STAT6 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description signal transducer and activator of transcription 6, interleukin-4 induced|The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] (NCBI Entrez Gene Database, 6778)
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Genes

246 genes differentially expressed following the STAT6 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CD28 CD28 molecule 2.29934
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 2.29934
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 2.29934
PPP1R9B protein phosphatase 1, regulatory subunit 9B 2.29934
MFAP5 microfibrillar associated protein 5 2.29934
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 2.29934
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 2.29934
TMEM45B transmembrane protein 45B 2.29934
CDCP2 CUB domain containing protein 2 2.29934
C18ORF63 chromosome 18 open reading frame 63 2.29934
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 2.29934
COL15A1 collagen, type XV, alpha 1 2.29934
ZNF831 zinc finger protein 831 2.29934
ADRA2A adrenoceptor alpha 2A 2.29934
CLRN2 clarin 2 2.29934
CELA2A chymotrypsin-like elastase family, member 2A 2.29934
LRRC63 leucine rich repeat containing 63 2.29934
LRRC32 leucine rich repeat containing 32 2.29934
ATP8B4 ATPase, class I, type 8B, member 4 2.29934
ARGFX arginine-fifty homeobox 2.29934
ARHGAP30 Rho GTPase activating protein 30 2.29934
HILPDA hypoxia inducible lipid droplet-associated 2.29338
TCF19 transcription factor 19 2.27799
BMF Bcl2 modifying factor 2.23711
FGF21 fibroblast growth factor 21 2.22646
FAM167A family with sequence similarity 167, member A 2.22646
COLEC10 collectin sub-family member 10 (C-type lectin) 2.22646
MGAM2 maltase-glucoamylase 2 (putative) 2.22646
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 2.22646
PRKCA protein kinase C, alpha 2.22646
GPR52 G protein-coupled receptor 52 2.22646
FGL2 fibrinogen-like 2 2.22646
KLRK1 killer cell lectin-like receptor subfamily K, member 1 2.22646
TRIM10 tripartite motif containing 10 2.22646
FOXA2 forkhead box A2 2.22646
KRT20 keratin 20, type I 2.22646
RIMBP3B RIMS binding protein 3B 2.22646
GMNC geminin coiled-coil domain containing 2.22646
ARRDC5 arrestin domain containing 5 2.22646
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 2.22646
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2.22646
AVPR2 arginine vasopressin receptor 2 2.22646
NRROS negative regulator of reactive oxygen species 2.22646
ANKRD34A ankyrin repeat domain 34A 2.22646
LYNX1 Ly6/neurotoxin 1 2.22646
EML1 echinoderm microtubule associated protein like 1 2.22646
GJB5 gap junction protein, beta 5, 31.1kDa 2.22646
TMEM191B transmembrane protein 191B 2.22646
AIF1L allograft inflammatory factor 1-like 2.22646
SLC25A45 solute carrier family 25, member 45 2.22646
SIGLEC7 sialic acid binding Ig-like lectin 7 2.22646
GSTM5 glutathione S-transferase mu 5 2.22646
CD96 CD96 molecule 2.22646
LURAP1L leucine rich adaptor protein 1-like 2.22646
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 2.22646
FMO1 flavin containing monooxygenase 1 2.22646
PAN2 PAN2 poly(A) specific ribonuclease subunit 2.22646
CXCL13 chemokine (C-X-C motif) ligand 13 2.22646
PNLIPRP3 pancreatic lipase-related protein 3 2.22646
CC2D1A coiled-coil and C2 domain containing 1A 2.22646
PROP1 PROP paired-like homeobox 1 2.22646
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.22646
CLXN calaxin 2.22646
SPMIP10 sperm microtubule inner protein 10 2.22646
JAML junction adhesion molecule like 2.22646
PCARE photoreceptor cilium actin regulator 2.22646
CBY2 chibby family member 2 2.22646
TMEM225B transmembrane protein 225B 2.22646
ACP7 acid phosphatase 7, tartrate resistant (putative) 2.22646
RHEX regulator of hemoglobinization and erythroid cell expansion 2.22646
H4C14 H4 clustered histone 14 2.22646
FCMR Fc fragment of IgM receptor 2.22646
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic 2.22646
OR7D2 olfactory receptor, family 7, subfamily D, member 2 2.22646
CST11 cystatin 11 2.22646
TARP TCR gamma alternate reading frame protein 2.22646
KLHL34 kelch-like family member 34 2.22646
ATP13A5 ATPase type 13A5 2.22646
NKX2-6 NK2 homeobox 6 2.22646
C1ORF87 chromosome 1 open reading frame 87 2.22646
CLDN9 claudin 9 2.22646
CLDN2 claudin 2 2.22646
OR51B5 olfactory receptor, family 51, subfamily B, member 5 2.22646
C1ORF162 chromosome 1 open reading frame 162 2.22646
TLR5 toll-like receptor 5 2.22646
SF3A2 splicing factor 3a, subunit 2, 66kDa 2.22646
GJD2 gap junction protein, delta 2, 36kDa 2.22646
SAA4 serum amyloid A4, constitutive 2.22646
ADIG adipogenin 2.22646
GPR132 G protein-coupled receptor 132 2.22646
LRRC71 leucine rich repeat containing 71 2.22646
LOC122455342 testis-specific serine/proline-rich protein 2.22646
CLEC18A C-type lectin domain family 18, member A 2.22646
CGB7 chorionic gonadotropin, beta polypeptide 7 2.22646
APOC2 apolipoprotein C-II 2.22646
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 2.22646
HKDC1 hexokinase domain containing 1 2.22646
WFDC5 WAP four-disulfide core domain 5 2.22646
IGFALS insulin-like growth factor binding protein, acid labile subunit 2.22646
POU1F1 POU class 1 homeobox 1 2.22646
TAS2R50 taste receptor, type 2, member 50 2.22646
NLRC3 NLR family, CARD domain containing 3 2.22646
EDN3 endothelin 3 2.22646
ERICH4 glutamate-rich 4 2.22646
LRRC46 leucine rich repeat containing 46 2.22646
FNDC8 fibronectin type III domain containing 8 2.22646
FNDC1 fibronectin type III domain containing 1 2.22646
MAGEA2B melanoma antigen family A2B 2.22646
LRCOL1 leucine rich colipase-like 1 2.22646
AGXT2 alanine--glyoxylate aminotransferase 2 2.22646
COL17A1 collagen, type XVII, alpha 1 2.22646
PLA1A phospholipase A1 member A 2.22646
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 2.22646
LDLRAD1 low density lipoprotein receptor class A domain containing 1 2.22646
SH2D1B SH2 domain containing 1B 2.22646
TCAP titin-cap 2.22646
RGS8 regulator of G-protein signaling 8 2.22646
LHX9 LIM homeobox 9 2.22646
GSDMA gasdermin A 2.22646
CTSW cathepsin W 2.22646
TSPYL6 TSPY-like 6 2.22646
PDCD1LG2 programmed cell death 1 ligand 2 2.22646
ANKRD55 ankyrin repeat domain 55 2.22646
RBM24 RNA binding motif protein 24 2.22646
TF transferrin 2.22646
TBX1 T-box 1 2.22646
SVOP SV2 related protein homolog (rat) 2.22646
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 2.22646
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 2.22646
PRSS54 protease, serine, 54 2.22646
PLEKHH3 pleckstrin homology domain containing, family H (with MyTH4 domain) member 3 2.22646
TMPRSS13 transmembrane protease, serine 13 2.22646
TAS2R10 taste receptor, type 2, member 10 2.22646
BMP3 bone morphogenetic protein 3 2.22646
ATG4D autophagy related 4D, cysteine peptidase 2.22646
TGM4 transglutaminase 4 2.22646
HEPN1 hepatocellular carcinoma, down-regulated 1 2.22646
CRYGA crystallin, gamma A 2.22646
IL37 interleukin 37 2.22646
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 2.22646
CHRDL2 chordin-like 2 2.22646
NCS1 neuronal calcium sensor 1 2.22646
AGBL2 ATP/GTP binding protein-like 2 2.22646
FAM9B family with sequence similarity 9, member B 2.22646
MISP mitotic spindle positioning 2.22646
GRAPL GRB2-related adaptor protein-like 2.22646
TRPM5 transient receptor potential cation channel, subfamily M, member 5 2.22646
PRSS50 protease, serine, 50 2.22646
BABAM1 BRISC and BRCA1 A complex member 1 2.22646
C3ORF49 chromosome 3 open reading frame 49 2.22646
PRR15L proline rich 15-like 2.22646
PLGLB1 plasminogen-like B1 2.22646
PSORS1C1 psoriasis susceptibility 1 candidate 1 2.22646
ROM1 retinal outer segment membrane protein 1 2.22646
PEX11B peroxisomal biogenesis factor 11 beta 2.22646
TMEM86B transmembrane protein 86B 2.22646
RERGL RERG/RAS-like 2.22646
GLT6D1 glycosyltransferase 6 domain containing 1 2.22646
LARP7 La ribonucleoprotein domain family, member 7 2.22646
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 2.22646
RALB v-ral simian leukemia viral oncogene homolog B 2.21937
C1ORF216 chromosome 1 open reading frame 216 2.19542
ZNF681 zinc finger protein 681 2.1438
INSL6 insulin-like 6 2.13057
PATL2 protein associated with topoisomerase II homolog 2 (yeast) 2.12246
SERPINE3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 2.12246
AP1M1 adaptor-related protein complex 1, mu 1 subunit 2.12246
ERG28 ergosterol biosynthesis 28 homolog 2.08946
BRPF3 bromodomain and PHD finger containing, 3 2.08782
SUMF2 sulfatase modifying factor 2 2.06887
NDN necdin, melanoma antigen (MAGE) family member 2.05816
DAPK3 death-associated protein kinase 3 2.05481
ZNF592 zinc finger protein 592 2.04971
PINLYP phospholipase A2 inhibitor and LY6/PLAUR domain containing 2.01195
LRRC49 leucine rich repeat containing 49 2.01123
MRRF mitochondrial ribosome recycling factor 2.00785

decreased expression

Symbol Name Standardized Value
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -2.29934
TEC tec protein tyrosine kinase -2.29934
TRAF3IP2 TRAF3 interacting protein 2 -2.29934
STRA6 stimulated by retinoic acid 6 -2.29934
CEACAM19 carcinoembryonic antigen-related cell adhesion molecule 19 -2.29934
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 -2.27799
NTNG2 netrin G2 -2.27799
EHD2 EH-domain containing 2 -2.22646
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 -2.22646
MEI1 meiosis inhibitor 1 -2.22646
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 -2.22646
TRPV6 transient receptor potential cation channel, subfamily V, member 6 -2.22646
PTGER3 prostaglandin E receptor 3 (subtype EP3) -2.22646
KAT5 K(lysine) acetyltransferase 5 -2.22646
TPM3 tropomyosin 3 -2.22646
PRR22 proline rich 22 -2.22646
PNMA8C PNMA family member 8C -2.22646
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -2.22646
LOX lysyl oxidase -2.22646
LOC124904542 uncharacterized LOC124904542 -2.22646
RAMACL RNA guanine-7 methyltransferase activating subunit like -2.22646
SMIM45 small integral membrane protein 45 -2.22646
CLTRN collectrin, amino acid transport regulator -2.22646
MARF1 meiosis regulator and mRNA stability factor 1 -2.22646
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 -2.22646
USP42 ubiquitin specific peptidase 42 -2.22646
ADORA2A adenosine A2a receptor -2.22646
ALOX5 arachidonate 5-lipoxygenase -2.22646
ANAPC10 anaphase promoting complex subunit 10 -2.22646
ROPN1 rhophilin associated tail protein 1 -2.22646
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) -2.22646
OR2A5 olfactory receptor, family 2, subfamily A, member 5 -2.22646
MOGAT3 monoacylglycerol O-acyltransferase 3 -2.22646
MDM4 MDM4, p53 regulator -2.22646
GALNS galactosamine (N-acetyl)-6-sulfatase -2.22646
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14 -2.22646
SYF2 SYF2 pre-mRNA-splicing factor -2.22646
WNT4 wingless-type MMTV integration site family, member 4 -2.22646
TMIGD2 transmembrane and immunoglobulin domain containing 2 -2.22646
SAFB scaffold attachment factor B -2.22646
CYP4X1 cytochrome P450, family 4, subfamily X, polypeptide 1 -2.22646
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced -2.22646
RSAD2 radical S-adenosyl methionine domain containing 2 -2.22646
SMIM17 small integral membrane protein 17 -2.22646
CD80 CD80 molecule -2.22646
RGS19 regulator of G-protein signaling 19 -2.22646
ABHD8 abhydrolase domain containing 8 -2.22646
CPLX1 complexin 1 -2.22646
ATG4A autophagy related 4A, cysteine peptidase -2.22646
STK33 serine/threonine kinase 33 -2.22646
LYPLA1 lysophospholipase I -2.22646
ZNF648 zinc finger protein 648 -2.22646
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -2.22646
TTC36 tetratricopeptide repeat domain 36 -2.22646
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -2.22405
ZNF536 zinc finger protein 536 -2.20107
KPTN kaptin (actin binding protein) -2.1953
F8A1 coagulation factor VIII-associated 1 -2.18133
GPR27 G protein-coupled receptor 27 -2.14058
C18ORF25 chromosome 18 open reading frame 25 -2.13067
PCYOX1L prenylcysteine oxidase 1 like -2.09242
DORIP1 dopamine receptor interacting protein 1 -2.08782
SEZ6L seizure related 6 homolog (mouse)-like -2.08782
VAT1L vesicle amine transport 1-like -2.08216
KLHL36 kelch-like family member 36 -2.07527
ODF2L outer dense fiber of sperm tails 2-like -2.0202
RBM17 RNA binding motif protein 17 -2.00785
APOB apolipoprotein B -2.00426
NPIPA5 nuclear pore complex interacting protein family, member A5 -2.00426
CHL1 cell adhesion molecule L1-like -2.00426