| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/4253236 |
| Similar Terms | |
| Downloads & Tools |
197 proteins with high or low expression in STX-0119 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GPR161 | G protein-coupled receptor 161 | 1.16 |
| TEN1 | TEN1 CST complex subunit | 1.12 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 1.0 |
| FAM13A | family with sequence similarity 13, member A | 0.99 |
| ADCY10 | adenylate cyclase 10 (soluble) | 0.82 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 0.68 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | 0.66 |
| CEP295 | centrosomal protein 295kDa | 0.65 |
| RUNDC1 | RUN domain containing 1 | 0.59 |
| RND3 | Rho family GTPase 3 | 0.59 |
| MIER2 | mesoderm induction early response 1, family member 2 | 0.55 |
| CEP128 | centrosomal protein 128kDa | 0.55 |
| ANKRD13B | ankyrin repeat domain 13B | 0.55 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.53 |
| RAD9A | RAD9 homolog A (S. pombe) | 0.52 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.49 |
| BRF2 | BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit | 0.42 |
| SSH2 | slingshot protein phosphatase 2 | 0.4 |
| JOSD1 | Josephin domain containing 1 | 0.39 |
| FBXO45 | F-box protein 45 | 0.39 |
| BAIAP2 | BAI1-associated protein 2 | 0.38 |
| GALNT5 | polypeptide N-acetylgalactosaminyltransferase 5 | 0.38 |
| ELL3 | elongation factor RNA polymerase II-like 3 | 0.37 |
| TCP11L1 | t-complex 11, testis-specific-like 1 | 0.37 |
| BICRA | BRD4 interacting chromatin remodeling complex associated protein | 0.35 |
| HGH1 | HGH1 homolog (S. cerevisiae) | 0.34 |
| TATDN2 | TatD DNase domain containing 2 | 0.33 |
| ZNF264 | zinc finger protein 264 | 0.33 |
| KIAA0753 | KIAA0753 | 0.32 |
| ZNF7 | zinc finger protein 7 | 0.32 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.31 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.31 |
| YY1AP1 | YY1 associated protein 1 | 0.3 |
| SYK | spleen tyrosine kinase | 0.3 |
| UNC13C | unc-13 homolog C (C. elegans) | 0.3 |
| CLUH | clustered mitochondria (cluA/CLU1) homolog | 0.29 |
| NDUFAB1 | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa | 0.29 |
| CCAR2 | cell cycle and apoptosis regulator 2 | 0.29 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.29 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.29 |
| TTC7A | tetratricopeptide repeat domain 7A | 0.28 |
| PRICKLE3 | prickle homolog 3 (Drosophila) | 0.28 |
| BTBD3 | BTB (POZ) domain containing 3 | 0.28 |
| HEATR5A | HEAT repeat containing 5A | 0.27 |
| ARMCX5 | armadillo repeat containing, X-linked 5 | 0.27 |
| KIFC3 | kinesin family member C3 | 0.27 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | 0.27 |
| FBXL8 | F-box and leucine-rich repeat protein 8 | 0.27 |
| RAB27B | RAB27B, member RAS oncogene family | 0.27 |
| VPS37C | vacuolar protein sorting 37 homolog C (S. cerevisiae) | 0.27 |
| ZNF76 | zinc finger protein 76 | 0.26 |
| UNC13D | unc-13 homolog D (C. elegans) | 0.26 |
| CCDC18 | coiled-coil domain containing 18 | 0.26 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.26 |
| UCHL5 | ubiquitin carboxyl-terminal hydrolase L5 | 0.26 |
| BAK1 | BCL2-antagonist/killer 1 | 0.25 |
| SH2B1 | SH2B adaptor protein 1 | 0.25 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.25 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.25 |
| ABCA13 | ATP-binding cassette, sub-family A (ABC1), member 13 | 0.25 |
| NABP1 | nucleic acid binding protein 1 | 0.25 |
| CEBPZOS | CEBPZ opposite strand | 0.25 |
| PLEKHF1 | pleckstrin homology domain containing, family F (with FYVE domain) member 1 | 0.24 |
| DUOX1 | dual oxidase 1 | 0.24 |
| CEP63 | centrosomal protein 63kDa | 0.24 |
| ZNF367 | zinc finger protein 367 | 0.24 |
| PRKCH | protein kinase C, eta | 0.24 |
| ZNF267 | zinc finger protein 267 | 0.24 |
| RAC3 | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) | 0.24 |
| MDK | midkine (neurite growth-promoting factor 2) | 0.24 |
| ROS1 | ROS proto-oncogene 1 , receptor tyrosine kinase | 0.23 |
| TAF1B | TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa | 0.23 |
| ALS2CL | ALS2 C-terminal like | 0.23 |
| ZNF670 | zinc finger protein 670 | 0.23 |
| LIN7A | lin-7 homolog A (C. elegans) | 0.23 |
| ITPKB | inositol-trisphosphate 3-kinase B | 0.23 |
| WDR19 | WD repeat domain 19 | 0.22 |
| N6AMT1 | N-6 adenine-specific DNA methyltransferase 1 (putative) | 0.22 |
| ITFG2 | integrin alpha FG-GAP repeat containing 2 | 0.22 |
| ZFYVE26 | zinc finger, FYVE domain containing 26 | 0.22 |
| RPGR | retinitis pigmentosa GTPase regulator | 0.22 |
| COMMD3-BMI1 | COMMD3-BMI1 readthrough | 0.22 |
| IL17RA | interleukin 17 receptor A | 0.22 |
| DNPH1 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | 0.22 |
| TICRR | TOPBP1-interacting checkpoint and replication regulator | 0.22 |
| CDCA7 | cell division cycle associated 7 | 0.22 |
| TMEM175 | transmembrane protein 175 | 0.22 |
| CCDC73 | coiled-coil domain containing 73 | 0.22 |
| PAFAH1B2 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) | 0.21 |
| GLT8D2 | glycosyltransferase 8 domain containing 2 | 0.21 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.21 |
| SEMA7A | semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) | 0.21 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 0.21 |
| ANKRD12 | ankyrin repeat domain 12 | 0.21 |
| YOD1 | YOD1 deubiquitinase | 0.21 |
| GKAP1 | G kinase anchoring protein 1 | 0.21 |
| DTNA | dystrobrevin, alpha | 0.2 |
| FOXRED2 | FAD-dependent oxidoreductase domain containing 2 | 0.2 |
| DOLPP1 | dolichyldiphosphatase 1 | 0.2 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | 0.2 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EME1 | essential meiotic structure-specific endonuclease 1 | -0.93 |
| SH2B3 | SH2B adaptor protein 3 | -0.86 |
| CKS1B | CDC28 protein kinase regulatory subunit 1B | -0.85 |
| FKBP1A | FK506 binding protein 1A, 12kDa | -0.77 |
| MYO3A | myosin IIIA | -0.75 |
| KHNYN | KH and NYN domain containing | -0.74 |
| MYORG | myogenesis regulating glycosidase (putative) | -0.71 |
| SNRPC | small nuclear ribonucleoprotein polypeptide C | -0.63 |
| ENO1 | enolase 1, (alpha) | -0.62 |
| METTL7A | methyltransferase like 7A | -0.6 |
| BCL9 | B-cell CLL/lymphoma 9 | -0.6 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.56 |
| CCDC82 | coiled-coil domain containing 82 | -0.54 |
| UVRAG | UV radiation resistance associated | -0.54 |
| ATXN1L | ataxin 1-like | -0.53 |
| CYP4F22 | cytochrome P450, family 4, subfamily F, polypeptide 22 | -0.49 |
| CHSY3 | chondroitin sulfate synthase 3 | -0.46 |
| TMEM51 | transmembrane protein 51 | -0.46 |
| ZDHHC18 | zinc finger, DHHC-type containing 18 | -0.46 |
| CACNA2D2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | -0.44 |
| HSPE1 | heat shock 10kDa protein 1 | -0.44 |
| MCM8 | minichromosome maintenance complex component 8 | -0.43 |
| GTF2A1 | general transcription factor IIA, 1, 19/37kDa | -0.43 |
| BLOC1S3 | biogenesis of lysosomal organelles complex-1, subunit 3 | -0.43 |
| FAM126B | family with sequence similarity 126, member B | -0.42 |
| ZYX | zyxin | -0.42 |
| FUNDC1 | FUN14 domain containing 1 | -0.42 |
| S100A14 | S100 calcium binding protein A14 | -0.42 |
| NRBF2 | nuclear receptor binding factor 2 | -0.41 |
| TPM4 | tropomyosin 4 | -0.41 |
| SERINC1 | serine incorporator 1 | -0.41 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.4 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.39 |
| CKS2 | CDC28 protein kinase regulatory subunit 2 | -0.39 |
| RMI2 | RecQ mediated genome instability 2 | -0.39 |
| CD58 | CD58 molecule | -0.39 |
| MAP3K9 | mitogen-activated protein kinase kinase kinase 9 | -0.38 |
| FBXO41 | F-box protein 41 | -0.38 |
| PYGO2 | pygopus family PHD finger 2 | -0.37 |
| ATL1 | atlastin GTPase 1 | -0.37 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.37 |
| WRB | tryptophan rich basic protein | -0.36 |
| CLDN3 | claudin 3 | -0.36 |
| COX10 | COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor | -0.35 |
| OSTM1 | osteopetrosis associated transmembrane protein 1 | -0.35 |
| BAG3 | BCL2-associated athanogene 3 | -0.35 |
| TMCO6 | transmembrane and coiled-coil domains 6 | -0.34 |
| NEBL | nebulette | -0.34 |
| PVR | poliovirus receptor | -0.34 |
| MID1IP1 | MID1 interacting protein 1 | -0.33 |
| DGKH | diacylglycerol kinase, eta | -0.33 |
| PET117 | PET117 homolog (S. cerevisiae) | -0.33 |
| TMOD1 | tropomodulin 1 | -0.33 |
| KLK6 | kallikrein-related peptidase 6 | -0.33 |
| RAMAC | RNA guanine-7 methyltransferase activating subunit | -0.32 |
| FAM89A | family with sequence similarity 89, member A | -0.32 |
| SF3B4 | splicing factor 3b, subunit 4, 49kDa | -0.32 |
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | -0.31 |
| MAPK7 | mitogen-activated protein kinase 7 | -0.31 |
| SHPRH | SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase | -0.31 |
| PKD2 | polycystic kidney disease 2 (autosomal dominant) | -0.31 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | -0.31 |
| PSMB10 | proteasome (prosome, macropain) subunit, beta type, 10 | -0.31 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | -0.31 |
| SPIRE1 | spire-type actin nucleation factor 1 | -0.31 |
| RTL6 | retrotransposon Gag like 6 | -0.31 |
| PACS2 | phosphofurin acidic cluster sorting protein 2 | -0.31 |
| CCDC85B | coiled-coil domain containing 85B | -0.31 |
| RASSF2 | Ras association (RalGDS/AF-6) domain family member 2 | -0.31 |
| PRIMPOL | primase and polymerase (DNA-directed) | -0.3 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.3 |
| DERPC | DERPC proline and glycine rich nuclear protein | -0.3 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | -0.3 |
| MCRIP1 | MAPK regulated corepressor interacting protein 1 | -0.3 |
| LYSMD2 | LysM, putative peptidoglycan-binding, domain containing 2 | -0.3 |
| ZNF430 | zinc finger protein 430 | -0.3 |
| ATP9A | ATPase, class II, type 9A | -0.3 |
| SOD1 | superoxide dismutase 1, soluble | -0.29 |
| PPP1R2B | PPP1R2 family member B | -0.29 |
| WTAP | Wilms tumor 1 associated protein | -0.29 |
| MT-ND4 | NADH dehydrogenase, subunit 4 (complex I) | -0.28 |
| NBEAL1 | neurobeachin-like 1 | -0.28 |
| NHLRC3 | NHL repeat containing 3 | -0.28 |
| YDJC | YdjC homolog (bacterial) | -0.28 |
| ADAT1 | adenosine deaminase, tRNA-specific 1 | -0.28 |
| ZNF581 | zinc finger protein 581 | -0.28 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.27 |
| TMEM104 | transmembrane protein 104 | -0.27 |
| STMN1 | stathmin 1 | -0.27 |
| CCDC158 | coiled-coil domain containing 158 | -0.27 |
| MXRA7 | matrix-remodelling associated 7 | -0.27 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | -0.27 |
| OTULINL | OTU deubiquitinase with linear linkage specificity like | -0.27 |
| JPT2 | Jupiter microtubule associated homolog 2 | -0.26 |
| ATP5IF1 | ATP synthase inhibitory factor subunit 1 | -0.26 |
| FGFBP1 | fibroblast growth factor binding protein 1 | -0.26 |
| LCMT2 | leucine carboxyl methyltransferase 2 | -0.26 |
