STAT3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description signal transducer and activator of transcription 3 (acute-phase response factor)|The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6774)
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Genes

308 genes differentially expressed following the STAT3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
NFILZ NFIL3 like basic leucine zipper 2.6874
TAL2 T-cell acute lymphocytic leukemia 2 2.6874
B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 2.6874
C11ORF16 chromosome 11 open reading frame 16 2.6874
SPINK9 serine peptidase inhibitor, Kazal type 9 2.6874
WNT9B wingless-type MMTV integration site family, member 9B 2.6874
GPR33 G protein-coupled receptor 33 (gene/pseudogene) 2.6874
MYH7 myosin, heavy chain 7, cardiac muscle, beta 2.6874
NEU4 sialidase 4 2.6874
APLN apelin 2.6874
PTGER4 prostaglandin E receptor 4 (subtype EP4) 2.6874
PLCD4 phospholipase C, delta 4 2.6874
PLET1 placenta expressed transcript 1 2.6874
S100A14 S100 calcium binding protein A14 2.6874
PHOX2A paired-like homeobox 2a 2.6874
GCM2 glial cells missing homolog 2 (Drosophila) 2.6874
ANGPTL5 angiopoietin-like 5 2.6874
C17ORF78 chromosome 17 open reading frame 78 2.6874
GCSAML germinal center-associated, signaling and motility-like 2.6874
GMFG glia maturation factor, gamma 2.6874
PTCRA pre T-cell antigen receptor alpha 2.6874
SPATA16 spermatogenesis associated 16 2.6874
FAM186A family with sequence similarity 186, member A 2.6874
SEZ6L seizure related 6 homolog (mouse)-like 2.66
PRICKLE3 prickle homolog 3 (Drosophila) 2.66
KREMEN2 kringle containing transmembrane protein 2 2.60184
RCSD1 RCSD domain containing 1 2.55882
GPHB5 glycoprotein hormone beta 5 2.55882
ARRDC5 arrestin domain containing 5 2.55882
RXFP3 relaxin/insulin-like family peptide receptor 3 2.55882
RGPD4 RANBP2-like and GRIP domain containing 4 2.55882
OR52H1 olfactory receptor, family 52, subfamily H, member 1 2.55882
CARD18 caspase recruitment domain family, member 18 2.55882
NRAP nebulin-related anchoring protein 2.55882
FOLR1 folate receptor 1 (adult) 2.55882
TPBGL trophoblast glycoprotein-like 2.55882
HBA2 hemoglobin, alpha 2 2.55882
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.55882
IL12RB1 interleukin 12 receptor, beta 1 2.55882
IL15RA interleukin 15 receptor, alpha 2.55882
TEX19 testis expressed 19 2.55882
OTUD6A OTU deubiquitinase 6A 2.55882
XCL1 chemokine (C motif) ligand 1 2.55882
RSPO3 R-spondin 3 2.55882
UMOD uromodulin 2.55882
ZBTB45 zinc finger and BTB domain containing 45 2.55882
GYPE glycophorin E (MNS blood group) 2.55882
GPR21 G protein-coupled receptor 21 2.55882
GPR22 G protein-coupled receptor 22 2.55882
SLC39A5 solute carrier family 39 (zinc transporter), member 5 2.55882
BLK BLK proto-oncogene, Src family tyrosine kinase 2.55882
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 2.55882
CABP4 calcium binding protein 4 2.55882
HAUS4 HAUS augmin-like complex, subunit 4 2.55882
TMEM132C transmembrane protein 132C 2.55882
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 2.55882
PRB2 proline-rich protein BstNI subfamily 2 2.55882
CCDC17 coiled-coil domain containing 17 2.55882
CALHM5 calcium homeostasis modulator family member 5 2.55882
SMIM33 small integral membrane protein 33 2.55882
FYB1 FYN binding protein 1 2.55882
TRPC7 transient receptor potential cation channel, subfamily C, member 7 2.55882
OR2T8 olfactory receptor, family 2, subfamily T, member 8 2.55882
LOC128125816 uncharacterized LOC128125816 2.55882
SMPX small muscle protein, X-linked 2.55882
GC group-specific component (vitamin D binding protein) 2.55882
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.55882
H2BC3 H2B clustered histone 3 2.55882
TBC1D3I TBC1 domain family member 3I 2.55882
LY6S-AS1 LY6S antisense RNA 1 2.55882
DRC3 dynein regulatory complex subunit 3 2.55882
PRRT1B proline rich transmembrane protein 1B 2.55882
PEAK3 PEAK family member 3 2.55882
CFAP276 cilia and flagella associated protein 276 2.55882
ARMH2 armadillo like helical domain containing 2 2.55882
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 2.55882
LY6K lymphocyte antigen 6 complex, locus K 2.55882
DYNLRB2 dynein, light chain, roadblock-type 2 2.55882
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.55882
LDHAL6B lactate dehydrogenase A-like 6B 2.55882
CBLN3 cerebellin 3 precursor 2.55882
OLAH oleoyl-ACP hydrolase 2.55882
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 2.55882
EDAR ectodysplasin A receptor 2.55882
NXPE4 neurexophilin and PC-esterase domain family, member 4 2.55882
IRF5 interferon regulatory factor 5 2.55882
PRKCE protein kinase C, epsilon 2.55882
TLR4 toll-like receptor 4 2.55882
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 2.55882
CNTN6 contactin 6 2.55882
FGFBP1 fibroblast growth factor binding protein 1 2.55882
BLNK B-cell linker 2.55882
NR0B1 nuclear receptor subfamily 0, group B, member 1 2.55882
ARMS2 age-related maculopathy susceptibility 2 2.55882
KLRF1 killer cell lectin-like receptor subfamily F, member 1 2.55882
DYM dymeclin 2.55882
ACKR5 atypical chemokine receptor 5 2.55882
C11ORF96 chromosome 11 open reading frame 96 2.55882
SLC22A24 solute carrier family 22, member 24 2.55882
PPY pancreatic polypeptide 2.55882
FEV FEV (ETS oncogene family) 2.55882
DUOXA1 dual oxidase maturation factor 1 2.55882
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 2.55882
IFT38 intraflagellar transport 38 2.55882
HCRT hypocretin (orexin) neuropeptide precursor 2.55882
VAV1 vav 1 guanine nucleotide exchange factor 2.55882
TMEM45B transmembrane protein 45B 2.55882
ARGFX arginine-fifty homeobox 2.55882
TGM7 transglutaminase 7 2.55882
KLK11 kallikrein-related peptidase 11 2.55882
KLK3 kallikrein-related peptidase 3 2.55882
HEPACAM hepatic and glial cell adhesion molecule 2.55882
ISL1 ISL LIM homeobox 1 2.55882
RORC RAR-related orphan receptor C 2.55882
KLHL1 kelch-like family member 1 2.55882
HSPA1L heat shock 70kDa protein 1-like 2.55882
C16ORF78 chromosome 16 open reading frame 78 2.55882
CERKL ceramide kinase-like 2.55882
CDH19 cadherin 19, type 2 2.55882
MAB21L3 mab-21-like 3 (C. elegans) 2.55882
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 2.55882
ZNF703 zinc finger protein 703 2.55882
CNTF ciliary neurotrophic factor 2.55882
APLNR apelin receptor 2.55882
KCNK4 potassium channel, two pore domain subfamily K, member 4 2.55882
ZNF735 zinc finger protein 735 2.55882
CYSLTR1 cysteinyl leukotriene receptor 1 2.55882
BAHCC1 BAH domain and coiled-coil containing 1 2.55882
ANGPTL3 angiopoietin-like 3 2.55882
SPINT4 serine peptidase inhibitor, Kunitz type 4 2.55882
BMP2 bone morphogenetic protein 2 2.55882
CSNK2A3 casein kinase 2, alpha 3 polypeptide 2.55882
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene) 2.55882
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 2.55882
GNG13 guanine nucleotide binding protein (G protein), gamma 13 2.55882
LRRIQ4 leucine-rich repeats and IQ motif containing 4 2.55882
MPL MPL proto-oncogene, thrombopoietin receptor 2.55882
KRT78 keratin 78, type II 2.55882
C1GALT1C1L C1GALT1-specific chaperone 1 like 2.55882
PPP1R27 protein phosphatase 1, regulatory subunit 27 2.55882
LRRN4 leucine rich repeat neuronal 4 2.55882
ZNF831 zinc finger protein 831 2.55882
HBZ hemoglobin, zeta 2.55882
ORM2 orosomucoid 2 2.55882
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 2.55882
CD34 CD34 molecule 2.55882
HRG histidine-rich glycoprotein 2.55882
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 2.55882
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 2.55882
SMIM17 small integral membrane protein 17 2.55882
CTRB1 chymotrypsinogen B1 2.55882
RNASE6 ribonuclease, RNase A family, k6 2.55882
RNASE9 ribonuclease, RNase A family, 9 (non-active) 2.55882
BCL2A1 BCL2-related protein A1 2.55882
ANKK1 ankyrin repeat and kinase domain containing 1 2.55882
OC90 otoconin 90 2.55882
PSG3 pregnancy specific beta-1-glycoprotein 3 2.55882
LRRC63 leucine rich repeat containing 63 2.55882
PLSCR4 phospholipid scramblase 4 2.54473
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 2.54473
ALAS1 5'-aminolevulinate synthase 1 2.54043
RAB39B RAB39B, member RAS oncogene family 2.54043
RSRP1 arginine/serine-rich protein 1 2.54043
ADTRP androgen-dependent TFPI-regulating protein 2.54043
MAP3K6 mitogen-activated protein kinase kinase kinase 6 2.54043
HTRA3 HtrA serine peptidase 3 2.54043
DBP D site of albumin promoter (albumin D-box) binding protein 2.54043
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 2.48696
NUP35 nucleoporin 35kDa 2.48138
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 2.46648
ZNF587B zinc finger protein 587B 2.45652
TRIM17 tripartite motif containing 17 2.44351
FRMD4B FERM domain containing 4B 2.44244
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 2.43091
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast) 2.41013
KRT86 keratin 86, type II 2.39679
SMIM47 small integral membrane protein 47 2.38457
CAPN1 calpain 1, (mu/I) large subunit 2.38159
CUBN cubilin (intrinsic factor-cobalamin receptor) 2.38159
TSPAN11 tetraspanin 11 2.38087
STC1 stanniocalcin 1 2.37539
TUBD1 tubulin, delta 1 2.36237
MACROD2 MACRO domain containing 2 2.35335
SIGMAR1 sigma non-opioid intracellular receptor 1 2.3389
CLDN6 claudin 6 2.30623
ZUP1 zinc finger containing ubiquitin peptidase 1 2.28695
ARHGEF37 Rho guanine nucleotide exchange factor (GEF) 37 2.26483
SCN4A sodium channel, voltage gated, type IV alpha subunit 2.25594
CUL3 cullin 3 2.2299
INTS8 integrator complex subunit 8 2.21297
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 2.20556
SPEG SPEG complex locus 2.19929
BMF Bcl2 modifying factor 2.19449
CCNL1 cyclin L1 2.17218
SRPX sushi-repeat containing protein, X-linked 2.17124
CCDC172 coiled-coil domain containing 172 2.17124
OGN osteoglycin 2.17124
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 2.17124
ARID5A AT rich interactive domain 5A (MRF1-like) 2.17124
GLB1L3 galactosidase, beta 1-like 3 2.14951
ZNF253 zinc finger protein 253 2.13034
ZBED8 zinc finger, BED-type containing 8 2.12218
CHCHD4 coiled-coil-helix-coiled-coil-helix domain containing 4 2.10978
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 2.03525
ZNF234 zinc finger protein 234 2.0258
PTAR1 protein prenyltransferase alpha subunit repeat containing 1 2.00981

decreased expression

Symbol Name Standardized Value
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -3.61172
ASPG asparaginase -2.6874
FBXO43 F-box protein 43 -2.6874
ZNF230 zinc finger protein 230 -2.6874
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -2.6874
SSC5D scavenger receptor cysteine rich family, 5 domains -2.66
FNDC11 fibronectin type III domain containing 11 -2.66
PTGER3 prostaglandin E receptor 3 (subtype EP3) -2.66
FSCN3 fascin actin-bundling protein 3, testicular -2.66
ILDR2 immunoglobulin-like domain containing receptor 2 -2.66
GSG1L GSG1-like -2.66
CD86 CD86 molecule -2.66
DGAT2 diacylglycerol O-acyltransferase 2 -2.61733
AP1G2 adaptor-related protein complex 1, gamma 2 subunit -2.55882
XPR1 xenotropic and polytropic retrovirus receptor 1 -2.55882
SNORC secondary ossification center associated regulator of chondrocyte maturation -2.55882
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 -2.55882
ZNF404 zinc finger protein 404 -2.55882
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 -2.55882
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -2.55882
SKA3 spindle and kinetochore associated complex subunit 3 -2.55882
SLC26A4 solute carrier family 26 (anion exchanger), member 4 -2.54043
C1ORF146 chromosome 1 open reading frame 146 -2.54043
MYO18B myosin XVIIIB -2.54043
SYT15 synaptotagmin XV -2.54043
CPB2 carboxypeptidase B2 (plasma) -2.54043
MMP21 matrix metallopeptidase 21 -2.54043
NXPH3 neurexophilin 3 -2.54043
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 -2.54043
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 -2.54043
TMEM179 transmembrane protein 179 -2.54043
GUCY2F guanylate cyclase 2F, retinal -2.54043
ROPN1B rhophilin associated tail protein 1B -2.54043
KLHL35 kelch-like family member 35 -2.54043
NXPH4 neurexophilin 4 -2.54043
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 -2.54043
PCDHGA9 protocadherin gamma subfamily A, 9 -2.54043
VSTM2A V-set and transmembrane domain containing 2A -2.54043
TUBB8 tubulin, beta 8 class VIII -2.54043
CD79B CD79b molecule, immunoglobulin-associated beta -2.54043
TMPRSS11E transmembrane protease, serine 11E -2.54043
SFXN3 sideroflexin 3 -2.54043
S1PR1 sphingosine-1-phosphate receptor 1 -2.54043
PDF peptide deformylase (mitochondrial) -2.54043
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 -2.54043
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 -2.54043
IER5L immediate early response 5-like -2.54043
DRD4 dopamine receptor D4 -2.54043
H4C14 H4 clustered histone 14 -2.54043
CFAP299 cilia and flagella associated protein 299 -2.54043
CH25H cholesterol 25-hydroxylase -2.54043
FBXO40 F-box protein 40 -2.54043
GPBP1 GC-rich promoter binding protein 1 -2.54043
PCDHGA4 protocadherin gamma subfamily A, 4 -2.54043
PSKH2 protein serine kinase H2 -2.54043
ANKRD33 ankyrin repeat domain 33 -2.54043
GLT6D1 glycosyltransferase 6 domain containing 1 -2.54043
ANKRD54 ankyrin repeat domain 54 -2.54043
C11ORF42 chromosome 11 open reading frame 42 -2.54043
FOXP3 forkhead box P3 -2.54043
TGM6 transglutaminase 6 -2.54043
CRHBP corticotropin releasing hormone binding protein -2.54043
CPSF4L cleavage and polyadenylation specific factor 4-like -2.54043
IDI2 isopentenyl-diphosphate delta isomerase 2 -2.54043
IRF9 interferon regulatory factor 9 -2.48138
RPIA ribose 5-phosphate isomerase A -2.39679
ZNF16 zinc finger protein 16 -2.38599
DENND2D DENN/MADD domain containing 2D -2.3635
REEP4 receptor accessory protein 4 -2.36237
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 -2.3463
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) -2.34246
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1 -2.325
SNAI3 snail family zinc finger 3 -2.30295
PRH1 proline-rich protein HaeIII subfamily 1 -2.29003
CKAP4 cytoskeleton-associated protein 4 -2.283
PXYLP1 2-phosphoxylose phosphatase 1 -2.25734
GPATCH2L G patch domain containing 2-like -2.25087
TMEM259 transmembrane protein 259 -2.23703
RIMOC1 RAB7A interacting MON1-CCZ1 complex subunit 1 -2.23703
TRNT1 tRNA nucleotidyl transferase, CCA-adding, 1 -2.23703
TOR1AIP1 torsin A interacting protein 1 -2.21274
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa -2.18171
MBLAC2 metallo-beta-lactamase domain containing 2 -2.17147
CSTB cystatin B (stefin B) -2.15463
RBM33 RNA binding motif protein 33 -2.15059
MED9 mediator complex subunit 9 -2.14782
SCGB2B2 secretoglobin, family 2B, member 2 -2.13311
CCDC102B coiled-coil domain containing 102B -2.12805
LINGO3 leucine rich repeat and Ig domain containing 3 -2.12154
DYNLT5 dynein light chain Tctex-type family member 5 -2.12154
AHNAK2 AHNAK nucleoprotein 2 -2.11887
CMTM1 CKLF-like MARVEL transmembrane domain containing 1 -2.11887
TTC1 tetratricopeptide repeat domain 1 -2.09782
ADAM28 ADAM metallopeptidase domain 28 -2.07638
TBC1D14 TBC1 domain family, member 14 -2.0732
ZNF837 zinc finger protein 837 -2.05353
ATOX1 antioxidant 1 copper chaperone -2.03525
NOXO1 NADPH oxidase organizer 1 -2.03525
SRSF7 serine/arginine-rich splicing factor 7 -2.03525
SHISAL2A shisa like 2A -2.03525
MLXIPL MLX interacting protein-like -2.02827
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa -2.00784