STAR Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description steroidogenic acute regulatory protein|The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6770)
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Genes

295 genes differentially expressed following the STAR gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 3.20474
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 3.20474
DNAI2 dynein, axonemal, intermediate chain 2 3.20474
SUN3 Sad1 and UNC84 domain containing 3 3.20474
PCDHB11 protocadherin beta 11 3.20474
CRYBA1 crystallin, beta A1 3.20474
CCDC27 coiled-coil domain containing 27 3.20474
SHCBP1L SHC SH2-domain binding protein 1-like 3.20474
SPINT3 serine peptidase inhibitor, Kunitz type, 3 3.20474
SMIM41 small integral membrane protein 41 3.20474
TTC22 tetratricopeptide repeat domain 22 3.20474
COL19A1 collagen, type XIX, alpha 1 3.20474
KISS1R KISS1 receptor 3.20474
CD1C CD1c molecule 3.20474
IGFL3 IGF-like family member 3 3.20474
CLCF1 cardiotrophin-like cytokine factor 1 3.20474
SFXN3 sideroflexin 3 3.16331
SLC26A1 solute carrier family 26 (anion exchanger), member 1 3.16331
FLI1 Fli-1 proto-oncogene, ETS transcription factor 3.16331
NANOS2 nanos homolog 2 (Drosophila) 3.16331
ZNF814 zinc finger protein 814 3.16331
PCDHGB3 protocadherin gamma subfamily B, 3 3.16331
UNC13C unc-13 homolog C (C. elegans) 3.16331
SIGLECL1 SIGLEC family like 1 3.16331
CNTNAP4 contactin associated protein-like 4 3.16331
NPPB natriuretic peptide B 3.16331
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 3.16331
TMEM176A transmembrane protein 176A 3.16331
ADAD1 adenosine deaminase domain containing 1 (testis-specific) 3.16331
TBATA thymus, brain and testes associated 3.16331
MYO1G myosin IG 3.16331
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 3.16331
TMC2 transmembrane channel-like 2 3.16331
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 3.16331
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 3.16331
SERTM1 serine-rich and transmembrane domain containing 1 3.16331
ZNF804B zinc finger protein 804B 3.16331
UBE2I ubiquitin-conjugating enzyme E2I 3.16331
LRRC61 leucine rich repeat containing 61 3.16331
TDRD1 tudor domain containing 1 3.16331
GLRA3 glycine receptor, alpha 3 3.16331
RGPD3 RANBP2-like and GRIP domain containing 3 3.16331
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 3.16331
PSCA prostate stem cell antigen 3.16331
LOC124903317 uncharacterized LOC124903317 3.16331
WNT8B wingless-type MMTV integration site family, member 8B 3.16331
MISP mitotic spindle positioning 3.16331
FAM161B family with sequence similarity 161, member B 3.16331
SCG2 secretogranin II 3.16331
RTL1 retrotransposon-like 1 3.16331
BDKRB1 bradykinin receptor B1 3.16331
TMPRSS3 transmembrane protease, serine 3 3.16331
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 3.16331
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 3.16331
GBP1 guanylate binding protein 1, interferon-inducible 3.16331
CES4A carboxylesterase 4A 3.16331
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 3.16331
HTD2 hydroxyacyl-thioester dehydratase type 2 3.16331
SLURP2 secreted LY6/PLAUR domain containing 2 3.16331
CLXN calaxin 3.16331
DNAAF6 dynein axonemal assembly factor 6 3.16331
ARMH2 armadillo like helical domain containing 2 3.16331
MUCL3 mucin like 3 3.16331
CTXND1 cortexin domain containing 1 3.16331
LOC124906010 uncharacterized LOC124906010 3.16331
PRRT1B proline rich transmembrane protein 1B 3.16331
SPATA25 spermatogenesis associated 25 3.16331
C15ORF62 chromosome 15 open reading frame 62 3.16331
PCDHGC5 protocadherin gamma subfamily C, 5 3.16331
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 3.16331
CD5 CD5 molecule 3.16331
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 3.16331
TSSK4 testis-specific serine kinase 4 3.16331
TAS2R5 taste receptor, type 2, member 5 3.16331
RAB44 RAB44, member RAS oncogene family 3.16331
TUBA3D tubulin, alpha 3d 3.16331
CLDN2 claudin 2 3.16331
TEX101 testis expressed 101 3.16331
ERVFRD-1 endogenous retrovirus group FRD, member 1 3.16331
ANXA10 annexin A10 3.16331
CATSPER3 cation channel, sperm associated 3 3.16331
TLR6 toll-like receptor 6 3.16331
PDE1B phosphodiesterase 1B, calmodulin-dependent 3.16331
RASAL3 RAS protein activator like 3 3.16331
LRRC72 leucine rich repeat containing 72 3.16331
COX8C cytochrome c oxidase subunit VIIIC 3.16331
LOC124900192 uncharacterized LOC124900192 3.16331
DHH desert hedgehog 3.16331
HHATL hedgehog acyltransferase-like 3.16331
ETNPPL ethanolamine-phosphate phospho-lyase 3.16331
THTPA thiamine triphosphatase 3.16331
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 3.16331
UBQLNL ubiquilin-like 3.16331
TESPA1 thymocyte expressed, positive selection associated 1 3.16331
POF1B premature ovarian failure, 1B 3.16331
NIM1K NIM1 serine/threonine protein kinase 3.16331
CH25H cholesterol 25-hydroxylase 3.16331
ORM2 orosomucoid 2 3.16331
EIF4E1B eukaryotic translation initiation factor 4E family member 1B 3.16331
CABP7 calcium binding protein 7 3.16331
MBOAT4 membrane bound O-acyltransferase domain containing 4 3.16331
IGSF10 immunoglobulin superfamily, member 10 3.16331
LRRC32 leucine rich repeat containing 32 3.16331
PSG3 pregnancy specific beta-1-glycoprotein 3 3.16331
CALHM1 calcium homeostasis modulator 1 3.16331
HELT helt bHLH transcription factor 3.16331
ISLR immunoglobulin superfamily containing leucine-rich repeat 3.16331
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 3.16331
C8ORF89 chromosome 8 open reading frame 89 3.16331
VWA3B von Willebrand factor A domain containing 3B 3.16331
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 3.16331
DRD2 dopamine receptor D2 3.16331
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 3.16331
ZNF596 zinc finger protein 596 3.16331
MAB21L1 mab-21-like 1 (C. elegans) 3.16331
TRADD TNFRSF1A-associated via death domain 3.16331
HK3 hexokinase 3 (white cell) 3.16331
FAM177B family with sequence similarity 177, member B 3.16331
TDRD10 tudor domain containing 10 3.16331
C8B complement component 8, beta polypeptide 3.16331
PMP2 peripheral myelin protein 2 3.16331
TBPL2 TATA box binding protein like 2 3.16331
TMEM45B transmembrane protein 45B 3.16331
TMPRSS13 transmembrane protease, serine 13 3.16331
CD8A CD8a molecule 3.16331
C10ORF105 chromosome 10 open reading frame 105 3.16331
SYTL4 synaptotagmin-like 4 3.16331
NYX nyctalopin 3.16331
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 3.16331
IFITM10 interferon induced transmembrane protein 10 3.16331
GPRC5D G protein-coupled receptor, class C, group 5, member D 3.16331
SHISA3 shisa family member 3 3.16331
TEX26 testis expressed 26 3.16331
OXER1 oxoeicosanoid (OXE) receptor 1 3.16331
POPDC2 popeye domain containing 2 3.16331
GOLGA8Q golgin A8 family, member Q 3.16331
PITX2 paired-like homeodomain 2 3.16331
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 3.16331
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 3.16331
GLT6D1 glycosyltransferase 6 domain containing 1 3.16331
POTEF POTE ankyrin domain family, member F 3.16331
GPR149 G protein-coupled receptor 149 3.16331
TMIGD3 transmembrane and immunoglobulin domain containing 3 3.16331
TYR tyrosinase 3.16331
ANKRD33 ankyrin repeat domain 33 3.16331
EPX eosinophil peroxidase 3.16331
PDCD1 programmed cell death 1 3.16331
FADS6 fatty acid desaturase 6 3.16331
PATE1 prostate and testis expressed 1 3.16331
MINAR1 membrane integral NOTCH2 associated receptor 1 3.12537
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 3.07053
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 3.06444
EEF1AKMT3 EEF1A lysine methyltransferase 3 3.06444
ASIC1 acid sensing (proton gated) ion channel 1 2.97279
TAOK1 TAO kinase 1 2.88957
ATXN2L ataxin 2-like 2.74007
AOPEP aminopeptidase O (putative) 2.69618
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) 2.63116
EYA2 EYA transcriptional coactivator and phosphatase 2 2.62516
M6PR mannose-6-phosphate receptor (cation dependent) 2.60658
DKK3 dickkopf WNT signaling pathway inhibitor 3 2.56868
PELI3 pellino E3 ubiquitin protein ligase family member 3 2.55062
NCKAP1 NCK-associated protein 1 2.51843
SFRP5 secreted frizzled-related protein 5 2.50876
ITFG1 integrin alpha FG-GAP repeat containing 1 2.48785
CHIC2 cysteine-rich hydrophobic domain 2 2.47315
TMEM220 transmembrane protein 220 2.46089
ANKRD13B ankyrin repeat domain 13B 2.42445
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 2.34822
PTMS parathymosin 2.29513
SLC22A17 solute carrier family 22, member 17 2.29513
RRAGA Ras-related GTP binding A 2.29104
ATXN10 ataxin 10 2.29104
TRIB2 tribbles pseudokinase 2 2.28979
GJC1 gap junction protein, gamma 1, 45kDa 2.26492
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 2.26492
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 2.23815
NUCB2 nucleobindin 2 2.2144
C12ORF60 chromosome 12 open reading frame 60 2.19674
SIX1 SIX homeobox 1 2.19629
ZNF607 zinc finger protein 607 2.19629
BSND barttin CLCNK-type chloride channel accessory beta subunit 2.19629
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 2.19629
TMT1B thiol methyltransferase 1B 2.17324
NAGK N-acetylglucosamine kinase 2.17324
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.15951
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.15951
TRAF4 TNF receptor-associated factor 4 2.1592
SLX9 SLX9 ribosome biogenesis factor 2.15668
TMEM123 transmembrane protein 123 2.15033
SAR1A secretion associated, Ras related GTPase 1A 2.11283
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 2.08519
RAB11FIP5 RAB11 family interacting protein 5 (class I) 2.06887
GDI2 GDP dissociation inhibitor 2 2.06887
PTPN7 protein tyrosine phosphatase, non-receptor type 7 2.06887
FLNC filamin C, gamma 2.06887
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) 2.06887
WNT9B wingless-type MMTV integration site family, member 9B 2.06887
MYBPC1 myosin binding protein C, slow type 2.06887
OR2B6 olfactory receptor, family 2, subfamily B, member 6 2.06887
ALS2CL ALS2 C-terminal like 2.06887
LHFPL1 lipoma HMGIC fusion partner-like 1 2.06887
RGS22 regulator of G-protein signaling 22 2.06887
FGD1 FYVE, RhoGEF and PH domain containing 1 2.06031
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 2.06031
RBM45 RNA binding motif protein 45 2.05518
PAK5 p21 (RAC1) activated kinase 5 2.047
RABEP1 rabaptin, RAB GTPase binding effector protein 1 2.03515
SSC4D scavenger receptor cysteine rich family, 4 domains 2.03
PRXL2C peroxiredoxin like 2C 2.02996
IRF7 interferon regulatory factor 7 2.00705

decreased expression

Symbol Name Standardized Value
GOLGA8R golgin A8 family, member R -3.20474
GRHL3 grainyhead-like 3 (Drosophila) -3.20474
DEUP1 deuterosome assembly protein 1 -3.20474
DOCK8 dedicator of cytokinesis 8 -3.20474
IL4I1 interleukin 4 induced 1 -3.20474
FRMPD2 FERM and PDZ domain containing 2 -3.20474
CFAP52 cilia and flagella associated protein 52 -3.20474
DENND2D DENN/MADD domain containing 2D -3.20474
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 -3.20474
C17ORF78 chromosome 17 open reading frame 78 -3.16331
MYO1H myosin IH -3.16331
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 -3.16331
ADTRP androgen-dependent TFPI-regulating protein -3.16331
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 -3.16331
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 -3.16331
FPR1 formyl peptide receptor 1 -3.16331
ELAVL2 ELAV like neuron-specific RNA binding protein 2 -3.16331
BABAM2 BRISC and BRCA1 A complex member 2 -3.16331
PNLIPRP2 pancreatic lipase-related protein 2 -3.16331
GPR83 G protein-coupled receptor 83 -3.16331
TAS1R1 taste receptor, type 1, member 1 -3.16331
DDTL D-dopachrome tautomerase-like -3.16331
IL1R1 interleukin 1 receptor, type I -3.16331
IL1R2 interleukin 1 receptor, type II -3.16331
CDKN2A cyclin-dependent kinase inhibitor 2A -3.16331
PCDHB13 protocadherin beta 13 -3.16331
ABHD1 abhydrolase domain containing 1 -3.16331
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) -3.16331
LCN2 lipocalin 2 -3.16331
C20ORF144 chromosome 20 open reading frame 144 -3.16331
NDE1 nudE neurodevelopment protein 1 -3.16331
FOXP2 forkhead box P2 -3.16331
SLA Src-like-adaptor -3.16331
TTBK1 tau tubulin kinase 1 -3.16331
CCDC3 coiled-coil domain containing 3 -3.16331
CASS4 Cas scaffolding protein family member 4 -3.16331
GJC3 gap junction protein, gamma 3, 30.2kDa -3.16331
GMPPA GDP-mannose pyrophosphorylase A -3.02491
ZNF785 zinc finger protein 785 -3.02491
PXMP4 peroxisomal membrane protein 4, 24kDa -2.93578
RBM44 RNA binding motif protein 44 -2.82245
INSL3 insulin-like 3 (Leydig cell) -2.82245
TYMP thymidine phosphorylase -2.75551
CCDC22 coiled-coil domain containing 22 -2.60702
MVB12B multivesicular body subunit 12B -2.58375
CD200 CD200 molecule -2.56868
CARD10 caspase recruitment domain family, member 10 -2.56168
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 -2.51046
RASA4B RAS p21 protein activator 4B -2.47003
NKD2 naked cuticle homolog 2 (Drosophila) -2.46373
PRMT7 protein arginine methyltransferase 7 -2.44616
SH2B1 SH2B adaptor protein 1 -2.41339
LAMA2 laminin, alpha 2 -2.37851
RBSN rabenosyn, RAB effector -2.3638
TTC23L tetratricopeptide repeat domain 23-like -2.28651
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -2.26492
RYR3 ryanodine receptor 3 -2.2638
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) -2.26155
PCNX3 pecanex 3 -2.25365
MRPL43 mitochondrial ribosomal protein L43 -2.22438
KIRREL1 kirre like nephrin family adhesion molecule 1 -2.2024
CD151 CD151 molecule (Raph blood group) -2.20057
NSG2 neuronal vesicle trafficking associated 2 -2.19995
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta -2.19457
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 -2.1759
RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1 -2.17348
GYPE glycophorin E (MNS blood group) -2.17348
FCRL5 Fc receptor-like 5 -2.17324
FAM184B family with sequence similarity 184, member B -2.16035
EXOG endo/exonuclease (5'-3'), endonuclease G-like -2.15799
TRIM44 tripartite motif containing 44 -2.11068
PATJ PATJ crumbs cell polarity complex component -2.08519
SELENON selenoprotein N -2.0849
CGRRF1 cell growth regulator with ring finger domain 1 -2.06887
JMJD7 jumonji domain containing 7 -2.06887
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) -2.06031
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase -2.06031
NR2C1 nuclear receptor subfamily 2, group C, member 1 -2.05193
OXA1L oxidase (cytochrome c) assembly 1-like -2.05193
PDXK pyridoxal (pyridoxine, vitamin B6) kinase -2.04251
AGGF1 angiogenic factor with G patch and FHA domains 1 -2.04195
RPS11 ribosomal protein S11 -2.04095
TMEM129 transmembrane protein 129, E3 ubiquitin protein ligase -2.03697
UBXN1 UBX domain protein 1 -2.02004