STAT3 Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description signal transducer and activator of transcription 3 (acute-phase response factor)|The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6774)
External Link http://www.ncbi.nlm.nih.gov/gene/6774
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183 interacting proteins for hub protein STAT3 from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
ALK anaplastic lymphoma receptor tyrosine kinase
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
AR androgen receptor
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCL3 B-cell CLL/lymphoma 3
BHLHE40 basic helix-loop-helix family, member e40
BMX BMX non-receptor tyrosine kinase
BRCA1 breast cancer 1, early onset
BTK Bruton agammaglobulinemia tyrosine kinase
CCND1 cyclin D1
CCP110 centriolar coiled coil protein 110kDa
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CDK2 cyclin-dependent kinase 2
CDK5 cyclin-dependent kinase 5
CDK9 cyclin-dependent kinase 9
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CISH cytokine inducible SH2-containing protein
CREBBP CREB binding protein
CRYAB crystallin, alpha B
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSF3R colony stimulating factor 3 receptor (granulocyte)
CTR9 CTR9, Paf1/RNA polymerase II complex component
CXCR4 chemokine (C-X-C motif) receptor 4
DAPK3 death-associated protein kinase 3
DAXX death-domain associated protein
DNMT1 DNA (cytosine-5-)-methyltransferase 1
EGFR epidermal growth factor receptor
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ELP2 elongator acetyltransferase complex subunit 2
EP300 E1A binding protein p300
EPHA3 EPH receptor A3
EPHA5 EPH receptor A5
EPHB1 EPH receptor B1
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
FER fer (fps/fes related) tyrosine kinase
FES FES proto-oncogene, tyrosine kinase
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
FGR FGR proto-oncogene, Src family tyrosine kinase
FHL2 four and a half LIM domains 2
FLT1 fms-related tyrosine kinase 1
FLT3 fms-related tyrosine kinase 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXM1 forkhead box M1
FYN FYN proto-oncogene, Src family tyrosine kinase
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1
GATA1 GATA binding protein 1 (globin transcription factor 1)
GATA2 GATA binding protein 2
GHR growth hormone receptor
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
GTF2I general transcription factor IIi
HAX1 HCLS1 associated protein X-1
HCK HCK proto-oncogene, Src family tyrosine kinase
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC3 histone deacetylase 3
HDAC4 histone deacetylase 4
HES1 hes family bHLH transcription factor 1
HES5 hes family bHLH transcription factor 5
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HNF1A HNF1 homeobox A
HOXC11 homeobox C11
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPB1 heat shock 27kDa protein 1
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNGR1 interferon gamma receptor 1
IGF1R insulin-like growth factor 1 receptor
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL17A interleukin 17A
IL17F interleukin 17F
IL1RAP interleukin 1 receptor accessory protein
IL23R interleukin 23 receptor
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL6R interleukin 6 receptor
IL6ST interleukin 6 signal transducer
IL7R interleukin 7 receptor
IL9R interleukin 9 receptor
INSR insulin receptor
IRAK1 interleukin-1 receptor-associated kinase 1
IRF9 interferon regulatory factor 9
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JAK3 Janus kinase 3
JUN jun proto-oncogene
KAT5 K(lysine) acetyltransferase 5
KDR kinase insert domain receptor
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KPNA1 karyopherin alpha 1 (importin alpha 5)
KPNA6 karyopherin alpha 6 (importin alpha 7)
KRT1 keratin 1, type II
LCK LCK proto-oncogene, Src family tyrosine kinase
LEP leptin
LEPR leptin receptor
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MET MET proto-oncogene, receptor tyrosine kinase
MLF2 myeloid leukemia factor 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYOD1 myogenic differentiation 1
NCOA1 nuclear receptor coactivator 1
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
NLK nemo-like kinase
NMI N-myc (and STAT) interactor
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PCBD2 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDIA3 protein disulfide isomerase family A, member 3
PELP1 proline, glutamate and leucine rich protein 1
PIAS1 protein inhibitor of activated STAT, 1
PIAS2 protein inhibitor of activated STAT, 2
PIAS3 protein inhibitor of activated STAT, 3
PIAS4 protein inhibitor of activated STAT, 4
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PML promyelocytic leukemia
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKCG protein kinase C, gamma
PRKCZ protein kinase C, zeta
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTMA prothymosin, alpha
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RB1 retinoblastoma 1
RBM8A RNA binding motif protein 8A
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RET ret proto-oncogene
RPA2 replication protein A2, 32kDa
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
SMAD1 SMAD family member 1
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SOCS3 suppressor of cytokine signaling 3
SOCS7 suppressor of cytokine signaling 7
SP1 Sp1 transcription factor
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1
STAP2 signal transducing adaptor family member 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STMN1 stathmin 1
STMN3 stathmin-like 3
SUMO4 small ubiquitin-like modifier 4
SYK spleen tyrosine kinase
TRIM28 tripartite motif containing 28
TRIP10 thyroid hormone receptor interactor 10
TSHR thyroid stimulating hormone receptor
TSLP thymic stromal lymphopoietin
TYK2 tyrosine kinase 2
ZNF148 zinc finger protein 148
ZNF467 zinc finger protein 467