STAT5A Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description signal transducer and activator of transcription 5A|The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013] (NCBI Entrez Gene Database, 6776)
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Genes

252 genes differentially expressed following the STAT5A gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SYCP2 synaptonemal complex protein 2 3.13802
GRXCR2 glutaredoxin, cysteine rich 2 3.13802
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 3.13802
TF transferrin 3.13802
PADI1 peptidyl arginine deiminase, type I 3.13802
TGM6 transglutaminase 6 3.13802
SPRR2A small proline-rich protein 2A 3.13802
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 3.13802
TM4SF1 transmembrane 4 L six family member 1 3.13802
PLIN4 perilipin 4 3.13802
PARP3 poly (ADP-ribose) polymerase family, member 3 3.13802
OR8D4 olfactory receptor, family 8, subfamily D, member 4 3.13802
RNF17 ring finger protein 17 3.13802
FETUB fetuin B 3.13802
CABCOCO1 ciliary associated calcium binding coiled-coil 1 3.13802
BCL2L15 BCL2-like 15 3.13802
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 3.13802
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 3.13802
C17ORF113 chromosome 17 open reading frame 113 3.13802
SPMAP2L sperm microtubule associated protein 2 like 3.13802
CFAP97D2 CFAP97 domain containing 2 3.13802
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 3.13802
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 3.13802
TMEM52B transmembrane protein 52B 3.13802
SPINT3 serine peptidase inhibitor, Kunitz type, 3 2.94546
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma 2.94546
RIMBP3C RIMS binding protein 3C 2.94546
LRRD1 leucine-rich repeats and death domain containing 1 2.94546
APOA2 apolipoprotein A-II 2.94546
NAPSA napsin A aspartic peptidase 2.94546
ALB albumin 2.94546
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 2.94546
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 2.94546
PLIN1 perilipin 1 2.94546
DIRAS3 DIRAS family, GTP-binding RAS-like 3 2.94546
FGL2 fibrinogen-like 2 2.94546
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 2.94546
TCHH trichohyalin 2.94546
GJB5 gap junction protein, beta 5, 31.1kDa 2.94546
HES5 hes family bHLH transcription factor 5 2.94546
ANKRD53 ankyrin repeat domain 53 2.94546
SIRPB2 signal-regulatory protein beta 2 2.94546
OR10A2 olfactory receptor, family 10, subfamily A, member 2 2.94546
MUC1 mucin 1, cell surface associated 2.94546
TMEM151A transmembrane protein 151A 2.94546
PDILT protein disulfide isomerase-like, testis expressed 2.94546
FAM153A family with sequence similarity 153, member A 2.94546
HBG2 hemoglobin, gamma G 2.94546
MEIOSIN meiosis initiator 2.94546
TYROBP TYRO protein tyrosine kinase binding protein 2.94546
H1-6 H1.6 linker histone, cluster member 2.94546
CCN3 cellular communication network factor 3 2.94546
CBLIF cobalamin binding intrinsic factor 2.94546
PLPP4 phospholipid phosphatase 4 2.94546
H1-8 H1.8 linker histone 2.94546
GARIN6 golgi associated RAB2 interactor family member 6 2.94546
CPHXL cytoplasmic polyadenylated homeobox like 2.94546
SMIM45 small integral membrane protein 45 2.94546
TMA7B translation machinery associated 7 homolog B 2.94546
CIMIP3 ciliary microtubule inner protein 3 2.94546
NOTCH2NLB notch 2 N-terminal like B 2.94546
TEX53 testis expressed 53 2.94546
ALX4 ALX homeobox 4 2.94546
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 2.94546
OASL 2'-5'-oligoadenylate synthetase-like 2.94546
GGT5 gamma-glutamyltransferase 5 2.94546
IL31RA interleukin 31 receptor A 2.94546
TLR1 toll-like receptor 1 2.94546
SLAMF7 SLAM family member 7 2.94546
RAG2 recombination activating gene 2 2.94546
NR0B1 nuclear receptor subfamily 0, group B, member 1 2.94546
C9 complement component 9 2.94546
ADIG adipogenin 2.94546
FGFBP2 fibroblast growth factor binding protein 2 2.94546
PNPLA1 patatin-like phospholipase domain containing 1 2.94546
TMEM119 transmembrane protein 119 2.94546
PRG4 proteoglycan 4 2.94546
KL klotho 2.94546
SPATA22 spermatogenesis associated 22 2.94546
DRC5 dynein regulatory complex subunit 5 2.94546
ADH6 alcohol dehydrogenase 6 (class V) 2.94546
PHOX2A paired-like homeobox 2a 2.94546
TEKT2 tektin 2 (testicular) 2.94546
CLEC18C C-type lectin domain family 18, member C 2.94546
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 2.94546
AGXT2 alanine--glyoxylate aminotransferase 2 2.94546
PCDHGA4 protocadherin gamma subfamily A, 4 2.94546
C22ORF42 chromosome 22 open reading frame 42 2.94546
CSF1R colony stimulating factor 1 receptor 2.94546
APOC4 apolipoprotein C-IV 2.94546
NPFFR1 neuropeptide FF receptor 1 2.94546
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 2.94546
AQP7 aquaporin 7 2.94546
KLHL6 kelch-like family member 6 2.94546
TIGIT T cell immunoreceptor with Ig and ITIM domains 2.94546
PCDH12 protocadherin 12 2.94546
FSHR follicle stimulating hormone receptor 2.94546
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 2.94546
CFH complement factor H 2.94546
PDK4 pyruvate dehydrogenase kinase, isozyme 4 2.94546
GOLGA8R golgin A8 family, member R 2.94546
TTC22 tetratricopeptide repeat domain 22 2.94546
NMBR neuromedin B receptor 2.94546
LYPD5 LY6/PLAUR domain containing 5 2.94546
PSG9 pregnancy specific beta-1-glycoprotein 9 2.94546
SLC38A8 solute carrier family 38, member 8 2.94546
DND1 DND microRNA-mediated repression inhibitor 1 2.94546
OR14J1 olfactory receptor, family 14, subfamily J, member 1 2.94546
PLA2G12B phospholipase A2, group XIIB 2.94546
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 2.94546
ITGB7 integrin, beta 7 2.94546
SMIM22 small integral membrane protein 22 2.94546
TCF21 transcription factor 21 2.94546
IHH indian hedgehog 2.94546
ABRA actin binding Rho activating protein 2.94546
MRGPRX2 MAS-related GPR, member X2 2.94546
SLITRK1 SLIT and NTRK-like family, member 1 2.94546
DCST1 DC-STAMP domain containing 1 2.94546
GPR179 G protein-coupled receptor 179 2.94546
PLGLB2 plasminogen-like B2 2.94546
C4BPA complement component 4 binding protein, alpha 2.94546
PADI6 peptidyl arginine deiminase, type VI 2.94546
SSX1 synovial sarcoma, X breakpoint 1 2.94546
PPP1R3G protein phosphatase 1, regulatory subunit 3G 2.94546
FAM25G family with sequence similarity 25, member G 2.94546
TBC1D21 TBC1 domain family, member 21 2.94546
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 2.94546
STEAP4 STEAP family member 4 2.94546
OR13A1 olfactory receptor, family 13, subfamily A, member 1 2.94546
IER5L immediate early response 5-like 2.94546
DMTN dematin actin binding protein 2.94546
WFDC13 WAP four-disulfide core domain 13 2.94546
HEMGN hemogen 2.94546
SPICE1 spindle and centriole associated protein 1 2.94091
G0S2 G0/G1 switch 2 2.80803
ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5 2.80803
GOLGA6L7 golgin A6 family like 7 2.80803
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 2.80803
KIF16B kinesin family member 16B 2.66409
PDE11A phosphodiesterase 11A 2.61241
SPMIP4 sperm microtubule inner protein 4 2.54705
PAIP2B poly(A) binding protein interacting protein 2B 2.39734
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 2.37354
ZFHX3 zinc finger homeobox 3 2.36862
RCL1 RNA terminal phosphate cyclase-like 1 2.36637
GPR146 G protein-coupled receptor 146 2.33077
VWA3A von Willebrand factor A domain containing 3A 2.33077
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 2.27924
MFSD2A major facilitator superfamily domain containing 2A 2.27417
KLC3 kinesin light chain 3 2.2714
BOK BCL2-related ovarian killer 2.24173
MB21D2 Mab-21 domain containing 2 2.24173
LARGE2 LARGE xylosyl- and glucuronyltransferase 2 2.22858
PEA15 phosphoprotein enriched in astrocytes 15 2.22838
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 2.22838
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 2.21773
GJD3 gap junction protein, delta 3, 31.9kDa 2.20501
GPR83 G protein-coupled receptor 83 2.20501
MFN2 mitofusin 2 2.19684
TRPC7 transient receptor potential cation channel, subfamily C, member 7 2.17187
GPR12 G protein-coupled receptor 12 2.17187
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 2.16454
FAXDC2 fatty acid hydroxylase domain containing 2 2.14415
RPA2 replication protein A2, 32kDa 2.11869
CEPT1 choline/ethanolamine phosphotransferase 1 2.08579
USP38 ubiquitin specific peptidase 38 2.0697
GLIS3 GLIS family zinc finger 3 2.02921
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae) 2.0265
LCTL lactase-like 2.02526
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 2.02423

decreased expression

Symbol Name Standardized Value
SMKR1 small lysine-rich protein 1 -3.13802
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) -3.13802
UPK3B uroplakin 3B -3.13802
ELAVL3 ELAV like neuron-specific RNA binding protein 3 -3.13802
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 -3.13802
DUSP10 dual specificity phosphatase 10 -2.94546
TRPM8 transient receptor potential cation channel, subfamily M, member 8 -2.94546
ACSM1 acyl-CoA synthetase medium-chain family member 1 -2.94546
MTOR mechanistic target of rapamycin (serine/threonine kinase) -2.94546
RPA4 replication protein A4, 30kDa -2.94546
TRAF3 TNF receptor-associated factor 3 -2.94546
SCIN scinderin -2.94546
DNAH2 dynein, axonemal, heavy chain 2 -2.94546
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha -2.94546
CRB1 crumbs family member 1, photoreceptor morphogenesis associated -2.94546
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 -2.94546
F7 coagulation factor VII (serum prothrombin conversion accelerator) -2.94546
GMFG glia maturation factor, gamma -2.94546
TDRD6 tudor domain containing 6 -2.94546
USP50 ubiquitin specific peptidase 50 -2.94546
STRIT1 small transmembrane regulator of ion transport 1 -2.94546
ZNF2 zinc finger protein 2 -2.94546
NYX nyctalopin -2.94546
TCAP titin-cap -2.94546
RBM20 RNA binding motif protein 20 -2.94546
CCER2 coiled-coil glutamate-rich protein 2 -2.94546
PRPH2 peripherin 2 (retinal degeneration, slow) -2.94546
PDCD1LG2 programmed cell death 1 ligand 2 -2.94546
KRT86 keratin 86, type II -2.94546
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1 -2.94546
WBP2NL WBP2 N-terminal like -2.94546
CRYBB2 crystallin, beta B2 -2.94546
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2 -2.88495
TMEM160 transmembrane protein 160 -2.73274
PRKCG protein kinase C, gamma -2.70224
C6ORF47 chromosome 6 open reading frame 47 -2.68088
NRP1 neuropilin 1 -2.65221
CCDC127 coiled-coil domain containing 127 -2.636
TMX2 thioredoxin-related transmembrane protein 2 -2.61259
IRF3 interferon regulatory factor 3 -2.55144
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1 -2.39493
ZFR2 zinc finger RNA binding protein 2 -2.36637
MYO19 myosin XIX -2.32794
TMSB15B thymosin beta 15B -2.27502
TIGD6 tigger transposable element derived 6 -2.27502
MAT2A methionine adenosyltransferase II, alpha -2.2714
CLIP3 CAP-GLY domain containing linker protein 3 -2.25348
EXOC2 exocyst complex component 2 -2.24173
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F -2.24173
PDZRN3 PDZ domain containing ring finger 3 -2.23861
NOXO1 NADPH oxidase organizer 1 -2.23294
TAS2R31 taste receptor, type 2, member 31 -2.23294
TAMALIN trafficking regulator and scaffold protein tamalin -2.22838
CPZ carboxypeptidase Z -2.20501
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2 -2.20501
GCA grancalcin, EF-hand calcium binding protein -2.20501
CARMIL3 capping protein regulator and myosin 1 linker 3 -2.20501
FRMD1 FERM domain containing 1 -2.20501
TRIP11 thyroid hormone receptor interactor 11 -2.1978
PALLD palladin, cytoskeletal associated protein -2.18491
TRAK1 trafficking protein, kinesin binding 1 -2.16347
TMEM269 transmembrane protein 269 -2.15614
TBC1D2 TBC1 domain family, member 2 -2.15397
DRC3 dynein regulatory complex subunit 3 -2.13654
ZNF324B zinc finger protein 324B -2.13654
HAUS7 HAUS augmin-like complex, subunit 7 -2.133
PPP1R8 protein phosphatase 1, regulatory subunit 8 -2.11207
PYCR1 pyrroline-5-carboxylate reductase 1 -2.11207
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 -2.0764
CNOT1 CCR4-NOT transcription complex, subunit 1 -2.07084
GPR63 G protein-coupled receptor 63 -2.07084
LRRC4C leucine rich repeat containing 4C -2.06925
LGI4 leucine-rich repeat LGI family, member 4 -2.05624
TRPC5 transient receptor potential cation channel, subfamily C, member 5 -2.05358
BCL2L11 BCL2-like 11 (apoptosis facilitator) -2.05296
SALL3 spalt-like transcription factor 3 -2.05296
ULK3 unc-51 like kinase 3 -2.046
PKN2 protein kinase N2 -2.0289
HLA-DRA major histocompatibility complex, class II, DR alpha -2.0265
TMEM265 transmembrane protein 265 -2.02646
ETV1 ets variant 1 -2.00635
EXOSC9 exosome component 9 -2.00205