.09268
CDCA7 cell division cycle associated 7 2.07645
MED29 mediator complex subunit 29 2.06769
LAP3 leucine aminopeptidase 3 2.06143
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 2.05397
PCDH7 protocadherin 7 2.0513
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) 2.04942
RNPEP arginyl aminopeptidase (aminopeptidase B) 2.04942
DDR1 discoidin domain receptor tyrosine kinase 1 2.02222
LRP2BP LRP2 binding protein 2.02222
SLC35A5 solute carrier family 35, member A5 2.02222
UCK2 uridine-cytidine kinase 2 2.01307

decreased expression

Symbol Name Standardized Value
MFSD2B major facilitator superfamily domain containing 2B -2.37949
KATNIP katanin interacting protein -2.37949
GPR108 G protein-coupled receptor 108 -2.31053
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.31017
NSMCE1 non-SMC element 1 homolog (S. cerevisiae) -2.31017
CHADL chondroadherin-like -2.31017
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 -2.31017
RALYL RALY RNA binding protein-like -2.31017
VMAC vimentin-type intermediate filament associated coiled-coil protein -2.31017
PPFIA2 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 -2.31017
NOXRED1 NADP-dependent oxidoreductase domain containing 1 -2.31017
MMRN2 multimerin 2 -2.31017
MARCHF9 membrane associated ring-CH-type finger 9 -2.31017
HEMK1 HemK methyltransferase family member 1 -2.31017
LYPD1 LY6/PLAUR domain containing 1 -2.31017
MAGIX MAGI family member, X-linked -2.31017
PTPN21 protein tyrosine phosphatase, non-receptor type 21 -2.31017
NDN necdin, melanoma antigen (MAGE) family member -2.31017
BRD3OS BRD3 opposite strand -2.31017
PODNL1 podocan-like 1 -2.30168
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H -2.30168
SMIM7 small integral membrane protein 7 -2.30168
MCHR1 melanin-concentrating hormone receptor 1 -2.30168
ATOH1 atonal homolog 1 (Drosophila) -2.30168
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B -2.30168
PRDM12 PR domain containing 12 -2.30168
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 -2.30168
BMP8B bone morphogenetic protein 8b -2.30168
SOX18 SRY (sex determining region Y)-box 18 -2.30168
FAM43B family with sequence similarity 43, member B -2.30168
CCDC17 coiled-coil domain containing 17 -2.30168
FAM3D family with sequence similarity 3, member D -2.30168
OSTN osteocrin -2.30168
GJA5 gap junction protein, alpha 5, 40kDa -2.30168
MUC1 mucin 1, cell surface associated -2.30168
ASB9 ankyrin repeat and SOCS box containing 9 -2.30168
IFNGR1 interferon gamma receptor 1 -2.30168
FAM131C family with sequence similarity 131, member C -2.30168
MNX1 motor neuron and pancreas homeobox 1 -2.30168
SNX33 sorting nexin 33 -2.30168
PCYT1A phosphate cytidylyltransferase 1, choline, alpha -2.30168
ABHD1 abhydrolase domain containing 1 -2.30168
PENK proenkephalin -2.30168
ECM1 extracellular matrix protein 1 -2.30168
CPZ carboxypeptidase Z -2.30168
ANKAR ankyrin and armadillo repeat containing -2.30168
EGR2 early growth response 2 -2.30168
CAMK2B calcium/calmodulin-dependent protein kinase II beta -2.30168
SEC14L3 SEC14-like 3 (S. cerevisiae) -2.30168
LYPD5 LY6/PLAUR domain containing 5 -2.30168
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -2.30168
AOC1 amine oxidase, copper containing 1 -2.30168
GFY golgi-associated, olfactory signaling regulator -2.30168
MZB1 marginal zone B and B1 cell-specific protein -2.30168
ZDHHC22 zinc finger, DHHC-type containing 22 -2.29469
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 -2.29173
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -2.29131
TSSK6 testis-specific serine kinase 6 -2.27959
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -2.27959
ANKRD50 ankyrin repeat domain 50 -2.27876
CATSPERB catsper channel auxiliary subunit beta -2.27876
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.27676
MED26 mediator complex subunit 26 -2.26336
ZNF185 zinc finger protein 185 (LIM domain) -2.24724
PIMREG PICALM interacting mitotic regulator -2.23609
TADA2A transcriptional adaptor 2A -2.22362
SPRY4 sprouty homolog 4 (Drosophila) -2.21787
ZBTB38 zinc finger and BTB domain containing 38 -2.21437
H1-1 H1.1 linker histone, cluster member -2.21369
ZNF385B zinc finger protein 385B -2.21369
FSTL3 follistatin-like 3 (secreted glycoprotein) -2.21369
TOGARAM2 TOG array regulator of axonemal microtubules 2 -2.21369
NPHP3 nephronophthisis 3 (adolescent) -2.21277
MSANTD2 Myb/SANT-like DNA-binding domain containing 2 -2.21085
SLC35B2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2 -2.20577
ZFP28 ZFP28 zinc finger protein -2.20547
H1-2 H1.2 linker histone, cluster member -2.20547
IFT70B intraflagellar transport 70B -2.20547
NKX3-1 NK3 homeobox 1 -2.20547
MEOX2 mesenchyme homeobox 2 -2.20547
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) -2.18703
TEKT3 tektin 3 -2.18703
ZBED1 zinc finger, BED-type containing 1 -2.18703
SSH1 slingshot protein phosphatase 1 -2.18323
AMBRA1 autophagy/beclin-1 regulator 1 -2.18323
ENTREP2 endosomal transmembrane epsin interactor 2 -2.1758
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.17278
LCK LCK proto-oncogene, Src family tyrosine kinase -2.17256
TMEM94 transmembrane protein 94 -2.15189
HDAC8 histone deacetylase 8 -2.10749
EFS embryonal Fyn-associated substrate -2.10033
DEDD2 death effector domain containing 2 -2.09329
MED25 mediator complex subunit 25 -2.09009
SMIM18 small integral membrane protein 18 -2.08824
KCNK13 potassium channel, two pore domain subfamily K, member 13 -2.0879
KIRREL2 kin of IRRE like 2 (Drosophila) -2.0879
USP49 ubiquitin specific peptidase 49 -2.08418
HOMEZ homeobox and leucine zipper encoding -2.07921
RAB32 RAB32, member RAS oncogene family -2.07779
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 -2.06636
SNX14 sorting nexin 14 -2.06531
WEE1 WEE1 G2 checkpoint kinase -2.04218
BEX1 brain expressed, X-linked 1 -2.02222
EWSR1 EWS RNA-binding protein 1 -2.02222
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.02222
PCDHGA1 protocadherin gamma subfamily A, 1 -2.00523