SW48 Gene Set

Dataset Achilles Cell Line Gene Essentiality Profiles
Category disease or phenotype associations
Type cell line
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Genes

244 gene knockdowns changing fitness of SW48 relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.

increased fitness

Symbol Name Standardized Value
HOXC8 homeobox C8 2.60029
TUSC1 tumor suppressor candidate 1 2.25679
PCDHGA10 protocadherin gamma subfamily A, 10 2.2153
OR7E91P olfactory receptor, family 7, subfamily E, member 91 pseudogene 2.1214
ELL elongation factor RNA polymerase II 2.04406
NOS2 nitric oxide synthase 2, inducible 2.04366
POLR1C polymerase (RNA) I polypeptide C, 30kDa 2.03907
RAB36 RAB36, member RAS oncogene family 1.96431
LAMB3 laminin, beta 3 1.94923
ATOH7 atonal homolog 7 (Drosophila) 1.93432
GNPAT glyceronephosphate O-acyltransferase 1.91157
SP2 Sp2 transcription factor 1.8925
CAPN9 calpain 9 1.7694
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast) 1.76347
UBTF upstream binding transcription factor, RNA polymerase I 1.74097
POLR3B polymerase (RNA) III (DNA directed) polypeptide B 1.71922
UBE2G1 ubiquitin-conjugating enzyme E2G 1 1.70185
ZNF689 zinc finger protein 689 1.69925
TARBP1 TAR (HIV-1) RNA binding protein 1 1.66784
HPCA hippocalcin 1.65213
PLD2 phospholipase D2 1.63251
ZNF83 zinc finger protein 83 1.6127
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 1.60963
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 1.60604
UBA1 ubiquitin-like modifier activating enzyme 1 1.59797
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 1.58944
EFCAB2 EF-hand calcium binding domain 2 1.57106
TICAM2 toll-like receptor adaptor molecule 2 1.54337
CABLES1 Cdk5 and Abl enzyme substrate 1 1.53784
AFG3L1P AFG3-like AAA ATPase 1, pseudogene 1.53081
CAMK1 calcium/calmodulin-dependent protein kinase I 1.5201
IL31RA interleukin 31 receptor A 1.48714
HOXD11 homeobox D11 1.47988
PHF3 PHD finger protein 3 1.47233
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 1.46923
FUBP3 far upstream element (FUSE) binding protein 3 1.46077
INMT indolethylamine N-methyltransferase 1.45664
METTL4 methyltransferase like 4 1.43731
ALPPL2 alkaline phosphatase, placental-like 2 1.43355
ABHD11 abhydrolase domain containing 11 1.42703
PECR peroxisomal trans-2-enoyl-CoA reductase 1.41411
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 1.40299
MCHR2 melanin-concentrating hormone receptor 2 1.4013
RPE ribulose-5-phosphate-3-epimerase 1.38795
IL7R interleukin 7 receptor 1.3655
IFT20 intraflagellar transport 20 1.35568
MAGED1 melanoma antigen family D1 1.3498
ZNF497 zinc finger protein 497 1.33397
MMP21 matrix metallopeptidase 21 1.32967
MYEF2 myelin expression factor 2 1.31839
RANBP1 RAN binding protein 1 1.30201
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 1.29897
LBX1 ladybird homeobox 1 1.29109
MMD2 monocyte to macrophage differentiation-associated 2 1.28553
RHBDD3 rhomboid domain containing 3 1.28266
STK38L serine/threonine kinase 38 like 1.28147
PAQR4 progestin and adipoQ receptor family member IV 1.27576
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1 1.27376
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit 1.27183
VEZF1 vascular endothelial zinc finger 1 1.27031
TPSG1 tryptase gamma 1 1.26934
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa 1.26461
RRM2 ribonucleotide reductase M2 1.258
LMNA lamin A/C 1.24445
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 1.23871
PIP5KL1 phosphatidylinositol-4-phosphate 5-kinase-like 1 1.23654
HIST1H2AK histone cluster 1, H2ak 1.23184
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 1.22827
PDIK1L PDLIM1 interacting kinase 1 like 1.22373
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 1.22137
HSD11B1L hydroxysteroid (11-beta) dehydrogenase 1-like 1.22081
BRPF3 bromodomain and PHD finger containing, 3 1.2127
UCN urocortin 1.19956
ADAT3 adenosine deaminase, tRNA-specific 3 1.1977
TPCN2 two pore segment channel 2 1.19191
IVNS1ABP influenza virus NS1A binding protein 1.18924
TONSL tonsoku-like, DNA repair protein 1.18818
GRAP GRB2-related adaptor protein 1.18789
RBM47 RNA binding motif protein 47 1.16892
HOXB6 homeobox B6 1.16634
NSRP1 nuclear speckle splicing regulatory protein 1 1.16542
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 1.16123
GDF10 growth differentiation factor 10 1.1492
RNPEP arginyl aminopeptidase (aminopeptidase B) 1.14897
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 1.14445
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 1.12963
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 1.1285
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 1.12637
HTRA4 HtrA serine peptidase 4 1.12212
FXYD2 FXYD domain containing ion transport regulator 2 1.12046
ARL9 ADP-ribosylation factor-like 9 1.11533
PHPT1 phosphohistidine phosphatase 1 1.11482
NXF3 nuclear RNA export factor 3 1.10814
ZNF358 zinc finger protein 358 1.10617
ADRB3 adrenoceptor beta 3 1.10542
CP ceruloplasmin (ferroxidase) 1.10512
AKR1E2 aldo-keto reductase family 1, member E2 1.10428
KCNG4 potassium channel, voltage gated modifier subfamily G, member 4 1.09637
NPHP4 nephronophthisis 4 1.09429
RAB28 RAB28, member RAS oncogene family 1.09121
HAAO 3-hydroxyanthranilate 3,4-dioxygenase 1.09111
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 1.08908
GRM8 glutamate receptor, metabotropic 8 1.08495
TAS2R1 taste receptor, type 2, member 1 1.08286
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 1.07825
RAB1B RAB1B, member RAS oncogene family 1.07787
MORF4L1 mortality factor 4 like 1 1.07736
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 1.07623
NDN necdin, melanoma antigen (MAGE) family member 1.07338
EPRS glutamyl-prolyl-tRNA synthetase 1.07216
HIST3H2A histone cluster 3, H2a 1.06609
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa 1.06089
CAPSL calcyphosine-like 1.0601
NUP54 nucleoporin 54kDa 1.05917
SLC7A10 solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10 1.05727
LPGAT1 lysophosphatidylglycerol acyltransferase 1 1.05424
C17ORF85 chromosome 17 open reading frame 85 1.05362
IL17RB interleukin 17 receptor B 1.05252
SOX18 SRY (sex determining region Y)-box 18 1.04704
TMED7-TICAM2 TMED7-TICAM2 readthrough 1.04387
EIF5A eukaryotic translation initiation factor 5A 1.04189
ZNF521 zinc finger protein 521 1.03827
ZBTB40 zinc finger and BTB domain containing 40 1.03487
HYOU1 hypoxia up-regulated 1 1.02516
RAB11A RAB11A, member RAS oncogene family 1.02454
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 1.01527
TRIM41 tripartite motif containing 41 1.01445
NUPL1 nucleoporin like 1 1.01234
EPHA8 EPH receptor A8 1.01225
PABPN1 poly(A) binding protein, nuclear 1 1.01139
DMTF1 cyclin D binding myb-like transcription factor 1 1.00847
HRK harakiri, BCL2 interacting protein 1.00838
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 1.00754
POLR2G polymerase (RNA) II (DNA directed) polypeptide G 1.00204
LPP LIM domain containing preferred translocation partner in lipoma 1.00153

decreased fitness

Symbol Name Standardized Value
DNTT DNA nucleotidylexotransferase -2.3553
ERP29 endoplasmic reticulum protein 29 -2.09024
PRSS48 protease, serine, 48 -2.03692
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -2.01735
FAS Fas cell surface death receptor -1.99573
ELF1 E74-like factor 1 (ets domain transcription factor) -1.92853
LDHB lactate dehydrogenase B -1.74424
PCDHA8 protocadherin alpha 8 -1.7203
CSF3R colony stimulating factor 3 receptor (granulocyte) -1.71025
ZSCAN5A zinc finger and SCAN domain containing 5A -1.70121
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 -1.66124
RAB35 RAB35, member RAS oncogene family -1.65958
NLRP3 NLR family, pyrin domain containing 3 -1.64225
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -1.60416
MORC1 MORC family CW-type zinc finger 1 -1.5861
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 -1.57492
EXO1 exonuclease 1 -1.56597
STS steroid sulfatase (microsomal), isozyme S -1.55348
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 -1.53882
CCL7 chemokine (C-C motif) ligand 7 -1.5221
GNPNAT1 glucosamine-phosphate N-acetyltransferase 1 -1.50366
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 -1.50184
PHF1 PHD finger protein 1 -1.475
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 -1.46554
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) -1.46526
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 -1.46071
BIRC8 baculoviral IAP repeat containing 8 -1.45637
GPR183 G protein-coupled receptor 183 -1.44609
LYPLAL1 lysophospholipase-like 1 -1.43223
VAMP7 vesicle-associated membrane protein 7 -1.41759
PRG3 proteoglycan 3 -1.39836
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 -1.39262
CPN1 carboxypeptidase N, polypeptide 1 -1.38127
EPHA4 EPH receptor A4 -1.37534
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5 -1.35386
GNG7 guanine nucleotide binding protein (G protein), gamma 7 -1.34421
MC3R melanocortin 3 receptor -1.33828
MYO1A myosin IA -1.33462
CCKBR cholecystokinin B receptor -1.33053
RGS17 regulator of G-protein signaling 17 -1.32865
PCDH11Y protocadherin 11 Y-linked -1.32853
CBR3 carbonyl reductase 3 -1.3265
CYLD cylindromatosis (turban tumor syndrome) -1.32613
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1 -1.31693
SLC26A6 solute carrier family 26 (anion exchanger), member 6 -1.31434
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 -1.30812
UBAP2 ubiquitin associated protein 2 -1.30223
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) -1.29392
RIN2 Ras and Rab interactor 2 -1.2917
GPR119 G protein-coupled receptor 119 -1.28596
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 -1.27888
TK1 thymidine kinase 1, soluble -1.26906
SLC26A11 solute carrier family 26 (anion exchanger), member 11 -1.26595
IL17RC interleukin 17 receptor C -1.26468
POLB polymerase (DNA directed), beta -1.25444
NLK nemo-like kinase -1.2532
PTEN phosphatase and tensin homolog -1.25014
SLC25A40 solute carrier family 25, member 40 -1.2316
LMO7 LIM domain 7 -1.2282
DCHS1 dachsous cadherin-related 1 -1.22016
ZNF781 zinc finger protein 781 -1.21888
PTENP1 phosphatase and tensin homolog pseudogene 1 (functional) -1.21092
GTF2A1L general transcription factor IIA, 1-like -1.18845
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 -1.18391
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -1.17762
IL1RAP interleukin 1 receptor accessory protein -1.17648
CXCL11 chemokine (C-X-C motif) ligand 11 -1.1677
CST11 cystatin 11 -1.16303
ZNF250 zinc finger protein 250 -1.16254
PCDHA4 protocadherin alpha 4 -1.1577
MCM4 minichromosome maintenance complex component 4 -1.15708
TRPM3 transient receptor potential cation channel, subfamily M, member 3 -1.15565
PPP1R9A protein phosphatase 1, regulatory subunit 9A -1.14656
FZD4 frizzled class receptor 4 -1.13979
KCTD3 potassium channel tetramerization domain containing 3 -1.1352
STON1-GTF2A1L STON1-GTF2A1L readthrough -1.13231
SOX30 SRY (sex determining region Y)-box 30 -1.13142
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) -1.12273
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -1.11572
ANPEP alanyl (membrane) aminopeptidase -1.11385
NME1 NME/NM23 nucleoside diphosphate kinase 1 -1.10477
IDI1 isopentenyl-diphosphate delta isomerase 1 -1.09591
ARF5 ADP-ribosylation factor 5 -1.09398
PCDHA13 protocadherin alpha 13 -1.09187
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -1.07767
HAL histidine ammonia-lyase -1.06882
EHBP1 EH domain binding protein 1 -1.06813
MMP14 matrix metallopeptidase 14 (membrane-inserted) -1.06768
FBXO9 F-box protein 9 -1.06576
PTS 6-pyruvoyltetrahydropterin synthase -1.05971
GLP2R glucagon-like peptide 2 receptor -1.05094
RAB23 RAB23, member RAS oncogene family -1.04828
RP1 retinitis pigmentosa 1 (autosomal dominant) -1.04287
MAP3K7 mitogen-activated protein kinase kinase kinase 7 -1.03369
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase) -1.02954
ZNF382 zinc finger protein 382 -1.02846
KRT17 keratin 17, type I -1.02817
HSDL1 hydroxysteroid dehydrogenase like 1 -1.02757
NCS1 neuronal calcium sensor 1 -1.01929
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) -1.01841
PCDHA6 protocadherin alpha 6 -1.01444
ACAA1 acetyl-CoA acyltransferase 1 -1.01229
IL2RA interleukin 2 receptor, alpha -1.0112
NME1-NME2 NME1-NME2 readthrough -1.01084
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta -1.00636
FRAS1 Fraser extracellular matrix complex subunit 1 -1.0019
ADAMDEC1 ADAM-like, decysin 1 -1.00188
ELMO2 engulfment and cell motility 2 -1.00171
SASH3 SAM and SH3 domain containing 3 -1.00089