SUMO1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description small ubiquitin-like modifier 1|This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7341)
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Genes

342 genes differentially expressed following the SUMO1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
RNF17 ring finger protein 17 2.54058
TUBB8 tubulin, beta 8 class VIII 2.54058
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.54058
TMPRSS11A transmembrane protease, serine 11A 2.54058
IL17B interleukin 17B 2.54058
C11ORF16 chromosome 11 open reading frame 16 2.54058
ANGPTL5 angiopoietin-like 5 2.54058
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.54058
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.54058
EIF3CL eukaryotic translation initiation factor 3, subunit C-like 2.54058
C10ORF90 chromosome 10 open reading frame 90 2.54058
NR1I2 nuclear receptor subfamily 1, group I, member 2 2.54058
DYDC1 DPY30 domain containing 1 2.54058
MYZAP myocardial zonula adherens protein 2.54058
IZUMO3 IZUMO family member 3 2.54058
CDH5 cadherin 5, type 2 (vascular endothelium) 2.54058
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 2.54058
PODNL1 podocan-like 1 2.54058
PTK6 protein tyrosine kinase 6 2.54058
C1ORF146 chromosome 1 open reading frame 146 2.54058
POU4F1 POU class 4 homeobox 1 2.54058
ADH6 alcohol dehydrogenase 6 (class V) 2.54058
NOP56 NOP56 ribonucleoprotein 2.54058
DNASE1L3 deoxyribonuclease I-like 3 2.46197
C1ORF141 chromosome 1 open reading frame 141 2.46197
CD69 CD69 molecule 2.46197
SHCBP1L SHC SH2-domain binding protein 1-like 2.46197
TEX13B testis expressed 13B 2.46197
CRX cone-rod homeobox 2.46197
RBPJ recombination signal binding protein for immunoglobulin kappa J region 2.46197
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 2.46197
ANKK1 ankyrin repeat and kinase domain containing 1 2.46197
CTRL chymotrypsin-like 2.46197
SPDYE11 speedy/RINGO cell cycle regulator family member E11 2.46197
ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 2.46197
OR2B6 olfactory receptor, family 2, subfamily B, member 6 2.46197
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 2.46197
MFAP5 microfibrillar associated protein 5 2.46197
DIRAS2 DIRAS family, GTP-binding RAS-like 2 2.46197
TNIP3 TNFAIP3 interacting protein 3 2.46197
STYXL2 serine/threonine/tyrosine interacting like 2 2.46197
NFAM1 NFAT activating protein with ITAM motif 1 2.46197
ASB17 ankyrin repeat and SOCS box containing 17 2.46197
REN renin 2.46197
PNISR PNN-interacting serine/arginine-rich protein 2.46197
SULT1A4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 2.46197
MAGEA2 melanoma antigen family A2 2.46197
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.46197
MTTP microsomal triglyceride transfer protein 2.46197
CCL5 chemokine (C-C motif) ligand 5 2.46197
OTUD6A OTU deubiquitinase 6A 2.46197
AZGP1 alpha-2-glycoprotein 1, zinc-binding 2.46197
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 2.46197
SPINK4 serine peptidase inhibitor, Kazal type 4 2.46197
NOTCH2NLB notch 2 N-terminal like B 2.46197
GBP6 guanylate binding protein family, member 6 2.46197
ROPN1B rhophilin associated tail protein 1B 2.46197
ACER1 alkaline ceramidase 1 2.46197
FRG2C FSHD region gene 2 family, member C 2.46197
FIMP1 fertilization-influencing membrane protein 1 2.46197
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 2.46197
OR1C1 olfactory receptor, family 1, subfamily C, member 1 2.46197
TMEM44 transmembrane protein 44 2.46197
MYEOV myeloma overexpressed 2.46197
ARX aristaless related homeobox 2.46197
STING1 stimulator of interferon response cGAMP interactor 1 2.46197
C4ORF54 chromosome 4 open reading frame 54 2.46197
ZNF593OS ZNF593 opposite strand 2.46197
STPG3 sperm-tail PG-rich repeat containing 3 2.46197
UBE2L5 ubiquitin conjugating enzyme E2 L5 2.46197
H2BW2 H2B.W histone 2 2.46197
ODAPH odontogenesis associated phosphoprotein 2.46197
CCDC187 coiled-coil domain containing 187 2.46197
PLAAT4 phospholipase A and acyltransferase 4 2.46197
DEPP1 DEPP autophagy regulator 1 2.46197
ZNF705D zinc finger protein 705D 2.46197
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 2.46197
OSTN osteocrin 2.46197
TPTE transmembrane phosphatase with tensin homology 2.46197
UROC1 urocanate hydratase 1 2.46197
PTP4A1 protein tyrosine phosphatase type IVA, member 1 2.46197
CHRD chordin 2.46197
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.46197
TMEM95 transmembrane protein 95 2.46197
KLHL33 kelch-like family member 33 2.46197
PCDHA2 protocadherin alpha 2 2.46197
NKX3-2 NK3 homeobox 2 2.46197
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.46197
GJD4 gap junction protein, delta 4, 40.1kDa 2.46197
PRDM7 PR domain containing 7 2.46197
ASIC4 acid sensing (proton gated) ion channel family member 4 2.46197
FOXK1 forkhead box K1 2.46197
NPIPB8 nuclear pore complex interacting protein family, member B8 2.46197
GDF7 growth differentiation factor 7 2.46197
SAA1 serum amyloid A1 2.46197
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 2.46197
CCR8 chemokine (C-C motif) receptor 8 2.46197
CCR3 chemokine (C-C motif) receptor 3 2.46197
NRN1 neuritin 1 2.46197
PNOC prepronociceptin 2.46197
S100Z S100 calcium binding protein Z 2.46197
CGB7 chorionic gonadotropin, beta polypeptide 7 2.46197
SLC36A3 solute carrier family 36, member 3 2.46197
CHRM4 cholinergic receptor, muscarinic 4 2.46197
VWA7 von Willebrand factor A domain containing 7 2.46197
IL19 interleukin 19 2.46197
TEKT1 tektin 1 2.46197
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 2.46197
PKM pyruvate kinase, muscle 2.46197
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 2.46197
C4BPA complement component 4 binding protein, alpha 2.46197
PTPN7 protein tyrosine phosphatase, non-receptor type 7 2.46197
CTXN3 cortexin 3 2.46197
DMRT1 doublesex and mab-3 related transcription factor 1 2.46197
ADAM20 ADAM metallopeptidase domain 20 2.46197
ZXDA zinc finger, X-linked, duplicated A 2.46197
OR2V2 olfactory receptor, family 2, subfamily V, member 2 2.46197
ADGRA1 adhesion G protein-coupled receptor A1 2.46197
LCN1 lipocalin 1 2.46197
CST7 cystatin F (leukocystatin) 2.46197
IL21R interleukin 21 receptor 2.46197
TDRD10 tudor domain containing 10 2.46197
SOWAHD sosondowah ankyrin repeat domain family member D 2.46197
PKDREJ polycystin (PKD) family receptor for egg jelly 2.46197
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 2.46197
IL36R interleukin 36 receptor 2.46197
OR2T12 olfactory receptor, family 2, subfamily T, member 12 2.46197
TMEM51 transmembrane protein 51 2.46197
PRSS54 protease, serine, 54 2.46197
SLFN12L schlafen family member 12-like 2.46197
C9ORF57 chromosome 9 open reading frame 57 2.46197
KCTD2 potassium channel tetramerization domain containing 2 2.46197
MMP12 matrix metallopeptidase 12 2.46197
HIGD2B HIG1 hypoxia inducible domain family, member 2B 2.46197
TSPAN19 tetraspanin 19 2.46197
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 2.46197
FAIM2 Fas apoptotic inhibitory molecule 2 2.46197
MYL4 myosin, light chain 4, alkali; atrial, embryonic 2.46197
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 2.46197
WNT10B wingless-type MMTV integration site family, member 10B 2.46197
OR2B11 olfactory receptor, family 2, subfamily B, member 11 2.46197
ETV2 ets variant 2 2.46197
NPY2R neuropeptide Y receptor Y2 2.46197
TEX29 testis expressed 29 2.46197
ZNF831 zinc finger protein 831 2.46197
NLRP14 NLR family, pyrin domain containing 14 2.46197
IL2RB interleukin 2 receptor, beta 2.46197
OXT oxytocin/neurophysin I prepropeptide 2.46197
MISP mitotic spindle positioning 2.46197
GNRH2 gonadotropin-releasing hormone 2 2.46197
KRTAP5-2 keratin associated protein 5-2 2.46197
BTBD19 BTB (POZ) domain containing 19 2.46197
IL33 interleukin 33 2.46197
LHX3 LIM homeobox 3 2.46197
LHX2 LIM homeobox 2 2.46197
MYOZ2 myozenin 2 2.46197
MYOZ1 myozenin 1 2.46197
NLRP6 NLR family, pyrin domain containing 6 2.46197
PFN2 profilin 2 2.46197
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 2.46197
NKX6-1 NK6 homeobox 1 2.46197
IGIP IgA-inducing protein 2.46197
CD22 CD22 molecule 2.46197
ZAR1 zygote arrest 1 2.4549
GLYATL1 glycine-N-acyltransferase-like 1 2.43605
ZEB1 zinc finger E-box binding homeobox 1 2.40889
CPHXL2 cytoplasmic polyadenylated homeobox like 2 2.40889
PTPN21 protein tyrosine phosphatase, non-receptor type 21 2.40889
CCDC25 coiled-coil domain containing 25 2.40889
ERICH6 glutamate-rich 6 2.40889
HAUS5 HAUS augmin-like complex, subunit 5 2.40889
CDC25B cell division cycle 25B 2.40889
GMPR guanosine monophosphate reductase 2.40889
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa 2.40889
BBS5 Bardet-Biedl syndrome 5 2.40889
KPTN kaptin (actin binding protein) 2.40889
EPB41 erythrocyte membrane protein band 4.1 2.40889
LOXL4 lysyl oxidase-like 4 2.40889
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 2.40889
CCDC85C coiled-coil domain containing 85C 2.40889
ADAMTSL2 ADAMTS-like 2 2.40101
REEP1 receptor accessory protein 1 2.39373
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.39373
ZBTB12 zinc finger and BTB domain containing 12 2.38283
DRC8 dynein regulatory complex subunit 8 2.38245
PRDM5 PR domain containing 5 2.36642
CECR2 cat eye syndrome chromosome region, candidate 2 2.36205
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase 2.3563
TSPAN15 tetraspanin 15 2.32763
UCMA upper zone of growth plate and cartilage matrix associated 2.30373
XK X-linked Kx blood group 2.30373
ARF6 ADP-ribosylation factor 6 2.29993
MTERF1 mitochondrial transcription termination factor 1 2.29666
TRAF2 TNF receptor-associated factor 2 2.28259
KBTBD6 kelch repeat and BTB (POZ) domain containing 6 2.28259
RASSF9 Ras association (RalGDS/AF-6) domain family (N-terminal) member 9 2.22885
SEC14L1 SEC14-like 1 (S. cerevisiae) 2.22885
CFAP20 cilia and flagella associated protein 20 2.18763
TCP1 t-complex 1 2.16574
COG1 component of oligomeric golgi complex 1 2.16177
SCD stearoyl-CoA desaturase (delta-9-desaturase) 2.16085
RHOXF1 Rhox homeobox family, member 1 2.15903
BMP6 bone morphogenetic protein 6 2.15671
AKAP8 A kinase (PRKA) anchor protein 8 2.13427
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 2.13427
OR2A12 olfactory receptor, family 2, subfamily A, member 12 2.12159
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.09115
PLPP3 phospholipid phosphatase 3 2.08425
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 2.08271
LDHA lactate dehydrogenase A 2.07544
PICALM phosphatidylinositol binding clathrin assembly protein 2.06483
MIX23 mitochondrial matrix import factor 23 2.0604
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 2.04354
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 2.03185
RELL2 RELT-like 2 2.03185
ELP1 elongator acetyltransferase complex subunit 1 2.03185
TMEM231 transmembrane protein 231 2.03064
DEMA1 DPM1 ER membrane anchor 1 2.00124

decreased expression

Symbol Name Standardized Value
SUMO1 small ubiquitin-like modifier 1 -2.54058
INVS inversin -2.54058
ADRA1A adrenoceptor alpha 1A -2.54058
SEC63 SEC63 homolog (S. cerevisiae) -2.46197
WDR44 WD repeat domain 44 -2.46197
CALCRL calcitonin receptor-like -2.46197
CHN1 chimerin 1 -2.46197
CPTP ceramide-1-phosphate transfer protein -2.46197
HYOU1 hypoxia up-regulated 1 -2.46197
R3HDM1 R3H domain containing 1 -2.46197
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -2.46197
OXTR oxytocin receptor -2.46197
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) -2.46197
ZNF469 zinc finger protein 469 -2.46197
GPR3 G protein-coupled receptor 3 -2.46197
SUOX sulfite oxidase -2.46197
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 -2.46197
CLYBL citrate lyase beta like -2.46197
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) -2.46197
MAP1B microtubule-associated protein 1B -2.46197
KHDC1 KH homology domain containing 1 -2.46197
JMJD7 jumonji domain containing 7 -2.43625
SERF2 small EDRK-rich factor 2 -2.42536
A1BG alpha-1-B glycoprotein -2.42358
MARCHF9 membrane associated ring-CH-type finger 9 -2.4175
C16ORF54 chromosome 16 open reading frame 54 -2.40889
CENPL centromere protein L -2.40889
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -2.40889
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 -2.40889
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 -2.40889
SMCO3 single-pass membrane protein with coiled-coil domains 3 -2.40889
ULBP3 UL16 binding protein 3 -2.40889
FXYD2 FXYD domain containing ion transport regulator 2 -2.40889
CD109 CD109 molecule -2.40889
NAPSA napsin A aspartic peptidase -2.40889
PFN4 profilin family, member 4 -2.40889
SLA Src-like-adaptor -2.40889
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 -2.40889
LEFTY1 left-right determination factor 1 -2.40889
KCNIP3 Kv channel interacting protein 3, calsenilin -2.40889
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 -2.40889
MAN1B1 mannosidase, alpha, class 1B, member 1 -2.40889
TTLL2 tubulin tyrosine ligase-like family member 2 -2.40889
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) -2.40889
LRRC61 leucine rich repeat containing 61 -2.40889
PAX7 paired box 7 -2.40889
ASGR2 asialoglycoprotein receptor 2 -2.40889
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 -2.40889
RAB44 RAB44, member RAS oncogene family -2.40889
RHOXF2 Rhox homeobox family, member 2 -2.40889
AMBP alpha-1-microglobulin/bikunin precursor -2.40889
SHOX2 short stature homeobox 2 -2.40889
FAM229A family with sequence similarity 229, member A -2.40889
EXTL1 exostosin-like glycosyltransferase 1 -2.40889
CERS6 ceramide synthase 6 -2.40889
AQP8 aquaporin 8 -2.40889
LCN2 lipocalin 2 -2.40889
AANAT aralkylamine N-acetyltransferase -2.40889
TRADD TNFRSF1A-associated via death domain -2.40889
HNRNPK heterogeneous nuclear ribonucleoprotein K -2.40889
KLK10 kallikrein-related peptidase 10 -2.40889
C22ORF42 chromosome 22 open reading frame 42 -2.40889
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 -2.40889
KCNK7 potassium channel, two pore domain subfamily K, member 7 -2.40889
CCER2 coiled-coil glutamate-rich protein 2 -2.40889
TSKS testis-specific serine kinase substrate -2.40889
ACE2 angiotensin I converting enzyme 2 -2.40889
ZNF534 zinc finger protein 534 -2.40889
SMTNL1 smoothelin-like 1 -2.40889
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 -2.40889
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 -2.40889
ANO3 anoctamin 3 -2.40889
MBOAT4 membrane bound O-acyltransferase domain containing 4 -2.40889
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G -2.40889
DRD3 dopamine receptor D3 -2.40889
SCYL2 SCY1-like 2 (S. cerevisiae) -2.38507
SPATA24 spermatogenesis associated 24 -2.38472
LTB4R leukotriene B4 receptor -2.38245
XYLT2 xylosyltransferase II -2.3712
FBXW10 F-box and WD repeat domain containing 10 -2.3712
SAFB2 scaffold attachment factor B2 -2.36506
IFTAP intraflagellar transport associated protein -2.36205
SYT14 synaptotagmin XIV -2.33668
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2 -2.32121
ZNF260 zinc finger protein 260 -2.30025
SDHAF1 succinate dehydrogenase complex assembly factor 1 -2.30025
ZNF34 zinc finger protein 34 -2.29993
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) -2.29993
VAT1L vesicle amine transport 1-like -2.29307
CHAMP1 chromosome alignment maintaining phosphoprotein 1 -2.28691
C2ORF81 chromosome 2 open reading frame 81 -2.28259
OR4D1 olfactory receptor, family 4, subfamily D, member 1 -2.28259
HYLS1 hydrolethalus syndrome 1 -2.2718
SDHAF3 succinate dehydrogenase complex assembly factor 3 -2.22887
TRIM3 tripartite motif containing 3 -2.22885
MACROD2 MACRO domain containing 2 -2.22048
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 -2.19386
ZNF628 zinc finger protein 628 -2.17438
S1PR5 sphingosine-1-phosphate receptor 5 -2.1737
SLC9C1 solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1 -2.17141
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase -2.17065
ZYX zyxin -2.16761
GRWD1 glutamate-rich WD repeat containing 1 -2.15403
ACOT13 acyl-CoA thioesterase 13 -2.13427
LGALS8 lectin, galactoside-binding, soluble, 8 -2.13427
HNRNPA1L3 heterogeneous nuclear ribonucleoprotein A1 like 3 -2.12386
ADAM9 ADAM metallopeptidase domain 9 -2.09807
MRPL36 mitochondrial ribosomal protein L36 -2.07143
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) -2.07143
TSLIG3B tRNA splicing ligase complex subunit 3B -2.06986
PCDHB10 protocadherin beta 10 -2.06837
IER5L immediate early response 5-like -2.06837
GPR183 G protein-coupled receptor 183 -2.06837
RFX4 regulatory factor X, 4 (influences HLA class II expression) -2.06483
LEKR1 leucine, glutamate and lysine rich 1 -2.0604
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) -2.0604
MAGEA4 melanoma antigen family A4 -2.0604
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 -2.03479
DIO2 deiodinase, iodothyronine, type II -2.03191
CNPY2 canopy FGF signaling regulator 2 -2.03185
MISFA mitochondrial sheath formation associated -2.03185
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -2.01853
CRELD1 cysteine-rich with EGF-like domains 1 -2.00414
ZIC3 Zic family member 3 -2.00124