SW1271 Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
Description cell line derived from Small Cell Lung Carcinoma Tumour (Cell Model Passports, SIDM01156)
External Link https://depmap.org/portal/cell_line/ACH-000890
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Genes

343 gene knockdowns changing fitness of SW1271 relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
CDH4 cadherin 4, type 1, R-cadherin (retinal) 17.7807
TSHZ3 teashirt zinc finger homeobox 3 17.4254
KDM4D lysine (K)-specific demethylase 4D 12.2266
ERBIN erbb2 interacting protein 10.5886
ASIP agouti signaling protein 9.94426
GGT7 gamma-glutamyltransferase 7 9.05657
KDM4E lysine (K)-specific demethylase 4E 8.85292
PANX1 pannexin 1 8.53474
HEPH hephaestin 8.314
FAM76B family with sequence similarity 76, member B 7.73696
C11ORF87 chromosome 11 open reading frame 87 7.52173
CEP126 centrosomal protein 126kDa 7.50701
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 7.08488
MYO1C myosin IC 7.00236
CA7 carbonic anhydrase VII 6.86557
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 6.73627
DUSP6 dual specificity phosphatase 6 6.71648
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 6.54507
OR52N5 olfactory receptor, family 52, subfamily N, member 5 6.4779
NPBWR1 neuropeptides B/W receptor 1 6.44889
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1 6.3285
SLC25A30 solute carrier family 25, member 30 6.26773
C19ORF12 chromosome 19 open reading frame 12 6.19376
ZNF536 zinc finger protein 536 6.16836
FST follistatin 6.15554
CDK5RAP1 CDK5 regulatory subunit associated protein 1 6.01019
DNAH9 dynein, axonemal, heavy chain 9 6.0062
TP53 tumor protein p53 6.00427
CASP5 caspase 5, apoptosis-related cysteine peptidase 5.83376
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit 5.7866
MIEF2 mitochondrial elongation factor 2 5.75503
MFSD6L major facilitator superfamily domain containing 6-like 5.66216
SHISA2 shisa family member 2 5.41635
SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 5.39565
SIX6 SIX homeobox 6 5.29351
WSCD2 WSC domain containing 2 5.28916
EIF1B eukaryotic translation initiation factor 1B 5.28051
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) 5.26279
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) 5.21962
PRDM14 PR domain containing 14 5.20562
C11ORF53 chromosome 11 open reading frame 53 5.19738
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 5.08699
CNGB3 cyclic nucleotide gated channel beta 3 4.95242
BHMT2 betaine--homocysteine S-methyltransferase 2 4.78212
CNTN5 contactin 5 4.70027
CD5 CD5 molecule 4.67316
TEKT3 tektin 3 4.65999
SCN10A sodium channel, voltage gated, type X alpha subunit 4.60574
SLC47A2 solute carrier family 47 (multidrug and toxin extrusion), member 2 4.57639
RNF6 ring finger protein (C3H2C3 type) 6 4.53269
CDH12 cadherin 12, type 2 (N-cadherin 2) 4.48529
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 4.45606
NECAB1 N-terminal EF-hand calcium binding protein 1 4.42149
GALNT16 polypeptide N-acetylgalactosaminyltransferase 16 4.3775
GSK3B glycogen synthase kinase 3 beta 4.27012
PURG purine-rich element binding protein G 4.24761
ANKRD6 ankyrin repeat domain 6 4.20035
HMOX1 heme oxygenase 1 4.18667
R3HDML R3H domain containing-like 4.17213
CPA6 carboxypeptidase A6 4.16601
SH3BGR SH3 domain binding glutamate-rich protein 4.11075
MMP24 matrix metallopeptidase 24 (membrane-inserted) 4.05348
SCAF8 SR-related CTD-associated factor 8 3.99468
PLCD1 phospholipase C, delta 1 3.96507
HIPK1 homeodomain interacting protein kinase 1 3.94358
TRPV2 transient receptor potential cation channel, subfamily V, member 2 3.92344
RHBDF2 rhomboid 5 homolog 2 (Drosophila) 3.87827
TMEM229B transmembrane protein 229B 3.84956
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 3.8037
TRPC4 transient receptor potential cation channel, subfamily C, member 4 3.79948
KIF3B kinesin family member 3B 3.79668
SEPTIN2 septin 2 3.7874
ZFYVE19 zinc finger, FYVE domain containing 19 3.78392
TLDC2 TBC/LysM-associated domain containing 2 3.75455
PLAUR plasminogen activator, urokinase receptor 3.71608
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 3.70846
LRRC8B leucine rich repeat containing 8 family, member B 3.7046
MMP7 matrix metallopeptidase 7 3.69825
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 3.67044
SIK2 salt-inducible kinase 2 3.65193
OR4C12 olfactory receptor, family 4, subfamily C, member 12 3.6409
FAM212B family with sequence similarity 212, member B 3.63939
SLC22A14 solute carrier family 22, member 14 3.61749
PRRT3 proline-rich transmembrane protein 3 3.56673
TMEM86A transmembrane protein 86A 3.56104
DEFB116 defensin, beta 116 3.55284
SEC14L6 SEC14-like 6 (S. cerevisiae) 3.54877
MYH2 myosin, heavy chain 2, skeletal muscle, adult 3.53514
ENDOD1 endonuclease domain containing 1 3.53179
CXXC5 CXXC finger protein 5 3.51785
RBM12B RNA binding motif protein 12B 3.48061
HPS1 Hermansky-Pudlak syndrome 1 3.46066
PDZD11 PDZ domain containing 11 3.45585
GDF2 growth differentiation factor 2 3.44713
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 3.43592
OR4C3 olfactory receptor, family 4, subfamily C, member 3 3.41573
ACAT1 acetyl-CoA acetyltransferase 1 3.38272
ZNF438 zinc finger protein 438 3.37117
TMEM72 transmembrane protein 72 3.36486
BTBD17 BTB (POZ) domain containing 17 3.35541
BPIFB1 BPI fold containing family B, member 1 3.33518
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 3.31026
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 3.29549
EMID1 EMI domain containing 1 3.2859
IQCK IQ motif containing K 3.25965
CSNK1A1L casein kinase 1, alpha 1-like 3.25542
VSIG4 V-set and immunoglobulin domain containing 4 3.2551
DNAH2 dynein, axonemal, heavy chain 2 3.22822
PHACTR4 phosphatase and actin regulator 4 3.20246
NKX2-5 NK2 homeobox 5 3.19364
SLC36A4 solute carrier family 36 (proton/amino acid symporter), member 4 3.19161
SDC1 syndecan 1 3.12991
OLFML3 olfactomedin-like 3 3.12788
SCNN1B sodium channel, non voltage gated 1 beta subunit 3.12597
MPPE1 metallophosphoesterase 1 3.09706
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1 3.09552
AFDN afadin, adherens junction formation factor 3.09446
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit 3.08991
SPART spartin 3.08684
CLYBL citrate lyase beta like 3.07834
LPCAT4 lysophosphatidylcholine acyltransferase 4 3.05943
GEM GTP binding protein overexpressed in skeletal muscle 3.0527
SSTR2 somatostatin receptor 2 3.05209
TM9SF4 transmembrane 9 superfamily protein member 4 3.04633
AWAT2 acyl-CoA wax alcohol acyltransferase 2 3.03892
LHFPL4 lipoma HMGIC fusion partner-like 4 3.03622
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 3.02198
ZBED2 zinc finger, BED-type containing 2 3.01469
FOXRED2 FAD-dependent oxidoreductase domain containing 2 3.01324
NOL4L nucleolar protein 4-like 2.99685
FUT10 fucosyltransferase 10 (alpha (1,3) fucosyltransferase) 2.99411
CDC20B cell division cycle 20B 2.96785
MTL5 metallothionein-like 5, testis-specific (tesmin) 2.95661
CUL4B cullin 4B 2.95614
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 2.95442
CDRT1 CMT1A duplicated region transcript 1 2.93971
GUCY1A2 guanylate cyclase 1, soluble, alpha 2 2.93842
CEP250 centrosomal protein 250kDa 2.93277
NPR3 natriuretic peptide receptor 3 2.91804
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1 2.90965
GRM4 glutamate receptor, metabotropic 4 2.89555
RIC8A RIC8 guanine nucleotide exchange factor A 2.89332
NONO non-POU domain containing, octamer-binding 2.89051
BCAR3 breast cancer anti-estrogen resistance 3 2.86883
KHSRP KH-type splicing regulatory protein 2.86483
ISX intestine-specific homeobox 2.859
C11ORF52 chromosome 11 open reading frame 52 2.85304
OR51B4 olfactory receptor, family 51, subfamily B, member 4 2.84526
NME5 NME/NM23 family member 5 2.83126
NCOA6 nuclear receptor coactivator 6 2.82417
TNRC6B trinucleotide repeat containing 6B 2.80814
OR4A5 olfactory receptor, family 4, subfamily A, member 5 2.80318
TTBK1 tau tubulin kinase 1 2.80203
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor 2.79167
DRAM2 DNA-damage regulated autophagy modulator 2 2.78046
BPIFA3 BPI fold containing family A, member 3 2.76607
CPNE1 copine I 2.76352
OR2L13 olfactory receptor, family 2, subfamily L, member 13 2.74097
PRDX1 peroxiredoxin 1 2.7407
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 2.73857
ZNF860 zinc finger protein 860 2.73572
EVA1A eva-1 homolog A (C. elegans) 2.73433
SIPA1L1 signal-induced proliferation-associated 1 like 1 2.72551
INPP5A inositol polyphosphate-5-phosphatase, 40kDa 2.71853
SLC25A48 solute carrier family 25, member 48 2.7149
FAM219A family with sequence similarity 219, member A 2.71362
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 2.71013
TBX15 T-box 15 2.70702
CXCL12 chemokine (C-X-C motif) ligand 12 2.70542
RCVRN recoverin 2.70292
STRADA STE20-related kinase adaptor alpha 2.70158
PIANP PILR alpha associated neural protein 2.70123
STON2 stonin 2 2.69435
LUZP1 leucine zipper protein 1 2.69178
FUT2 fucosyltransferase 2 (secretor status included) 2.68616
FBXO42 F-box protein 42 2.68596
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit 2.67522
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 2.67051
POGLUT3 protein O-glucosyltransferase 3 2.66874
LBP lipopolysaccharide binding protein 2.66629
ZBTB47 zinc finger and BTB domain containing 47 2.66506
EPS8L3 EPS8-like 3 2.66066
PRR9 proline rich 9 2.65901
CDH26 cadherin 26 2.64527
HOXC11 homeobox C11 2.63787
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 2.61653
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 2.61517
LYPD1 LY6/PLAUR domain containing 1 2.61212
ZFYVE1 zinc finger, FYVE domain containing 1 2.60816
APTX aprataxin 2.60648
IGHMBP2 immunoglobulin mu binding protein 2 2.60372
ITGA6 integrin, alpha 6 2.60213
C2ORF50 chromosome 2 open reading frame 50 2.60005
PTPN1 protein tyrosine phosphatase, non-receptor type 1 2.59241
LRRC75B leucine rich repeat containing 75B 2.59221
MSANTD4 Myb/SANT-like DNA-binding domain containing 4 with coiled-coils 2.5913
TASP1 taspase, threonine aspartase, 1 2.58361
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 2.57642
GREM1 gremlin 1, DAN family BMP antagonist 2.57414
OR2T29 olfactory receptor, family 2, subfamily T, member 29 2.5686
TMEM41A transmembrane protein 41A 2.56662
WNT11 wingless-type MMTV integration site family, member 11 2.56501
SH3BP1 SH3-domain binding protein 1 2.56378
ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 2.56216
CLEC4M C-type lectin domain family 4, member M 2.55403
CDCP2 CUB domain containing protein 2 2.54519
SCAND1 SCAN domain containing 1 2.54431
NLGN3 neuroligin 3 2.54154
PHF14 PHD finger protein 14 2.54017
PRKD1 protein kinase D1 2.53877
CERCAM cerebral endothelial cell adhesion molecule 2.53255
SYNGR1 synaptogyrin 1 2.52524
GSTP1 glutathione S-transferase pi 1 2.52412
PROSER1 proline and serine rich 1 2.49585
TEF thyrotrophic embryonic factor 2.49332
MARK3 MAP/microtubule affinity-regulating kinase 3 2.49125
IFT27 intraflagellar transport 27 2.48765
DLX4 distal-less homeobox 4 2.48414
ERMN ermin, ERM-like protein 2.46405
RCE1 Ras converting CAAX endopeptidase 1 2.46112
LHX6 LIM homeobox 6 2.45631
OR56B1 olfactory receptor, family 56, subfamily B, member 1 2.45492
FSTL5 follistatin-like 5 2.45173
HYDIN HYDIN, axonemal central pair apparatus protein 2.44867
STAR steroidogenic acute regulatory protein 2.43513
C7ORF50 chromosome 7 open reading frame 50 2.42607
ELMO2 engulfment and cell motility 2 2.42602
OR2G3 olfactory receptor, family 2, subfamily G, member 3 2.41891
SLAMF9 SLAM family member 9 2.41743
SUN5 Sad1 and UNC84 domain containing 5 2.41402
PNRC2 proline-rich nuclear receptor coactivator 2 2.41389
CCM2L cerebral cavernous malformation 2-like 2.4085
GRAP2 GRB2-related adaptor protein 2 2.39731
RNF113B ring finger protein 113B 2.38276
PPP6R3 protein phosphatase 6, regulatory subunit 3 2.37896
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 2.37794
ENPEP glutamyl aminopeptidase (aminopeptidase A) 2.353
KRT23 keratin 23, type I 2.34777
CTBS chitobiase, di-N-acetyl- 2.34652
CCDC6 coiled-coil domain containing 6 2.34275
RPE65 retinal pigment epithelium-specific protein 65kDa 2.33962
GLG1 golgi glycoprotein 1 2.32757
OR6B1 olfactory receptor, family 6, subfamily B, member 1 2.32624
SPNS1 spinster homolog 1 (Drosophila) 2.3232
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 2.3231
KRT25 keratin 25, type I 2.32112
SAMD4A sterile alpha motif domain containing 4A 2.31584
IFI44L interferon-induced protein 44-like 2.31552
MCTP1 multiple C2 domains, transmembrane 1 2.3153
TRIM55 tripartite motif containing 55 2.30232
HDLBP high density lipoprotein binding protein 2.29696
EMC2 ER membrane protein complex subunit 2 2.28308
XKRX XK, Kell blood group complex subunit-related, X-linked 2.27936
NOX4 NADPH oxidase 4 2.2752
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 2.27356
IQCE IQ motif containing E 2.26959
GABRP gamma-aminobutyric acid (GABA) A receptor, pi 2.26544
LYPLA1 lysophospholipase I 2.26072
OR2T27 olfactory receptor, family 2, subfamily T, member 27 2.25596
LHX5 LIM homeobox 5 2.24629
TP53BP1 tumor protein p53 binding protein 1 2.24385
PDZD2 PDZ domain containing 2 2.24339
ACTL7A actin-like 7A 2.24144
FNDC1 fibronectin type III domain containing 1 2.23389
CSDE1 cold shock domain containing E1, RNA-binding 2.23348
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 2.23094
MFAP3L microfibrillar-associated protein 3-like 2.22951
FAM69C family with sequence similarity 69, member C 2.22372
TRAK1 trafficking protein, kinesin binding 1 2.22114
KRT33A keratin 33A, type I 2.22045
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) 2.21689
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 2.21273
ABHD11 abhydrolase domain containing 11 2.21023
PGBD2 piggyBac transposable element derived 2 2.20217
ZNF561 zinc finger protein 561 2.1957
PMEL premelanosome protein 2.19487
SLC7A3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 2.19465
FAM217A family with sequence similarity 217, member A 2.19432
PRSS53 protease, serine, 53 2.19414
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant 2.19005
N4BP2L2 NEDD4 binding protein 2-like 2 2.18682
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 2.1863
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 2.18029
PCDHB4 protocadherin beta 4 2.17278
PYROXD2 pyridine nucleotide-disulphide oxidoreductase domain 2 2.17276
COLCA2 colorectal cancer associated 2 2.17265
SUN2 Sad1 and UNC84 domain containing 2 2.16674
SLC26A8 solute carrier family 26 (anion exchanger), member 8 2.16516
LRRC37A3 leucine rich repeat containing 37, member A3 2.16231
NRDC nardilysin convertase 2.16073
JPH4 junctophilin 4 2.14063
VCL vinculin 2.12852
SMAP1 small ArfGAP 1 2.12674
DUSP15 dual specificity phosphatase 15 2.12415
ZNF287 zinc finger protein 287 2.11885
FLNB filamin B, beta 2.1181
SLC16A9 solute carrier family 16, member 9 2.10914
CNTNAP2 contactin associated protein-like 2 2.10794
CARD6 caspase recruitment domain family, member 6 2.10644
DPY19L3 dpy-19-like 3 (C. elegans) 2.10192
YPEL1 yippee-like 1 (Drosophila) 2.10086
KIF19 kinesin family member 19 2.09989
NDUFAF2 NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 2.08397
BCL2L15 BCL2-like 15 2.08261
LIMK2 LIM domain kinase 2 2.08043
ARL8B ADP-ribosylation factor-like 8B 2.07948
KCNA10 potassium channel, voltage gated shaker related subfamily A, member 10 2.07648
GPR142 G protein-coupled receptor 142 2.07515
COP1 COP1 E3 ubiquitin ligase 2.07309
GLT8D1 glycosyltransferase 8 domain containing 1 2.07063
TRIOBP TRIO and F-actin binding protein 2.06786
STAC SH3 and cysteine rich domain 2.06548
FAM198A family with sequence similarity 198, member A 2.06506
ZC4H2 zinc finger, C4H2 domain containing 2.05969
NEK5 NIMA-related kinase 5 2.059
VAT1 vesicle amine transport 1 2.05596
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 2.05217
SAMD13 sterile alpha motif domain containing 13 2.05056
BMP4 bone morphogenetic protein 4 2.04685
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 2.04318
ADAM30 ADAM metallopeptidase domain 30 2.04292
GPR35 G protein-coupled receptor 35 2.04282
OXNAD1 oxidoreductase NAD-binding domain containing 1 2.03325
MMP3 matrix metallopeptidase 3 2.03239
IL2RG interleukin 2 receptor, gamma 2.032
TMEM95 transmembrane protein 95 2.02926
TPBGL trophoblast glycoprotein-like 2.0279
MIDEAS mitotic deacetylase associated SANT domain protein 2.02288
SYNPO2L synaptopodin 2-like 2.02214
CPNE7 copine VII 2.02166
SPATA18 spermatogenesis associated 18 2.01866
CLCF1 cardiotrophin-like cytokine factor 1 2.01815
AWAT1 acyl-CoA wax alcohol acyltransferase 1 2.01756
HOXC4 homeobox C4 2.01725
HIST1H3C histone cluster 1, H3c 2.01611
PRR7 proline rich 7 (synaptic) 2.015
IFI27 interferon, alpha-inducible protein 27 2.01392
C1ORF194 chromosome 1 open reading frame 194 2.01375
APOL1 apolipoprotein L, 1 2.01332
PSKH2 protein serine kinase H2 2.0086
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 2.00654
SHISA9 shisa family member 9 2.0031
PLCB2 phospholipase C, beta 2 2.00062