STAT1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description signal transducer and activator of transcription 1, 91kDa|The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6772)
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Genes

313 genes differentially expressed following the STAT1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
OR52A5 olfactory receptor, family 52, subfamily A, member 5 3.281
REN renin 3.281
ASMT acetylserotonin O-methyltransferase 3.281
THRSP thyroid hormone responsive 3.281
GNAT3 guanine nucleotide binding protein, alpha transducing 3 3.281
TDRD6 tudor domain containing 6 3.281
LRRC10B leucine rich repeat containing 10B 3.281
TMEM217 transmembrane protein 217 3.281
CRX cone-rod homeobox 3.281
HMGN1 high mobility group nucleosome binding domain 1 3.281
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 3.281
XCL1 chemokine (C motif) ligand 1 3.281
IL22RA1 interleukin 22 receptor, alpha 1 3.281
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 3.281
NANOS2 nanos homolog 2 (Drosophila) 3.281
CD160 CD160 molecule 3.281
PNMA5 paraneoplastic Ma antigen family member 5 3.281
TMEM100 transmembrane protein 100 3.281
PAX7 paired box 7 3.281
SULT1A4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 3.281
SIGLEC9 sialic acid binding Ig-like lectin 9 3.281
RIMBP3C RIMS binding protein 3C 3.281
LONRF3 LON peptidase N-terminal domain and ring finger 3 3.281
TREML2 triggering receptor expressed on myeloid cells-like 2 3.281
TRAF3IP3 TRAF3 interacting protein 3 3.281
ANXA8 annexin A8 3.281
PF4V1 platelet factor 4 variant 1 3.281
TGM4 transglutaminase 4 3.281
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 3.281
LYZL4 lysozyme-like 4 3.281
SLC34A3 solute carrier family 34 (type II sodium/phosphate cotransporter), member 3 3.281
IL10RA interleukin 10 receptor, alpha 3.281
PRAP1 proline-rich acidic protein 1 3.281
ANKRD30B ankyrin repeat domain 30B 3.281
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) 3.281
OXT oxytocin/neurophysin I prepropeptide 3.281
BFSP2 beaded filament structural protein 2, phakinin 3.281
PRDM13 PR domain containing 13 3.281
HMX1 H6 family homeobox 1 3.281
CSNK2A3 casein kinase 2, alpha 3 polypeptide 3.281
OIT3 oncoprotein induced transcript 3 3.281
ASPA aspartoacylase 3.281
SMCO1 single-pass membrane protein with coiled-coil domains 1 3.281
GRM6 glutamate receptor, metabotropic 6 3.281
LAMP3 lysosomal-associated membrane protein 3 3.281
LOC124900192 uncharacterized LOC124900192 3.281
ADGRG7 adhesion G protein-coupled receptor G7 3.281
BNC1 basonuclin 1 3.281
PKD2L1 polycystic kidney disease 2-like 1 3.281
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 3.281
PDF peptide deformylase (mitochondrial) 3.281
LMNTD1 lamin tail domain containing 1 3.281
TMPRSS7 transmembrane protease, serine 7 3.281
TMPRSS3 transmembrane protease, serine 3 3.281
TRIM31 tripartite motif containing 31 3.281
PNLIPRP1 pancreatic lipase-related protein 1 3.281
LTB4R2 leukotriene B4 receptor 2 3.281
FAM90A11 family with sequence similarity 90 member A11 3.281
CIMAP2 ciliary microtubule associated protein 2 3.281
CIMIP2C ciliary microtubule inner protein 2C 3.281
CBY2 chibby family member 2 3.281
TMEM275 transmembrane protein 275 3.281
ANGPTL8 angiopoietin like 8 3.281
NECTIN4 nectin cell adhesion molecule 4 3.281
DEFB108B defensin, beta 108B 3.281
UNC93A unc-93 homolog A (C. elegans) 3.281
PIRT phosphoinositide-interacting regulator of transient receptor potential channels 3.281
SPATA22 spermatogenesis associated 22 3.281
GATA6 GATA binding protein 6 3.281
PCDHB11 protocadherin beta 11 3.281
IZUMO4 IZUMO family member 4 3.281
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 3.281
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 3.281
GPR75 G protein-coupled receptor 75 3.281
COX4I2 cytochrome c oxidase subunit IV isoform 2 (lung) 3.281
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 3.281
CARD16 caspase recruitment domain family, member 16 3.281
SLC26A9 solute carrier family 26 (anion exchanger), member 9 3.281
LTBP2 latent transforming growth factor beta binding protein 2 3.281
CLDN5 claudin 5 3.281
SOAT2 sterol O-acyltransferase 2 3.281
MOV10L1 Mov10 RISC complex RNA helicase like 1 3.281
ASIC5 acid sensing (proton gated) ion channel family member 5 3.281
GPR85 G protein-coupled receptor 85 3.281
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 3.281
KCNT1 potassium channel, sodium activated subfamily T, member 1 3.281
TBX5 T-box 5 3.281
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 3.281
LDHAL6B lactate dehydrogenase A-like 6B 3.281
NPPC natriuretic peptide C 3.281
RHAG Rh-associated glycoprotein 3.281
CRYBB2 crystallin, beta B2 3.281
ALOXE3 arachidonate lipoxygenase 3 3.281
C17ORF99 chromosome 17 open reading frame 99 3.281
SIAH3 siah E3 ubiquitin protein ligase family member 3 3.281
KLK14 kallikrein-related peptidase 14 3.281
TEX12 testis expressed 12 3.281
PRPH peripherin 3.281
CTXN2 cortexin 2 3.281
SPEF1 sperm flagellar 1 3.281
IFNL4 interferon, lambda 4 (gene/pseudogene) 3.281
DRD2 dopamine receptor D2 3.281
C22ORF42 chromosome 22 open reading frame 42 3.281
C9ORF64 chromosome 9 open reading frame 64 3.281
MKRN3 makorin ring finger protein 3 3.281
GML glycosylphosphatidylinositol anchored molecule like 3.281
TDRD10 tudor domain containing 10 3.281
FAM177B family with sequence similarity 177, member B 3.281
APOC4 apolipoprotein C-IV 3.281
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 3.281
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 3.281
ZGLP1 zinc finger, GATA-like protein 1 3.281
NT5DC4 5'-nucleotidase domain containing 4 3.281
DMRT1 doublesex and mab-3 related transcription factor 1 3.281
CASQ2 calsequestrin 2 (cardiac muscle) 3.281
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 3.281
DKK1 dickkopf WNT signaling pathway inhibitor 1 3.281
WNT4 wingless-type MMTV integration site family, member 4 3.281
LGALS9C lectin, galactoside-binding, soluble, 9C 3.281
PLA2G5 phospholipase A2, group V 3.281
MB myoglobin 3.281
VMO1 vitelline membrane outer layer 1 homolog (chicken) 3.281
ORM2 orosomucoid 2 3.281
LYPD5 LY6/PLAUR domain containing 5 3.281
PLCD4 phospholipase C, delta 4 3.281
GSTA2 glutathione S-transferase alpha 2 3.281
CRHBP corticotropin releasing hormone binding protein 3.281
NR5A1 nuclear receptor subfamily 5, group A, member 1 3.281
TMEM31 transmembrane protein 31 3.281
GPR68 G protein-coupled receptor 68 3.281
PENK proenkephalin 3.281
HIGD2B HIG1 hypoxia inducible domain family, member 2B 3.281
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 3.281
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 3.281
SLITRK6 SLIT and NTRK-like family, member 6 3.281
KCNK4 potassium channel, two pore domain subfamily K, member 4 3.281
LRRC43 leucine rich repeat containing 43 3.281
ALAS2 5'-aminolevulinate synthase 2 3.281
NR2E1 nuclear receptor subfamily 2, group E, member 1 3.281
PTGDR prostaglandin D2 receptor (DP) 3.281
NGB neuroglobin 3.281
BMX BMX non-receptor tyrosine kinase 3.281
SCN3B sodium channel, voltage gated, type III beta subunit 3.281
EPX eosinophil peroxidase 3.281
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 3.281
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 3.281
KRT15 keratin 15, type I 3.281
TMIGD2 transmembrane and immunoglobulin domain containing 2 3.281
MR1 major histocompatibility complex, class I-related 3.281
HSPB9 heat shock protein, alpha-crystallin-related, B9 3.281
RERGL RERG/RAS-like 3.281
FGF18 fibroblast growth factor 18 3.281
PATE2 prostate and testis expressed 2 3.281
BTNL2 butyrophilin-like 2 3.281
HHIPL2 HHIP-like 2 3.281
TNR tenascin R 3.281
TBC1D28 TBC1 domain family, member 28 3.281
MAPK11 mitogen-activated protein kinase 11 3.281
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 3.281
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 3.18017
ARFGEF3 ARFGEF family member 3 3.05791
GPR20 G protein-coupled receptor 20 2.89972
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 2.89972
TSPAN33 tetraspanin 33 2.86275
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 2.80786
RUNX1 runt-related transcription factor 1 2.78841
SAMD1 sterile alpha motif domain containing 1 2.7048
THBS2 thrombospondin 2 2.69637
LTC4S leukotriene C4 synthase 2.68232
NTPCR nucleoside-triphosphatase, cancer-related 2.63403
ARF1 ADP-ribosylation factor 1 2.57269
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 2.54984
NPNT nephronectin 2.49099
ALOX15 arachidonate 15-lipoxygenase 2.49099
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 2.49099
MORC2 MORC family CW-type zinc finger 2 2.4702
SNTG2 syntrophin, gamma 2 2.44914
C11ORF98 chromosome 11 open reading frame 98 2.43551
MRPS36 mitochondrial ribosomal protein S36 2.41058
CNBP CCHC-type zinc finger, nucleic acid binding protein 2.39536
DCTN2 dynactin 2 (p50) 2.35531
CRACR2A calcium release activated channel regulator 2A 2.34545
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) 2.34173
MAGEE1 melanoma antigen family E1 2.34076
PSPN persephin 2.33617
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.33219
ZC3H13 zinc finger CCCH-type containing 13 2.33219
LRRC36 leucine rich repeat containing 36 2.3093
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 2.22264
PCYOX1L prenylcysteine oxidase 1 like 2.22264
HOOK2 hook microtubule-tethering protein 2 2.19631
CLCNKB chloride channel, voltage-sensitive Kb 2.19426
BHMT betaine--homocysteine S-methyltransferase 2.19426
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 2.19426
STX19 syntaxin 19 2.19426
LMX1B LIM homeobox transcription factor 1, beta 2.19108
PGAP4 post-GPI attachment to proteins GalNAc transferase 4 2.18829
PGK1 phosphoglycerate kinase 1 2.18829
AASS aminoadipate-semialdehyde synthase 2.18829
FSD1 fibronectin type III and SPRY domain containing 1 2.18675
SLF1 SMC5-SMC6 complex localization factor 1 2.17084
NAXD NAD(P)HX dehydratase 2.16729
VARS1 valyl-tRNA synthetase 1 2.16083
SGK3 serum/glucocorticoid regulated kinase family, member 3 2.15
TLCD2 TLC domain containing 2 2.1481
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 2.13282
ZNF382 zinc finger protein 382 2.11974
SAMM50 SAMM50 sorting and assembly machinery component 2.11974
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A 2.11974
NCDN neurochondrin 2.11046
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 2.10928
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 2.1005
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) 2.07682
PRELID3B PRELI domain containing 3B 2.07201
MPDU1 mannose-P-dolichol utilization defect 1 2.05215
HMGA1 high mobility group AT-hook 1 2.01544
ADGRL2 adhesion G protein-coupled receptor L2 2.00917
BUB3 BUB3 mitotic checkpoint protein 2.00496
RENBP renin binding protein 2.00124

decreased expression

Symbol Name Standardized Value
PRRT4 proline-rich transmembrane protein 4 -3.281
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) -3.281
SPATS1 spermatogenesis associated, serine-rich 1 -3.281
ZNF804B zinc finger protein 804B -3.281
FAM161B family with sequence similarity 161, member B -3.281
R3HDML R3H domain containing-like -3.281
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 -3.281
CORIN corin, serine peptidase -3.281
GPAT3 glycerol-3-phosphate acyltransferase 3 -3.281
ITPKA inositol-trisphosphate 3-kinase A -3.281
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 -3.281
MYH2 myosin, heavy chain 2, skeletal muscle, adult -3.281
DLL4 delta-like 4 (Drosophila) -3.281
IL5RA interleukin 5 receptor, alpha -3.281
LECT2 leukocyte cell-derived chemotaxin 2 -3.281
SLC25A45 solute carrier family 25, member 45 -3.281
TMEM179 transmembrane protein 179 -3.281
CD300A CD300a molecule -3.281
NEU4 sialidase 4 -3.281
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic -3.281
DUSP8 dual specificity phosphatase 8 -3.281
MGARP mitochondria-localized glutamic acid-rich protein -3.281
RDH16 retinol dehydrogenase 16 (all-trans) -3.281
OTP orthopedia homeobox -3.281
LY96 lymphocyte antigen 96 -3.281
ACP7 acid phosphatase 7, tartrate resistant (putative) -3.281
KLF9 Kruppel-like factor 9 -3.281
CBX7 chromobox homolog 7 -3.281
CAGE1 cancer antigen 1 -3.281
SCNN1D sodium channel, non voltage gated 1 delta subunit -3.281
KLHDC8A kelch domain containing 8A -3.281
CCNI2 cyclin I family, member 2 -3.281
EXTL1 exostosin-like glycosyltransferase 1 -3.281
RNF112 ring finger protein 112 -3.281
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 -3.281
DEFB131B defensin beta 131B -3.281
SEZ6L seizure related 6 homolog (mouse)-like -3.281
KLHL14 kelch-like family member 14 -3.18017
CLTCL1 clathrin, heavy chain-like 1 -3.11964
ATP7A ATPase, Cu++ transporting, alpha polypeptide -3.04532
WWOX WW domain containing oxidoreductase -3.003
ABHD16A abhydrolase domain containing 16A -2.99027
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -2.81002
MAGEF1 melanoma antigen family F1 -2.78907
C12ORF43 chromosome 12 open reading frame 43 -2.78177
RUMY1 regulator of UNG2 and MKLN1 interacting yippee protein 1 -2.77406
RUNDC3A RUN domain containing 3A -2.77383
SH2D2A SH2 domain containing 2A -2.77078
HDAC9 histone deacetylase 9 -2.5583
BLTP2 bridge-like lipid transfer protein family member 2 -2.54642
LINGO1 leucine rich repeat and Ig domain containing 1 -2.51675
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 -2.50968
SMCO2 single-pass membrane protein with coiled-coil domains 2 -2.50968
ZNF518A zinc finger protein 518A -2.48345
THAP12 THAP domain containing 12 -2.44914
VWC2L von Willebrand factor C domain containing protein 2-like -2.44914
GRAMD1B GRAM domain containing 1B -2.41858
GAGE10 G antigen 10 -2.38701
BTN1A1 butyrophilin, subfamily 1, member A1 -2.38701
CSMD2 CUB and Sushi multiple domains 2 -2.37642
TSEN34 TSEN34 tRNA splicing endonuclease subunit -2.32806
TRNP1 TMF1-regulated nuclear protein 1 -2.31431
CHCHD1 coiled-coil-helix-coiled-coil-helix domain containing 1 -2.31052
NAGS N-acetylglutamate synthase -2.298
EVA1C eva-1 homolog C (C. elegans) -2.29205
STAT1 signal transducer and activator of transcription 1, 91kDa -2.29025
CDC73 cell division cycle 73 -2.2711
SPTLC3 serine palmitoyltransferase, long chain base subunit 3 -2.26544
NBPF8 neuroblastoma breakpoint family, member 8 -2.26544
AGBL5 ATP/GTP binding protein-like 5 -2.24777
MCRIP2 MAPK regulated corepressor interacting protein 2 -2.246
SUCO SUN domain containing ossification factor -2.22264
TARBP2 TAR (HIV-1) RNA binding protein 2 -2.22264
C12ORF42 chromosome 12 open reading frame 42 -2.22225
SLA2 Src-like-adaptor 2 -2.22225
NWD1 NACHT and WD repeat domain containing 1 -2.19631
DYNLT5 dynein light chain Tctex-type family member 5 -2.19631
ZNF582 zinc finger protein 582 -2.19631
ANGPT4 angiopoietin 4 -2.18675
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha -2.18675
VSTM2B V-set and transmembrane domain containing 2B -2.18675
TBPL1 TBP-like 1 -2.17481
PDZD11 PDZ domain containing 11 -2.13621
ZNF74 zinc finger protein 74 -2.136
PRMT2IP PRMT2 interacting protein -2.0901
ZBTB8B zinc finger and BTB domain containing 8B -2.08087
RBP2 retinol binding protein 2, cellular -2.07201
GABRR3 gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene) -2.03886
ZBTB35 zinc finger and BTB domain containing 35 -2.03158
CDC27 cell division cycle 27 -2.02129
CSE1L CSE1 chromosome segregation 1-like (yeast) -2.02129
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 -2.00882
TMEM98 transmembrane protein 98 -2.00859
LRRC51 leucine rich repeat containing 51 -2.00769