STAT4 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description signal transducer and activator of transcription 4|The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 6775)
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Genes

358 genes differentially expressed following the STAT4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PCDHA3 protocadherin alpha 3 2.67922
SIGLECL1 SIGLEC family like 1 2.67922
EGFL8 EGF-like-domain, multiple 8 2.67922
SPINK6 serine peptidase inhibitor, Kazal type 6 2.67922
TMEM176B transmembrane protein 176B 2.67922
AKR1C4 aldo-keto reductase family 1, member C4 2.67922
THAP5 THAP domain containing 5 2.67922
MUC1 mucin 1, cell surface associated 2.67922
ZNF662 zinc finger protein 662 2.67922
EPPIN epididymal peptidase inhibitor 2.67922
SOX17 SRY (sex determining region Y)-box 17 2.67922
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 2.67922
ZNF503 zinc finger protein 503 2.67922
CHADL chondroadherin-like 2.67922
RAB44 RAB44, member RAS oncogene family 2.67922
RNF151 ring finger protein 151 2.67922
WEE2 WEE1 homolog 2 (S. pombe) 2.67922
GPR6 G protein-coupled receptor 6 2.67922
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.67922
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 2.67922
HLX H2.0-like homeobox 2.67922
RNF17 ring finger protein 17 2.67922
CD6 CD6 molecule 2.67922
ZACN zinc activated ligand-gated ion channel 2.67922
PCDHGB3 protocadherin gamma subfamily B, 3 2.67922
TBX15 T-box 15 2.67922
IQCJ IQ motif containing J 2.67922
NPIPA8 nuclear pore complex interacting protein family, member A8 2.67922
MMP20 matrix metallopeptidase 20 2.67922
TRPC5OS TRPC5 opposite strand 2.67922
BMP3 bone morphogenetic protein 3 2.67922
SLC39A12 solute carrier family 39 (zinc transporter), member 12 2.67922
REM2 RAS (RAD and GEM)-like GTP binding 2 2.67922
NMUR2 neuromedin U receptor 2 2.67922
SPON2 spondin 2, extracellular matrix protein 2.67922
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 2.67922
TDO2 tryptophan 2,3-dioxygenase 2.67922
SPDYE11 speedy/RINGO cell cycle regulator family member E11 2.67922
MEIKIN meiotic kinetochore factor 2.67922
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 2.67922
DUSP10 dual specificity phosphatase 10 2.67922
PROB1 proline-rich basic protein 1 2.67922
PAX4 paired box 4 2.67922
CEP295NL CEP295 N-terminal like 2.67922
NEU4 sialidase 4 2.67922
SSTR3 somatostatin receptor 3 2.67922
PTGFR prostaglandin F receptor (FP) 2.67922
RPL3L ribosomal protein L3-like 2.67922
ZNF618 zinc finger protein 618 2.67922
UBA7 ubiquitin-like modifier activating enzyme 7 2.67922
LEP leptin 2.67922
NXPE1 neurexophilin and PC-esterase domain family, member 1 2.67922
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 2.67922
CALHM5 calcium homeostasis modulator family member 5 2.67922
ERVW-1 endogenous retrovirus group W, member 1 2.67922
CPS1 carbamoyl-phosphate synthase 1, mitochondrial 2.67922
ARX aristaless related homeobox 2.67922
ALDOB aldolase B, fructose-bisphosphate 2.67922
PCDHGA9 protocadherin gamma subfamily A, 9 2.67922
GBP2 guanylate binding protein 2, interferon-inducible 2.67922
MCHR1 melanin-concentrating hormone receptor 1 2.67922
ROPN1B rhophilin associated tail protein 1B 2.67922
GPR35 G protein-coupled receptor 35 2.67922
TEKTIP1 tektin bundle interacting protein 1 2.67922
CFAP141 cilia and flagella associated protein 141 2.67922
H1-8 H1.8 linker histone 2.67922
CIMIP4 ciliary microtubule inner protein 4 2.67922
LY6S-AS1 LY6S antisense RNA 1 2.67922
LINC02268 long intergenic non-protein coding RNA 2268 2.67922
KIF1C-AS1 KIF1C antisense RNA 1 2.67922
PRRT1B proline rich transmembrane protein 1B 2.67922
RAMACL RNA guanine-7 methyltransferase activating subunit like 2.67922
SMIM45 small integral membrane protein 45 2.67922
SPAAR small regulatory polypeptide of amino acid response 2.67922
GLYATL1B glycine-N-acyltransferase like 1B 2.67922
MUCL3 mucin like 3 2.67922
DNAAF1 dynein, axonemal, assembly factor 1 2.67922
KRT80 keratin 80, type II 2.67922
CATSPERT catsper channel auxiliary subunit tau 2.67922
EXOC3L4 exocyst complex component 3-like 4 2.67922
NPFF neuropeptide FF-amide peptide precursor 2.67922
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.67922
KLRF1 killer cell lectin-like receptor subfamily F, member 1 2.67922
SLC9A4 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 2.67922
MIA melanoma inhibitory activity 2.67922
C1ORF162 chromosome 1 open reading frame 162 2.67922
SCRT1 scratch family zinc finger 1 2.67922
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 2.67922
OR2J1 olfactory receptor, family 2, subfamily J, member 1 (gene/pseudogene) 2.67922
TIMD4 T-cell immunoglobulin and mucin domain containing 4 2.67922
TAS1R2 taste receptor, type 1, member 2 2.67922
GDF6 growth differentiation factor 6 2.67922
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 2.67922
C1QTNF9B C1q and tumor necrosis factor related protein 9B 2.67922
IQCF1 IQ motif containing F1 2.67922
ADRB1 adrenoceptor beta 1 2.67922
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 2.67922
PRDM7 PR domain containing 7 2.67922
MROH5 maestro heat-like repeat family member 5 2.67922
TUBA4B tubulin, alpha 4b 2.67922
HNF1A HNF1 homeobox A 2.67922
IL16 interleukin 16 2.67922
DAO D-amino-acid oxidase 2.67922
POTEJ POTE ankyrin domain family, member J 2.67922
FLRT3 fibronectin leucine rich transmembrane protein 3 2.67922
MORC1 MORC family CW-type zinc finger 1 2.67922
VAX1 ventral anterior homeobox 1 2.67922
SLC38A3 solute carrier family 38, member 3 2.67922
LRRC43 leucine rich repeat containing 43 2.67922
TMEM132D transmembrane protein 132D 2.67922
ZNF132 zinc finger protein 132 2.67922
IP6K3 inositol hexakisphosphate kinase 3 2.67922
KRTAP21-2 keratin associated protein 21-2 2.67922
ONECUT3 one cut homeobox 3 2.67922
LY6G6D lymphocyte antigen 6 complex, locus G6D 2.67922
PSORS1C1 psoriasis susceptibility 1 candidate 1 2.67922
SUN3 Sad1 and UNC84 domain containing 3 2.67922
DBX2 developing brain homeobox 2 2.67922
CALML5 calmodulin-like 5 2.67922
TCF21 transcription factor 21 2.67922
AKR1B15 aldo-keto reductase family 1, member B15 2.67922
GPR50 G protein-coupled receptor 50 2.67922
FCN3 ficolin (collagen/fibrinogen domain containing) 3 2.67922
PDCD1LG2 programmed cell death 1 ligand 2 2.67922
HAMP hepcidin antimicrobial peptide 2.67922
OR56A3 olfactory receptor, family 56, subfamily A, member 3 2.67922
SFRP4 secreted frizzled-related protein 4 2.67922
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 2.67922
AKNAD1 AKNA domain containing 1 2.67922
ARG1 arginase 1 2.67922
COL17A1 collagen, type XVII, alpha 1 2.67922
FAM209A family with sequence similarity 209, member A 2.67922
IL1B interleukin 1, beta 2.67922
LMOD2 leiomodin 2 (cardiac) 2.67922
FBXO40 F-box protein 40 2.67922
NOX1 NADPH oxidase 1 2.67922
EGR3 early growth response 3 2.67922
CST4 cystatin S 2.67922
OTC ornithine carbamoyltransferase 2.67922
BTNL8 butyrophilin-like 8 2.67922
CFAP47 cilia and flagella associated protein 47 2.67922
HHATL hedgehog acyltransferase-like 2.67922
CYSLTR2 cysteinyl leukotriene receptor 2 2.67922
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1 2.67922
FBXL22 F-box and leucine-rich repeat protein 22 2.67922
C17ORF99 chromosome 17 open reading frame 99 2.67922
NLRP5 NLR family, pyrin domain containing 5 2.67922
LY6G6C lymphocyte antigen 6 complex, locus G6C 2.67922
ICAM5 intercellular adhesion molecule 5, telencephalin 2.67922
LPA lipoprotein, Lp(a) 2.67922
POPDC2 popeye domain containing 2 2.67922
ZNF648 zinc finger protein 648 2.67922
CHRDL2 chordin-like 2 2.67922
LAG3 lymphocyte-activation gene 3 2.67922
NKPD1 NTPase, KAP family P-loop domain containing 1 2.67922
NRGN neurogranin (protein kinase C substrate, RC3) 2.67922
DNAH8 dynein, axonemal, heavy chain 8 2.67922
MNX1 motor neuron and pancreas homeobox 1 2.67922
ERAP2 endoplasmic reticulum aminopeptidase 2 2.67922
HP haptoglobin 2.67922
UPK1B uroplakin 1B 2.67922
KRTAP4-9 keratin associated protein 4-9 2.67922
PRSS22 protease, serine, 22 2.67922
SOST sclerostin 2.67922
CYGB cytoglobin 2.67922
AMPD1 adenosine monophosphate deaminase 1 2.67922
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 2.67922
IL37 interleukin 37 2.67922
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.67922
IFNE interferon, epsilon 2.67922
TICAM1 toll-like receptor adaptor molecule 1 2.67922
TRPM8 transient receptor potential cation channel, subfamily M, member 8 2.67922
SAMD4A sterile alpha motif domain containing 4A 2.67922
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 2.67922
WFDC10A WAP four-disulfide core domain 10A 2.67922
A1CF APOBEC1 complementation factor 2.67922
CNR2 cannabinoid receptor 2 (macrophage) 2.67922
SFTA2 surfactant associated 2 2.67922
ZC3H3 zinc finger CCCH-type containing 3 2.67922
ANXA8 annexin A8 2.67922
MATN2 matrilin 2 2.63131
AATF apoptosis antagonizing transcription factor 2.60581
ZNF714 zinc finger protein 714 2.60567
OTX1 orthodenticle homeobox 1 2.60235
ADRA2B adrenoceptor alpha 2B 2.60235
HFE hemochromatosis 2.59331
IL4I1 interleukin 4 induced 1 2.53569
CEP83 centrosomal protein 83kDa 2.52335
PRDM6 PR domain containing 6 2.49694
MED25 mediator complex subunit 25 2.49694
SETBP1 SET binding protein 1 2.49638
SPINT1 serine peptidase inhibitor, Kunitz type 1 2.48657
KCTD20 potassium channel tetramerization domain containing 20 2.48657
SRXN1 sulfiredoxin 1 2.48354
AASS aminoadipate-semialdehyde synthase 2.48354
MRRF mitochondrial ribosome recycling factor 2.47446
SPNS1 spinster homolog 1 (Drosophila) 2.43642
MRPS6 mitochondrial ribosomal protein S6 2.41301
CRACDL CRACD like 2.39718
FANK1 fibronectin type III and ankyrin repeat domains 1 2.39718
FN3K fructosamine 3 kinase 2.36217
CMKLR2 chemerin chemokine-like receptor 2 2.36017
NUP214 nucleoporin 214kDa 2.33099
SDE2 SDE2 telomere maintenance homolog (S. pombe) 2.33099
ZNF717 zinc finger protein 717 2.32617
EMCN endomucin 2.32015
VAMP7 vesicle-associated membrane protein 7 2.32015
NCAPD2 non-SMC condensin I complex, subunit D2 2.31104
SLC4A3 solute carrier family 4 (anion exchanger), member 3 2.26774
SLC10A3 solute carrier family 10, member 3 2.26774
MTFR1 mitochondrial fission regulator 1 2.21239
FIGN fidgetin 2.21239
COQ7 coenzyme Q7 homolog, ubiquinone (yeast) 2.18579
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 2.18552
FBLIM1 filamin binding LIM protein 1 2.164
CFD complement factor D (adipsin) 2.15354
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 2.1492
TBC1D32 TBC1 domain family, member 32 2.14395
RECK reversion-inducing-cysteine-rich protein with kazal motifs 2.14185
MARK3 MAP/microtubule affinity-regulating kinase 3 2.13834
EXOC6B exocyst complex component 6B 2.13489
RNF11 ring finger protein 11 2.11756
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 2.10338
MSMO1 methylsterol monooxygenase 1 2.10008
TUBB4B tubulin, beta 4B class IVb 2.10008
ZNF737 zinc finger protein 737 2.08885
TACO1 translational activator of mitochondrially encoded cytochrome c oxidase I 2.084
TMEM134 transmembrane protein 134 2.084
TNNT1 troponin T type 1 (skeletal, slow) 2.07829
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 2.06424
TUBB3 tubulin, beta 3 class III 2.05749
C1ORF54 chromosome 1 open reading frame 54 2.05749
GBGT1 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 2.04021
ZDHHC23 zinc finger, DHHC-type containing 23 2.03589
GABPB1 GA binding protein transcription factor, beta subunit 1 2.03589
RWDD2B RWD domain containing 2B 2.03304
FNBP1 formin binding protein 1 2.02971
PINK1 PTEN induced putative kinase 1 2.02355
ZNF775 zinc finger protein 775 2.00991
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 2.00991

decreased expression

Symbol Name Standardized Value
WBP1 WW domain binding protein 1 -2.67922
AUP1 ancient ubiquitous protein 1 -2.67922
RAPSN receptor-associated protein of the synapse -2.67922
PTGES prostaglandin E synthase -2.67922
ZNF469 zinc finger protein 469 -2.67922
ANXA9 annexin A9 -2.67922
FOXP2 forkhead box P2 -2.67922
FDPS farnesyl diphosphate synthase -2.67922
CERS3 ceramide synthase 3 -2.67922
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 -2.67922
PCDHA12 protocadherin alpha 12 -2.67922
MTCP1 mature T-cell proliferation 1 -2.67922
ZNF354A zinc finger protein 354A -2.67922
H2BC8 H2B clustered histone 8 -2.67922
H4C13 H4 clustered histone 13 -2.67922
SLC25A29 solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 -2.67922
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) -2.67922
PLAC1 placenta-specific 1 -2.67922
LTB4R leukotriene B4 receptor -2.67922
LONP1 lon peptidase 1, mitochondrial -2.67922
ABT1 activator of basal transcription 1 -2.67364
LXN latexin -2.63156
SCTR secretin receptor -2.60235
OR6A2 olfactory receptor, family 6, subfamily A, member 2 -2.60235
LRRC66 leucine rich repeat containing 66 -2.60235
BMP8B bone morphogenetic protein 8b -2.60235
SGCE sarcoglycan, epsilon -2.60235
DNAAF19 dynein axonemal assembly factor 19 -2.60235
NWD1 NACHT and WD repeat domain containing 1 -2.60235
MARCHF10 membrane associated ring-CH-type finger 10 -2.60235
SFTPB surfactant protein B -2.60235
CABCOCO1 ciliary associated calcium binding coiled-coil 1 -2.60235
PIRT phosphoinositide-interacting regulator of transient receptor potential channels -2.60235
FAM107A family with sequence similarity 107, member A -2.60235
RGS22 regulator of G-protein signaling 22 -2.60235
SH3TC2 SH3 domain and tetratricopeptide repeats 2 -2.60235
PDE1B phosphodiesterase 1B, calmodulin-dependent -2.60235
OR2A7 olfactory receptor, family 2, subfamily A, member 7 -2.60235
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 -2.60235
FOXA2 forkhead box A2 -2.60235
CCNB3 cyclin B3 -2.60235
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) -2.60235
ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 -2.60235
SHOC1 shortage in chiasmata 1 -2.60235
SOX30 SRY (sex determining region Y)-box 30 -2.60235
SLC14A2 solute carrier family 14 (urea transporter), member 2 -2.60235
SCT secretin -2.60235
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3 -2.60235
ZNF471 zinc finger protein 471 -2.60235
PLA2G4B phospholipase A2, group IVB (cytosolic) -2.60235
RGS11 regulator of G-protein signaling 11 -2.60235
ATP10B ATPase, class V, type 10B -2.60235
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 -2.60235
OPRK1 opioid receptor, kappa 1 -2.60235
SDS serine dehydratase -2.60235
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide -2.60235
MST1 macrophage stimulating 1 -2.60235
NINJ1 ninjurin 1 -2.59331
RPL31 ribosomal protein L31 -2.5011
IFNAR2 interferon (alpha, beta and omega) receptor 2 -2.49694
BCKDK branched chain ketoacid dehydrogenase kinase -2.48975
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase -2.48657
ACKR4 atypical chemokine receptor 4 -2.45299
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 -2.43642
CSNK2A2 casein kinase 2, alpha prime polypeptide -2.4251
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -2.40833
HYAL3 hyaluronoglucosaminidase 3 -2.39823
SPDYE16 speedy/RINGO cell cycle regulator family member E16 -2.39823
SSBP3 single stranded DNA binding protein 3 -2.39823
RAD51D RAD51 paralog D -2.39718
ROR2 receptor tyrosine kinase-like orphan receptor 2 -2.3337
ZNF414 zinc finger protein 414 -2.32786
MRPS5 mitochondrial ribosomal protein S5 -2.3209
MAP7D1 MAP7 domain containing 1 -2.3158
SF3B3 splicing factor 3b, subunit 3, 130kDa -2.31104
FGFR3 fibroblast growth factor receptor 3 -2.30256
CAMKMT calmodulin-lysine N-methyltransferase -2.29971
NSUN4 NOP2/Sun domain family, member 4 -2.29722
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 -2.27711
SERTAD2 SERTA domain containing 2 -2.25929
RPP30 ribonuclease P/MRP 30kDa subunit -2.25662
DUSP7 dual specificity phosphatase 7 -2.2397
ZNF749 zinc finger protein 749 -2.21239
AFAP1 actin filament associated protein 1 -2.21239
SAMD1 sterile alpha motif domain containing 1 -2.21239
ATP5IF1 ATP synthase inhibitory factor subunit 1 -2.20723
INTS8 integrator complex subunit 8 -2.20723
RNF44 ring finger protein 44 -2.19748
ZNF773 zinc finger protein 773 -2.18552
CCDC110 coiled-coil domain containing 110 -2.17127
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 -2.16941
EOLA2 endothelium and lymphocyte associated ASCH domain 2 -2.1492
ARG2 arginase 2 -2.14285
COG4 component of oligomeric golgi complex 4 -2.14005
LIMS2 LIM and senescent cell antigen-like domains 2 -2.13642
EEF1G eukaryotic translation elongation factor 1 gamma -2.13429
CENPL centromere protein L -2.13392
ERV3-1 endogenous retrovirus group 3, member 1 -2.12603
RPL36AL ribosomal protein L36a-like -2.09551
DCAF13 DDB1 and CUL4 associated factor 13 -2.08885
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae) -2.08885
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 -2.08793
PRDX4 peroxiredoxin 4 -2.084
SLC31A1 solute carrier family 31 (copper transporter), member 1 -2.084
GSG1L GSG1-like -2.08312
SPATA20 spermatogenesis associated 20 -2.08312
ZBTB14 zinc finger and BTB domain containing 14 -2.0708
MRPS15 mitochondrial ribosomal protein S15 -2.06749
SLC39A13 solute carrier family 39 (zinc transporter), member 13 -2.06518
TPT1 tumor protein, translationally-controlled 1 -2.06104
CAMSAP1 calmodulin regulated spectrin-associated protein 1 -2.03682
HEPH hephaestin -2.03682
ENHO energy homeostasis associated -2.03608
ITPRIPL1 inositol 1,4,5-trisphosphate receptor interacting protein-like 1 -2.03528
KLHL15 kelch-like family member 15 -2.02486
GTPBP1 GTP binding protein 1 -2.02092
PTPMT1 protein tyrosine phosphatase, mitochondrial 1 -2.01985
VTA1 vesicle (multivesicular body) trafficking 1 -2.00697