STK11 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description serine/threonine kinase 11|This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6794)
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Genes

338 genes differentially expressed following the STK11 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CDH22 cadherin 22, type 2 2.92044
NOX1 NADPH oxidase 1 2.92044
CD300LF CD300 molecule-like family member f 2.92044
SMIM17 small integral membrane protein 17 2.92044
NRGN neurogranin (protein kinase C substrate, RC3) 2.92044
PTPN20 protein tyrosine phosphatase, non-receptor type 20 2.92044
PGAM4 phosphoglycerate mutase family member 4 2.92044
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 2.92044
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 2.92044
KISS1 KiSS-1 metastasis-suppressor 2.92044
GYPB glycophorin B (MNS blood group) 2.92044
MSC musculin 2.92044
LDHC lactate dehydrogenase C 2.92044
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 2.92044
KY kyphoscoliosis peptidase 2.92044
PCDHGA3 protocadherin gamma subfamily A, 3 2.92044
TAS2R19 taste receptor, type 2, member 19 2.92044
VXN vexin 2.92044
NR4A3 nuclear receptor subfamily 4, group A, member 3 2.92044
ARHGAP20 Rho GTPase activating protein 20 2.92044
NOTCH2NLB notch 2 N-terminal like B 2.92044
LRRC8C-DT LRRC8C divergent transcript 2.92044
GPR12 G protein-coupled receptor 12 2.92044
DRC5 dynein regulatory complex subunit 5 2.92044
CCDC154 coiled-coil domain containing 154 2.92044
ZNF662 zinc finger protein 662 2.82039
PON1 paraoxonase 1 2.82039
C1QTNF9 C1q and tumor necrosis factor related protein 9 2.82039
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 2.82039
TSSK4 testis-specific serine kinase 4 2.82039
GPR52 G protein-coupled receptor 52 2.82039
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 2.82039
TREM2 triggering receptor expressed on myeloid cells 2 2.82039
GNLY granulysin 2.82039
FGD2 FYVE, RhoGEF and PH domain containing 2 2.82039
CFHR3 complement factor H-related 3 2.82039
ANKRD22 ankyrin repeat domain 22 2.82039
PLIN1 perilipin 1 2.82039
TAS2R13 taste receptor, type 2, member 13 2.82039
HYAL4 hyaluronoglucosaminidase 4 2.82039
DDN dendrin 2.82039
PTGER4 prostaglandin E receptor 4 (subtype EP4) 2.82039
TDRD9 tudor domain containing 9 2.82039
LGI1 leucine-rich, glioma inactivated 1 2.82039
GNRH2 gonadotropin-releasing hormone 2 2.82039
MUC20 mucin 20, cell surface associated 2.82039
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) 2.82039
DIO3 deiodinase, iodothyronine, type III 2.82039
SLC39A12 solute carrier family 39 (zinc transporter), member 12 2.82039
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 2.82039
NRROS negative regulator of reactive oxygen species 2.82039
OTUD6A OTU deubiquitinase 6A 2.82039
XCL2 chemokine (C motif) ligand 2 2.82039
SCNN1G sodium channel, non voltage gated 1 gamma subunit 2.82039
NUGGC nuclear GTPase, germinal center associated 2.82039
MYOM3 myomesin 3 2.82039
SLC23A3 solute carrier family 23, member 3 2.82039
ARSF arylsulfatase F 2.82039
SPRR1B small proline-rich protein 1B 2.82039
C16ORF82 chromosome 16 open reading frame 82 2.82039
GJB3 gap junction protein, beta 3, 31kDa 2.82039
HSFX3 heat shock transcription factor family, X-linked member 3 2.82039
ALDOB aldolase B, fructose-bisphosphate 2.82039
C3AR1 complement component 3a receptor 1 2.82039
MCHR2 melanin-concentrating hormone receptor 2 2.82039
GPR35 G protein-coupled receptor 35 2.82039
PNLIPRP3 pancreatic lipase-related protein 3 2.82039
FOXN4 forkhead box N4 2.82039
MYPN myopalladin 2.82039
GC group-specific component (vitamin D binding protein) 2.82039
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 2.82039
SELE selectin E 2.82039
H3-5 H3.5 histone 2.82039
SRARP steroid receptor associated and regulated protein 2.82039
LHFPL7 LHFPL tetraspan subfamily member 7 2.82039
CIBAR2 CBY1 interacting BAR domain containing 2 2.82039
PPDPFL pancreatic progenitor cell differentiation and proliferation factor like 2.82039
ANKRD40CL ANKRD40 C-terminal like 2.82039
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 2.82039
LOC122539214 Zinc finger protein LOC122539214 2.82039
CATSPERH catsper channel auxiliary subunit eta 2.82039
FAM237B family with sequence similarity 237 member B 2.82039
HTR3D 5-hydroxytryptamine (serotonin) receptor 3D, ionotropic 2.82039
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 2.82039
ATP6V1G3 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3 2.82039
ZSWIM2 zinc finger, SWIM-type containing 2 2.82039
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 2.82039
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 2.82039
TMEM276-ZFTRAF1 TMEM276-ZFTRAF1 readthrough 2.82039
DMP1 dentin matrix acidic phosphoprotein 1 2.82039
RPS10 ribosomal protein S10 2.82039
ACOT1 acyl-CoA thioesterase 1 2.82039
ZNF432 zinc finger protein 432 2.82039
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 2.82039
GAST gastrin 2.82039
C3ORF80 chromosome 3 open reading frame 80 2.82039
ASIC5 acid sensing (proton gated) ion channel family member 5 2.82039
OR2D3 olfactory receptor, family 2, subfamily D, member 3 2.82039
ALG10B ALG10B, alpha-1,2-glucosyltransferase 2.82039
S100P S100 calcium binding protein P 2.82039
GJD2 gap junction protein, delta 2, 36kDa 2.82039
PRRT4 proline-rich transmembrane protein 4 2.82039
RNF113B ring finger protein 113B 2.82039
UBL4B ubiquitin-like 4B 2.82039
TLR4 toll-like receptor 4 2.82039
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 2.82039
CSF3R colony stimulating factor 3 receptor (granulocyte) 2.82039
HHLA2 HERV-H LTR-associating 2 2.82039
ADAMDEC1 ADAM-like, decysin 1 2.82039
KLHL41 kelch-like family member 41 2.82039
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 2.82039
MEFV Mediterranean fever 2.82039
PAGE4 P antigen family, member 4 (prostate associated) 2.82039
DRD2 dopamine receptor D2 2.82039
PCDHGA2 protocadherin gamma subfamily A, 2 2.82039
PRSS2 protease, serine, 2 (trypsin 2) 2.82039
ADGRA1 adhesion G protein-coupled receptor A1 2.82039
NTSR2 neurotensin receptor 2 2.82039
DRD1 dopamine receptor D1 2.82039
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 2.82039
SLC25A52 solute carrier family 25, member 52 2.82039
VAX2 ventral anterior homeobox 2 2.82039
FNDC1 fibronectin type III domain containing 1 2.82039
ZSCAN4 zinc finger and SCAN domain containing 4 2.82039
RGS8 regulator of G-protein signaling 8 2.82039
URAD ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase 2.82039
NUPR1 nuclear protein, transcriptional regulator, 1 2.82039
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 2.82039
CTRB1 chymotrypsinogen B1 2.82039
NKX6-1 NK6 homeobox 1 2.82039
IL25 interleukin 25 2.82039
OTP orthopedia homeobox 2.82039
CASQ2 calsequestrin 2 (cardiac muscle) 2.82039
PLA2G5 phospholipase A2, group V 2.82039
TTC24 tetratricopeptide repeat domain 24 2.82039
STRC stereocilin 2.82039
SLC38A3 solute carrier family 38, member 3 2.82039
NOBOX NOBOX oogenesis homeobox 2.82039
EGR2 early growth response 2 2.82039
MYEOV myeloma overexpressed 2.82039
LRRC15 leucine rich repeat containing 15 2.82039
HK3 hexokinase 3 (white cell) 2.82039
PRR35 proline rich 35 2.82039
SIGLEC16 sialic acid binding Ig-like lectin 16 (gene/pseudogene) 2.82039
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 2.82039
DLX3 distal-less homeobox 3 2.82039
SLC36A3 solute carrier family 36, member 3 2.82039
TECRL trans-2,3-enoyl-CoA reductase-like 2.82039
PASD1 PAS domain containing 1 2.82039
SPAG6 sperm associated antigen 6 2.82039
OTOL1 otolin 1 2.82039
CCDC83 coiled-coil domain containing 83 2.82039
DHRS9 dehydrogenase/reductase (SDR family) member 9 2.82039
RASEF RAS and EF-hand domain containing 2.82039
TMPRSS12 transmembrane (C-terminal) protease, serine 12 2.82039
FRMPD1 FERM and PDZ domain containing 1 2.82039
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.82039
NXF2 nuclear RNA export factor 2 2.82039
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 2.82039
NR2F1 nuclear receptor subfamily 2, group F, member 1 2.82039
NPR3 natriuretic peptide receptor 3 2.82039
SNTN sentan, cilia apical structure protein 2.82039
APOL6 apolipoprotein L, 6 2.82039
PLGLB1 plasminogen-like B1 2.82039
LST1 leukocyte specific transcript 1 2.82039
ACY3 aminoacylase 3 2.82039
THEM5 thioesterase superfamily member 5 2.82039
SPACA4 sperm acrosome associated 4 2.82039
WFDC10A WAP four-disulfide core domain 10A 2.82039
EIF5 eukaryotic translation initiation factor 5 2.79624
CLDN3 claudin 3 2.76117
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 2.73363
TAPBPL TAP binding protein-like 2.71442
CLEC4G C-type lectin domain family 4, member G 2.71442
XK X-linked Kx blood group 2.71442
H4C12 H4 clustered histone 12 2.71442
IPCEF1 interaction protein for cytohesin exchange factors 1 2.70054
ACVR1C activin A receptor, type IC 2.69855
TBC1D10A TBC1 domain family, member 10A 2.679
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa 2.67494
PEX3 peroxisomal biogenesis factor 3 2.66275
FKBP1A FK506 binding protein 1A, 12kDa 2.61806
NEK3 NIMA-related kinase 3 2.51873
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 2.51873
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.49238
PRDX6 peroxiredoxin 6 2.48872
DCTPP1 dCTP pyrophosphatase 1 2.48872
LLGL2 lethal giant larvae homolog 2 (Drosophila) 2.44865
EML3 echinoderm microtubule associated protein like 3 2.43631
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A 2.43037
RAB37 RAB37, member RAS oncogene family 2.37196
FBXO2 F-box protein 2 2.36448
TMX3 thioredoxin-related transmembrane protein 3 2.34037
BCO1 beta-carotene oxygenase 1 2.31748
TMPRSS13 transmembrane protease, serine 13 2.31748
GINS2 GINS complex subunit 2 (Psf2 homolog) 2.31352
ZCCHC8 zinc finger, CCHC domain containing 8 2.29511
PHF5A PHD finger protein 5A 2.28479
WNT9B wingless-type MMTV integration site family, member 9B 2.28479
SPIRE1 spire-type actin nucleation factor 1 2.2569
RAB44 RAB44, member RAS oncogene family 2.25375
LDLRAD2 low density lipoprotein receptor class A domain containing 2 2.25375
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 2.25375
UNC50 unc-50 homolog (C. elegans) 2.25053
SEC13 SEC13 homolog (S. cerevisiae) 2.25053
ZFR2 zinc finger RNA binding protein 2 2.25053
ATP7A ATPase, Cu++ transporting, alpha polypeptide 2.24564
HDAC7 histone deacetylase 7 2.20913
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 2.20765
NOXA1 NADPH oxidase activator 1 2.20507
MMP21 matrix metallopeptidase 21 2.1764
ACP2 acid phosphatase 2, lysosomal 2.16144
ITGA9 integrin, alpha 9 2.13073
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa 2.13073
CARHSP1 calcium regulated heat stable protein 1, 24kDa 2.13039
ZKSCAN5 zinc finger with KRAB and SCAN domains 5 2.11866
NXPH2 neurexophilin 2 2.10151
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 2.09637
ENDOV endonuclease V 2.09162
SUMF2 sulfatase modifying factor 2 2.08202
PFN1 profilin 1 2.07013
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 2.05537
NEK4 NIMA-related kinase 4 2.03891
NUP98 nucleoporin 98kDa 2.01134
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 2.0096
ATP5PB ATP synthase peripheral stalk-membrane subunit b 2.00385

decreased expression

Symbol Name Standardized Value
TMEM184A transmembrane protein 184A -2.92044
AOAH acyloxyacyl hydrolase (neutrophil) -2.92044
NLRP1 NLR family, pyrin domain containing 1 -2.92044
GCNT7 glucosaminyl (N-acetyl) transferase family member 7 -2.92044
GCOM1 GRINL1A complex locus 1 -2.82039
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 -2.82039
GP1BA glycoprotein Ib (platelet), alpha polypeptide -2.82039
TSNAX translin-associated factor X -2.82039
CDC20B cell division cycle 20B -2.82039
PRR29 proline rich 29 -2.82039
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) -2.82039
ARR3 arrestin 3, retinal (X-arrestin) -2.82039
WFDC11 WAP four-disulfide core domain 11 -2.82039
WDR45B WD repeat domain 45B -2.82039
ADIRF adipogenesis regulatory factor -2.82039
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -2.82039
KIAA0825 KIAA0825 -2.82039
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -2.82039
OLFML2A olfactomedin-like 2A -2.82039
AHSG alpha-2-HS-glycoprotein -2.82039
STK31 serine/threonine kinase 31 -2.82039
GHRH growth hormone releasing hormone -2.82039
NOX3 NADPH oxidase 3 -2.82039
BHMT2 betaine--homocysteine S-methyltransferase 2 -2.82039
BTN1A1 butyrophilin, subfamily 1, member A1 -2.82039
CIROZ ciliated left-right organizer protein containing ZP-N domains -2.82039
NR1H2 nuclear receptor subfamily 1, group H, member 2 -2.82039
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 -2.82039
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 -2.82039
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 -2.82039
PLEKHA8 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 -2.82039
ELOA2 elongin A2 -2.82039
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 -2.82039
AADACL3 arylacetamide deacetylase-like 3 -2.82039
B3GAT1 beta-1,3-glucuronyltransferase 1 -2.82039
NRIP2 nuclear receptor interacting protein 2 -2.82039
PLEKHM3 pleckstrin homology domain containing, family M, member 3 -2.82039
MAGED4 melanoma antigen family D4 -2.82039
TMEM217 transmembrane protein 217 -2.82039
LRRC10B leucine rich repeat containing 10B -2.82039
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 -2.82039
C22ORF42 chromosome 22 open reading frame 42 -2.82039
PLEKHN1 pleckstrin homology domain containing, family N member 1 -2.82039
TLL1 tolloid-like 1 -2.81207
CALML4 calmodulin-like 4 -2.69855
WDR62 WD repeat domain 62 -2.69673
ATAD5 ATPase family, AAA domain containing 5 -2.65326
GAP43 growth associated protein 43 -2.64561
CD247 CD247 molecule -2.64174
ZNF547 zinc finger protein 547 -2.606
HES3 hes family bHLH transcription factor 3 -2.57452
SHISAL2A shisa like 2A -2.57452
CD200R1 CD200 receptor 1 -2.57452
MPPED2 metallophosphoesterase domain containing 2 -2.48894
MAOA monoamine oxidase A -2.48311
ITGB1BP1 integrin beta 1 binding protein 1 -2.47842
MARCHF3 membrane associated ring-CH-type finger 3 -2.47842
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 -2.47404
WIPF2 WAS/WASL interacting protein family, member 2 -2.47266
FANCA Fanconi anemia, complementation group A -2.4262
PLB1 phospholipase B1 -2.41894
DIAPH2 diaphanous-related formin 2 -2.40707
VAMP4 vesicle-associated membrane protein 4 -2.40707
ANG angiogenin, ribonuclease, RNase A family, 5 -2.39424
STAC2 SH3 and cysteine rich domain 2 -2.38463
ZNF723 zinc finger protein 723 -2.37196
A4GALT alpha 1,4-galactosyltransferase -2.36448
IFT54 intraflagellar transport 54 -2.34627
PLEKHA7 pleckstrin homology domain containing, family A member 7 -2.34627
TRIM11 tripartite motif containing 11 -2.32712
TPM1 tropomyosin 1 (alpha) -2.29831
EFCAB7 EF-hand calcium binding domain 7 -2.2823
HAUS4 HAUS augmin-like complex, subunit 4 -2.25763
MACF1 microtubule-actin crosslinking factor 1 -2.25053
DHDDS dehydrodolichyl diphosphate synthase -2.22163
SATB2 SATB homeobox 2 -2.21042
NACAD NAC alpha domain containing -2.20913
ZFPL1 zinc finger protein-like 1 -2.20507
ZNF790 zinc finger protein 790 -2.18348
FSCN3 fascin actin-bundling protein 3, testicular -2.18329
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 -2.1764
CTSA cathepsin A -2.16846
ZNF875 zinc finger protein 875 -2.16558
TRDMT1 tRNA aspartic acid methyltransferase 1 -2.14616
HOMEZ homeobox and leucine zipper encoding -2.14448
OPHN1 oligophrenin 1 -2.12669
HABP4 hyaluronan binding protein 4 -2.12576
CLYBL citrate lyase beta like -2.12153
TOP1MT topoisomerase (DNA) I, mitochondrial -2.11939
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -2.11866
PDE3B phosphodiesterase 3B, cGMP-inhibited -2.10787
ENTREP3 endosomal transmembrane epsin interactor 3 -2.10787
FGF2 fibroblast growth factor 2 (basic) -2.09637
TNMD tenomodulin -2.09227
C17ORF114 chromosome 17 open reading frame 114 -2.09227
RUNDC3A RUN domain containing 3A -2.09227
MLPH melanophilin -2.08894
SIRT1 sirtuin 1 -2.08894
ZNF713 zinc finger protein 713 -2.08359
SLC35F5 solute carrier family 35, member F5 -2.07568
LBP lipopolysaccharide binding protein -2.07568
MTNAP1 mitochondrial nucleoid associated protein 1 -2.07013
AHCTF1 AT hook containing transcription factor 1 -2.06255
ZNF284 zinc finger protein 284 -2.05379
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -2.04445
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 -2.03891
FKBP9 FK506 binding protein 9, 63 kDa -2.0382
METTL2B methyltransferase like 2B -2.03475
ERCC8 excision repair cross-complementation group 8 -2.03345
VAMP8 vesicle-associated membrane protein 8 -2.01559
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 -2.01372
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -2.01134