ST14 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description suppression of tumorigenicity 14 (colon carcinoma)|The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6768)
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Genes

339 genes differentially expressed following the ST14 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
WNK3 WNK lysine deficient protein kinase 3 2.6085
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 2.6085
NPPC natriuretic peptide C 2.6085
OR4D9 olfactory receptor, family 4, subfamily D, member 9 2.6085
LYZL6 lysozyme-like 6 2.6085
RPA4 replication protein A4, 30kDa 2.6085
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 2.6085
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 2.6085
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 2.6085
ATP13A4 ATPase type 13A4 2.6085
LPO lactoperoxidase 2.6085
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 2.6085
CIBAR2 CBY1 interacting BAR domain containing 2 2.6085
LAPTM5 lysosomal protein transmembrane 5 2.6085
SHISA3 shisa family member 3 2.6085
CXORF65 chromosome X open reading frame 65 2.59268
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 2.59268
SH2D6 SH2 domain containing 6 2.59268
WEE2 WEE1 homolog 2 (S. pombe) 2.59268
OR10A6 olfactory receptor, family 10, subfamily A, member 6 (gene/pseudogene) 2.59268
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.59268
PNMA5 paraneoplastic Ma antigen family member 5 2.59268
CD14 CD14 molecule 2.59268
GPR6 G protein-coupled receptor 6 2.59268
GNLY granulysin 2.59268
ALOX15 arachidonate 15-lipoxygenase 2.59268
C1ORF162 chromosome 1 open reading frame 162 2.59268
LRRD1 leucine-rich repeats and death domain containing 1 2.59268
SCGN secretagogin, EF-hand calcium binding protein 2.59268
FETUB fetuin B 2.59268
GRIA2 glutamate receptor, ionotropic, AMPA 2 2.59268
GYS2 glycogen synthase 2 (liver) 2.59268
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 2.59268
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 2.59268
LOC105378220 macrophage receptor MARCO-like 2.59268
CFAP58 cilia and flagella associated protein 58 2.59268
ZNF804B zinc finger protein 804B 2.59268
FGF8 fibroblast growth factor 8 (androgen-induced) 2.59268
METTL21C methyltransferase like 21C 2.59268
MUC22 mucin 22 2.59268
OR1D2 olfactory receptor, family 1, subfamily D, member 2 2.59268
CIITA class II, major histocompatibility complex, transactivator 2.59268
ASPA aspartoacylase 2.59268
GIMAP2 GTPase, IMAP family member 2 2.59268
MEIKIN meiotic kinetochore factor 2.59268
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 2.59268
C2ORF80 chromosome 2 open reading frame 80 2.59268
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 2.59268
DNASE1 deoxyribonuclease I 2.59268
SPDEF SAM pointed domain containing ETS transcription factor 2.59268
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 2.59268
OR56B2 olfactory receptor family 56 subfamily B member 2 2.59268
SPRR2F small proline-rich protein 2F 2.59268
MLN motilin 2.59268
PLCZ1 phospholipase C, zeta 1 2.59268
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 2.59268
DHFR dihydrofolate reductase 2.59268
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 2.59268
LOC114841035 uncharacterized LOC114841035 2.59268
ZNF729 zinc finger protein 729 2.59268
TCERG1L transcription elongation regulator 1-like 2.59268
SPIC Spi-C transcription factor (Spi-1/PU.1 related) 2.59268
AVPR1B arginine vasopressin receptor 1B 2.59268
NOTCH2NLB notch 2 N-terminal like B 2.59268
CIMAP1D CIMAP1 family member D 2.59268
H2BK1 H2B.K variant histone 1 2.59268
H3C3 H3 clustered histone 3 2.59268
CLXN calaxin 2.59268
DEPP1 DEPP autophagy regulator 1 2.59268
SLURP2 secreted LY6/PLAUR domain containing 2 2.59268
FYB1 FYN binding protein 1 2.59268
WDR64 WD repeat domain 64 2.59268
XKR3 XK, Kell blood group complex subunit-related family, member 3 2.59268
LY6H lymphocyte antigen 6 complex, locus H 2.59268
DTHD1 death domain containing 1 2.59268
ACOT4 acyl-CoA thioesterase 4 2.59268
ACTL10 actin-like 10 2.59268
ACTL8 actin-like 8 2.59268
ZNF436 zinc finger protein 436 2.59268
TMEM229A transmembrane protein 229A 2.59268
PLG plasminogen 2.59268
ATP13A5 ATPase type 13A5 2.59268
PCDHB11 protocadherin beta 11 2.59268
THPO thrombopoietin 2.59268
GAST gastrin 2.59268
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 2.59268
SELL selectin L 2.59268
FAM107A family with sequence similarity 107, member A 2.59268
HNF1A HNF1 homeobox A 2.59268
FAM131C family with sequence similarity 131, member C 2.59268
CAPN8 calpain 8 2.59268
C1QL2 complement component 1, q subcomponent-like 2 2.59268
MSX1 msh homeobox 1 2.59268
DNAI1 dynein, axonemal, intermediate chain 1 2.59268
HOXB3 homeobox B3 2.59268
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 2.59268
EMP1 epithelial membrane protein 1 2.59268
IL36R interleukin 36 receptor 2.59268
MEFV Mediterranean fever 2.59268
AKNAD1 AKNA domain containing 1 2.59268
CTAGE9 CTAGE family, member 9 2.59268
CXCR5 chemokine (C-X-C motif) receptor 5 2.59268
HHATL hedgehog acyltransferase-like 2.59268
BTNL3 butyrophilin-like 3 2.59268
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 2.59268
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 2.59268
OR56A3 olfactory receptor, family 56, subfamily A, member 3 2.59268
BRDT bromodomain, testis-specific 2.59268
ENDOU endonuclease, polyU-specific 2.59268
A3GALT2 alpha 1,3-galactosyltransferase 2 2.59268
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 2.59268
APOH apolipoprotein H (beta-2-glycoprotein I) 2.59268
FEZF2 FEZ family zinc finger 2 2.59268
PCDHGA7 protocadherin gamma subfamily A, 7 2.59268
C15ORF61 chromosome 15 open reading frame 61 2.59268
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 2.59268
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 2.59268
TEX29 testis expressed 29 2.59268
TTC22 tetratricopeptide repeat domain 22 2.59268
EOMES eomesodermin 2.59268
HPGDS hematopoietic prostaglandin D synthase 2.59268
GPR150 G protein-coupled receptor 150 2.59268
TSPAN19 tetraspanin 19 2.59268
NKX6-2 NK6 homeobox 2 2.59268
CSDC2 cold shock domain containing C2, RNA binding 2.59268
CTSS cathepsin S 2.59268
ZC3H12D zinc finger CCCH-type containing 12D 2.59268
TG thyroglobulin 2.59268
RIPPLY2 ripply transcriptional repressor 2 2.59268
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 2.59268
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 2.59268
TBX1 T-box 1 2.59268
ISL2 ISL LIM homeobox 2 2.59268
DMTN dematin actin binding protein 2.59268
NTSR2 neurotensin receptor 2 2.59268
ANXA8 annexin A8 2.59268
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 2.59268
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21 2.59268
ITPKA inositol-trisphosphate 3-kinase A 2.59268
PADI4 peptidyl arginine deiminase, type IV 2.59268
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 2.59268
DUOXA1 dual oxidase maturation factor 1 2.59268
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 2.59268
HEPACAM hepatic and glial cell adhesion molecule 2.59268
POTEF POTE ankyrin domain family, member F 2.59268
CLNK cytokine-dependent hematopoietic cell linker 2.59268
DSPP dentin sialophosphoprotein 2.59268
FAM199X family with sequence similarity 199, X-linked 2.59268
TBCK TBC1 domain containing kinase 2.59268
PRR35 proline rich 35 2.59268
GLYAT glycine-N-acyltransferase 2.59268
ROM1 retinal outer segment membrane protein 1 2.59268
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 2.59096
LOC390937 Ets2 repressor factor-like 2.59096
POLR3H polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) 2.58549
ZFAT zinc finger and AT hook domain containing 2.58364
DPY19L2 dpy-19-like 2 (C. elegans) 2.57234
DCTN4 dynactin 4 (p62) 2.52964
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 2.52513
NPM3 nucleophosmin/nucleoplasmin 3 2.52378
KAT6A K(lysine) acetyltransferase 6A 2.475
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 2.47052
TYMS thymidylate synthetase 2.46357
AFAP1L1 actin filament associated protein 1-like 1 2.45022
GRK5 G protein-coupled receptor kinase 5 2.45022
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) 2.41227
BTK Bruton agammaglobulinemia tyrosine kinase 2.37285
DEFB134 defensin, beta 134 2.37285
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 2.37285
EAF1 ELL associated factor 1 2.35466
PPCDC phosphopantothenoylcysteine decarboxylase 2.35074
RAB40B RAB40B, member RAS oncogene family 2.34557
APH1A APH1A gamma secretase subunit 2.33986
TJP2 tight junction protein 2 2.33902
PML promyelocytic leukemia 2.32608
SQLE squalene epoxidase 2.31917
TRPM7 transient receptor potential cation channel, subfamily M, member 7 2.29469
ERCC4 excision repair cross-complementation group 4 2.29365
ZFAND5 zinc finger, AN1-type domain 5 2.29365
EIF3H eukaryotic translation initiation factor 3, subunit H 2.29365
ZNF112 zinc finger protein 112 2.29365
DAGLB diacylglycerol lipase, beta 2.28677
GALK2 galactokinase 2 2.28055
MTURN maturin, neural progenitor differentiation regulator homolog (Xenopus) 2.27703
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 2.23537
UBE2Q2 ubiquitin-conjugating enzyme E2Q family member 2 2.23024
SCLY selenocysteine lyase 2.2106
ELOVL6 ELOVL fatty acid elongase 6 2.2106
PIF1 PIF1 5'-to-3' DNA helicase 2.2106
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) 2.19379
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5 2.18251
DPH5 diphthamide biosynthesis 5 2.18251
ASF1B anti-silencing function 1B histone chaperone 2.173
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 2.16523
GVQW3 GVQW motif containing 3 2.15115
PRDM11 PR domain containing 11 2.14964
PRIM2 primase, DNA, polypeptide 2 (58kDa) 2.14869
SCAP SREBF chaperone 2.13735
BTBD17 BTB (POZ) domain containing 17 2.13501
SNAI3 snail family zinc finger 3 2.13077
DOLK dolichol kinase 2.13077
FZD4 frizzled class receptor 4 2.11294
RBM42 RNA binding motif protein 42 2.11294
ZNF827 zinc finger protein 827 2.11218
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 2.105
SPC25 SPC25, NDC80 kinetochore complex component 2.09236
SVBP small vasohibin binding protein 2.08466
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 2.06488
GPR82 G protein-coupled receptor 82 2.05736
PPL periplakin 2.05621
PHF11 PHD finger protein 11 2.03975
SYT1 synaptotagmin I 2.03804
WBP1 WW domain binding protein 1 2.02558
BBS7 Bardet-Biedl syndrome 7 2.02482
DDX25 DEAD (Asp-Glu-Ala-Asp) box helicase 25 2.01415
ACSS2 acyl-CoA synthetase short-chain family member 2 2.01414
UPP1 uridine phosphorylase 1 2.00908

decreased expression

Symbol Name Standardized Value
TEKTIP1 tektin bundle interacting protein 1 -2.6085
SRL sarcalumenin -2.6085
TNN tenascin N -2.6085
NAGS N-acetylglutamate synthase -2.6085
ZHX1 zinc fingers and homeoboxes 1 -2.6085
ZFP3 ZFP3 zinc finger protein -2.6085
ADM5 adrenomedullin 5 (putative) -2.6085
SLC31A2 solute carrier family 31 (copper transporter), member 2 -2.6085
ZSCAN22 zinc finger and SCAN domain containing 22 -2.6085
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 -2.6085
SMIM38 small integral membrane protein 38 -2.6065
METAP1 methionyl aminopeptidase 1 -2.60106
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 -2.59268
PITX3 paired-like homeodomain 3 -2.59268
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D -2.59268
HES3 hes family bHLH transcription factor 3 -2.59268
ACCS 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional) -2.59268
PAX6 paired box 6 -2.59268
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 -2.59268
STK31 serine/threonine kinase 31 -2.59268
F7 coagulation factor VII (serum prothrombin conversion accelerator) -2.59268
TACC1 transforming, acidic coiled-coil containing protein 1 -2.59268
RIMBP2 RIMS binding protein 2 -2.59268
LCN12 lipocalin 12 -2.59268
SLC26A8 solute carrier family 26 (anion exchanger), member 8 -2.59268
CFL2 cofilin 2 (muscle) -2.59268
H4C12 H4 clustered histone 12 -2.59268
PEAK3 PEAK family member 3 -2.59268
TMEM225B transmembrane protein 225B -2.59268
CSP2 CS pseudogene 2 -2.59268
TAFA3 TAFA chemokine like family member 3 -2.59268
FIMP1 fertilization-influencing membrane protein 1 -2.59268
HSPA8 heat shock 70kDa protein 8 -2.59268
LBHD1 LBH domain containing 1 -2.59268
MLANA melan-A -2.59268
PTRHD1 peptidyl-tRNA hydrolase domain containing 1 -2.59268
TMEM179 transmembrane protein 179 -2.59268
C1QL3 complement component 1, q subcomponent-like 3 -2.59268
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic -2.59268
PCDHB13 protocadherin beta 13 -2.59268
CPED1 cadherin-like and PC-esterase domain containing 1 -2.59268
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 -2.59268
TPRKB TP53RK binding protein -2.59268
LOC122526780 uncharacterized LOC122526780 -2.59268
EIF4E1B eukaryotic translation initiation factor 4E family member 1B -2.59268
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled -2.59268
ADAM7 ADAM metallopeptidase domain 7 -2.59268
ARR3 arrestin 3, retinal (X-arrestin) -2.59268
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) -2.59268
AQP4 aquaporin 4 -2.59268
ARHGAP42 Rho GTPase activating protein 42 -2.59268
FOXP2 forkhead box P2 -2.59268
PCDHGB1 protocadherin gamma subfamily B, 1 -2.59268
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 -2.59268
CDK20 cyclin-dependent kinase 20 -2.59268
ZNF133 zinc finger protein 133 -2.59268
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 -2.59268
IGF2R insulin-like growth factor 2 receptor -2.59268
ZCCHC12 zinc finger, CCHC domain containing 12 -2.59268
ZNF276 zinc finger protein 276 -2.59149
DTX3 deltex 3, E3 ubiquitin ligase -2.59096
SDHAF3 succinate dehydrogenase complex assembly factor 3 -2.50705
CCDC78 coiled-coil domain containing 78 -2.48859
SLC44A4 solute carrier family 44, member 4 -2.48859
RINT1 RAD50 interactor 1 -2.46317
CUTA cutA divalent cation tolerance homolog (E. coli) -2.45022
DNAH2 dynein, axonemal, heavy chain 2 -2.44185
NOMO1 NODAL modulator 1 -2.39425
PRDM10 PR domain containing 10 -2.39385
CSMD2 CUB and Sushi multiple domains 2 -2.37285
GLMN glomulin, FKBP associated protein -2.37285
PTPRU protein tyrosine phosphatase, receptor type, U -2.35076
IRS2 insulin receptor substrate 2 -2.35076
B3GALT6 UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6 -2.34995
ARHGAP21 Rho GTPase activating protein 21 -2.3466
GLI3 GLI family zinc finger 3 -2.33986
ST14 suppression of tumorigenicity 14 (colon carcinoma) -2.32608
NRP2 neuropilin 2 -2.32608
NCF2 neutrophil cytosolic factor 2 -2.31917
FAF2 Fas associated factor family member 2 -2.30932
WDR91 WD repeat domain 91 -2.29863
MECP2 methyl CpG binding protein 2 -2.29365
IL17C interleukin 17C -2.29365
DAZAP2 DAZ associated protein 2 -2.29365
KLHL9 kelch-like family member 9 -2.2896
RMC1 regulator of MON1-CCZ1 -2.28739
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -2.26979
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -2.25854
YBX3 Y box binding protein 3 -2.22343
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -2.21411
ZNF766 zinc finger protein 766 -2.2106
RABEP2 rabaptin, RAB GTPase binding effector protein 2 -2.173
SERTAD2 SERTA domain containing 2 -2.16523
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 -2.14993
WBP2 WW domain binding protein 2 -2.14993
C8ORF76 chromosome 8 open reading frame 76 -2.14411
FABP7 fatty acid binding protein 7, brain -2.14052
MXD3 MAX dimerization protein 3 -2.14052
STAU1 staufen double-stranded RNA binding protein 1 -2.14052
FGFR3 fibroblast growth factor receptor 3 -2.14052
DNM1L dynamin 1-like -2.13724
HARBI1 harbinger transposase derived 1 -2.12965
VEZF1 vascular endothelial zinc finger 1 -2.12662
HTATSF1 HIV-1 Tat specific factor 1 -2.11294
ANKRD45 ankyrin repeat domain 45 -2.11294
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 -2.11245
PROCA1 protein interacting with cyclin A1 -2.11058
ZDHHC9 zinc finger, DHHC-type containing 9 -2.09156
ANXA3 annexin A3 -2.07569
SLC45A1 solute carrier family 45, member 1 -2.05621
UBXN2A UBX domain protein 2A -2.05104
CYLD cylindromatosis (turban tumor syndrome) -2.05104
FAM162B family with sequence similarity 162, member B -2.04896
TKT transketolase -2.04434
DOCK1 dedicator of cytokinesis 1 -2.04193
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 -2.03804
CNMD chondromodulin -2.02482
WBP4 WW domain binding protein 4 -2.01414
ZBTB1 zinc finger and BTB domain containing 1 -2.01194
BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1 -2.01194
INTS7 integrator complex subunit 7 -2.00487
TPP1 tripeptidyl peptidase I -2.00431