STX1A Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description syntaxin 1A (brain)|This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] (NCBI Entrez Gene Database, 6804)
External Link http://www.ncbi.nlm.nih.gov/gene/6804
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208 interacting proteins for STX1A from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
ALDOC aldolase C, fructose-bisphosphate
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
ATP4B ATPase, H+/K+ exchanging, beta polypeptide
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
BASP1 brain abundant, membrane attached signal protein 1
CA4 carbonic anhydrase IV
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CACNG2 calcium channel, voltage-dependent, gamma subunit 2
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CATSPER1 cation channel, sperm associated 1
CATSPER2 cation channel, sperm associated 2
CATSPER3 cation channel, sperm associated 3
CATSPER4 cation channel, sperm associated 4
CATSPERB catsper channel auxiliary subunit beta
CATSPERD catsper channel auxiliary subunit delta
CATSPERG catsper channel auxiliary subunit gamma
CCSER2 coiled-coil serine-rich protein 2
CD59 CD59 molecule, complement regulatory protein
CDK5 cyclin-dependent kinase 5
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHRM2 cholinergic receptor, muscarinic 2
CHRM4 cholinergic receptor, muscarinic 4
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle)
CLIC2 chloride intracellular channel 2
CLTC clathrin, heavy chain (Hc)
CNGA1 cyclic nucleotide gated channel alpha 1
CNGB1 cyclic nucleotide gated channel beta 1
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CNTN1 contactin 1
COX5A cytochrome c oxidase subunit Va
COX5B cytochrome c oxidase subunit Vb
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
COX6C cytochrome c oxidase subunit VIc
CPLX1 complexin 1
CPLX2 complexin 2
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
CYC1 cytochrome c-1
DAPK1 death-associated protein kinase 1
DIRAS2 DIRAS family, GTP-binding RAS-like 2
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5
DPYSL2 dihydropyrimidinase-like 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FBN2 fibrillin 2
FKBP1B FK506 binding protein 1B, 12.6 kDa
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GFAP glial fibrillary acidic protein
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GPM6A glycoprotein M6A
GRM2 glutamate receptor, metabotropic 2
GRM3 glutamate receptor, metabotropic 3
HSPA8 heat shock 70kDa protein 8
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic
HTR3D 5-hydroxytryptamine (serotonin) receptor 3D, ionotropic
HTT huntingtin
INS insulin
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KIF5B kinesin family member 5B
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
MCOLN1 mucolipin 1
MCOLN2 mucolipin 2
MCOLN3 mucolipin 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha
NAPB N-ethylmaleimide-sensitive factor attachment protein, beta
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)
NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
NEGR1 neuronal growth regulator 1
NPTN neuroplastin
NRF1 nuclear respiratory factor 1
NSF N-ethylmaleimide-sensitive factor
NTM neurotrimin
OPCML opioid binding protein/cell adhesion molecule-like
ORAI1 ORAI calcium release-activated calcium modulator 1
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
PLP1 proteolipid protein 1
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PRNP prion protein
PSEN1 presenilin 1
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
RAB27A RAB27A, member RAS oncogene family
RAB3A RAB3A, member RAS oncogene family
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RIMS1 regulating synaptic membrane exocytosis 1
RNF40 ring finger protein 40, E3 ubiquitin protein ligase
RYR1 ryanodine receptor 1 (skeletal)
RYR2 ryanodine receptor 2 (cardiac)
RYR3 ryanodine receptor 3
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCNN1B sodium channel, non voltage gated 1 beta subunit
SCNN1G sodium channel, non voltage gated 1 gamma subunit
SDCBP syndecan binding protein (syntenin)
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SEPT2 septin 2
SEPT5 septin 5
SEPT7 septin 7
SIRPA signal-regulatory protein alpha
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SNAP23 synaptosomal-associated protein, 23kDa
SNAP25 synaptosomal-associated protein, 25kDa
SNAP29 synaptosomal-associated protein, 29kDa
SNPH syntaphilin
SRI sorcin
STIM1 stromal interaction molecule 1
STX1B syntaxin 1B
STX8 syntaxin 8
STXBP1 syntaxin binding protein 1
STXBP2 syntaxin binding protein 2
STXBP5 syntaxin binding protein 5 (tomosyn)
STXBP6 syntaxin binding protein 6 (amisyn)
SYBU syntabulin (syntaxin-interacting)
SYP synaptophysin
SYT1 synaptotagmin I
SYT2 synaptotagmin II
SYT4 synaptotagmin IV
SYT7 synaptotagmin VII
SYTL4 synaptotagmin-like 4
THY1 Thy-1 cell surface antigen
TPCN1 two pore segment channel 1
TPCN2 two pore segment channel 2
TPP1 tripeptidyl peptidase I
TRDMT1 tRNA aspartic acid methyltransferase 1
TRDN triadin
TRPA1 transient receptor potential cation channel, subfamily A, member 1
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TRPC4 transient receptor potential cation channel, subfamily C, member 4
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TRPC6 transient receptor potential cation channel, subfamily C, member 6
TRPC7 transient receptor potential cation channel, subfamily C, member 7
TRPM1 transient receptor potential cation channel, subfamily M, member 1
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TRPM3 transient receptor potential cation channel, subfamily M, member 3
TRPM6 transient receptor potential cation channel, subfamily M, member 6
TRPM7 transient receptor potential cation channel, subfamily M, member 7
TRPM8 transient receptor potential cation channel, subfamily M, member 8
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TRPV2 transient receptor potential cation channel, subfamily V, member 2
TRPV3 transient receptor potential cation channel, subfamily V, member 3
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TRPV5 transient receptor potential cation channel, subfamily V, member 5
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TXLNA taxilin alpha
TXLNB taxilin beta
UNC13B unc-13 homolog B (C. elegans)
UQCRC1 ubiquinol-cytochrome c reductase core protein I
UQCRC2 ubiquinol-cytochrome c reductase core protein II
UQCRH ubiquinol-cytochrome c reductase hinge protein
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VAMP5 vesicle-associated membrane protein 5
VAMP7 vesicle-associated membrane protein 7
VAMP8 vesicle-associated membrane protein 8
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
VDAC1 voltage-dependent anion channel 1
VDAC2 voltage-dependent anion channel 2
VDAC3 voltage-dependent anion channel 3
VIM vimentin
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae)
VPS18 vacuolar protein sorting 18 homolog (S. cerevisiae)
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma