STAT3 Gene Set

Dataset TRANSFAC Curated Transcription Factor Targets
Category genomics
Type transcription factor
Description signal transducer and activator of transcription 3 (acute-phase response factor)|The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6774)
External Link http://www.ncbi.nlm.nih.gov/gene/6774
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Genes

166 target genes of the STAT3 transcription factor in low- or high-throughput transcription factor functional studies from the TRANSFAC Curated Transcription Factor Targets dataset.

Symbol Name
ADM2 adrenomedullin 2
ALKBH6 alkB, alkylation repair homolog 6 (E. coli)
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARF3 ADP-ribosylation factor 3
ARHGAP8 Rho GTPase activating protein 8
ARL6IP6 ADP-ribosylation factor-like 6 interacting protein 6
ARX aristaless related homeobox
ASIC2 acid sensing (proton gated) ion channel 2
ASIC4 acid sensing (proton gated) ion channel family member 4
ASXL1 additional sex combs like transcriptional regulator 1
BCAM basal cell adhesion molecule (Lutheran blood group)
BCL7A B-cell CLL/lymphoma 7A
BMI1 BMI1 proto-oncogene, polycomb ring finger
BMP4 bone morphogenetic protein 4
BNC1 basonuclin 1
BTBD1 BTB (POZ) domain containing 1
CA10 carbonic anhydrase X
CALU calumenin
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1
CCL2 chemokine (C-C motif) ligand 2
CHRM1 cholinergic receptor, muscarinic 1
CISH cytokine inducible SH2-containing protein
CLDN5 claudin 5
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
CPA4 carboxypeptidase A4
CPLX2 complexin 2
CRTAC1 cartilage acidic protein 1
CTGF connective tissue growth factor
CXORF36 chromosome X open reading frame 36
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
EGR1 early growth response 1
EGR3 early growth response 3
EIF4E eukaryotic translation initiation factor 4E
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EIF5A eukaryotic translation initiation factor 5A
ELMO1 engulfment and cell motility 1
EPHA7 EPH receptor A7
FBN2 fibrillin 2
FBXL3 F-box and leucine-rich repeat protein 3
FLRT1 fibronectin leucine rich transmembrane protein 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO4 forkhead box O4
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1
GEN1 GEN1 Holliday junction 5' flap endonuclease
GPC3 glypican 3
GPHN gephyrin
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D
HEYL hes-related family bHLH transcription factor with YRPW motif-like
HNRNPR heterogeneous nuclear ribonucleoprotein R
HOXB13 homeobox B13
HOXB4 homeobox B4
HOXB9 homeobox B9
HOXC4 homeobox C4
HOXC6 homeobox C6
HS6ST3 heparan sulfate 6-O-sulfotransferase 3
ICAM1 intercellular adhesion molecule 1
IFT43 intraflagellar transport 43
IL18BP interleukin 18 binding protein
IRF1 interferon regulatory factor 1
IRX5 iroquois homeobox 5
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3
KCNT2 potassium channel, sodium activated subfamily T, member 2
KIRREL3 kin of IRRE like 3 (Drosophila)
KMT2A lysine (K)-specific methyltransferase 2A
KPNB1 karyopherin (importin) beta 1
LRP2 low density lipoprotein receptor-related protein 2
LTA lymphotoxin alpha
LTBP1 latent transforming growth factor beta binding protein 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAML1 mastermind-like 1 (Drosophila)
MATN4 matrilin 4
MEIS2 Meis homeobox 2
MID1IP1 MID1 interacting protein 1
MIR22HG MIR22 host gene
MIS12 MIS12 kinetochore complex component
MNT MAX network transcriptional repressor
MOB3C MOB kinase activator 3C
MTMR14 myotubularin related protein 14
MTPAP mitochondrial poly(A) polymerase
MYT1 myelin transcription factor 1
NAPB N-ethylmaleimide-sensitive factor attachment protein, beta
NAV2 neuron navigator 2
NCAM1 neural cell adhesion molecule 1
NCOA5 nuclear receptor coactivator 5
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NELL2 NEL-like 2 (chicken)
NFAM1 NFAT activating protein with ITAM motif 1
NPAS4 neuronal PAS domain protein 4
NR1D1 nuclear receptor subfamily 1, group D, member 1
PCBP4 poly(rC) binding protein 4
PGF placental growth factor
PPFIA2 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
PROS1 protein S (alpha)
PTMS parathymosin
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like
REM2 RAS (RAD and GEM)-like GTP binding 2
RGS3 regulator of G-protein signaling 3
RND1 Rho family GTPase 1
RNF213 ring finger protein 213
RPUSD4 RNA pseudouridylate synthase domain containing 4
S100A14 S100 calcium binding protein A14
SCUBE3 signal peptide, CUB domain, EGF-like 3
SDC1 syndecan 1
SDHAF2 succinate dehydrogenase complex assembly factor 2
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SET SET nuclear proto-oncogene
SGMS1 sphingomyelin synthase 1
SHOX2 short stature homeobox 2
SLC35A5 solute carrier family 35, member A5
SLC38A5 solute carrier family 38, member 5
SLCO5A1 solute carrier organic anion transporter family, member 5A1
SMG7 SMG7 nonsense mediated mRNA decay factor
SP6 Sp6 transcription factor
SPON1 spondin 1, extracellular matrix protein
SPTBN2 spectrin, beta, non-erythrocytic 2
ST7L suppression of tumorigenicity 7 like
SV2B synaptic vesicle glycoprotein 2B
TAOK1 TAO kinase 1
TAOK2 TAO kinase 2
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TJAP1 tight junction associated protein 1 (peripheral)
TM9SF1 transmembrane 9 superfamily member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM180 transmembrane protein 180
TMEM229B transmembrane protein 229B
TMEM37 transmembrane protein 37
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TNRC6A trinucleotide repeat containing 6A
TRAF4 TNF receptor-associated factor 4
TRIB2 tribbles pseudokinase 2
TRIP10 thyroid hormone receptor interactor 10
TSC22D4 TSC22 domain family, member 4
UBE4B ubiquitination factor E4B
UBR1 ubiquitin protein ligase E3 component n-recognin 1
UBR5 ubiquitin protein ligase E3 component n-recognin 5
UBTF upstream binding transcription factor, RNA polymerase I
UPK2 uroplakin 2
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
VCL vinculin
VEZF1 vascular endothelial zinc finger 1
VIP vasoactive intestinal peptide
VSNL1 visinin-like 1
WDR81 WD repeat domain 81
WEE1 WEE1 G2 checkpoint kinase
WNT4 wingless-type MMTV integration site family, member 4
YY1 YY1 transcription factor
ZBTB11 zinc finger and BTB domain containing 11
ZBTB17 zinc finger and BTB domain containing 17
ZBTB25 zinc finger and BTB domain containing 25
ZBTB9 zinc finger and BTB domain containing 9
ZC3H18-AS1 ZC3H18 antisense RNA 1 (head to head)
ZFYVE9 zinc finger, FYVE domain containing 9
ZHX2 zinc fingers and homeoboxes 2
ZNF112 zinc finger protein 112
ZNF296 zinc finger protein 296
ZSWIM8 zinc finger, SWIM-type containing 8