| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | signal transducer and activator of transcription 4|The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 6775) |
| External Link | https://ncbi.nlm.nih.gov/gene/6775 |
| Similar Terms | |
| Downloads & Tools |
498 genes differentially expressed following the STAT4 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTK2 | protein tyrosine kinase 2 | 0.016455 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | 0.0106383 |
| CPVL | carboxypeptidase, vitellogenic-like | 0.0106273 |
| KIF20A | kinesin family member 20A | 0.00984741 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.00979774 |
| ADI1 | acireductone dioxygenase 1 | 0.00918015 |
| NUSAP1 | nucleolar and spindle associated protein 1 | 0.00911935 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | 0.00853718 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | 0.00838712 |
| MS4A6A | membrane-spanning 4-domains, subfamily A, member 6A | 0.00826178 |
| FASN | fatty acid synthase | 0.00806299 |
| HMGB2 | high mobility group box 2 | 0.00805982 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.00801589 |
| ECI2 | enoyl-CoA delta isomerase 2 | 0.00796705 |
| CENPU | centromere protein U | 0.00781591 |
| NMU | neuromedin U | 0.00770481 |
| TFF3 | trefoil factor 3 (intestinal) | 0.0076958 |
| CST3 | cystatin C | 0.00768828 |
| SYNGR3 | synaptogyrin 3 | 0.00763228 |
| TMX1 | thioredoxin-related transmembrane protein 1 | 0.00759316 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | 0.00751358 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.00739883 |
| PBK | PDZ binding kinase | 0.00729334 |
| PHTF2 | putative homeodomain transcription factor 2 | 0.00724348 |
| ATP8A1 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 | 0.00722303 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | 0.00720769 |
| AKR7A3 | aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) | 0.00709942 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | 0.00707265 |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) | 0.00707134 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | 0.0069729 |
| DHFR | dihydrofolate reductase | 0.00694898 |
| GZMK | granzyme K (granzyme 3; tryptase II) | 0.0069192 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0068716 |
| UBE2S | ubiquitin-conjugating enzyme E2S | 0.00686454 |
| RPA3 | replication protein A3, 14kDa | 0.00685794 |
| BIRC5 | baculoviral IAP repeat containing 5 | 0.00685791 |
| FGL2 | fibrinogen-like 2 | 0.00681201 |
| CTSC | cathepsin C | 0.00678114 |
| METTL7A | methyltransferase like 7A | 0.00677859 |
| CCNA2 | cyclin A2 | 0.00677236 |
| KANK2 | KN motif and ankyrin repeat domains 2 | 0.00674071 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | 0.00671316 |
| H2AX | H2A.X variant histone | 0.00670793 |
| HSDL2 | hydroxysteroid dehydrogenase like 2 | 0.0066449 |
| CCL19 | chemokine (C-C motif) ligand 19 | 0.00653376 |
| TRMT5 | tRNA methyltransferase 5 | 0.00649823 |
| RACGAP1 | Rac GTPase activating protein 1 | 0.0064943 |
| TOB1 | transducer of ERBB2, 1 | 0.00646166 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.00635793 |
| ZBTB18 | zinc finger and BTB domain containing 18 | 0.00631042 |
| DCXR | dicarbonyl/L-xylulose reductase | 0.00630035 |
| TMEM14B | transmembrane protein 14B | 0.00629478 |
| PRIM1 | primase, DNA, polypeptide 1 (49kDa) | 0.00628924 |
| MPHOSPH9 | M-phase phosphoprotein 9 | 0.00619709 |
| DCK | deoxycytidine kinase | 0.00619511 |
| PLS3 | plastin 3 | 0.00616827 |
| PTTG1 | pituitary tumor-transforming 1 | 0.00616741 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.00614148 |
| BCHE | butyrylcholinesterase | 0.00614069 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | 0.00613602 |
| GINS1 | GINS complex subunit 1 (Psf1 homolog) | 0.00612181 |
| LYZ | lysozyme | 0.00611818 |
| CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha | 0.00610732 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.00610175 |
| FAM216A | family with sequence similarity 216, member A | 0.0060902 |
| CHN2 | chimerin 2 | 0.00606021 |
| CIT | citron rho-interacting serine/threonine kinase | 0.00603728 |
| LBR | lamin B receptor | 0.00596362 |
| CENPF | centromere protein F, 350/400kDa | 0.00594948 |
| AURKA | aurora kinase A | 0.0059476 |
| FGFR3 | fibroblast growth factor receptor 3 | 0.00588985 |
| HOXB6 | homeobox B6 | 0.00588961 |
| RNASE6 | ribonuclease, RNase A family, k6 | 0.00587792 |
| CCNB2 | cyclin B2 | 0.0058745 |
| ZCCHC24 | zinc finger, CCHC domain containing 24 | 0.00582374 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.00582206 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | 0.00582042 |
| PRDX4 | peroxiredoxin 4 | 0.00581248 |
| IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 | 0.0058056 |
| SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase | 0.00579883 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0057983 |
| SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | 0.00579378 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.00577697 |
| SPCS3 | signal peptidase complex subunit 3 homolog (S. cerevisiae) | 0.00577246 |
| GNG10 | guanine nucleotide binding protein (G protein), gamma 10 | 0.00573682 |
| DEK | DEK proto-oncogene | 0.00571183 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.00569943 |
| POLG2 | polymerase (DNA directed), gamma 2, accessory subunit | 0.00569874 |
| PSRC1 | proline/serine-rich coiled-coil 1 | 0.00568765 |
| COMMD8 | COMM domain containing 8 | 0.0056672 |
| SLC2A4RG | SLC2A4 regulator | 0.00566694 |
| CCNF | cyclin F | 0.00560919 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | 0.0056022 |
| CD2 | CD2 molecule | 0.00559665 |
| TMEM106C | transmembrane protein 106C | 0.00554384 |
| CD320 | CD320 molecule | 0.00552846 |
| SUCLG2 | succinate-CoA ligase, GDP-forming, beta subunit | 0.0055168 |
| KRT18 | keratin 18, type I | 0.00551403 |
| RNF138 | ring finger protein 138, E3 ubiquitin protein ligase | 0.00548068 |
| RGS5 | regulator of G-protein signaling 5 | 0.00547523 |
| PRF1 | perforin 1 (pore forming protein) | 0.00546665 |
| CDC20 | cell division cycle 20 | 0.00546563 |
| TSNAX | translin-associated factor X | 0.00543962 |
| FKBP10 | FK506 binding protein 10, 65 kDa | 0.00543525 |
| PLN | phospholamban | 0.00543177 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.00540798 |
| HMGB3 | high mobility group box 3 | 0.00538821 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.00538326 |
| SPON2 | spondin 2, extracellular matrix protein | 0.00538307 |
| COQ8A | coenzyme Q8A | 0.00537613 |
| LMNB1 | lamin B1 | 0.00537508 |
| ERLIN2 | ER lipid raft associated 2 | 0.00536371 |
| CD99 | CD99 molecule | 0.00535336 |
| TOM1L1 | target of myb1 (chicken)-like 1 | 0.00535129 |
| TYMS | thymidylate synthetase | 0.0053448 |
| INSIG1 | insulin induced gene 1 | 0.00534134 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.00533915 |
| RAB20 | RAB20, member RAS oncogene family | 0.00533485 |
| CD81 | CD81 molecule | 0.00533336 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.00533077 |
| CRLF1 | cytokine receptor-like factor 1 | 0.00532191 |
| RMI1 | RecQ mediated genome instability 1 | 0.00530531 |
| CDC7 | cell division cycle 7 | 0.00527647 |
| AKAP11 | A kinase (PRKA) anchor protein 11 | 0.00526295 |
| SUZ12 | SUZ12 polycomb repressive complex 2 subunit | 0.00525638 |
| PRPS2 | phosphoribosyl pyrophosphate synthetase 2 | 0.00524436 |
| UBL3 | ubiquitin-like 3 | 0.00523799 |
| GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | 0.0052346 |
| RNF130 | ring finger protein 130 | 0.00521345 |
| SRP9 | signal recognition particle 9kDa | 0.00517929 |
| DCP2 | decapping mRNA 2 | 0.00516257 |
| NEK2 | NIMA-related kinase 2 | 0.00516035 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.00514862 |
| TACC3 | transforming, acidic coiled-coil containing protein 3 | 0.00514384 |
| RRM2 | ribonucleotide reductase M2 | 0.00513573 |
| PPA2 | pyrophosphatase (inorganic) 2 | 0.00510984 |
| CDCA4 | cell division cycle associated 4 | 0.00510171 |
| CDK1 | cyclin-dependent kinase 1 | 0.00509727 |
| NPTX2 | neuronal pentraxin II | 0.00509117 |
| LAPTM4B | lysosomal protein transmembrane 4 beta | 0.00508763 |
| CD302 | CD302 molecule | 0.00503549 |
| KCNE4 | potassium channel, voltage gated subfamily E regulatory beta subunit 4 | 0.00502559 |
| HLTF | helicase-like transcription factor | 0.00502031 |
| FBXO5 | F-box protein 5 | 0.0050198 |
| NEK7 | NIMA-related kinase 7 | 0.00500794 |
| ELOVL6 | ELOVL fatty acid elongase 6 | 0.00499208 |
| STMN1 | stathmin 1 | 0.00499017 |
| NRGN | neurogranin (protein kinase C substrate, RC3) | 0.00496989 |
| PLK1 | polo-like kinase 1 | 0.00496898 |
| PPP1R2 | protein phosphatase 1, regulatory (inhibitor) subunit 2 | 0.00496481 |
| APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B | 0.00495543 |
| MCM6 | minichromosome maintenance complex component 6 | 0.00492457 |
| STK17A | serine/threonine kinase 17a | 0.00492288 |
| RFC5 | replication factor C (activator 1) 5, 36.5kDa | 0.004922 |
| OIP5 | Opa interacting protein 5 | 0.00490542 |
| PRDX2 | peroxiredoxin 2 | 0.00489274 |
| NKG7 | natural killer cell granule protein 7 | 0.00486776 |
| CCNE2 | cyclin E2 | 0.00485828 |
| CCR5 | chemokine (C-C motif) receptor 5 (gene/pseudogene) | 0.00485717 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.00482788 |
| B3GNT1 | 0.00481298 | |
| GRB14 | growth factor receptor-bound protein 14 | 0.00480761 |
| SSX2IP | synovial sarcoma, X breakpoint 2 interacting protein | 0.00480739 |
| USP1 | ubiquitin specific peptidase 1 | 0.00480672 |
| NDRG3 | NDRG family member 3 | 0.00479222 |
| TMX4 | thioredoxin-related transmembrane protein 4 | 0.00479052 |
| CLEC11A | C-type lectin domain family 11, member A | 0.00478969 |
| DNAJC12 | DnaJ (Hsp40) homolog, subfamily C, member 12 | 0.004788 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.00477631 |
| TBC1D4 | TBC1 domain family, member 4 | 0.00477189 |
| OTULINL | OTU deubiquitinase with linear linkage specificity like | 0.00476236 |
| SEPP1 | selenoprotein P, plasma, 1 | 0.00475111 |
| KCNJ8 | potassium channel, inwardly rectifying subfamily J, member 8 | 0.0047474 |
| APMAP | adipocyte plasma membrane associated protein | 0.00474719 |
| EXOSC4 | exosome component 4 | 0.00473725 |
| CCDC47 | coiled-coil domain containing 47 | 0.00473176 |
| SPTSSA | serine palmitoyltransferase, small subunit A | 0.00472455 |
| MICU2 | mitochondrial calcium uptake 2 | 0.00471693 |
| CHKB | choline kinase beta | 0.00471592 |
| MBL2 | mannose-binding lectin (protein C) 2, soluble | 0.00470875 |
| DEPDC1 | DEP domain containing 1 | 0.0047045 |
| PLAT | plasminogen activator, tissue | 0.00469327 |
| AKAP7 | A kinase (PRKA) anchor protein 7 | 0.00467937 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | 0.00467747 |
| PNMA1 | paraneoplastic Ma antigen 1 | 0.00467348 |
| COPS4 | COP9 signalosome subunit 4 | 0.00466965 |
| NEIL3 | nei endonuclease VIII-like 3 (E. coli) | 0.00466776 |
| FOXF1 | forkhead box F1 | 0.0046661 |
| IMPDH2 | IMP (inosine 5'-monophosphate) dehydrogenase 2 | 0.00465327 |
| RNASEH2A | ribonuclease H2, subunit A | 0.00465164 |
| HELLS | helicase, lymphoid-specific | 0.00464778 |
| BANK1 | B-cell scaffold protein with ankyrin repeats 1 | 0.00464533 |
| GEMIN2 | gem (nuclear organelle) associated protein 2 | 0.00463963 |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) | 0.00462614 |
| MYCL | v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog | 0.0046156 |
| SIDT2 | SID1 transmembrane family, member 2 | 0.0046144 |
| TMED7 | transmembrane emp24 protein transport domain containing 7 | 0.00460984 |
| PRKACB | protein kinase, cAMP-dependent, catalytic, beta | 0.00460263 |
| C12ORF29 | chromosome 12 open reading frame 29 | 0.00459704 |
| P2RY14 | purinergic receptor P2Y, G-protein coupled, 14 | 0.00457978 |
| MAGED1 | melanoma antigen family D1 | 0.00457961 |
| ATP13A3 | ATPase type 13A3 | 0.00457406 |
| MXRA7 | matrix-remodelling associated 7 | 0.0045703 |
| SNX10 | sorting nexin 10 | 0.00456493 |
| HAT1 | histone acetyltransferase 1 | 0.00456433 |
| CBX3 | chromobox homolog 3 | 0.00456403 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | 0.00455885 |
| MCM2 | minichromosome maintenance complex component 2 | 0.00453321 |
| EXPH5 | exophilin 5 | 0.00452914 |
| DSE | dermatan sulfate epimerase | 0.00452656 |
| CDT1 | chromatin licensing and DNA replication factor 1 | 0.00452196 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.00451967 |
| NINJ2 | ninjurin 2 | 0.00451609 |
| AMD1 | adenosylmethionine decarboxylase 1 | 0.0045154 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.00449881 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.00449838 |
| C7 | complement component 7 | 0.00449461 |
| IGFLR1 | IGF-like family receptor 1 | 0.00448721 |
| GPRC5C | G protein-coupled receptor, class C, group 5, member C | 0.00447697 |
| COPS7A | COP9 signalosome subunit 7A | 0.00447637 |
| GSTA4 | glutathione S-transferase alpha 4 | 0.00447272 |
| LAMP5 | lysosomal-associated membrane protein family, member 5 | 0.00447021 |
| CADM1 | cell adhesion molecule 1 | 0.00445841 |
| IL2RB | interleukin 2 receptor, beta | 0.00445805 |
| ATF1 | activating transcription factor 1 | 0.00445706 |
| TBL1X | transducin (beta)-like 1X-linked | 0.00444778 |
| FCER1A | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide | 0.0044434 |
| SLBP | stem-loop binding protein | 0.00444319 |
| NCAPG | non-SMC condensin I complex, subunit G | 0.0044401 |
| ANXA6 | annexin A6 | 0.00443556 |
| ASF1A | anti-silencing function 1A histone chaperone | 0.00443318 |
| TMEM106B | transmembrane protein 106B | 0.00442456 |
| PAK1 | p21 protein (Cdc42/Rac)-activated kinase 1 | 0.00442432 |
| APPL1 | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 | 0.00440756 |
| SPC25 | SPC25, NDC80 kinetochore complex component | 0.00440605 |
| NR2F2 | nuclear receptor subfamily 2, group F, member 2 | 0.00438056 |
| ZNF239 | zinc finger protein 239 | 0.00436928 |
| OCRL | oculocerebrorenal syndrome of Lowe | 0.00436306 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.00435849 |
| TMEM38B | transmembrane protein 38B | 0.00434893 |
| PLA2G12A | phospholipase A2, group XIIA | 0.0043127 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | 0.00430956 |
| KLHL23 | kelch-like family member 23 | 0.00430051 |
| GPR171 | G protein-coupled receptor 171 | 0.00429289 |
| SLC3A1 | solute carrier family 3 (amino acid transporter heavy chain), member 1 | 0.00429256 |
| PTGER3 | prostaglandin E receptor 3 (subtype EP3) | 0.00429122 |
| GTSE1 | G-2 and S-phase expressed 1 | 0.00428989 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.00428972 |
| ERI2 | ERI1 exoribonuclease family member 2 | 0.00428781 |
| SAP30 | Sin3A-associated protein, 30kDa | 0.00427683 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0155333 |
| ADM | adrenomedullin | -0.0135928 |
| KRT14 | keratin 14, type I | -0.0134969 |
| HSPA1A | heat shock 70kDa protein 1A | -0.0134206 |
| ANXA1 | annexin A1 | -0.0131259 |
| S100A8 | S100 calcium binding protein A8 | -0.0129551 |
| GLOD4 | glyoxalase domain containing 4 | -0.0126851 |
| S100A9 | S100 calcium binding protein A9 | -0.0125529 |
| KRT15 | keratin 15, type I | -0.0117253 |
| SLPI | secretory leukocyte peptidase inhibitor | -0.0116781 |
| EMP1 | epithelial membrane protein 1 | -0.0108601 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | -0.0107254 |
| KRT23 | keratin 23, type I | -0.0102254 |
| KLK10 | kallikrein-related peptidase 10 | -0.0102196 |
| ASS1 | argininosuccinate synthase 1 | -0.00981387 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | -0.00981054 |
| EIF5A | eukaryotic translation initiation factor 5A | -0.00962239 |
| FABP4 | fatty acid binding protein 4, adipocyte | -0.00933849 |
| MMP7 | matrix metallopeptidase 7 | -0.00919807 |
| MVP | major vault protein | -0.0091793 |
| KRT17 | keratin 17, type I | -0.0091422 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | -0.00901297 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.00901247 |
| TRIM29 | tripartite motif containing 29 | -0.00892794 |
| MT1X | metallothionein 1X | -0.00891274 |
| STC2 | stanniocalcin 2 | -0.00887163 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | -0.00878126 |
| FNDC3B | fibronectin type III domain containing 3B | -0.00870922 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | -0.00870729 |
| CSTA | cystatin A (stefin A) | -0.00868767 |
| USP7 | ubiquitin specific peptidase 7 (herpes virus-associated) | -0.00862041 |
| AQP3 | aquaporin 3 (Gill blood group) | -0.00859022 |
| IL1RN | interleukin 1 receptor antagonist | -0.0085178 |
| HIST1H2BD | histone cluster 1, H2bd | -0.00849367 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.00843945 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.00841972 |
| ABLIM1 | actin binding LIM protein 1 | -0.00834819 |
| CYBA | cytochrome b-245, alpha polypeptide | -0.00832055 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.00828238 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | -0.00817321 |
| PITX3 | paired-like homeodomain 3 | -0.00796802 |
| IER5 | immediate early response 5 | -0.00788854 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.00783317 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.00781099 |
| CRYAB | crystallin, alpha B | -0.00768087 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | -0.0075825 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | -0.00757805 |
| RRAGD | Ras-related GTP binding D | -0.00756834 |
| MX1 | MX dynamin-like GTPase 1 | -0.00756487 |
| GPNMB | glycoprotein (transmembrane) nmb | -0.00755843 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | -0.00755136 |
| HIST1H2AC | histone cluster 1, H2ac | -0.00746911 |
| LCN2 | lipocalin 2 | -0.00745511 |
| DNMT3A | DNA (cytosine-5-)-methyltransferase 3 alpha | -0.00736675 |
| KRT7 | keratin 7, type II | -0.00734509 |
| OXTR | oxytocin receptor | -0.00731413 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | -0.00724354 |
| DUSP5 | dual specificity phosphatase 5 | -0.00719568 |
| KYNU | kynureninase | -0.00715945 |
| SPRR3 | small proline-rich protein 3 | -0.00715405 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | -0.00714103 |
| SPRR1B | small proline-rich protein 1B | -0.00713603 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | -0.00712236 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.00712221 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | -0.00711998 |
| RGCC | regulator of cell cycle | -0.00710382 |
| CTSD | cathepsin D | -0.00704377 |
| CLTB | clathrin, light chain B | -0.00698107 |
| PERP | PERP, TP53 apoptosis effector | -0.00697139 |
| DDX21 | DEAD (Asp-Glu-Ala-Asp) box helicase 21 | -0.00696471 |
| CRISP3 | cysteine-rich secretory protein 3 | -0.00696015 |
| ACKR3 | atypical chemokine receptor 3 | -0.00694423 |
| KRT5 | keratin 5, type II | -0.00692704 |
| TPD52 | tumor protein D52 | -0.00689865 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | -0.00689105 |
| SIRPA | signal-regulatory protein alpha | -0.00687774 |
| RALB | v-ral simian leukemia viral oncogene homolog B | -0.00683115 |
| SCPEP1 | serine carboxypeptidase 1 | -0.00672692 |
| MT1G | metallothionein 1G | -0.00672185 |
| CRABP2 | cellular retinoic acid binding protein 2 | -0.00671091 |
| PI3 | peptidase inhibitor 3, skin-derived | -0.00670454 |
| VPS37B | vacuolar protein sorting 37 homolog B (S. cerevisiae) | -0.00667209 |
| ZIC1 | Zic family member 1 | -0.00666757 |
| BHLHE41 | basic helix-loop-helix family, member e41 | -0.00665551 |
| FGB | fibrinogen beta chain | -0.0066223 |
| CEACAM7 | carcinoembryonic antigen-related cell adhesion molecule 7 | -0.00662126 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.00661626 |
| MT1HL1 | metallothionein 1H-like 1 | -0.00657209 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.00654462 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.00652664 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.00644908 |
| KRT13 | keratin 13, type I | -0.00643436 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.0063827 |
| TICAM1 | toll-like receptor adaptor molecule 1 | -0.00637982 |
| KRT6A | keratin 6A, type II | -0.00637954 |
| LAMB3 | laminin, beta 3 | -0.00633978 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.00633123 |
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | -0.00629432 |
| MT1E | metallothionein 1E | -0.00626295 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.00624757 |
| EIF6 | eukaryotic translation initiation factor 6 | -0.00621899 |
| EGR1 | early growth response 1 | -0.0061859 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | -0.00617987 |
| ETHE1 | ethylmalonic encephalopathy 1 | -0.00617208 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.00614697 |
| CLIC5 | chloride intracellular channel 5 | -0.00611996 |
| ANXA2P2 | annexin A2 pseudogene 2 | -0.00610815 |
| KRT16 | keratin 16, type I | -0.0060984 |
| CTSS | cathepsin S | -0.00609418 |
| PPL | periplakin | -0.0060662 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | -0.00606568 |
| MT1H | metallothionein 1H | -0.00605578 |
| SCEL | sciellin | -0.00604336 |
| ZC3H12A | zinc finger CCCH-type containing 12A | -0.00600969 |
| ATF4 | activating transcription factor 4 | -0.00597867 |
| ATP6V0E1 | ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 | -0.00593355 |
| S100A12 | S100 calcium binding protein A12 | -0.00593046 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0058954 |
| SCD5 | stearoyl-CoA desaturase 5 | -0.00587705 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.00586635 |
| KDM5A | lysine (K)-specific demethylase 5A | -0.00586113 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F | -0.00584441 |
| S100A7 | S100 calcium binding protein A7 | -0.00583674 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | -0.00581341 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | -0.00580994 |
| BTG3 | BTG family, member 3 | -0.00575287 |
| CRYBG1 | crystallin beta-gamma domain containing 1 | -0.00575089 |
| TPD52L1 | tumor protein D52-like 1 | -0.00573274 |
| RRAGC | Ras-related GTP binding C | -0.00571922 |
| LAMC2 | laminin, gamma 2 | -0.00571752 |
| POU2AF1 | POU class 2 associating factor 1 | -0.00569639 |
| KLK11 | kallikrein-related peptidase 11 | -0.00569627 |
| PRTN3 | proteinase 3 | -0.0056854 |
| SWAP70 | SWAP switching B-cell complex 70kDa subunit | -0.00568336 |
| PDZK1IP1 | PDZK1 interacting protein 1 | -0.00568205 |
| APOD | apolipoprotein D | -0.00566424 |
| RHCG | Rh family, C glycoprotein | -0.00563657 |
| PIM1 | Pim-1 proto-oncogene, serine/threonine kinase | -0.0056296 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.00562573 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.00562194 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 | -0.00561939 |
| H1-2 | H1.2 linker histone, cluster member | -0.00561737 |
| PIP | prolactin-induced protein | -0.0056109 |
| MME | membrane metallo-endopeptidase | -0.00558655 |
| TSPO | translocator protein (18kDa) | -0.00555002 |
| FADS3 | fatty acid desaturase 3 | -0.00554674 |
| TNFAIP6 | tumor necrosis factor, alpha-induced protein 6 | -0.00553689 |
| ECM1 | extracellular matrix protein 1 | -0.0055228 |
| MT1F | metallothionein 1F | -0.00551139 |
| TP53I3 | tumor protein p53 inducible protein 3 | -0.00551129 |
| CLCA4 | chloride channel accessory 4 | -0.00550554 |
| KRT81 | keratin 81, type II | -0.00548579 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | -0.00545711 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.00542636 |
| FXYD5 | FXYD domain containing ion transport regulator 5 | -0.00540642 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.00539334 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.0053837 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | -0.00538208 |
| EPS8L2 | EPS8-like 2 | -0.00537761 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.00537384 |
| UGT2B28 | UDP glucuronosyltransferase 2 family, polypeptide B28 | -0.00537312 |
| CDA | cytidine deaminase | -0.0053528 |
| INAVA | innate immunity activator | -0.00535202 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -0.00534755 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.00533059 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | -0.00531992 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | -0.00531737 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.00531603 |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | -0.00531375 |
| MGLL | monoglyceride lipase | -0.00530551 |
| PRAME | preferentially expressed antigen in melanoma | -0.00528373 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -0.00527283 |
| CSTB | cystatin B (stefin B) | -0.00526304 |
| KLK13 | kallikrein-related peptidase 13 | -0.00525993 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0052457 |
| MBD2 | methyl-CpG binding domain protein 2 | -0.00523718 |
| AOC1 | amine oxidase, copper containing 1 | -0.00523451 |
| PLIN2 | perilipin 2 | -0.00521083 |
| LYPD3 | LY6/PLAUR domain containing 3 | -0.00520607 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.00520513 |
| C10ORF10 | chromosome 10 open reading frame 10 | -0.00520233 |
| ABCG2 | ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) | -0.0051986 |
| RABEP2 | rabaptin, RAB GTPase binding effector protein 2 | -0.0051796 |
| RND3 | Rho family GTPase 3 | -0.00517892 |
| SNAP25 | synaptosomal-associated protein, 25kDa | -0.00516656 |
| MFAP5 | microfibrillar associated protein 5 | -0.00516473 |
| KRT6B | keratin 6B, type II | -0.00515823 |
| SLC2A5 | solute carrier family 2 (facilitated glucose/fructose transporter), member 5 | -0.00515294 |
| HMOX1 | heme oxygenase 1 | -0.00513791 |
| CX3CL1 | chemokine (C-X3-C motif) ligand 1 | -0.00512729 |
| DOCK9 | dedicator of cytokinesis 9 | -0.00512571 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 | -0.00511576 |
| MT1M | metallothionein 1M | -0.00511319 |
| AZU1 | azurocidin 1 | -0.0051125 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.00510736 |
| MZB1 | marginal zone B and B1 cell-specific protein | -0.00510661 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | -0.00510603 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | -0.00509374 |
| IL1B | interleukin 1, beta | -0.00508846 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.005088 |
| MYBPC1 | myosin binding protein C, slow type | -0.00507366 |
| TRAF3IP2 | TRAF3 interacting protein 2 | -0.00507314 |
| CLDN10 | claudin 10 | -0.0050707 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.00505971 |
| IFNGR1 | interferon gamma receptor 1 | -0.00505423 |
| BID | BH3 interacting domain death agonist | -0.00504158 |
| FN1 | fibronectin 1 | -0.00502551 |
| CD38 | CD38 molecule | -0.00502456 |
| TNF | tumor necrosis factor | -0.00501095 |
| CRNN | cornulin | -0.00498782 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.00498067 |
| VTCN1 | V-set domain containing T cell activation inhibitor 1 | -0.00497838 |
| SPRR1A | small proline-rich protein 1A | -0.00497622 |
| LITAF | lipopolysaccharide-induced TNF factor | -0.00497389 |
| MIA | melanoma inhibitory activity | -0.00492931 |
| DCX | doublecortin | -0.004926 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | -0.00492217 |
| EPS8L1 | EPS8-like 1 | -0.00491395 |
| TMEM45A | transmembrane protein 45A | -0.00491393 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | -0.00491118 |
| KLHL24 | kelch-like family member 24 | -0.00491056 |
| CLDN8 | claudin 8 | -0.0049064 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | -0.00490519 |
| TRIM16 | tripartite motif containing 16 | -0.00488505 |
| GRN | granulin | -0.00486479 |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 | -0.00485925 |
| HTRA1 | HtrA serine peptidase 1 | -0.0048573 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | -0.0048554 |
| PARP6 | poly (ADP-ribose) polymerase family, member 6 | -0.00484851 |
| VNN1 | vanin 1 | -0.00483274 |
| RBM34 | RNA binding motif protein 34 | -0.00482763 |
| MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B | -0.00482551 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | -0.00481284 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.00481004 |
| GSN | gelsolin | -0.00480723 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0048005 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.00479805 |
| ATP6V1F | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | -0.00476613 |
| INHBB | inhibin, beta B | -0.0047488 |
| CA12 | carbonic anhydrase XII | -0.00474742 |
| FABP7 | fatty acid binding protein 7, brain | -0.00474233 |
| CFD | complement factor D (adipsin) | -0.00474102 |
| BCL3 | B-cell CLL/lymphoma 3 | -0.00471227 |
| PTK2B | protein tyrosine kinase 2 beta | -0.00470677 |
| AFTPH | aftiphilin | -0.0046931 |
| BRINP1 | bone morphogenetic protein/retinoic acid inducible neural-specific 1 | -0.00468981 |
| OPTN | optineurin | -0.00468682 |
| ELANE | elastase, neutrophil expressed | -0.00466257 |
