STAT6 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description signal transducer and activator of transcription 6, interleukin-4 induced|The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] (NCBI Entrez Gene Database, 6778)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GNF2_STAT6
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Genes

79 co-expressed genes for STAT6 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
ADPGK ADP-dependent glucokinase
ANXA11 annexin A11
ARF6 ADP-ribosylation factor 6
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
B2M beta-2-microglobulin
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2
C17ORF62 chromosome 17 open reading frame 62
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1
CASP4 caspase 4, apoptosis-related cysteine peptidase
CD48 CD48 molecule
CD53 CD53 molecule
CLIC1 chloride intracellular channel 1
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
CORO1A coronin, actin binding protein, 1A
CORO7 coronin 7
CYBA cytochrome b-245, alpha polypeptide
DAZAP2 DAZ associated protein 2
DOCK2 dedicator of cytokinesis 2
ELF4 E74-like factor 4 (ets domain transcription factor)
EMP3 epithelial membrane protein 3
EVI2B ecotropic viral integration site 2B
FMNL1 formin-like 1
FXYD5 FXYD domain containing ion transport regulator 5
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GMIP GEM interacting protein
GPSM3 G-protein signaling modulator 3
GRK6 G protein-coupled receptor kinase 6
HCLS1 hematopoietic cell-specific Lyn substrate 1
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
ICAM3 intercellular adhesion molecule 3
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IQGAP1 IQ motif containing GTPase activating protein 1
JUNB jun B proto-oncogene
LAPTM5 lysosomal protein transmembrane 5
LAT2 linker for activation of T cells family, member 2
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LSP1 lymphocyte-specific protein 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MBD2 methyl-CpG binding domain protein 2
MOB1A MOB kinase activator 1A
MSN moesin
MYD88 myeloid differentiation primary response 88
OSTF1 osteoclast stimulating factor 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PRR13 proline rich 13
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RIN3 Ras and Rab interactor 3
RNASET2 ribonuclease T2
SEC11A SEC11 homolog A (S. cerevisiae)
SELL selectin L
SERP1 stress-associated endoplasmic reticulum protein 1
SNAP23 synaptosomal-associated protein, 23kDa
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TAPBP TAP binding protein (tapasin)
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TGFB1 transforming growth factor, beta 1
TRIM38 tripartite motif containing 38
TYK2 tyrosine kinase 2
USP3 ubiquitin specific peptidase 3
VAV1 vav 1 guanine nucleotide exchange factor
WAS Wiskott-Aldrich syndrome
ZCCHC6 zinc finger, CCHC domain containing 6