SU8686 Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
Description cell line derived from Pancreatic Carcinoma Metastasis (Cell Model Passports, SIDM01188)
External Link https://depmap.org/portal/cell_line/ACH-000114
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Genes

352 gene knockdowns changing fitness of SU8686 relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
C19ORF54 chromosome 19 open reading frame 54 28.9252
MIA melanoma inhibitory activity 27.9415
C12ORF40 chromosome 12 open reading frame 40 22.1316
ZNF546 zinc finger protein 546 21.8753
PLD3 phospholipase D family, member 3 20.8756
FXYD7 FXYD domain containing ion transport regulator 7 20.6833
VRK3 vaccinia related kinase 3 19.9835
LGALS16 lectin, galactoside-binding, soluble, 16 19.3649
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3 19.3353
BLVRB biliverdin reductase B 18.643
FBXO27 F-box protein 27 16.9228
DLL3 delta-like 3 (Drosophila) 16.6022
SYCN syncollin 16.123
CPNE8 copine VIII 16.0644
SELV selenoprotein V 16.0557
CLC Charcot-Leyden crystal galectin 15.9038
ZNF473 zinc finger protein 473 15.4575
TTC9B tetratricopeptide repeat domain 9B 15.364
NUMBL numb homolog (Drosophila)-like 15.2836
FAM187B family with sequence similarity 187, member B 14.9924
IZUMO2 IZUMO family member 2 14.8393
SPTBN4 spectrin, beta, non-erythrocytic 4 14.7679
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 13.7638
RINL Ras and Rab interactor-like 13.7022
MAP3K10 mitogen-activated protein kinase kinase kinase 10 13.2888
HIPK4 homeodomain interacting protein kinase 4 13.0714
CCER2 coiled-coil glutamate-rich protein 2 13.0074
SHKBP1 SH3KBP1 binding protein 1 12.773
ITPKC inositol-trisphosphate 3-kinase C 12.6891
EID2B EP300 interacting inhibitor of differentiation 2B 12.3396
MYH14 myosin, heavy chain 14, non-muscle 11.5689
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 11.2764
ARHGAP33 Rho GTPase activating protein 33 11.039
MGP matrix Gla protein 10.9338
ZFP36 ZFP36 ring finger protein 10.9013
SERTAD3 SERTA domain containing 3 10.8844
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B 10.6546
LGALS13 lectin, galactoside-binding, soluble, 13 10.6018
RAB4B RAB4B, member RAS oncogene family 10.3424
C19ORF47 chromosome 19 open reading frame 47 9.73668
PTPRO protein tyrosine phosphatase, receptor type, O 9.69603
ZNF726 zinc finger protein 726 9.57236
COQ8B coenzyme Q8B 9.56034
PAPL iron/zinc purple acid phosphatase-like protein 9.39151
FXYD3 FXYD domain containing ion transport regulator 3 9.38486
ECH1 enoyl CoA hydratase 1, peroxisomal 9.32227
GRAMD1A GRAM domain containing 1A 9.20096
GMFG glia maturation factor, gamma 9.15639
IFNL1 interferon, lambda 1 9.10685
LGALS14 lectin, galactoside-binding, soluble, 14 9.0586
PRX periaxin 8.85168
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 8.76969
FFAR1 free fatty acid receptor 1 8.20526
LRFN1 leucine rich repeat and fibronectin type III domain containing 1 8.10555
ZNF461 zinc finger protein 461 8.07048
U2AF1L4 U2 small nuclear RNA auxiliary factor 1-like 4 8.00712
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 7.84481
SERTAD1 SERTA domain containing 1 7.6518
SIRT2 sirtuin 2 7.59262
ALKBH6 alkB, alkylation repair homolog 6 (E. coli) 7.59156
CNTD2 cyclin N-terminal domain containing 2 7.57715
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) 7.3665
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 7.25966
LRFN3 leucine rich repeat and fibronectin type III domain containing 3 7.23355
LY6G6C lymphocyte antigen 6 complex, locus G6C 7.18123
TUT7 terminal uridylyl transferase 7 7.13244
ETV2 ets variant 2 7.05264
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 6.91796
RGL2 ral guanine nucleotide dissociation stimulator-like 2 6.75115
BHLHE41 basic helix-loop-helix family, member e41 6.60737
ZNF599 zinc finger protein 599 6.41667
ZNF792 zinc finger protein 792 6.32695
DDR1 discoidin domain receptor tyrosine kinase 1 6.22385
TMEM217 transmembrane protein 217 6.21657
KIF21A kinesin family member 21A 6.16733
EGLN2 egl-9 family hypoxia-inducible factor 2 6.0862
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 6.0352
CAPRIN2 caprin family member 2 6.02827
ZNF99 zinc finger protein 99 5.94658
TENT2 terminal nucleotidyltransferase 2 5.94213
IFNL3 interferon, lambda 3 5.94111
HCST hematopoietic cell signal transducer 5.93033
CUL7 cullin 7 5.83944
AKT2 v-akt murine thymoma viral oncogene homolog 2 5.83435
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 5.81275
ERP27 endoplasmic reticulum protein 27 5.78815
DERA deoxyribose-phosphate aldolase (putative) 5.7091
SMIM15 small integral membrane protein 15 5.58313
EID2 EP300 interacting inhibitor of differentiation 2 5.56857
SSPN sarcospan 5.5267
SBSN suprabasin 5.3878
FXYD1 FXYD domain containing ion transport regulator 1 5.31316
PTK7 protein tyrosine kinase 7 (inactive) 5.30268
CASC1 cancer susceptibility candidate 1 5.28768
CD22 CD22 molecule 5.23228
NOMO1 NODAL modulator 1 5.21098
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 5.20471
LY6G5C lymphocyte antigen 6 complex, locus G5C 5.16818
COL11A2 collagen, type XI, alpha 2 5.10923
UPK1A uroplakin 1A 5.01984
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 4.99341
PRODH2 proline dehydrogenase (oxidase) 2 4.98364
PSORS1C1 psoriasis susceptibility 1 candidate 1 4.98357
FFAR2 free fatty acid receptor 2 4.94667
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 4.94189
FXYD5 FXYD domain containing ion transport regulator 5 4.92446
LSM1 LSM1, U6 small nuclear RNA associated 4.89333
MAG myelin associated glycoprotein 4.86485
IL12A interleukin 12A 4.67577
LGI4 leucine-rich repeat LGI family, member 4 4.66601
ZNF737 zinc finger protein 737 4.66356
NCR3 natural cytotoxicity triggering receptor 3 4.64163
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 4.57954
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 4.57591
KIRREL2 kin of IRRE like 2 (Drosophila) 4.546
F13B coagulation factor XIII, B polypeptide 4.48088
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 4.42554
PPP2R5D protein phosphatase 2, regulatory subunit B', delta 4.4151
LMNTD1 lamin tail domain containing 1 4.38121
TMEM147 transmembrane protein 147 4.34051
VEGFA vascular endothelial growth factor A 4.21347
NPY2R neuropeptide Y receptor Y2 4.19195
TYROBP TYRO protein tyrosine kinase binding protein 4.12276
MAPK13 mitogen-activated protein kinase 13 4.0383
NOTCH4 notch 4 4.02247
PRF1 perforin 1 (pore forming protein) 4.00916
TRIM68 tripartite motif containing 68 3.99769
OR4X1 olfactory receptor, family 4, subfamily X, member 1 (gene/pseudogene) 3.97014
LMO3 LIM domain only 3 (rhombotin-like 2) 3.96213
GPR1 G protein-coupled receptor 1 3.94355
NCR2 natural cytotoxicity triggering receptor 2 3.93827
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 3.91886
ZNF318 zinc finger protein 318 3.91864
YIPF3 Yip1 domain family, member 3 3.7859
SP110 SP110 nuclear body protein 3.70529
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 3.65556
TJAP1 tight junction associated protein 1 (peripheral) 3.64951
KLC4 kinesin light chain 4 3.61923
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 3.59019
PTHLH parathyroid hormone-like hormone 3.57632
APLP1 amyloid beta (A4) precursor-like protein 1 3.57395
SYNE4 spectrin repeat containing, nuclear envelope family member 4 3.56982
SCUBE3 signal peptide, CUB domain, EGF-like 3 3.56161
TMEM71 transmembrane protein 71 3.53805
KTN1 kinectin 1 (kinesin receptor) 3.47283
IRGM immunity-related GTPase family, M 3.4451
ZNF98 zinc finger protein 98 3.44315
ZNF829 zinc finger protein 829 3.41887
CNN3 calponin 3, acidic 3.40847
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase 3.40712
ACYP2 acylphosphatase 2, muscle type 3.38288
MTARC1 mitochondrial amidoxime reducing component 1 3.35271
SNX7 sorting nexin 7 3.3411
TREM1 triggering receptor expressed on myeloid cells 1 3.33086
C19ORF57 chromosome 19 open reading frame 57 3.32806
HYKK hydroxylysine kinase 3.31923
APOM apolipoprotein M 3.31612
CLIP3 CAP-GLY domain containing linker protein 3 3.30578
DLK2 delta-like 2 homolog (Drosophila) 3.29743
GNPDA2 glucosamine-6-phosphate deaminase 2 3.28306
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 3.27788
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 3.27184
FBXO3 F-box protein 3 3.26236
SLC25A42 solute carrier family 25, member 42 3.20564
DOCK5 dedicator of cytokinesis 5 3.1963
CUL9 cullin 9 3.19442
C6ORF15 chromosome 6 open reading frame 15 3.18616
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta 3.18472
UTP14C UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) 3.18195
ZNF420 zinc finger protein 420 3.17945
POLH polymerase (DNA directed), eta 3.17868
DIS3L2 DIS3 like 3'-5' exoribonuclease 2 3.17069
KANSL1L KAT8 regulatory NSL complex subunit 1-like 3.16054
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) 3.10646
LIN37 lin-37 DREAM MuvB core complex component 3.08854
ZNF181 zinc finger protein 181 3.07591
GLRX glutaredoxin (thioltransferase) 3.07562
TRERF1 transcriptional regulating factor 1 3.07475
CXORF36 chromosome X open reading frame 36 3.04704
MOSPD3 motile sperm domain containing 3 3.01797
ACOX1 acyl-CoA oxidase 1, palmitoyl 3.01766
SOCS1 suppressor of cytokine signaling 1 3.0102
ZNF566 zinc finger protein 566 2.9905
IZUMO3 IZUMO family member 3 2.98652
ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 2.98313
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 2.9774
GNMT glycine N-methyltransferase 2.96984
FBXW10 F-box and WD repeat domain containing 10 2.95667
WFDC8 WAP four-disulfide core domain 8 2.92044
N4BP1 NEDD4 binding protein 1 2.91304
SP100 SP100 nuclear antigen 2.8998
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 2.8949
HCLS1 hematopoietic cell-specific Lyn substrate 1 2.88509
MGST1 microsomal glutathione S-transferase 1 2.87459
PTPRJ protein tyrosine phosphatase, receptor type, J 2.87297
RGL3 ral guanine nucleotide dissociation stimulator-like 3 2.86912
LIPH lipase, member H 2.86005
MYPN myopalladin 2.85597
SLC38A4 solute carrier family 38, member 4 2.83886
TCP11 t-complex 11, testis-specific 2.82959
TP53BP2 tumor protein p53 binding protein 2 2.82438
ZNF565 zinc finger protein 565 2.82094
HMGXB4 HMG box domain containing 4 2.81957
CRIP3 cysteine-rich protein 3 2.8053
TRIB2 tribbles pseudokinase 2 2.79576
ZFAND3 zinc finger, AN1-type domain 3 2.78461
IQCG IQ motif containing G 2.78103
ZNF382 zinc finger protein 382 2.75627
MTMR2 myotubularin related protein 2 2.75615
SYNE2 spectrin repeat containing, nuclear envelope 2 2.7497
RAP1GAP2 RAP1 GTPase activating protein 2 2.74299
TAAR2 trace amine associated receptor 2 2.73374
RAB18 RAB18, member RAS oncogene family 2.72904
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 2.72872
EFCAB13 EF-hand calcium binding domain 13 2.7034
ADIRF adipogenesis regulatory factor 2.68285
NLRC5 NLR family, CARD domain containing 5 2.68226
CEL carboxyl ester lipase 2.66413
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 2.64969
CCDC170 coiled-coil domain containing 170 2.63744
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 2.59958
KCNRG potassium channel regulator 2.59878
TMEM31 transmembrane protein 31 2.5931
C1ORF146 chromosome 1 open reading frame 146 2.59195
KLF3 Kruppel-like factor 3 (basic) 2.5881
ZBTB5 zinc finger and BTB domain containing 5 2.5714
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 2.5629
PATZ1 POZ (BTB) and AT hook containing zinc finger 1 2.55488
LIFR leukemia inhibitory factor receptor alpha 2.55322
PLEKHA5 pleckstrin homology domain containing, family A member 5 2.55164
TMX4 thioredoxin-related transmembrane protein 4 2.54942
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.54485
KRTAP5-6 keratin associated protein 5-6 2.53534
ZBTB46 zinc finger and BTB domain containing 46 2.51191
GLT8D1 glycosyltransferase 8 domain containing 1 2.50043
LSR lipolysis stimulated lipoprotein receptor 2.49612
EPB41L5 erythrocyte membrane protein band 4.1 like 5 2.49581
PROSER1 proline and serine rich 1 2.49476
C6 complement component 6 2.49217
SLC44A4 solute carrier family 44, member 4 2.47981
HOXA2 homeobox A2 2.47441
CCDC74A coiled-coil domain containing 74A 2.45979
ARHGAP4 Rho GTPase activating protein 4 2.45514
OR51T1 olfactory receptor, family 51, subfamily T, member 1 2.45318
TPST1 tyrosylprotein sulfotransferase 1 2.45313
SLFN5 schlafen family member 5 2.44394
HSPB6 heat shock protein, alpha-crystallin-related, B6 2.4434
SDHAF1 succinate dehydrogenase complex assembly factor 1 2.43646
KRTDAP keratinocyte differentiation-associated protein 2.43557
HIP1 huntingtin interacting protein 1 2.42877
CHPT1 choline phosphotransferase 1 2.42718
PICK1 protein interacting with PRKCA 1 2.4245
RPRML reprimo-like 2.42131
OR7D2 olfactory receptor, family 7, subfamily D, member 2 2.41962
XAGE2 X antigen family, member 2 2.41773
CHURC1 churchill domain containing 1 2.41653
ZNF76 zinc finger protein 76 2.41637
ZNF729 zinc finger protein 729 2.41569
RSU1 Ras suppressor protein 1 2.41524
DMKN dermokine 2.41472
FAM81B family with sequence similarity 81, member B 2.39109
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 2.39057
TSPO2 translocator protein 2 2.38004
GTPBP2 GTP binding protein 2 2.3685
BRDT bromodomain, testis-specific 2.36507
ESR2 estrogen receptor 2 (ER beta) 2.34349
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 2.34033
CLPSL1 colipase-like 1 2.34005
FUBP1 far upstream element (FUSE) binding protein 1 2.33345
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 2.32771
THBS1 thrombospondin 1 2.32669
SLF2 SMC5-SMC6 complex localization factor 2 2.32656
GAS2L2 growth arrest-specific 2 like 2 2.32539
PRPH2 peripherin 2 (retinal degeneration, slow) 2.32518
DEFB116 defensin, beta 116 2.32197
TBC1D26 TBC1 domain family, member 26 2.31743
APOL2 apolipoprotein L, 2 2.31714
DYM dymeclin 2.31482
FBXO17 F-box protein 17 2.31251
SLCO1B1 solute carrier organic anion transporter family, member 1B1 2.30896
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase 2.30739
DACT2 dishevelled-binding antagonist of beta-catenin 2 2.29304
SAMD4B sterile alpha motif domain containing 4B 2.27764
IGFLR1 IGF-like family receptor 1 2.26727
RHBDD1 rhomboid domain containing 1 2.26214
PDE6H phosphodiesterase 6H, cGMP-specific, cone, gamma 2.26173
CHEK2 checkpoint kinase 2 2.25593
FRMD3 FERM domain containing 3 2.25557
C4ORF26 chromosome 4 open reading frame 26 2.24389
ZNF219 zinc finger protein 219 2.2429
TCAF1 TRPM8 channel-associated factor 1 2.24269
TNIP1 TNFAIP3 interacting protein 1 2.24222
L3HYPDH L-3-hydroxyproline dehydratase (trans-) 2.222
NPW neuropeptide W 2.2171
CTSH cathepsin H 2.21678
C1ORF162 chromosome 1 open reading frame 162 2.21578
PTBP2 polypyrimidine tract binding protein 2 2.21223
OR2Z1 olfactory receptor, family 2, subfamily Z, member 1 2.21118
CDK16 cyclin-dependent kinase 16 2.21102
SEPTIN5 septin 5 2.20384
TPGS2 tubulin polyglutamylase complex subunit 2 2.19662
LRRC73 leucine rich repeat containing 73 2.1966
HPN hepsin 2.1947
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 2.19366
OR10R2 olfactory receptor, family 10, subfamily R, member 2 2.19263
CR2 complement component (3d/Epstein Barr virus) receptor 2 2.18059
INTS13 integrator complex subunit 13 2.17975
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 2.17466
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.17043
SNRPA small nuclear ribonucleoprotein polypeptide A 2.16682
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 2.16418
PPP1R36 protein phosphatase 1, regulatory subunit 36 2.16091
CC2D1A coiled-coil and C2 domain containing 1A 2.16038
RTP4 receptor (chemosensory) transporter protein 4 2.15958
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 2.15957
SH2D1A SH2 domain containing 1A 2.15172
C1ORF234 chromosome 1 open reading frame 234 2.14913
MANSC4 MANSC domain containing 4 2.14327
TRAPPC3L trafficking protein particle complex 3-like 2.12474
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 2.12393
COL4A4 collagen, type IV, alpha 4 2.12131
TRABD2B TraB domain containing 2B 2.11109
OR10H4 olfactory receptor, family 10, subfamily H, member 4 2.10569
ZNF148 zinc finger protein 148 2.10452
LMOD2 leiomodin 2 (cardiac) 2.10428
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 2.10193
PRKG1 protein kinase, cGMP-dependent, type I 2.10077
UBE3C ubiquitin protein ligase E3C 2.09325
WFDC5 WAP four-disulfide core domain 5 2.08891
STARD5 StAR-related lipid transfer (START) domain containing 5 2.08121
EPB41L2 erythrocyte membrane protein band 4.1-like 2 2.07908
IL19 interleukin 19 2.07854
MX2 MX dynamin-like GTPase 2 2.07664
ZNF730 zinc finger protein 730 2.07453
NELL2 NEL-like 2 (chicken) 2.07373
LRIF1 ligand dependent nuclear receptor interacting factor 1 2.05481
DCAF8L1 DDB1 and CUL4 associated factor 8-like 1 2.05385
PIP5KL1 phosphatidylinositol-4-phosphate 5-kinase-like 1 2.05368
KRT6C keratin 6C, type II 2.05134
C18ORF63 chromosome 18 open reading frame 63 2.0442
ZBTB12 zinc finger and BTB domain containing 12 2.04364
FBXO42 F-box protein 42 2.0377
CFH complement factor H 2.0361
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2 2.03467
HLA-DOA major histocompatibility complex, class II, DO alpha 2.03359
OR10J1 olfactory receptor, family 10, subfamily J, member 1 2.01965
ZCCHC12 zinc finger, CCHC domain containing 12 2.01903
SYNGAP1 synaptic Ras GTPase activating protein 1 2.01727
NEU1 sialidase 1 (lysosomal sialidase) 2.01646
ATL3 atlastin GTPase 3 2.01438
PRRC1 proline-rich coiled-coil 1 2.01135
IPO5 importin 5 2.00464