| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | signal transducer and activator of transcription 2, 113kDa|The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] (NCBI Entrez Gene Database, 6773) |
| External Link | https://ncbi.nlm.nih.gov/gene/6773 |
| Similar Terms | |
| Downloads & Tools |
500 genes differentially expressed following the STAT2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0414534 |
| PEG10 | paternally expressed 10 | 0.0173641 |
| DNMT3A | DNA (cytosine-5-)-methyltransferase 3 alpha | 0.0160926 |
| KRT14 | keratin 14, type I | 0.0142618 |
| NVL | nuclear VCP-like | 0.0122093 |
| FN1 | fibronectin 1 | 0.0118055 |
| HTRA1 | HtrA serine peptidase 1 | 0.0116949 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0116258 |
| STC2 | stanniocalcin 2 | 0.0110752 |
| SYNGR3 | synaptogyrin 3 | 0.01097 |
| S100A7 | S100 calcium binding protein A7 | 0.0108522 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | 0.0103682 |
| CSTA | cystatin A (stefin A) | 0.0103341 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0103255 |
| PXDN | peroxidasin | 0.0101781 |
| CD9 | CD9 molecule | 0.00976863 |
| COCH | cochlin | 0.00958227 |
| ASS1 | argininosuccinate synthase 1 | 0.00957096 |
| CST6 | cystatin E/M | 0.00938844 |
| CRABP2 | cellular retinoic acid binding protein 2 | 0.00914984 |
| CRCT1 | cysteine-rich C-terminal 1 | 0.00900477 |
| TMEM45A | transmembrane protein 45A | 0.00886034 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 0.00879977 |
| SPRR1B | small proline-rich protein 1B | 0.00879874 |
| RFTN1 | raftlin, lipid raft linker 1 | 0.00866299 |
| CALML5 | calmodulin-like 5 | 0.00859532 |
| KLK5 | kallikrein-related peptidase 5 | 0.00856401 |
| POLG2 | polymerase (DNA directed), gamma 2, accessory subunit | 0.00855359 |
| GLOD4 | glyoxalase domain containing 4 | 0.00853821 |
| DLK1 | delta-like 1 homolog (Drosophila) | 0.00850524 |
| NEFH | neurofilament, heavy polypeptide | 0.00848957 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.00848017 |
| MS4A1 | membrane-spanning 4-domains, subfamily A, member 1 | 0.0084066 |
| HSPA1A | heat shock 70kDa protein 1A | 0.00838235 |
| WT1 | Wilms tumor 1 | 0.00830492 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | 0.00821629 |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | 0.00809435 |
| PRPF4 | pre-mRNA processing factor 4 | 0.00809025 |
| CTSD | cathepsin D | 0.00804287 |
| CRYBG1 | crystallin beta-gamma domain containing 1 | 0.00798786 |
| KRT16 | keratin 16, type I | 0.0078585 |
| TYRP1 | tyrosinase-related protein 1 | 0.0078102 |
| EFHD1 | EF-hand domain family, member D1 | 0.00765462 |
| NSG1 | neuron specific gene family member 1 | 0.00763807 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | 0.00759836 |
| KRT1 | keratin 1, type II | 0.00752676 |
| CA12 | carbonic anhydrase XII | 0.00751745 |
| DDX21 | DEAD (Asp-Glu-Ala-Asp) box helicase 21 | 0.00744342 |
| GPX7 | glutathione peroxidase 7 | 0.00742311 |
| KRT5 | keratin 5, type II | 0.00740075 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | 0.00736777 |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 | 0.00730331 |
| S100A9 | S100 calcium binding protein A9 | 0.00729876 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | 0.00728424 |
| S100A8 | S100 calcium binding protein A8 | 0.00723267 |
| IGSF3 | immunoglobulin superfamily, member 3 | 0.00722788 |
| COL6A3 | collagen, type VI, alpha 3 | 0.00720909 |
| SWAP70 | SWAP switching B-cell complex 70kDa subunit | 0.00718445 |
| NPIPB3 | nuclear pore complex interacting protein family, member B3 | 0.00717032 |
| TTC39A | tetratricopeptide repeat domain 39A | 0.007167 |
| FGG | fibrinogen gamma chain | 0.00712956 |
| CYB5A | cytochrome b5 type A (microsomal) | 0.00708963 |
| NXN | nucleoredoxin | 0.00707453 |
| HOPX | HOP homeobox | 0.00703298 |
| KRT17 | keratin 17, type I | 0.00700423 |
| HAL | histidine ammonia-lyase | 0.00690861 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.00689907 |
| MEF2C | myocyte enhancer factor 2C | 0.00686457 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 0.00685168 |
| RNF167 | ring finger protein 167 | 0.00684584 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.00682948 |
| TSPYL5 | TSPY-like 5 | 0.0068259 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | 0.0068181 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | 0.00676887 |
| AZU1 | azurocidin 1 | 0.00669312 |
| JADE3 | jade family PHD finger 3 | 0.00666081 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 0.00665165 |
| SCUBE2 | signal peptide, CUB domain, EGF-like 2 | 0.00663573 |
| LOR | loricrin | 0.00662077 |
| SFTPB | surfactant protein B | 0.00658219 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 0.00656701 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.00655826 |
| RHCG | Rh family, C glycoprotein | 0.00655133 |
| PEG3 | paternally expressed 3 | 0.00654847 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.00654215 |
| KRT6A | keratin 6A, type II | 0.00650851 |
| NOP53 | NOP53 ribosome biogenesis factor | 0.00646751 |
| ELOVL4 | ELOVL fatty acid elongase 4 | 0.00646488 |
| GNG5 | guanine nucleotide binding protein (G protein), gamma 5 | 0.00646067 |
| GM2A | GM2 ganglioside activator | 0.00644292 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.00641307 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.00639767 |
| SELE | selectin E | 0.00638894 |
| IER5 | immediate early response 5 | 0.00635033 |
| OPN3 | opsin 3 | 0.00631836 |
| AGO3 | argonaute RISC catalytic component 3 | 0.00631417 |
| AMOTL2 | angiomotin like 2 | 0.00628932 |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | 0.0062856 |
| POLR2L | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa | 0.00626723 |
| HSPA8 | heat shock 70kDa protein 8 | 0.00623454 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.00620876 |
| PPL | periplakin | 0.00617316 |
| KLK7 | kallikrein-related peptidase 7 | 0.00616414 |
| ICAM2 | intercellular adhesion molecule 2 | 0.00615758 |
| XIC | X chromosome inactivation center | 0.00612044 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.00610175 |
| MATN2 | matrilin 2 | 0.00603929 |
| WASL | Wiskott-Aldrich syndrome-like | 0.00599964 |
| NAV2 | neuron navigator 2 | 0.00599306 |
| SGCE | sarcoglycan, epsilon | 0.00596444 |
| SPRR2B | small proline-rich protein 2B | 0.00595325 |
| GALNT14 | polypeptide N-acetylgalactosaminyltransferase 14 | 0.00593452 |
| RAB38 | RAB38, member RAS oncogene family | 0.00591533 |
| MYBPC1 | myosin binding protein C, slow type | 0.00591014 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.00588676 |
| SEPHS2 | selenophosphate synthetase 2 | 0.00587994 |
| FAM110B | family with sequence similarity 110, member B | 0.00586354 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.00585476 |
| S100A14 | S100 calcium binding protein A14 | 0.00584983 |
| CKM | creatine kinase, muscle | 0.00584601 |
| EFNA1 | ephrin-A1 | 0.0058445 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | 0.00582981 |
| CTSA | cathepsin A | 0.0058292 |
| SOAT1 | sterol O-acyltransferase 1 | 0.00580963 |
| EGFL6 | EGF-like-domain, multiple 6 | 0.00571916 |
| DCLK1 | doublecortin-like kinase 1 | 0.00571038 |
| VAMP8 | vesicle-associated membrane protein 8 | 0.00570555 |
| KCNN2 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 | 0.00570248 |
| BCAT2 | branched chain amino-acid transaminase 2, mitochondrial | 0.00566991 |
| CCN3 | cellular communication network factor 3 | 0.00566681 |
| SHROOM2 | shroom family member 2 | 0.00563535 |
| CCDC88A | coiled-coil domain containing 88A | 0.00562358 |
| ZNF185 | zinc finger protein 185 (LIM domain) | 0.00562355 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.00561146 |
| POSTN | periostin, osteoblast specific factor | 0.00560057 |
| KRT15 | keratin 15, type I | 0.00559485 |
| PKP1 | plakophilin 1 | 0.00558914 |
| FOSL2 | FOS-like antigen 2 | 0.00558177 |
| ESF1 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) | 0.00557225 |
| QPRT | quinolinate phosphoribosyltransferase | 0.00553931 |
| GUSBP3 | glucuronidase, beta pseudogene 3 | 0.00552093 |
| GRN | granulin | 0.00550655 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | 0.00548488 |
| RBM26 | RNA binding motif protein 26 | 0.00548053 |
| ZBED2 | zinc finger, BED-type containing 2 | 0.00546235 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.00546084 |
| DHCR24 | 24-dehydrocholesterol reductase | 0.00545686 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.00545531 |
| LITAF | lipopolysaccharide-induced TNF factor | 0.00545473 |
| CTH | cystathionine gamma-lyase | 0.00544515 |
| C1ORF50 | chromosome 1 open reading frame 50 | 0.00542994 |
| ARMCX6 | armadillo repeat containing, X-linked 6 | 0.00542191 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | 0.0054181 |
| ACTA1 | actin, alpha 1, skeletal muscle | 0.00541587 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.00541211 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.00540046 |
| SIRT3 | sirtuin 3 | 0.00538896 |
| OXTR | oxytocin receptor | 0.00538383 |
| IVL | involucrin | 0.00537382 |
| MNT | MAX network transcriptional repressor | 0.00535908 |
| MICAL1 | microtubule associated monooxygenase, calponin and LIM domain containing 1 | 0.00535755 |
| PMEL | premelanosome protein | 0.00534728 |
| GTF2H2B | general transcription factor IIH, polypeptide 2B (pseudogene) | 0.00533171 |
| SCEL | sciellin | 0.00532839 |
| EREG | epiregulin | 0.00532814 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | 0.00532812 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0053215 |
| CTSG | cathepsin G | 0.00530836 |
| ABCA3 | ATP-binding cassette, sub-family A (ABC1), member 3 | 0.00530651 |
| INTS6 | integrator complex subunit 6 | 0.00529749 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.00529733 |
| C14ORF132 | chromosome 14 open reading frame 132 | 0.00528827 |
| CTSV | cathepsin V | 0.00525042 |
| HAUS3 | HAUS augmin-like complex, subunit 3 | 0.00523825 |
| CD22 | CD22 molecule | 0.00523395 |
| SOCS2 | suppressor of cytokine signaling 2 | 0.00518674 |
| ANKRD11 | ankyrin repeat domain 11 | 0.00518157 |
| UBAP2 | ubiquitin associated protein 2 | 0.00517745 |
| SPINK5 | serine peptidase inhibitor, Kazal type 5 | 0.00516895 |
| WDR26 | WD repeat domain 26 | 0.00514672 |
| PTK2B | protein tyrosine kinase 2 beta | 0.00514012 |
| CNIH4 | cornichon family AMPA receptor auxiliary protein 4 | 0.00513856 |
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 | 0.00513758 |
| PARD3 | par-3 family cell polarity regulator | 0.00513684 |
| RRAGC | Ras-related GTP binding C | 0.00513492 |
| ASCC1 | activating signal cointegrator 1 complex subunit 1 | 0.00513066 |
| SIKE1 | suppressor of IKBKE 1 | 0.00512214 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0051207 |
| TP73-AS1 | TP73 antisense RNA 1 | 0.00511701 |
| KIF1A | kinesin family member 1A | 0.00510702 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.00510581 |
| EMX2 | empty spiracles homeobox 2 | 0.00509022 |
| DSG1 | desmoglein 1 | 0.00508257 |
| UGT2B17 | UDP glucuronosyltransferase 2 family, polypeptide B17 | 0.00506449 |
| LOC283683 | uncharacterized LOC283683 | 0.00506215 |
| ZNF750 | zinc finger protein 750 | 0.00505707 |
| ZBTB10 | zinc finger and BTB domain containing 10 | 0.00505698 |
| MLPH | melanophilin | 0.00504208 |
| MMP13 | matrix metallopeptidase 13 | 0.005036 |
| ENAH | enabled homolog (Drosophila) | 0.00500068 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0050005 |
| APOD | apolipoprotein D | 0.00497954 |
| EIF3L | eukaryotic translation initiation factor 3, subunit L | 0.00497104 |
| SPATA20 | spermatogenesis associated 20 | 0.00497028 |
| CALML3 | calmodulin-like 3 | 0.00496957 |
| PLA1A | phospholipase A1 member A | 0.00496483 |
| CDSN | corneodesmosin | 0.00496181 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | 0.00496057 |
| MYO1B | myosin IB | 0.00495221 |
| HOMER3 | homer scaffolding protein 3 | 0.00494766 |
| CCND2 | cyclin D2 | 0.00494705 |
| CWH43 | cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) | 0.00494377 |
| RPN2 | ribophorin II | 0.00494294 |
| CHRNA9 | cholinergic receptor, nicotinic, alpha 9 (neuronal) | 0.00493086 |
| MAFG | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G | 0.0049218 |
| COL4A3 | collagen, type IV, alpha 3 (Goodpasture antigen) | 0.00492076 |
| ZNF43 | zinc finger protein 43 | 0.00491664 |
| PKD1P1 | polycystic kidney disease 1 (autosomal dominant) pseudogene 1 | 0.00491524 |
| ZIC1 | Zic family member 1 | 0.00491493 |
| GPR137B | G protein-coupled receptor 137B | 0.00490925 |
| SEMA4C | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C | 0.00490233 |
| FLRT3 | fibronectin leucine rich transmembrane protein 3 | 0.00489836 |
| EP300 | E1A binding protein p300 | 0.00489434 |
| KLHL24 | kelch-like family member 24 | 0.00489072 |
| NPY | neuropeptide Y | 0.00488549 |
| DEFB1 | defensin, beta 1 | 0.00488292 |
| YBX3 | Y box binding protein 3 | 0.00488183 |
| COL4A5 | collagen, type IV, alpha 5 | 0.00487794 |
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 | 0.00487292 |
| COG7 | component of oligomeric golgi complex 7 | 0.00487053 |
| ALOX15B | arachidonate 15-lipoxygenase, type B | 0.00485661 |
| RETREG2 | reticulophagy regulator family member 2 | 0.00482855 |
| CHRNA1 | cholinergic receptor, nicotinic, alpha 1 (muscle) | 0.00482331 |
| CDH3 | cadherin 3, type 1, P-cadherin (placental) | 0.00482255 |
| IPO13 | importin 13 | 0.00482064 |
| GDPD3 | glycerophosphodiester phosphodiesterase domain containing 3 | 0.00481959 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.00481699 |
| LBH | limb bud and heart development | 0.00481533 |
| SPRR1A | small proline-rich protein 1A | 0.00481148 |
| RHOD | ras homolog family member D | 0.00480168 |
| TUBB2B | tubulin, beta 2B class IIb | 0.00478255 |
| TCHH | trichohyalin | 0.00477925 |
| SVIL | supervillin | 0.00476906 |
| GPR143 | G protein-coupled receptor 143 | 0.00476251 |
| RGS20 | regulator of G-protein signaling 20 | 0.00476176 |
| ENO3 | enolase 3 (beta, muscle) | 0.0047551 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.00475243 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.00474964 |
| ZBTB35 | zinc finger and BTB domain containing 35 | 0.00474468 |
| TP53TG1 | TP53 target 1 (non-protein coding) | 0.00474447 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -0.0163981 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | -0.0152367 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | -0.0137206 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.013567 |
| GRIA2 | glutamate receptor, ionotropic, AMPA 2 | -0.0132538 |
| CFH | complement factor H | -0.0126229 |
| KRT19 | keratin 19, type I | -0.012147 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | -0.0121083 |
| UBE2S | ubiquitin-conjugating enzyme E2S | -0.0118884 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | -0.0118002 |
| IFI44L | interferon-induced protein 44-like | -0.0110552 |
| SFRP1 | secreted frizzled-related protein 1 | -0.010916 |
| REG1A | regenerating islet-derived 1 alpha | -0.0108929 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -0.0108852 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0108006 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0102316 |
| IFI44 | interferon-induced protein 44 | -0.0102221 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0100446 |
| C1R | complement component 1, r subcomponent | -0.00967805 |
| MAP7 | microtubule-associated protein 7 | -0.00959095 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.00953569 |
| LXN | latexin | -0.00951002 |
| NTS | neurotensin | -0.00950535 |
| SORD | sorbitol dehydrogenase | -0.00945952 |
| ZBTB18 | zinc finger and BTB domain containing 18 | -0.00937885 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.00934723 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.00925849 |
| PLSCR1 | phospholipid scramblase 1 | -0.00910712 |
| RNF128 | ring finger protein 128, E3 ubiquitin protein ligase | -0.00906448 |
| MDFIC | MyoD family inhibitor domain containing | -0.00898343 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | -0.00883115 |
| ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide | -0.00880523 |
| CFI | complement factor I | -0.00871294 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.00866941 |
| REG3A | regenerating islet-derived 3 alpha | -0.00859566 |
| SCD5 | stearoyl-CoA desaturase 5 | -0.00858703 |
| CCR2 | chemokine (C-C motif) receptor 2 | -0.00857031 |
| ASPH | aspartate beta-hydroxylase | -0.00856912 |
| PTK2 | protein tyrosine kinase 2 | -0.00855724 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.00852248 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.00850901 |
| EVI2A | ecotropic viral integration site 2A | -0.00849397 |
| MX1 | MX dynamin-like GTPase 1 | -0.00844662 |
| GALNT12 | polypeptide N-acetylgalactosaminyltransferase 12 | -0.00840705 |
| RTP4 | receptor (chemosensory) transporter protein 4 | -0.00831213 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.00826888 |
| FCGR2A | Fc fragment of IgG, low affinity IIa, receptor (CD32) | -0.00820537 |
| MS4A4A | membrane-spanning 4-domains, subfamily A, member 4A | -0.00819795 |
| LTF | lactotransferrin | -0.00817221 |
| C1S | complement component 1, s subcomponent | -0.00816186 |
| BTBD3 | BTB (POZ) domain containing 3 | -0.00814431 |
| CFB | complement factor B | -0.00807515 |
| TMEM176B | transmembrane protein 176B | -0.00805465 |
| MYRF | myelin regulatory factor | -0.00791934 |
| DUOX2 | dual oxidase 2 | -0.00788178 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.00783782 |
| CPVL | carboxypeptidase, vitellogenic-like | -0.00783284 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.00779971 |
| PAK1 | p21 protein (Cdc42/Rac)-activated kinase 1 | -0.00779023 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.00778017 |
| CD163 | CD163 molecule | -0.00775834 |
| PTTG1 | pituitary tumor-transforming 1 | -0.00771433 |
| GPX2 | glutathione peroxidase 2 | -0.00757561 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.00756364 |
| SDC2 | syndecan 2 | -0.00754047 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | -0.00754006 |
| GSTO1 | glutathione S-transferase omega 1 | -0.00738302 |
| CD48 | CD48 molecule | -0.00733446 |
| DCN | decorin | -0.00729328 |
| APOL1 | apolipoprotein L, 1 | -0.00725683 |
| TMEM176A | transmembrane protein 176A | -0.00725564 |
| HMGCS2 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) | -0.00723358 |
| GATM | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | -0.00723124 |
| ADD3 | adducin 3 (gamma) | -0.00722838 |
| CD2 | CD2 molecule | -0.00722544 |
| TXNIP | thioredoxin interacting protein | -0.00720565 |
| USP18 | ubiquitin specific peptidase 18 | -0.00717586 |
| ANKRD6 | ankyrin repeat domain 6 | -0.00713681 |
| MS4A6A | membrane-spanning 4-domains, subfamily A, member 6A | -0.00713618 |
| FGL2 | fibrinogen-like 2 | -0.00713337 |
| TLR1 | toll-like receptor 1 | -0.00711859 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | -0.00711813 |
| EPCAM | epithelial cell adhesion molecule | -0.007037 |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | -0.00703443 |
| C3 | complement component 3 | -0.00703416 |
| TFF1 | trefoil factor 1 | -0.00702561 |
| XAF1 | XIAP associated factor 1 | -0.0070199 |
| CHPT1 | choline phosphotransferase 1 | -0.00698235 |
| MX2 | MX dynamin-like GTPase 2 | -0.00697437 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0069694 |
| HCP5 | HLA complex P5 (non-protein coding) | -0.00696243 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | -0.00692603 |
| ALOX5 | arachidonate 5-lipoxygenase | -0.00691218 |
| RCAN1 | regulator of calcineurin 1 | -0.00690573 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.00690415 |
| PBK | PDZ binding kinase | -0.00689961 |
| CCNB1 | cyclin B1 | -0.00682762 |
| PLXNC1 | plexin C1 | -0.0067977 |
| HS3ST1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 | -0.00677157 |
| DCK | deoxycytidine kinase | -0.00673019 |
| ITGA6 | integrin, alpha 6 | -0.00671622 |
| SHTN1 | shootin 1 | -0.00670169 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.00667216 |
| FYB1 | FYN binding protein 1 | -0.00666677 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0066595 |
| CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | -0.00663996 |
| TSPAN8 | tetraspanin 8 | -0.00661325 |
| CCR5 | chemokine (C-C motif) receptor 5 (gene/pseudogene) | -0.00661228 |
| ADAM28 | ADAM metallopeptidase domain 28 | -0.00658696 |
| FCER1A | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide | -0.00658588 |
| P2RY14 | purinergic receptor P2Y, G-protein coupled, 14 | -0.00657883 |
| FOXF1 | forkhead box F1 | -0.00656742 |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa | -0.00656167 |
| SH3BP4 | SH3-domain binding protein 4 | -0.00653209 |
| CA9 | carbonic anhydrase IX | -0.00651426 |
| GOLGA8A | golgin A8 family, member A | -0.00648211 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.00646357 |
| CD300A | CD300a molecule | -0.00645219 |
| OLFM4 | olfactomedin 4 | -0.00641709 |
| PID1 | phosphotyrosine interaction domain containing 1 | -0.00641384 |
| CHN2 | chimerin 2 | -0.00640403 |
| LPAR6 | lysophosphatidic acid receptor 6 | -0.0063662 |
| MOCOS | molybdenum cofactor sulfurase | -0.00635971 |
| TMPRSS4 | transmembrane protease, serine 4 | -0.00633989 |
| ECI2 | enoyl-CoA delta isomerase 2 | -0.00632067 |
| CLEC4A | C-type lectin domain family 4, member A | -0.00629488 |
| PRDX2 | peroxiredoxin 2 | -0.00625011 |
| SPON1 | spondin 1, extracellular matrix protein | -0.00621815 |
| ATP10B | ATPase, class V, type 10B | -0.00619297 |
| CXCL11 | chemokine (C-X-C motif) ligand 11 | -0.00618134 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 | -0.00617601 |
| C3AR1 | complement component 3a receptor 1 | -0.00617384 |
| DEFA6 | defensin, alpha 6, Paneth cell-specific | -0.00616053 |
| CASP1 | caspase 1, apoptosis-related cysteine peptidase | -0.00614373 |
| OPHN1 | oligophrenin 1 | -0.00614209 |
| GPM6A | glycoprotein M6A | -0.00613614 |
| ANOS1 | anosmin 1 | -0.00613522 |
| CDC20 | cell division cycle 20 | -0.00612432 |
| JCHAIN | joining chain of multimeric IgA and IgM | -0.00610283 |
| GALC | galactosylceramidase | -0.00607847 |
| DACT1 | dishevelled-binding antagonist of beta-catenin 1 | -0.0060766 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.00607633 |
| PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 | -0.00606653 |
| SERPINA5 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | -0.00605254 |
| GLUL | glutamate-ammonia ligase | -0.00604396 |
| HNMT | histamine N-methyltransferase | -0.00604342 |
| ANXA10 | annexin A10 | -0.00603716 |
| ADAMDEC1 | ADAM-like, decysin 1 | -0.00602999 |
| TSPAN13 | tetraspanin 13 | -0.00602421 |
| AXL | AXL receptor tyrosine kinase | -0.00602381 |
| FCER1G | Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide | -0.00600135 |
| FCGR3B | Fc fragment of IgG, low affinity IIIb, receptor (CD16b) | -0.00599378 |
| DEFA5 | defensin, alpha 5, Paneth cell-specific | -0.00598952 |
| H2AX | H2A.X variant histone | -0.00598661 |
| PTCH1 | patched 1 | -0.00597649 |
| UGT8 | UDP glycosyltransferase 8 | -0.00596707 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | -0.00596493 |
| FBLN5 | fibulin 5 | -0.00594228 |
| PRIM1 | primase, DNA, polypeptide 1 (49kDa) | -0.00592722 |
| KDM5D | lysine (K)-specific demethylase 5D | -0.00592464 |
| TADA2A | transcriptional adaptor 2A | -0.0059212 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.00590786 |
| CP | ceruloplasmin (ferroxidase) | -0.00589255 |
| LPXN | leupaxin | -0.00588338 |
| SERPING1 | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | -0.00587506 |
| INHBA | inhibin, beta A | -0.00587332 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0058516 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | -0.00584504 |
| SLA | Src-like-adaptor | -0.00584468 |
| FZD6 | frizzled class receptor 6 | -0.00583724 |
| CLEC7A | C-type lectin domain family 7, member A | -0.00583636 |
| CYP2J2 | cytochrome P450, family 2, subfamily J, polypeptide 2 | -0.00583564 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.00583559 |
| WNT5A | wingless-type MMTV integration site family, member 5A | -0.00583511 |
| SPA17 | sperm autoantigenic protein 17 | -0.0058331 |
| SLAMF7 | SLAM family member 7 | -0.00582586 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.00581946 |
| IGF1 | insulin-like growth factor 1 (somatomedin C) | -0.00581932 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.00578845 |
| IFI35 | interferon-induced protein 35 | -0.00578503 |
| CLCN3 | chloride channel, voltage-sensitive 3 | -0.00578474 |
| NFE2L3 | nuclear factor, erythroid 2-like 3 | -0.00576412 |
| NSMCE4A | non-SMC element 4 homolog A (S. cerevisiae) | -0.00575165 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.00573517 |
| PLN | phospholamban | -0.00572894 |
| CDC45 | cell division cycle 45 | -0.00572328 |
| EHF | ets homologous factor | -0.00572187 |
| PLPP3 | phospholipid phosphatase 3 | -0.00571921 |
| LGALS4 | lectin, galactoside-binding, soluble, 4 | -0.00571637 |
| CPA3 | carboxypeptidase A3 (mast cell) | -0.00571335 |
| KRT20 | keratin 20, type I | -0.00570933 |
| CTSK | cathepsin K | -0.00570429 |
| ABHD10 | abhydrolase domain containing 10 | -0.00570293 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | -0.00568812 |
| E2F2 | E2F transcription factor 2 | -0.0056843 |
| EPHB2 | EPH receptor B2 | -0.00568105 |
| CCL11 | chemokine (C-C motif) ligand 11 | -0.00566948 |
| CD209 | CD209 molecule | -0.00566399 |
| GCK | glucokinase (hexokinase 4) | -0.00566039 |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | -0.00565541 |
| APOL6 | apolipoprotein L, 6 | -0.00564799 |
| SAMHD1 | SAM domain and HD domain 1 | -0.00563985 |
| GALNT3 | polypeptide N-acetylgalactosaminyltransferase 3 | -0.00562281 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | -0.00562203 |
| ERAP2 | endoplasmic reticulum aminopeptidase 2 | -0.00561868 |
| IGFBP6 | insulin-like growth factor binding protein 6 | -0.00559903 |
| MFAP5 | microfibrillar associated protein 5 | -0.00559879 |
| IDO1 | indoleamine 2,3-dioxygenase 1 | -0.00559342 |
| FGFR3 | fibroblast growth factor receptor 3 | -0.00558535 |
| SPINK4 | serine peptidase inhibitor, Kazal type 4 | -0.00557022 |
| THYN1 | thymocyte nuclear protein 1 | -0.0055699 |
| CENPX | centromere protein X | -0.00556784 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.00555519 |
| NAT1 | N-acetyltransferase 1 (arylamine N-acetyltransferase) | -0.00555517 |
| NELL2 | NEL-like 2 (chicken) | -0.00554007 |
| PLAT | plasminogen activator, tissue | -0.00553976 |
| MAN1C1 | mannosidase, alpha, class 1C, member 1 | -0.00553344 |
| CCN2 | cellular communication network factor 2 | -0.00552646 |
| TM4SF4 | transmembrane 4 L six family member 4 | -0.00551432 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | -0.00551414 |
| METTL7A | methyltransferase like 7A | -0.00550784 |
| GIMAP4 | GTPase, IMAP family member 4 | -0.00550567 |
| PLS1 | plastin 1 | -0.00549506 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.00549057 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | -0.00547705 |
| KIF20A | kinesin family member 20A | -0.00546633 |
| F13A1 | coagulation factor XIII, A1 polypeptide | -0.00546025 |
| ALDOB | aldolase B, fructose-bisphosphate | -0.00545988 |
| TCF12 | transcription factor 12 | -0.00545573 |
| NQO2 | NAD(P)H dehydrogenase, quinone 2 | -0.00543669 |
| MMP12 | matrix metallopeptidase 12 | -0.00543403 |
| DMBT1 | deleted in malignant brain tumors 1 | -0.00543056 |
| RNF130 | ring finger protein 130 | -0.00541987 |
| CCR1 | chemokine (C-C motif) receptor 1 | -0.0054192 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -0.00539894 |
| CEL | carboxyl ester lipase | -0.00538729 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.00537721 |
| SCARB2 | scavenger receptor class B, member 2 | -0.00537492 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | -0.00537005 |
| GPR171 | G protein-coupled receptor 171 | -0.00536743 |
| CFHR2 | complement factor H-related 2 | -0.00535727 |
| LUM | lumican | -0.00533738 |
| GIMAP5 | GTPase, IMAP family member 5 | -0.0053238 |
| CALML4 | calmodulin-like 4 | -0.00531674 |
| DUT | deoxyuridine triphosphatase | -0.00531646 |
| CCNG1 | cyclin G1 | -0.00530828 |
| UBA7 | ubiquitin-like modifier activating enzyme 7 | -0.00530817 |
| COL10A1 | collagen, type X, alpha 1 | -0.0053076 |
| GYPC | glycophorin C (Gerbich blood group) | -0.00530413 |
| GIMAP6 | GTPase, IMAP family member 6 | -0.00528387 |
