STX2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description syntaxin 2|The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2054)
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Genes

331 genes differentially expressed following the STX2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
EFHB EF-hand domain family, member B 2.44238
SACK1A scaffolding CK1 anchoring protein A 2.44238
SLC26A1 solute carrier family 26 (anion exchanger), member 1 2.44238
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 2.44238
SLC46A3 solute carrier family 46, member 3 2.44238
LRRTM2 leucine rich repeat transmembrane neuronal 2 2.44238
CELF6 CUGBP, Elav-like family member 6 2.44238
PLIN1 perilipin 1 2.44238
MUC6 mucin 6, oligomeric mucus/gel-forming 2.44238
DCAF4L2 DDB1 and CUL4 associated factor 4-like 2 2.44238
OR1A1 olfactory receptor, family 1, subfamily A, member 1 2.44238
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 2.44238
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 2.44238
TXLNB taxilin beta 2.44238
HINT3 histidine triad nucleotide binding protein 3 2.44238
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 2.44238
LBHD1 LBH domain containing 1 2.44238
USH1G Usher syndrome 1G (autosomal recessive) 2.44238
SRPX2 sushi-repeat containing protein, X-linked 2 2.44238
ELF4 E74-like factor 4 (ets domain transcription factor) 2.44238
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 2.44238
GGNBP2 gametogenetin binding protein 2 2.44238
SOX1 SRY (sex determining region Y)-box 1 2.44238
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 2.44238
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 2.44238
PCDHB6 protocadherin beta 6 2.44238
NCF1 neutrophil cytosolic factor 1 2.44238
DEFB124 defensin, beta 124 2.44238
TDRD6 tudor domain containing 6 2.44238
LCN15 lipocalin 15 2.44238
CD68 CD68 molecule 2.44238
CD69 CD69 molecule 2.44238
MEIKIN meiotic kinetochore factor 2.44238
COPG2 coatomer protein complex, subunit gamma 2 2.44238
LRRIQ4 leucine-rich repeats and IQ motif containing 4 2.44238
MUC20 mucin 20, cell surface associated 2.44238
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 2.44238
RGL4 ral guanine nucleotide dissociation stimulator-like 4 2.44238
C11ORF87 chromosome 11 open reading frame 87 2.44238
EBNA1BP2 EBNA1 binding protein 2 2.44238
CCNB3 cyclin B3 2.44238
AMTN amelotin 2.44238
UMOD uromodulin 2.44238
PDZD9 PDZ domain containing 9 2.44238
CXORF65 chromosome X open reading frame 65 2.44238
CCL5 chemokine (C-C motif) ligand 5 2.44238
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 2.44238
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit 2.44238
NOL7 nucleolar protein 7, 27kDa 2.44238
ARSF arylsulfatase F 2.44238
MMP20 matrix metallopeptidase 20 2.44238
IZUMO1 izumo sperm-egg fusion 1 2.44238
COXFA4L3 cytochrome c oxidase associated subunit FA4L3 2.44238
LORICRIN loricrin cornified envelope precursor protein 2.44238
STYXL2 serine/threonine/tyrosine interacting like 2 2.44238
PCDHGA9 protocadherin gamma subfamily A, 9 2.44238
SAPCD1 suppressor APC domain containing 1 2.44238
YIPF7 Yip1 domain family, member 7 2.44238
ROPN1B rhophilin associated tail protein 1B 2.44238
UBN1 ubinuclein 1 2.44238
OR2T8 olfactory receptor, family 2, subfamily T, member 8 2.44238
SPRR2F small proline-rich protein 2F 2.44238
FMO1 flavin containing monooxygenase 1 2.44238
RNF227 ring finger protein 227 2.44238
PPDPFL pancreatic progenitor cell differentiation and proliferation factor like 2.44238
UBE2L5 ubiquitin conjugating enzyme E2 L5 2.44238
CATSPERT catsper channel auxiliary subunit tau 2.44238
SCPPPQ1 secretory calcium-binding phosphoprotein proline-glutamine rich 1 2.44238
DNAAF19 dynein axonemal assembly factor 19 2.44238
REELD1 reeler domain containing 1 2.44238
C17ORF114 chromosome 17 open reading frame 114 2.44238
H4C12 H4 clustered histone 12 2.44238
TMEM238L transmembrane protein 238 like 2.44238
H3C14 H3 clustered histone 14 2.44238
MYMK myomaker, myoblast fusion factor 2.44238
CFAP73 cilia and flagella associated protein 73 2.44238
LMNTD1 lamin tail domain containing 1 2.44238
ACSL5 acyl-CoA synthetase long-chain family member 5 2.44238
CEBPZOS CEBPZ opposite strand 2.44238
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 2.44238
C10ORF67 chromosome 10 open reading frame 67 2.44238
ACTA1 actin, alpha 1, skeletal muscle 2.44238
MAG myelin associated glycoprotein 2.44238
OR7C1 olfactory receptor, family 7, subfamily C, member 1 2.44238
NXPE1 neurexophilin and PC-esterase domain family, member 1 2.44238
IRF8 interferon regulatory factor 8 2.44238
LGALS7B lectin, galactoside-binding, soluble, 7B 2.44238
GGT5 gamma-glutamyltransferase 5 2.44238
RHOXF2 Rhox homeobox family, member 2 2.44238
GZMM granzyme M (lymphocyte met-ase 1) 2.44238
MYH13 myosin, heavy chain 13, skeletal muscle 2.44238
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 2.44238
CNGA4 cyclic nucleotide gated channel alpha 4 2.44238
LGSN lengsin, lens protein with glutamine synthetase domain 2.44238
LRRC73 leucine rich repeat containing 73 2.44238
CLDN22 claudin 22 2.44238
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 2.44238
LENG9 leukocyte receptor cluster (LRC) member 9 2.44238
INSRR insulin receptor-related receptor 2.44238
C6ORF118 chromosome 6 open reading frame 118 2.44238
C1QL3 complement component 1, q subcomponent-like 3 2.44238
CFAP45 cilia and flagella associated protein 45 2.44238
LIPJ lipase, family member J 2.44238
ATOH1 atonal homolog 1 (Drosophila) 2.44238
A3GALT2 alpha 1,3-galactosyltransferase 2 2.44238
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.44238
PCDHGA4 protocadherin gamma subfamily A, 4 2.44238
CCL13 chemokine (C-C motif) ligand 13 2.44238
SLC22A24 solute carrier family 22, member 24 2.44238
ZC3H11D zinc finger CCCH-type containing 11D 2.44238
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 2.44238
PLCL1 phospholipase C-like 1 2.44238
UBAC2 UBA domain containing 2 2.44238
PRSS38 protease, serine, 38 2.44238
NT5C1B 5'-nucleotidase, cytosolic IB 2.44238
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 2.44238
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 2.44238
ZNF624 zinc finger protein 624 2.44238
GLYATL3 glycine-N-acyltransferase-like 3 2.44238
KCNK4 potassium channel, two pore domain subfamily K, member 4 2.44238
RHPN1 rhophilin, Rho GTPase binding protein 1 2.44238
SMKR1 small lysine-rich protein 1 2.44238
TCEANC transcription elongation factor A (SII) N-terminal and central domain containing 2.44238
POF1B premature ovarian failure, 1B 2.44238
EFCAB3 EF-hand calcium binding domain 3 2.44238
UBQLNL ubiquilin-like 2.44238
C11ORF91 chromosome 11 open reading frame 91 2.44238
ZNF112 zinc finger protein 112 2.44238
CA5A carbonic anhydrase VA, mitochondrial 2.44238
DAW1 dynein assembly factor with WDR repeat domains 1 2.44238
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 2.44238
FAM151A family with sequence similarity 151, member A 2.44238
LMX1B LIM homeobox transcription factor 1, beta 2.44238
SFTA2 surfactant associated 2 2.44238
SYT5 synaptotagmin V 2.44238
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 2.44238
GJC2 gap junction protein, gamma 2, 47kDa 2.44238
FBXL19 F-box and leucine-rich repeat protein 19 2.44238
UPK1A uroplakin 1A 2.44238
CALM1 calmodulin 1 (phosphorylase kinase, delta) 2.44238
ABI3 ABI family, member 3 2.44238
OTP orthopedia homeobox 2.44238
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 2.44238
SLC22A31 solute carrier family 22, member 31 2.44238
SLC38A8 solute carrier family 38, member 8 2.44238
GTF2H2 general transcription factor IIH, polypeptide 2, 44kDa 2.44238
CTRB1 chymotrypsinogen B1 2.44238
CD27 CD27 molecule 2.44238
RGS4 regulator of G-protein signaling 4 2.44238
ORM1 orosomucoid 1 2.44238
IGIP IgA-inducing protein 2.44238
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like 2.44238
PLA2G2C phospholipase A2, group IIC 2.44238
SEZ6L seizure related 6 homolog (mouse)-like 2.44238
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 2.44238
TMEM52B transmembrane protein 52B 2.44238
WNK4 WNK lysine deficient protein kinase 4 2.44238
OR6B1 olfactory receptor, family 6, subfamily B, member 1 2.44238
PRDM1 PR domain containing 1, with ZNF domain 2.44238
LKAAEAR1 LKAAEAR motif containing 1 2.44238
DCST1 DC-STAMP domain containing 1 2.44238
CD226 CD226 molecule 2.44238
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 2.44238
TRAF3IP3 TRAF3 interacting protein 3 2.44238
MAGEA2 melanoma antigen family A2 2.44238
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 2.44238
CPLX1 complexin 1 2.44238
RSPH1 radial spoke head 1 homolog (Chlamydomonas) 2.44238
GRP gastrin-releasing peptide 2.44238
SPX spexin hormone 2.44238
LDHC lactate dehydrogenase C 2.44238
PLA2G10 phospholipase A2, group X 2.44238
FAM161B family with sequence similarity 161, member B 2.44238
RNASE9 ribonuclease, RNase A family, 9 (non-active) 2.44238
TWIST1 twist family bHLH transcription factor 1 2.44238
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 2.44238
CD86 CD86 molecule 2.44238
COL11A2 collagen, type XI, alpha 2 2.44238
TBC1D21 TBC1 domain family, member 21 2.44238
AQP3 aquaporin 3 (Gill blood group) 2.44238
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 2.44238
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 2.44238
GPR50 G protein-coupled receptor 50 2.44238
ANKRD62 ankyrin repeat domain 62 2.44238
EPO erythropoietin 2.44238
A1CF APOBEC1 complementation factor 2.44238
APOH apolipoprotein H (beta-2-glycoprotein I) 2.44238
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 2.43251
NUP153 nucleoporin 153kDa 2.42961
FAM178B family with sequence similarity 178, member B 2.40251
GCKR glucokinase (hexokinase 4) regulator 2.40251
LHX6 LIM homeobox 6 2.40251
PEX5L peroxisomal biogenesis factor 5-like 2.3993
INAFM1 InaF-motif containing 1 2.37615
H2AZ2 H2A.Z variant histone 2 2.37283
BCDIN3D BCDIN3 domain containing 2.36285
NEK2 NIMA-related kinase 2 2.35791
SACK1H scaffolding CK1 anchoring protein H 2.30344
SAMD1 sterile alpha motif domain containing 1 2.30344
TMBIM4 transmembrane BAX inhibitor motif containing 4 2.26553
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 2.26261
EYA3 EYA transcriptional coactivator and phosphatase 3 2.25271
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 2.22881
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 2.20707
SERP1 stress-associated endoplasmic reticulum protein 1 2.19904
APCDD1L adenomatosis polyposis coli down-regulated 1-like 2.18946
PA2G4 proliferation-associated 2G4, 38kDa 2.18864
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 2.13304
CHSY3 chondroitin sulfate synthase 3 2.12854
CREBBP CREB binding protein 2.11873
RING1 ring finger protein 1 2.09202
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 2.0913
KPNB1 karyopherin (importin) beta 1 2.08701
RASA2 RAS p21 protein activator 2 2.08289
ASS1 argininosuccinate synthase 1 2.07659
MKI67 marker of proliferation Ki-67 2.06993
PTGES3 prostaglandin E synthase 3 (cytosolic) 2.06613
WDR1 WD repeat domain 1 2.06528
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa 2.06477
DUSP16 dual specificity phosphatase 16 2.06164
CLCN5 chloride channel, voltage-sensitive 5 2.03899
VAMP8 vesicle-associated membrane protein 8 2.03883
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 2.03174
ZNF385D zinc finger protein 385D 2.01457
SYNC syncoilin, intermediate filament protein 2.01384
AMOTL2 angiomotin like 2 2.01384
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 2.00796

decreased expression

Symbol Name Standardized Value
MYL11 myosin light chain 11 -2.44238
TINCR tissue differentiation-inducing non-protein coding RNA -2.44238
NME5 NME/NM23 family member 5 -2.44238
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 -2.44238
EFNA1 ephrin-A1 -2.44238
DRP2 dystrophin related protein 2 -2.44238
FRRS1 ferric-chelate reductase 1 -2.44238
SHD Src homology 2 domain containing transforming protein D -2.44238
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -2.44238
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) -2.44238
C2ORF76 chromosome 2 open reading frame 76 -2.44238
RPH3A rabphilin 3A -2.44238
PSD4 pleckstrin and Sec7 domain containing 4 -2.44238
RDH16 retinol dehydrogenase 16 (all-trans) -2.44238
ICAM5 intercellular adhesion molecule 5, telencephalin -2.44238
ZFP36 ZFP36 ring finger protein -2.44238
IFT54 intraflagellar transport 54 -2.44238
PPP1R3E protein phosphatase 1, regulatory subunit 3E -2.44238
GSTM3 glutathione S-transferase mu 3 (brain) -2.44238
NXPH4 neurexophilin 4 -2.44238
BORCS6 BLOC-1 related complex subunit 6 -2.44238
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 -2.44238
LINGO2 leucine rich repeat and Ig domain containing 2 -2.44238
KIF13B kinesin family member 13B -2.44238
KLB klotho beta -2.44238
MUCL3 mucin like 3 -2.44238
GDF3 growth differentiation factor 3 -2.44238
DDTL D-dopachrome tautomerase-like -2.44238
SPAG4 sperm associated antigen 4 -2.44238
FIZ1 FLT3-interacting zinc finger 1 -2.44238
C19ORF47 chromosome 19 open reading frame 47 -2.44238
RSPH14 radial spoke head 14 homolog (Chlamydomonas) -2.44238
ARHGAP9 Rho GTPase activating protein 9 -2.44238
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) -2.44238
OR2A7 olfactory receptor, family 2, subfamily A, member 7 -2.44238
SOX7 SRY (sex determining region Y)-box 7 -2.44238
PROKR1 prokineticin receptor 1 -2.44238
DNAJB7 DnaJ (Hsp40) homolog, subfamily B, member 7 -2.44238
MROH7 maestro heat-like repeat family member 7 -2.44238
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) -2.44238
SOWAHD sosondowah ankyrin repeat domain family member D -2.44238
ERICH6 glutamate-rich 6 -2.44238
MAN2A2 mannosidase, alpha, class 2A, member 2 -2.44238
ZNF546 zinc finger protein 546 -2.44238
NKX1-2 NK1 homeobox 2 -2.44238
NR6A1 nuclear receptor subfamily 6, group A, member 1 -2.44238
AGER advanced glycosylation end product-specific receptor -2.44238
TMED2 transmembrane emp24 domain trafficking protein 2 -2.44238
SNCB synuclein, beta -2.44238
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A -2.44238
LIME1 Lck interacting transmembrane adaptor 1 -2.44238
VWA2 von Willebrand factor A domain containing 2 -2.44238
CPN1 carboxypeptidase N, polypeptide 1 -2.44238
TGS1 trimethylguanosine synthase 1 -2.44238
COL5A3 collagen, type V, alpha 3 -2.44238
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) -2.44238
COMTD1 catechol-O-methyltransferase domain containing 1 -2.44238
GAL3ST4 galactose-3-O-sulfotransferase 4 -2.44238
SLC51B solute carrier family 51, beta subunit -2.44238
PTGDR prostaglandin D2 receptor (DP) -2.44238
LSR lipolysis stimulated lipoprotein receptor -2.44238
STAB2 stabilin 2 -2.44238
C22ORF23 chromosome 22 open reading frame 23 -2.44238
MACROH2A1 macroH2A.1 histone -2.43892
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -2.42961
ERBB4 erb-b2 receptor tyrosine kinase 4 -2.40573
HNRNPM heterogeneous nuclear ribonucleoprotein M -2.40339
FAM171A2 family with sequence similarity 171, member A2 -2.38506
RAB17 RAB17, member RAS oncogene family -2.38506
SYT4 synaptotagmin IV -2.37132
CDYL chromodomain protein, Y-like -2.36285
RRAGB Ras-related GTP binding B -2.33312
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2 -2.32774
ARMCX6 armadillo repeat containing, X-linked 6 -2.32774
MICALL1 MICAL-like 1 -2.32769
PPP6R3 protein phosphatase 6, regulatory subunit 3 -2.32107
OSTC oligosaccharyltransferase complex subunit (non-catalytic) -2.30821
VIRMA vir like m6A methyltransferase associated -2.30582
POLM polymerase (DNA directed), mu -2.25993
CDK3 cyclin-dependent kinase 3 -2.25798
EXOC8 exocyst complex component 8 -2.25798
LHCGR luteinizing hormone/choriogonadotropin receptor -2.25798
NUP37 nucleoporin 37kDa -2.22109
YPEL2 yippee-like 2 (Drosophila) -2.20365
NF1 neurofibromin 1 -2.19253
TCF25 transcription factor 25 (basic helix-loop-helix) -2.18546
MCM9 minichromosome maintenance complex component 9 -2.18307
NT5DC1 5'-nucleotidase domain containing 1 -2.17861
ZDHHC11 zinc finger, DHHC-type containing 11 -2.17861
EFCAB14 EF-hand calcium binding domain 14 -2.17861
B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) -2.16284
AKAP6 A kinase (PRKA) anchor protein 6 -2.16284
KIF24 kinesin family member 24 -2.13255
TMEM74 transmembrane protein 74 -2.11193
MIPOL1 mirror-image polydactyly 1 -2.10304
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -2.10304
METAP2 methionyl aminopeptidase 2 -2.07659
CHMP1B charged multivesicular body protein 1B -2.03899
FKBP14 FK506 binding protein 14, 22 kDa -2.03899
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 -2.03659
CRB2 crumbs family member 2 -2.03659
EEF1AKMT4 EEF1A lysine methyltransferase 4 -2.01384
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -2.01384
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1 -2.00254