STAT2 Gene Set

Dataset ENCODE Transcription Factor Targets
Category genomics
Type transcription factor
Description signal transducer and activator of transcription 2, 113kDa|The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] (NCBI Entrez Gene Database, 6773)
External Link http://www.ncbi.nlm.nih.gov/gene/6773
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Genes

249 target genes of the STAT2 transcription factor in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.

Symbol Name
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ACAA1 acetyl-CoA acyltransferase 1
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6
ADPRHL2 ADP-ribosylhydrolase like 2
AIM2 absent in melanoma 2
AKT2 v-akt murine thymoma viral oncogene homolog 2
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANKRD45 ankyrin repeat domain 45
ANXA2R annexin A2 receptor
APOL1 apolipoprotein L, 1
APOL2 apolipoprotein L, 2
APOL6 apolipoprotein L, 6
ARHGAP11B Rho GTPase activating protein 11B
ARL5B ADP-ribosylation factor-like 5B
ARRDC4 arrestin domain containing 4
ATP13A1 ATPase type 13A1
AZI2 5-azacytidine induced 2
B2M beta-2-microglobulin
BAG1 BCL2-associated athanogene
BAK1 BCL2-antagonist/killer 1
BATF2 basic leucine zipper transcription factor, ATF-like 2
BLZF1 basic leucine zipper nuclear factor 1
BRCA2 breast cancer 2, early onset
BST2 bone marrow stromal cell antigen 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C14ORF159 chromosome 14 open reading frame 159
C17ORF62 chromosome 17 open reading frame 62
C19ORF66 chromosome 19 open reading frame 66
C5ORF56 chromosome 5 open reading frame 56
C6ORF48 chromosome 6 open reading frame 48
CBX3 chromobox homolog 3
CCDC9 coiled-coil domain containing 9
CD274 CD274 molecule
CD33 CD33 molecule
CD68 CD68 molecule
CDK17 cyclin-dependent kinase 17
CHMP5 charged multivesicular body protein 5
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
CMTR1 cap methyltransferase 1
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CREBRF CREB3 regulatory factor
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSF1 colony stimulating factor 1 (macrophage)
CUTA cutA divalent cation tolerance homolog (E. coli)
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DCLRE1C DNA cross-link repair 1C
DCP1A decapping mRNA 1A
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
DGCR8 DGCR8 microprocessor complex subunit
DGKE diacylglycerol kinase, epsilon 64kDa
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DTX3L deltex 3 like, E3 ubiquitin ligase
EARS2 glutamyl-tRNA synthetase 2, mitochondrial
ECE1 endothelin converting enzyme 1
EHD4 EH-domain containing 4
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ENY2 enhancer of yellow 2 homolog (Drosophila)
EPSTI1 epithelial stromal interaction 1 (breast)
EXOSC9 exosome component 9
FAM20B family with sequence similarity 20, member B
FAM46A family with sequence similarity 46, member A
FBXO36 F-box protein 36
FOXP1 forkhead box P1
GCLM glutamate-cysteine ligase, modifier subunit
GMPR guanosine monophosphate reductase
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4
GNG5 guanine nucleotide binding protein (G protein), gamma 5
GSTK1 glutathione S-transferase kappa 1
GTPBP2 GTP binding protein 2
HELZ2 helicase with zinc finger 2, transcriptional coactivator
HEMGN hemogen
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HEXDC hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing
HIRA histone cell cycle regulator
HLA-E major histocompatibility complex, class I, E
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPR heterogeneous nuclear ribonucleoprotein R
HSPA1L heat shock 70kDa protein 1-like
ICAM1 intercellular adhesion molecule 1
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
IFI35 interferon-induced protein 35
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IRF1 interferon regulatory factor 1
IRF2 interferon regulatory factor 2
IRF7 interferon regulatory factor 7
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
KCTD14 potassium channel tetramerization domain containing 14
KIF2A kinesin heavy chain member 2A
KLHL6 kelch-like family member 6
KMT2E lysine (K)-specific methyltransferase 2E
LAP3 leucine aminopeptidase 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGALS9 lectin, galactoside-binding, soluble, 9
LINC01011 long intergenic non-protein coding RNA 1011
LNPEP leucyl/cystinyl aminopeptidase
LOC153684 uncharacterized LOC153684
LOC648691
LOC728743 zinc finger protein pseudogene
MAD2L1BP MAD2L1 binding protein
MAGOHB mago-nashi homolog B (Drosophila)
MAK male germ cell-associated kinase
MDC1 mediator of DNA-damage checkpoint 1
MED16 mediator complex subunit 16
MIR1205 microRNA 1205
MIR17 microRNA 17
MIR18A microRNA 18a
MIR19A microRNA 19a
MIR19B1 microRNA 19b-1
MIR20A microRNA 20a
MIR4529 microRNA 4529
MIR4738 microRNA 4738
MIR641 microRNA 641
MIR92A1 microRNA 92a-1
MIR92B microRNA 92b
MOV10 Mov10 RISC complex RNA helicase
MRPL40 mitochondrial ribosomal protein L40
MT2A metallothionein 2A
MUC1 mucin 1, cell surface associated
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
MYD88 myeloid differentiation primary response 88
N4BP1 NEDD4 binding protein 1
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative)
NADK NAD kinase
NAMPT nicotinamide phosphoribosyltransferase
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha
NBN nibrin
NCOA7 nuclear receptor coactivator 7
NKAIN1 Na+/K+ transporting ATPase interacting 1
NME7 NME/NM23 family member 7
NMI N-myc (and STAT) interactor
NUDCD1 NudC domain containing 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OASL 2'-5'-oligoadenylate synthetase-like
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
OGFR opioid growth factor receptor
PARP10 poly (ADP-ribose) polymerase family, member 10
PARP12 poly (ADP-ribose) polymerase family, member 12
PARP14 poly (ADP-ribose) polymerase family, member 14
PARP9 poly (ADP-ribose) polymerase family, member 9
PGAM1 phosphoglycerate mutase 1 (brain)
PHF11 PHD finger protein 11
PI4K2B phosphatidylinositol 4-kinase type 2 beta
PLSCR1 phospholipid scramblase 1
PML promyelocytic leukemia
PNPT1 polyribonucleotide nucleotidyltransferase 1
PNRC2 proline-rich nuclear receptor coactivator 2
POLR1B polymerase (RNA) I polypeptide B, 128kDa
POU3F2 POU class 3 homeobox 2
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PRAME preferentially expressed antigen in melanoma
PRKCE protein kinase C, epsilon
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
RANBP1 RAN binding protein 1
RBBP6 retinoblastoma binding protein 6
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RBM43 RNA binding motif protein 43
RFC2 replication factor C (activator 1) 2, 40kDa
RNU11 RNA, U11 small nuclear
RSAD2 radical S-adenosyl methionine domain containing 2
RTP4 receptor (chemosensory) transporter protein 4
SAMD9 sterile alpha motif domain containing 9
SAMD9L sterile alpha motif domain containing 9-like
SAMHD1 SAM domain and HD domain 1
SAP130 Sin3A-associated protein, 130kDa
SCAMP1 secretory carrier membrane protein 1
SCN9A sodium channel, voltage gated, type IX alpha subunit
SCYL3 SCY1-like 3 (S. cerevisiae)
SDE2 SDE2 telomere maintenance homolog (S. pombe)
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
SLC25A44 solute carrier family 25, member 44
SLFN12 schlafen family member 12
SLFN5 schlafen family member 5
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
SNORA67 small nucleolar RNA, H/ACA box 67
SNORD12B small nucleolar RNA, C/D box 12B
SNORD12C small nucleolar RNA, C/D box 12C
SNORD48 small nucleolar RNA, C/D box 48
SOCS1 suppressor of cytokine signaling 1
SP100 SP100 nuclear antigen
SP110 SP110 nuclear body protein
SP140L SP140 nuclear body protein-like
SSBP1 single-stranded DNA binding protein 1, mitochondrial
SSR1 signal sequence receptor, alpha
STARD5 StAR-related lipid transfer (START) domain containing 5
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STX16 syntaxin 16
STX16-NPEPL1 STX16-NPEPL1 readthrough (NMD candidate)
SYNGAP1 synaptic Ras GTPase activating protein 1
TDRD7 tudor domain containing 7
TMEM140 transmembrane protein 140
TMEM62 transmembrane protein 62
TMPO thymopoietin
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TOR1AIP1 torsin A interacting protein 1
TRIM14 tripartite motif containing 14
TRIM21 tripartite motif containing 21
TRIM22 tripartite motif containing 22
TRIM25 tripartite motif containing 25
TRIM38 tripartite motif containing 38
TRIM5 tripartite motif containing 5
TRIM56 tripartite motif containing 56
TRIP12 thyroid hormone receptor interactor 12
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TXNIP thioredoxin interacting protein
UBA7 ubiquitin-like modifier activating enzyme 7
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UBFD1 ubiquitin family domain containing 1
UBR1 ubiquitin protein ligase E3 component n-recognin 1
UNC93B1 unc-93 homolog B1 (C. elegans)
UNK unkempt family zinc finger
USF1 upstream transcription factor 1
USP18 ubiquitin specific peptidase 18
WARS tryptophanyl-tRNA synthetase
WBP4 WW domain binding protein 4
WDR25 WD repeat domain 25
XAF1 XIAP associated factor 1
XRN1 5'-3' exoribonuclease 1
YDJC YdjC homolog (bacterial)
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZFAS1 ZNFX1 antisense RNA 1
ZNF107 zinc finger protein 107
ZNFX1 zinc finger, NFX1-type containing 1
ZSCAN31 zinc finger and SCAN domain containing 31