STAT5B Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description signal transducer and activator of transcription 5B|The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6777)
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Genes

348 genes differentially expressed following the STAT5B gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TSGA13 testis specific, 13 3.43923
ALKAL1 ALK and LTK ligand 1 3.43923
TRIM50 tripartite motif containing 50 3.43923
RGS8 regulator of G-protein signaling 8 3.43923
CXCL2 chemokine (C-X-C motif) ligand 2 3.43923
TACR2 tachykinin receptor 2 3.43923
WDR87 WD repeat domain 87 3.43923
ERVFRD-1 endogenous retrovirus group FRD, member 1 3.43923
F2 coagulation factor II (thrombin) 3.43923
VAX2 ventral anterior homeobox 2 3.43923
EPN3 epsin 3 3.43923
PCDHA11 protocadherin alpha 11 3.43923
RERGL RERG/RAS-like 3.43923
CELF6 CUGBP, Elav-like family member 6 3.43923
OSTN osteocrin 3.43923
NMBR neuromedin B receptor 3.43923
ADAM21 ADAM metallopeptidase domain 21 3.43923
GARIN6 golgi associated RAB2 interactor family member 6 3.43923
PHOX2A paired-like homeobox 2a 3.43923
CIMIP3 ciliary microtubule inner protein 3 3.43923
CDHR5 cadherin-related family member 5 3.43923
VWA3A von Willebrand factor A domain containing 3A 3.43923
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 3.43923
ANXA10 annexin A10 3.43923
GPR149 G protein-coupled receptor 149 3.43923
CCDC87 coiled-coil domain containing 87 3.43923
HCST hematopoietic cell signal transducer 3.43923
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 3.43923
IL6 interleukin 6 3.43923
NXPH3 neurexophilin 3 3.31086
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 3.31086
FPR1 formyl peptide receptor 1 3.31086
ITK IL2-inducible T-cell kinase 3.31086
NAPSA napsin A aspartic peptidase 3.31086
TAS2R5 taste receptor, type 2, member 5 3.31086
OR8A1 olfactory receptor, family 8, subfamily A, member 1 3.31086
IGFL2 IGF-like family member 2 3.31086
OR4N2 olfactory receptor, family 4, subfamily N, member 2 3.31086
FGF21 fibroblast growth factor 21 3.31086
JAG1 jagged 1 3.31086
TMEM95 transmembrane protein 95 3.31086
ENPP7 ectonucleotide pyrophosphatase/phosphodiesterase 7 3.31086
TM4SF5 transmembrane 4 L six family member 5 3.31086
CRH corticotropin releasing hormone 3.31086
S100A1 S100 calcium binding protein A1 3.31086
CRX cone-rod homeobox 3.31086
CTXN3 cortexin 3 3.31086
SHE Src homology 2 domain containing E 3.31086
GNG13 guanine nucleotide binding protein (G protein), gamma 13 3.31086
NPIPA8 nuclear pore complex interacting protein family, member A8 3.31086
TRPC5OS TRPC5 opposite strand 3.31086
CSNK2A3 casein kinase 2, alpha 3 polypeptide 3.31086
UBA7 ubiquitin-like modifier activating enzyme 7 3.31086
LOC107986837 uncharacterized LOC107986837 3.31086
TRIM73 tripartite motif containing 73 3.31086
TBX15 T-box 15 3.31086
BLK BLK proto-oncogene, Src family tyrosine kinase 3.31086
MRPL53 mitochondrial ribosomal protein L53 3.31086
HBA1 hemoglobin, alpha 1 3.31086
FAM90A1 family with sequence similarity 90, member A1 3.31086
FETUB fetuin B 3.31086
GRIA2 glutamate receptor, ionotropic, AMPA 2 3.31086
TAS2R8 taste receptor, type 2, member 8 3.31086
MFAP5 microfibrillar associated protein 5 3.31086
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 3.31086
PNMA6F PNMA family member 6F 3.31086
PNMA8B PNMA family member 8B 3.31086
GIPC3 GIPC PDZ domain containing family, member 3 3.31086
HAO2 hydroxyacid oxidase 2 (long chain) 3.31086
ALDOB aldolase B, fructose-bisphosphate 3.31086
ZAR1 zygote arrest 1 3.31086
YIPF7 Yip1 domain family, member 7 3.31086
AVPR1A arginine vasopressin receptor 1A 3.31086
MYH4 myosin, heavy chain 4, skeletal muscle 3.31086
HTRA4 HtrA serine peptidase 4 3.31086
CFAP157 cilia and flagella associated protein 157 3.31086
ODAPH odontogenesis associated phosphoprotein 3.31086
GARIN4 golgi associated RAB2 interactor family member 4 3.31086
SMIM45 small integral membrane protein 45 3.31086
SPAAR small regulatory polypeptide of amino acid response 3.31086
H4C14 H4 clustered histone 14 3.31086
SERTM2 serine rich and transmembrane domain containing 2 3.31086
PEAK3 PEAK family member 3 3.31086
IHO1 interactor of HORMAD1 1 3.31086
STPG3 sperm-tail PG-rich repeat containing 3 3.31086
MEIOSIN meiosis initiator 3.31086
PPDPFL pancreatic progenitor cell differentiation and proliferation factor like 3.31086
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8 3.31086
MYEOV myeloma overexpressed 3.31086
BARX1 BARX homeobox 1 3.31086
SBSN suprabasin 3.31086
LOC124901449 uncharacterized LOC124901449 3.31086
CASP14 caspase 14, apoptosis-related cysteine peptidase 3.31086
CCR9 chemokine (C-C motif) receptor 9 3.31086
KLRF1 killer cell lectin-like receptor subfamily F, member 1 3.31086
MIP major intrinsic protein of lens fiber 3.31086
NPIPB9 nuclear pore complex interacting protein family, member B9 3.31086
LDHAL6B lactate dehydrogenase A-like 6B 3.31086
VCX3B variable charge, X-linked 3B 3.31086
TARM1 T cell-interacting, activating receptor on myeloid cells 1 3.31086
FRY furry homolog (Drosophila) 3.31086
GC group-specific component (vitamin D binding protein) 3.31086
ZNF441 zinc finger protein 441 3.31086
IMPG1 interphotoreceptor matrix proteoglycan 1 3.31086
GATA6 GATA binding protein 6 3.31086
LTK leukocyte receptor tyrosine kinase 3.31086
SOAT2 sterol O-acyltransferase 2 3.31086
ASZ1 ankyrin repeat, SAM and basic leucine zipper domain containing 1 3.31086
COX8C cytochrome c oxidase subunit VIIIC 3.31086
LRRC73 leucine rich repeat containing 73 3.31086
SCN10A sodium channel, voltage gated, type X alpha subunit 3.31086
PDCD1 programmed cell death 1 3.31086
NPFFR1 neuropeptide FF receptor 1 3.31086
CPA3 carboxypeptidase A3 (mast cell) 3.31086
CDH10 cadherin 10, type 2 (T2-cadherin) 3.31086
CYS1 cystin 1 3.31086
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 3.31086
CGB7 chorionic gonadotropin, beta polypeptide 7 3.31086
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 3.31086
DRD5 dopamine receptor D5 3.31086
OR52K1 olfactory receptor, family 52, subfamily K, member 1 3.31086
MUC13 mucin 13, cell surface associated 3.31086
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 3.31086
TSPAN32 tetraspanin 32 3.31086
IL17REL interleukin 17 receptor E-like 3.31086
CCL27 chemokine (C-C motif) ligand 27 3.31086
OR56A3 olfactory receptor, family 56, subfamily A, member 3 3.31086
ZNF541 zinc finger protein 541 3.31086
GRK1 G protein-coupled receptor kinase 1 3.31086
CRYBB2 crystallin, beta B2 3.31086
S100Z S100 calcium binding protein Z 3.31086
KLF1 Kruppel-like factor 1 (erythroid) 3.31086
CLEC18C C-type lectin domain family 18, member C 3.31086
ISLR immunoglobulin superfamily containing leucine-rich repeat 3.31086
TEKT2 tektin 2 (testicular) 3.31086
FAM151A family with sequence similarity 151, member A 3.31086
SP140L SP140 nuclear body protein-like 3.31086
MEPE matrix extracellular phosphoglycoprotein 3.31086
CNGB1 cyclic nucleotide gated channel beta 1 3.31086
NPY2R neuropeptide Y receptor Y2 3.31086
C22ORF31 chromosome 22 open reading frame 31 3.31086
TMEM255A transmembrane protein 255A 3.31086
GOLGA8S golgin A8 family, member S 3.31086
ITGAD integrin, alpha D 3.31086
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 3.31086
GSC2 goosecoid homeobox 2 3.31086
TEX19 testis expressed 19 3.31086
LRRC19 leucine rich repeat containing 19 3.31086
HK3 hexokinase 3 (white cell) 3.31086
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 3.31086
CTXN2 cortexin 2 3.31086
ARL13A ADP-ribosylation factor-like 13A 3.31086
C7ORF33 chromosome 7 open reading frame 33 3.31086
OTOP2 otopetrin 2 3.31086
TAGAP T-cell activation RhoGTPase activating protein 3.31086
WFDC8 WAP four-disulfide core domain 8 3.31086
IL17A interleukin 17A 3.31086
TMPRSS12 transmembrane (C-terminal) protease, serine 12 3.31086
OR6J1 olfactory receptor, family 6, subfamily J, member 1 (gene/pseudogene) 3.31086
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 3.31086
ANKRD33 ankyrin repeat domain 33 3.31086
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 3.31086
BPIFC BPI fold containing family C 3.31086
TDO2 tryptophan 2,3-dioxygenase 3.31086
SPAG8 sperm associated antigen 8 3.31086
MCF2 MCF.2 cell line derived transforming sequence 3.31086
GREM1 gremlin 1, DAN family BMP antagonist 3.31086
NLRP8 NLR family, pyrin domain containing 8 3.31086
TMPRSS15 transmembrane protease, serine 15 3.31086
NRGN neurogranin (protein kinase C substrate, RC3) 3.31086
CD226 CD226 molecule 3.31086
GHRH growth hormone releasing hormone 3.31086
SPON2 spondin 2, extracellular matrix protein 3.31086
WFDC11 WAP four-disulfide core domain 11 3.31086
GNG2 guanine nucleotide binding protein (G protein), gamma 2 3.25552
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.85833
IFT122 intraflagellar transport 122 2.76569
DHDDS dehydrodolichyl diphosphate synthase 2.74322
IL3RA interleukin 3 receptor, alpha (low affinity) 2.72476
CEP89 centrosomal protein 89kDa 2.68851
KDSR 3-ketodihydrosphingosine reductase 2.67296
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) 2.67296
CIPC CLOCK-interacting pacemaker 2.66782
STK4 serine/threonine kinase 4 2.66301
PCNP PEST proteolytic signal containing nuclear protein 2.62684
CCDC183 coiled-coil domain containing 183 2.58809
SMC1B structural maintenance of chromosomes 1B 2.56146
ADM5 adrenomedullin 5 (putative) 2.53328
SLC35A4 solute carrier family 35, member A4 2.53214
PGS1 phosphatidylglycerophosphate synthase 1 2.47231
FAM3B family with sequence similarity 3, member B 2.45645
RAD54L RAD54-like (S. cerevisiae) 2.44024
CATSPERZ catsper channel auxiliary subunit zeta 2.43209
CTSO cathepsin O 2.43209
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 2.40272
EFS embryonal Fyn-associated substrate 2.37017
CNN1 calponin 1, basic, smooth muscle 2.3597
ZNF98 zinc finger protein 98 2.3544
ZBTB18 zinc finger and BTB domain containing 18 2.34746
RNF128 ring finger protein 128, E3 ubiquitin protein ligase 2.32803
CSF1R colony stimulating factor 1 receptor 2.29762
LINGO1 leucine rich repeat and Ig domain containing 1 2.29504
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) 2.29504
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 2.29053
CCL25 chemokine (C-C motif) ligand 25 2.29053
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2.29053
LEKR1 leucine, glutamate and lysine rich 1 2.29053
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 2.29053
TTPA tocopherol (alpha) transfer protein 2.29053
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 2.29053
TCP1 t-complex 1 2.28587
TTF1 transcription termination factor, RNA polymerase I 2.28064
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 2.25239
WDR17 WD repeat domain 17 2.22417
DIRAS1 DIRAS family, GTP-binding RAS-like 1 2.20931
CNTRL centriolin 2.20931
AMACR alpha-methylacyl-CoA racemase 2.19012
OSGEP O-sialoglycoprotein endopeptidase 2.18846
RAB10 RAB10, member RAS oncogene family 2.18846
GEMIN4 gem (nuclear organelle) associated protein 4 2.18598
FOXO3B forkhead box O3B pseudogene 2.16535
FEZ1 fasciculation and elongation protein zeta 1 (zygin I) 2.15907
NANS N-acetylneuraminic acid synthase 2.15631
RPA1 replication protein A1, 70kDa 2.11588
EPHB1 EPH receptor B1 2.10934
FIZ1 FLT3-interacting zinc finger 1 2.10683
PRNP prion protein 2.10522
DYNC2I1 dynein 2 intermediate chain 1 2.10522
THAP11 THAP domain containing 11 2.10522
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 2.10522
RBM41 RNA binding motif protein 41 2.10522
NOM1 nucleolar protein with MIF4G domain 1 2.10522
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 2.08042
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 2.08022
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 2.08022
RPS7 ribosomal protein S7 2.07763
ELOC elongin C 2.07371
SLX4IP SLX4 interacting protein 2.0519
DTNA dystrobrevin, alpha 2.04248
BHMT betaine--homocysteine S-methyltransferase 2.04126
TJP2 tight junction protein 2 2.04126
ATF4 activating transcription factor 4 2.02099
SAYSD1 SAYSVFN motif domain containing 1 2.02045
TMUB2 transmembrane and ubiquitin-like domain containing 2 2.02035
DDIT4L DNA-damage-inducible transcript 4-like 2.02035
SFXN4 sideroflexin 4 2.01574
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) 2.00757

decreased expression

Symbol Name Standardized Value
NABP1 nucleic acid binding protein 1 -3.43923
MMP28 matrix metallopeptidase 28 -3.43923
SH3TC2 SH3 domain and tetratricopeptide repeats 2 -3.36907
NRIP2 nuclear receptor interacting protein 2 -3.36907
PGBD2 piggyBac transposable element derived 2 -3.31086
STAT5B signal transducer and activator of transcription 5B -3.31086
BTN3A2 butyrophilin, subfamily 3, member A2 -3.31086
LRRC63 leucine rich repeat containing 63 -3.28107
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 -3.28107
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 -3.28107
OR56A1 olfactory receptor, family 56, subfamily A, member 1 -3.28107
RNF112 ring finger protein 112 -3.28107
GNG8 guanine nucleotide binding protein (G protein), gamma 8 -3.28107
CCDC17 coiled-coil domain containing 17 -3.28107
ZNF396 zinc finger protein 396 -3.28107
UPK3A uroplakin 3A -3.28107
SNAI3 snail family zinc finger 3 -3.28107
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 -3.28107
ARID5A AT rich interactive domain 5A (MRF1-like) -3.28107
POU5F2 POU domain class 5, transcription factor 2 -3.28107
OR4M2 olfactory receptor, family 4, subfamily M, member 2 -3.28107
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 -3.28107
SH2D7 SH2 domain containing 7 -3.28107
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 -3.28107
INHBA inhibin, beta A -3.28107
NRROS negative regulator of reactive oxygen species -3.28107
ZC2HC1B zinc finger, C2HC-type containing 1B -3.28107
DEFB131B defensin beta 131B -3.28107
SFTPD surfactant protein D -3.28107
ACSBG2 acyl-CoA synthetase bubblegum family member 2 -3.28107
TTLL2 tubulin tyrosine ligase-like family member 2 -3.28107
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A -3.28107
CCDC38 coiled-coil domain containing 38 -3.28107
PLD6 phospholipase D family, member 6 -3.15301
SBSPON somatomedin B and thrombospondin, type 1 domain containing -3.12701
CIMAP3 ciliary microtubule associated protein 3 -3.0219
SH2D3C SH2 domain containing 3C -2.87186
ZNF845 zinc finger protein 845 -2.86175
FLNC filamin C, gamma -2.81024
ZNF222 zinc finger protein 222 -2.81024
EPHA2 EPH receptor A2 -2.76659
WDR36 WD repeat domain 36 -2.73331
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 -2.68851
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -2.66782
MSANTD3 Myb/SANT-like DNA-binding domain containing 3 -2.66782
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 -2.66782
FAM13C family with sequence similarity 13, member C -2.63562
NPHP1 nephronophthisis 1 (juvenile) -2.60495
DTWD2 DTW domain containing 2 -2.59661
CLVS2 clavesin 2 -2.5376
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 -2.49129
TXNDC17 thioredoxin domain containing 17 -2.45769
EXD3 exonuclease 3'-5' domain containing 3 -2.44443
PDHB pyruvate dehydrogenase (lipoamide) beta -2.43208
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria -2.41962
TMEM191C transmembrane protein 191C -2.41811
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -2.41811
LCP1 lymphocyte cytosolic protein 1 (L-plastin) -2.40272
SBK2 SH3 domain binding kinase family, member 2 -2.40272
INSYN2B inhibitory synaptic factor family member 2B -2.3597
TRAPPC12 trafficking protein particle complex 12 -2.3544
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.3544
TRIM2 tripartite motif containing 2 -2.31868
HBEGF heparin-binding EGF-like growth factor -2.29762
NUDCD2 NudC domain containing 2 -2.29504
RASL10B RAS-like, family 10, member B -2.29053
CTSD cathepsin D -2.28064
RASL11A RAS-like, family 11, member A -2.26646
YY2 YY2 transcription factor -2.26646
PAQR3 progestin and adipoQ receptor family member III -2.25148
HMGB3 high mobility group box 3 -2.25026
CEP128 centrosomal protein 128kDa -2.24744
MIOS missing oocyte, meiosis regulator, homolog (Drosophila) -2.23753
GRIK5 glutamate receptor, ionotropic, kainate 5 -2.22657
BTBD6 BTB (POZ) domain containing 6 -2.22417
JPT2 Jupiter microtubule associated homolog 2 -2.21529
PTCH2 patched 2 -2.20972
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle -2.20931
GCHFR GTP cyclohydrolase I feedback regulator -2.19212
BBS5 Bardet-Biedl syndrome 5 -2.18249
ARB2A ARB2 cotranscriptional regulator A -2.18249
TMEM121B transmembrane protein 121B -2.18249
MRPL9 mitochondrial ribosomal protein L9 -2.18022
LMO2 LIM domain only 2 (rhombotin-like 1) -2.16813
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.1637
POMK protein-O-mannose kinase -2.1629
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F -2.15631
SSC5D scavenger receptor cysteine rich family, 5 domains -2.15381
MAP3K7 mitogen-activated protein kinase kinase kinase 7 -2.15312
SYNJ2BP synaptojanin 2 binding protein -2.14718
SYNPO synaptopodin -2.13015
ACIN1 apoptotic chromatin condensation inducer 1 -2.12476
TMEM9B TMEM9 domain family, member B -2.12476
ADAM9 ADAM metallopeptidase domain 9 -2.10522
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 -2.08638
NAA20 N(alpha)-acetyltransferase 20, NatB catalytic subunit -2.06972
ZNF528 zinc finger protein 528 -2.0519
FAT1 FAT atypical cadherin 1 -2.04088
LY75 lymphocyte antigen 75 -2.02242
CHRM5 cholinergic receptor, muscarinic 5 -2.02242
ZKSCAN4 zinc finger with KRAB and SCAN domains 4 -2.00247