STRADA Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description STE20-related kinase adaptor alpha|The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009] (NCBI Entrez Gene Database, 92335)
External Link http://www.ncbi.nlm.nih.gov/gene/92335
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Genes

34 interacting proteins for STRADA from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
BRSK1 BR serine/threonine kinase 1
BRSK2 BR serine/threonine kinase 2
CAB39 calcium binding protein 39
CAB39L calcium binding protein 39-like
CDC37 cell division cycle 37
FBXL19 F-box and leucine-rich repeat protein 19
FKBP5 FK506 binding protein 5
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1B heat shock 70kDa protein 1B
KIF23 kinesin family member 23
LIMS1 LIM and senescent cell antigen-like domains 1
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK4 MAP/microtubule affinity-regulating kinase 4
NRF1 nuclear respiratory factor 1
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit
RPAP3 RNA polymerase II associated protein 3
SIK1 salt-inducible kinase 1
SIK2 salt-inducible kinase 2
SIK3 SIK family kinase 3
SMAD4 SMAD family member 4
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
STK11 serine/threonine kinase 11
STRADB STE20-related kinase adaptor beta
UBC ubiquitin C
USP11 ubiquitin specific peptidase 11
XPO1 exportin 1