STAU1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description staufen double-stranded RNA binding protein 1|Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6780)
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Genes

321 genes differentially expressed following the STAU1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
THPO thrombopoietin 2.86138
CARD14 caspase recruitment domain family, member 14 2.86138
TREM2 triggering receptor expressed on myeloid cells 2 2.86138
IYD iodotyrosine deiodinase 2.86138
SCGN secretagogin, EF-hand calcium binding protein 2.86138
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 2.86138
PI16 peptidase inhibitor 16 2.86138
BSND barttin CLCNK-type chloride channel accessory beta subunit 2.86138
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 2.86138
TMEM176A transmembrane protein 176A 2.86138
LY86 lymphocyte antigen 86 2.86138
RHOXF2B Rhox homeobox family, member 2B 2.86138
PRB4 proline-rich protein BstNI subfamily 4 2.86138
OASL 2'-5'-oligoadenylate synthetase-like 2.86138
HDC histidine decarboxylase 2.86138
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 2.86138
HNF4A hepatocyte nuclear factor 4, alpha 2.86138
CFHR4 complement factor H-related 4 2.86138
TPBGL trophoblast glycoprotein-like 2.86138
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 2.86138
FAM187B family with sequence similarity 187, member B 2.86138
FABP1 fatty acid binding protein 1, liver 2.86138
CELA3A chymotrypsin-like elastase family, member 3A 2.86138
ZNF182 zinc finger protein 182 2.86138
RABGAP1L RAB GTPase activating protein 1-like 2.86138
OXCT1 3-oxoacid CoA transferase 1 2.86138
TTLL8 tubulin tyrosine ligase-like family member 8 2.86138
COPG1 coatomer protein complex, subunit gamma 1 2.86138
SPDYE11 speedy/RINGO cell cycle regulator family member E11 2.86138
HBZ hemoglobin, zeta 2.86138
BFSP2 beaded filament structural protein 2, phakinin 2.86138
TAS2R13 taste receptor, type 2, member 13 2.86138
TRAM1 translocation associated membrane protein 1 2.86138
PECAM1 platelet/endothelial cell adhesion molecule 1 2.86138
INSM2 insulinoma-associated 2 2.86138
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 2.86138
AFM afamin 2.86138
OR10A4 olfactory receptor, family 10, subfamily A, member 4 2.86138
C8ORF48 chromosome 8 open reading frame 48 2.86138
ARHGAP36 Rho GTPase activating protein 36 2.86138
ZNF716 zinc finger protein 716 2.86138
GPR26 G protein-coupled receptor 26 2.86138
SPINT3 serine peptidase inhibitor, Kunitz type, 3 2.86138
MRC1 mannose receptor, C type 1 2.86138
LOC124906892 uncharacterized LOC124906892 2.86138
CABCOCO1 ciliary associated calcium binding coiled-coil 1 2.86138
CCN6 cellular communication network factor 6 2.86138
DEPP1 DEPP autophagy regulator 1 2.86138
TMEM275 transmembrane protein 275 2.86138
GMCL2 germ cell-less 2, spermatogenesis associated 2.86138
ARX aristaless related homeobox 2.86138
OR10H1 olfactory receptor, family 10, subfamily H, member 1 2.86138
GPX5 glutathione peroxidase 5 2.86138
BNC1 basonuclin 1 2.86138
FREY1 Frey regulator of sperm-oocyte fusion 1 2.86138
PPDPFL pancreatic progenitor cell differentiation and proliferation factor like 2.86138
COXFA4L3 cytochrome c oxidase associated subunit FA4L3 2.86138
SPATA31F3 SPATA31 subfamily F member 3 2.86138
TEKTL1 tektin like 1 2.86138
SPATA31H1 SPATA31 subfamily H member 1 2.86138
CIMIP2C ciliary microtubule inner protein 2C 2.86138
SPDYE8 speedy/RINGO cell cycle regulator family member E8 2.86138
NOTCH2NLB notch 2 N-terminal like B 2.86138
GNG5B G protein subunit gamma 5B 2.86138
LHFPL7 LHFPL tetraspan subfamily member 7 2.86138
OR2T8 olfactory receptor, family 2, subfamily T, member 8 2.86138
SPRR2A small proline-rich protein 2A 2.86138
CFAP45 cilia and flagella associated protein 45 2.86138
MIA melanoma inhibitory activity 2.86138
AWAT1 acyl-CoA wax alcohol acyltransferase 1 2.86138
TFEC transcription factor EC 2.86138
MSX2 msh homeobox 2 2.86138
C10ORF67 chromosome 10 open reading frame 67 2.86138
CBLN2 cerebellin 2 precursor 2.86138
ANXA10 annexin A10 2.86138
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 2.86138
INSRR insulin receptor-related receptor 2.86138
CELA2A chymotrypsin-like elastase family, member 2A 2.86138
SAG S-antigen; retina and pineal gland (arrestin) 2.86138
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 2.86138
LRRN4CL LRRN4 C-terminal like 2.86138
MOV10L1 Mov10 RISC complex RNA helicase like 1 2.86138
TAS1R2 taste receptor, type 1, member 2 2.86138
FGFBP3 fibroblast growth factor binding protein 3 2.86138
C7ORF57 chromosome 7 open reading frame 57 2.86138
RGS21 regulator of G-protein signaling 21 2.86138
BARX2 BARX homeobox 2 2.86138
ACTA1 actin, alpha 1, skeletal muscle 2.86138
FAM177B family with sequence similarity 177, member B 2.86138
ZMYND10 zinc finger, MYND-type containing 10 2.86138
PDCD1 programmed cell death 1 2.86138
CALML5 calmodulin-like 5 2.86138
HELT helt bHLH transcription factor 2.86138
WDFY4 WDFY family member 4 2.86138
DHH desert hedgehog 2.86138
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 2.86138
RGCC regulator of cell cycle 2.86138
PATE4 prostate and testis expressed 4 2.86138
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 2.86138
EPO erythropoietin 2.86138
GH2 growth hormone 2 2.86138
MMP1 matrix metallopeptidase 1 2.86138
COL22A1 collagen, type XXII, alpha 1 2.86138
LY6G6C lymphocyte antigen 6 complex, locus G6C 2.86138
EPHA10 EPH receptor A10 2.86138
ZNF479 zinc finger protein 479 2.86138
ONECUT3 one cut homeobox 3 2.86138
KRT16 keratin 16, type I 2.86138
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 2.86138
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 2.86138
KLF1 Kruppel-like factor 1 (erythroid) 2.86138
FAM163A family with sequence similarity 163, member A 2.86138
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 2.86138
WNT7B wingless-type MMTV integration site family, member 7B 2.86138
AGXT2 alanine--glyoxylate aminotransferase 2 2.86138
P2RY10 purinergic receptor P2Y, G-protein coupled, 10 2.86138
CYSLTR1 cysteinyl leukotriene receptor 1 2.86138
CTAGE9 CTAGE family, member 9 2.86138
MUC13 mucin 13, cell surface associated 2.86138
VWA3B von Willebrand factor A domain containing 3B 2.86138
C10ORF120 chromosome 10 open reading frame 120 2.86138
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 2.86138
PHOSPHO1 phosphatase, orphan 1 2.86138
C17ORF99 chromosome 17 open reading frame 99 2.86138
IL9R interleukin 9 receptor 2.86138
KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4 2.86138
ABRA actin binding Rho activating protein 2.86138
GCGR glucagon receptor 2.86138
RGS4 regulator of G-protein signaling 4 2.86138
MYLK3 myosin light chain kinase 3 2.86138
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 2.86138
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 2.86138
CPN2 carboxypeptidase N, polypeptide 2 2.86138
WNT10B wingless-type MMTV integration site family, member 10B 2.86138
EPHB3 EPH receptor B3 2.86138
FAM9B family with sequence similarity 9, member B 2.86138
WNT2 wingless-type MMTV integration site family member 2 2.86138
GOLGA8M golgin A8 family, member M 2.86138
PRDM8 PR domain containing 8 2.86138
OIT3 oncoprotein induced transcript 3 2.86138
MYL2 myosin, light chain 2, regulatory, cardiac, slow 2.86138
SPACA7 sperm acrosome associated 7 2.86138
CSTB cystatin B (stefin B) 2.86138
TMEM52B transmembrane protein 52B 2.86138
CD226 CD226 molecule 2.86138
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 2.86138
CDH17 cadherin 17, LI cadherin (liver-intestine) 2.86138
PSG11 pregnancy specific beta-1-glycoprotein 11 2.86138
ADRA1B adrenoceptor alpha 1B 2.86138
PADI4 peptidyl arginine deiminase, type IV 2.86138
SYNGR4 synaptogyrin 4 2.86138
F13B coagulation factor XIII, B polypeptide 2.86138
TECRL trans-2,3-enoyl-CoA reductase-like 2.86138
IL33 interleukin 33 2.86138
RGS8 regulator of G-protein signaling 8 2.86138
PSG6 pregnancy specific beta-1-glycoprotein 6 2.86138
LHX3 LIM homeobox 3 2.86138
NEUROD4 neuronal differentiation 4 2.86138
SOSTDC1 sclerostin domain containing 1 2.86138
GCSAML germinal center-associated, signaling and motility-like 2.86138
PTH2 parathyroid hormone 2 2.84304
SGF29 SAGA complex associated factor 29 2.8155
REP15 RAB15 effector protein 2.81363
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 2.81363
C1ORF94 chromosome 1 open reading frame 94 2.75152
XRN1 5'-3' exoribonuclease 1 2.75152
NELFB negative elongation factor complex member B 2.74763
DHRS11 dehydrogenase/reductase (SDR family) member 11 2.73516
STOM stomatin 2.662
TMEM233 transmembrane protein 233 2.63213
NSF N-ethylmaleimide-sensitive factor 2.62797
N4BP1 NEDD4 binding protein 1 2.62223
DNALI1 dynein, axonemal, light intermediate chain 1 2.60886
TNFAIP8L2-SCNM1 TNFAIP8L2-SCNM1 readthrough 2.52993
PABIR3 PABIR family member 3 2.51034
KTI12 KTI12 homolog, chromatin associated (S. cerevisiae) 2.49281
ATP5MC1 ATP synthase membrane subunit c locus 1 2.44677
FARSA phenylalanyl-tRNA synthetase, alpha subunit 2.44036
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 2.44036
RAP1GAP2 RAP1 GTPase activating protein 2 2.42518
TBK1 TANK-binding kinase 1 2.3947
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.36373
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa 2.34011
ARSK arylsulfatase family, member K 2.33674
ADCY2 adenylate cyclase 2 (brain) 2.33128
HIGD1A HIG1 hypoxia inducible domain family, member 1A 2.30644
DLL4 delta-like 4 (Drosophila) 2.27744
SHE Src homology 2 domain containing E 2.27744
SIRT3 sirtuin 3 2.27744
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 2.27744
CTRL chymotrypsin-like 2.27744
SYT15B synaptotagmin 15B 2.24406
LARP7 La ribonucleoprotein domain family, member 7 2.22062
BCAS4 breast carcinoma amplified sequence 4 2.21282
ZNF462 zinc finger protein 462 2.21003
ERN1 endoplasmic reticulum to nucleus signaling 1 2.20222
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 2.19914
POFUT3 protein O-fucosyltransferase 3 2.19524
ISM1 isthmin 1, angiogenesis inhibitor 2.1903
KIAA1549 KIAA1549 2.16955
CD160 CD160 molecule 2.16935
FBXO7 F-box protein 7 2.14851
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 2.14511
TBC1D17 TBC1 domain family, member 17 2.14035
TRMT61A tRNA methyltransferase 61A 2.13828
ERVFRD-1 endogenous retrovirus group FRD, member 1 2.09961
SYNGAP1 synaptic Ras GTPase activating protein 1 2.09698
METRN meteorin, glial cell differentiation regulator 2.09698
HMCN1 hemicentin 1 2.07912
MBNL1 muscleblind-like splicing regulator 1 2.06963
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 2.05112
PFDN4 prefoldin subunit 4 2.02631
GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 2.02631
PDE3A phosphodiesterase 3A, cGMP-inhibited 2.02631

decreased expression

Symbol Name Standardized Value
C1QTNF1 C1q and tumor necrosis factor related protein 1 -2.86138
OR51I2 olfactory receptor, family 51, subfamily I, member 2 -2.86138
LIPH lipase, member H -2.86138
SPDYE2B speedy/RINGO cell cycle regulator family member E2B -2.86138
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -2.86138
PMP2 peripheral myelin protein 2 -2.86138
MAMDC4 MAM domain containing 4 -2.86138
BTNL2 butyrophilin-like 2 -2.86138
HJV hemojuvelin BMP co-receptor -2.86138
PDF peptide deformylase (mitochondrial) -2.86138
FAM110B family with sequence similarity 110, member B -2.86138
C8ORF74 chromosome 8 open reading frame 74 -2.86138
GUCY1A2 guanylate cyclase 1, soluble, alpha 2 -2.86138
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) -2.86138
UCN urocortin -2.86138
HCRTR1 hypocretin (orexin) receptor 1 -2.86138
SYT15 synaptotagmin XV -2.86138
ALPK2 alpha-kinase 2 -2.86138
C11ORF87 chromosome 11 open reading frame 87 -2.86138
GATA4 GATA binding protein 4 -2.86138
PLET1 placenta expressed transcript 1 -2.86138
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D -2.86138
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 -2.86138
LOC122526780 uncharacterized LOC122526780 -2.86138
RELT RELT tumor necrosis factor receptor -2.86138
PLA2G2C phospholipase A2, group IIC -2.86138
CTXN2 cortexin 2 -2.86138
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 -2.86138
TEX19 testis expressed 19 -2.86138
TEKT5 tektin 5 -2.86138
DNAJC19 DnaJ (Hsp40) homolog, subfamily C, member 19 -2.86138
USP11 ubiquitin specific peptidase 11 -2.85634
TCTN1 tectonic family member 1 -2.85371
DKK2 dickkopf WNT signaling pathway inhibitor 2 -2.83699
JPH2 junctophilin 2 -2.83699
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) -2.83699
ADAM12 ADAM metallopeptidase domain 12 -2.83699
NPY neuropeptide Y -2.77202
ACTC1 actin, alpha, cardiac muscle 1 -2.73358
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 -2.72918
CACNB3 calcium channel, voltage-dependent, beta 3 subunit -2.68032
EBPL emopamil binding protein-like -2.66311
STAU1 staufen double-stranded RNA binding protein 1 -2.63288
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 -2.61365
BOP1 block of proliferation 1 -2.54848
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -2.54661
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 -2.52867
TMPRSS5 transmembrane protease, serine 5 -2.52867
FOXP2 forkhead box P2 -2.52867
EGF epidermal growth factor -2.49427
MUC12 mucin 12, cell surface associated -2.49427
TACR3 tachykinin receptor 3 -2.45023
CLNK cytokine-dependent hematopoietic cell linker -2.44118
PRKCD protein kinase C, delta -2.44118
ZFP28 ZFP28 zinc finger protein -2.44118
SCARF2 scavenger receptor class F, member 2 -2.43747
UPP2 uridine phosphorylase 2 -2.42599
LOXHD1 lipoxygenase homology domains 1 -2.41211
ZC3H7B zinc finger CCCH-type containing 7B -2.40938
KDM5C lysine (K)-specific demethylase 5C -2.37135
BTNL8 butyrophilin-like 8 -2.35192
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 -2.35192
ZNF418 zinc finger protein 418 -2.33868
ZNF514 zinc finger protein 514 -2.31184
QPCTL glutaminyl-peptide cyclotransferase-like -2.31176
CMYA5 cardiomyopathy associated 5 -2.3038
ARL6 ADP-ribosylation factor-like 6 -2.27744
CER1 cerberus 1, DAN family BMP antagonist -2.27164
ESR2 estrogen receptor 2 (ER beta) -2.26416
DPH6 diphthamine biosynthesis 6 -2.26132
MKX mohawk homeobox -2.24302
COMMD7 COMM domain containing 7 -2.23127
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -2.21948
KIF6 kinesin family member 6 -2.20544
CLDN23 claudin 23 -2.20533
SOCS1 suppressor of cytokine signaling 1 -2.20533
LOC124904542 uncharacterized LOC124904542 -2.20533
UBE2L5 ubiquitin conjugating enzyme E2 L5 -2.20533
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma -2.20276
METTL2B methyltransferase like 2B -2.19383
B3GAT2 beta-1,3-glucuronyltransferase 2 -2.17546
GOT1 glutamic-oxaloacetic transaminase 1, soluble -2.16532
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.16528
NRG2 neuregulin 2 -2.16121
ZBTB41 zinc finger and BTB domain containing 41 -2.15774
TTLL2 tubulin tyrosine ligase-like family member 2 -2.15372
MST1R macrophage stimulating 1 receptor -2.15372
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 -2.15267
PKNOX1 PBX/knotted 1 homeobox 1 -2.14851
PSEN2 presenilin 2 -2.14851
LIN7B lin-7 homolog B (C. elegans) -2.12298
ERGIC3 ERGIC and golgi 3 -2.11866
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 -2.10248
THYN1 thymocyte nuclear protein 1 -2.10144
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17 -2.09698
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) -2.08722
WDR83OS WD repeat domain 83 opposite strand -2.07487
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.06963
CSRNP2 cysteine-serine-rich nuclear protein 2 -2.06963
DLAT dihydrolipoamide S-acetyltransferase -2.05477
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) -2.05477
SLC60A1 solute carrier family 60 member 1 -2.05477
PEX7 peroxisomal biogenesis factor 7 -2.02631
XTBD1 XRN2 binding domain containing 1 -2.02631
CDC40 cell division cycle 40 -2.02631
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) -2.02312
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) -2.00649