STRADB Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description STE20-related kinase adaptor beta|This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011] (NCBI Entrez Gene Database, 55437)
External Link http://www.ncbi.nlm.nih.gov/gene/55437
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Genes

35 interacting proteins for STRADB from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
BRSK1 BR serine/threonine kinase 1
BRSK2 BR serine/threonine kinase 2
CAB39 calcium binding protein 39
CAB39L calcium binding protein 39-like
CDC37 cell division cycle 37
ELAVL1 ELAV like RNA binding protein 1
FKBP5 FK506 binding protein 5
GRB2 growth factor receptor-bound protein 2
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1B heat shock 70kDa protein 1B
KIF23 kinesin family member 23
LIMS1 LIM and senescent cell antigen-like domains 1
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK4 MAP/microtubule affinity-regulating kinase 4
NEB nebulin
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit
RPAP3 RNA polymerase II associated protein 3
SIK1 salt-inducible kinase 1
SIK2 salt-inducible kinase 2
SIK3 SIK family kinase 3
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
STK11 serine/threonine kinase 11
STRADA STE20-related kinase adaptor alpha
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
USP11 ubiquitin specific peptidase 11
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase